期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 438, 期 2, 页码 329-333出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.07.071
关键词
Drosophila melanogaster; Zelda (Zld); Larval wing disc
资金
- University of Athens
The transcription factor Zelda plays a pivotal role in promoting the maternal to zygotic transition during embryogenesis in Drosophila melanogaster. However, little is known about its role later in development. Here we are showing that Zelda is essential for proper wing development through gain and loss of function experiments. Zelda's transcript variants RB, RC and RD are present in imaginal wing discs of third instar larvae and the production of 2 protein isoforms of similar to 180 and similar to 70 kD was detected in the same tissue. In ChIP experiments using larval wing discs, Zelda was found to bind to a region of the optomotor-blind gene, suggesting an interaction with a Dpp target that promotes wing growth and patterning. (C) 2013 Elsevier Inc. All rights reserved.
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