期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 440, 期 4, 页码 640-645出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.09.115
关键词
Synaptojanin; Inositol polyphosphate phosphatase; Spermatogenesis; Non-canonical promoter; Mouse
资金
- INBRE program of the National Institutes of Health [P20 RR016463]
- North Carolina State University [NC07313]
Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis. Transcription of Synj2 is thought to occur from one of two promoters based on analysis of a variable 5' untranslated region. Clustering all known mouse Synj2 transcripts led us to uncover a novel subset of transcripts that appears to derive from a region located within intron 7. We identified two alternate splice variants emanating from use of this promoter. These alternate splice variants manifest developmental stage specificity and somatic versus gametic differences in expression. (C) 2013 Elsevier Inc. All rights reserved.
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