期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 437, 期 1, 页码 79-86出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.06.040
关键词
Thio-Cl-IB-MECA; Anti-angiogenesis; PI3K/AKT/mTOR; ERK; Endothelial cells
资金
- National Research Foundation
- Korean Government (MEST) [2009-0083533]
- Seoul RBD program [10541]
Although A(3)AR agonists exhibit a variety of biological activities including anticancer effects, their possible anti-angiogenic effects have not yet been investigated. In the present study, we assayed the anti-angiogenic activity of thio-Cl-IB-MECA, a novel A(3)AR agonist, in cultured HUVECs and mES/EB-derived endothelial cells. Thio-Cl-IB-MECA inhibited migration and tube formation by endothelial cells and dramatically decreased ex vivo microvessel sprouting in cultured mouse aortic rings. The anti-angiogenic activity of thio-Cl-IB-MECA was associated with suppression of the expression of the endothelial biomarker PECAM via regulation of PI3K/AKT/mTOR and ERIK signaling in mES/EB-derived endothelial cells. (c) 2013 Elsevier Inc. All rights reserved.
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