Article
Biochemistry & Molecular Biology
Qiling Tang, Hongce Chen, Zihao Mai, Han Sun, LingJun Xu, Guihao Wu, Zhuang Tu, Xuecheng Cheng, Xiaoping Wang, Tongsheng Chen
Summary: Abivertinib (AC) is a novel epidermal growth factor receptor tyrosine kinase inhibitor that exhibits highly efficient antitumor activity. This study demonstrates that AC can induce both reactive oxygen species (ROS)-dependent apoptosis and ferroptosis in tumor cells. The Bim- and Bax-mediated mitochondrial pathways play a dominant role in AC-induced ferroptosis and apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kaiming Li, Mark F. van Delft, Grant Dewson
Summary: Apoptotic cell death plays important roles in physiological and pathological processes, especially in cancer therapy and neurodegenerative diseases. Inhibitors of apoptosis have emerged as a potential strategy to combat pathological cell loss, serving as important research tools due to their mechanisms of action, advantages, and limitations.
Review
Biochemistry & Molecular Biology
Peticha Tanprasert, Sirikan Limpakan (Yamada), Siriporn C. Chattipakorn, Nipon Chattipakorn, Krekwit Shinlapawittayatorn
Summary: This review discusses the homeostasis of gastric cancer cells and highlights the potential role of mitochondria in gastric cancer therapy.
Article
Oncology
Fei Peng, Weisong Cai, Jianping Li, Haohuan Li
Summary: This study demonstrates that ClC-5 downregulation induces apoptosis in osteosarcoma cells via the activation of the mitochondria-dependent apoptotic pathway. Lowering intracellular Cl- concentration increases cell viability, while knockdown of ClC-5 promotes apoptosis and disrupts cell survival in osteosarcoma. The interaction between ClC-5 and Bax, along with the promotion of Bax translocation, plays a crucial role in this apoptotic process.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Hanmin Tang, Jing Wang, Xuehui Luo, Qi Wang, Jie Chen, Xinyue Zhang, Qiuting Li, Chengyi Gao, Yuesen Li, Suxia Han
Summary: The apoptosis-related gene prognostic index (ARGPI) can serve as a promising biomarker for determining the risk of colon cancer progression, as well as molecular and immune characteristics and chemotherapeutic benefit. Through molecular analysis, it is a reliable method to predict the prognosis of colon cancer patients and assist doctors in formulating more effective treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Atefeh Maddah, Nasrin Ziamajidi, Hossein Khosravi, Hiva Danesh, Roghayeh Abbasalipourkabir
Summary: This study investigated the apoptotic and anti-cancer effect of gold nanoparticles on HCT-116 colon cancer cells. The results showed that treatment with nanoparticles led to an increase in the expression of Bax and P53 genes, a decrease in the expression of Bcl-2 and CCNB1 genes, and an increase in the level of apoptosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Hylde Zirpoli, Sergey A. Sosunov, Zoya Niatsetskaya, Korapat Mayurasakorn, Denny Joseph Manual Kollareth, Charles N. Serhan, Vadim S. Ten, Richard J. Deckelbaum
Summary: Mitochondria-related cell death pathways play a crucial role in ischemic brain injury, and the administration of neuroprotectin D1 (NPD1) post-injury can rapidly provide neuroprotection by preserving mitochondrial membrane structure and reducing BAX mitochondrial translocation and activation.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Liu, Shiyao Cui, Wenle Li, Hongqing Xie, Liangen Shi
Summary: This study investigated the anti-colon cancer effects of Phellinus baumii polyphenol (PBP) and its potential mechanisms using network pharmacology and experimental verification. The results showed that PBP significantly inhibited cell proliferation, promoted apoptosis, and arrested the cell cycle in S phase, suggesting its potential as an alternative therapeutic strategy for colon cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Almog Nadir, Anna Shteinfer-Kuzmine, Swaroop Kumar Pandey, Juan Ortas, Daniel Kerekes, Varda Shoshan-Barmatz
Summary: This study identified three different plant extracts that can effectively induce cell death and focused on the most potent extract. The extract kills tumor cells through multiple mechanisms, including impairing cell energy and metabolism, generating reactive oxygen species, increasing intracellular calcium levels, and inducing mitochondria-mediated apoptosis. In a mouse model of glioblastoma, the extract inhibits tumor growth and induces massive tumor cell death, including cancer stem cells, by inhibiting blood supply and modulating the tumor microenvironment. These findings suggest that the plant extract has potential as a cancer therapeutic.
Review
Medicine, Research & Experimental
Sheema Hashem, Tayyiba Akbar Ali, Sabah Akhtar, Sabah Nisar, Geetanjali Sageena, Shahid Ali, Sharefa Al-Mannai, Lubna Therachiyil, Rashid Mir, Imadeldin Elfaki, Mohammad Muzaffar Mir, Farrukh Jamal, Tariq Masoodi, Shahab Uddin, Mayank Singh, Mohammad Haris, Muzafar Macha, Ajaz A. Bhat
Summary: Cancer is a major cause of death and a burden to healthcare system. Natural products, with their accessibility, applicability, and reduced cytotoxicity, have been an important source of anticancer drugs. They play a major role in cancer treatment by modulating cancer microenvironment and different signaling pathways, mainly cell death pathways and embryonic developmental pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Hong Namkoong, Bomi Lee, Gayathri Swaminathan, Seong-Joon Koh, Stephan Rogalla, Maria D. Paraskevopoulou, Jay Tang, David Mikhail, Laren S. Becker, Aida Habtezion
Summary: This study reveals the important role of the GPR15-GPR15L axis in promoting a tumor-suppressive immune microenvironment and uncovers a novel, colon-specific therapeutic target for CRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shireesha Manturthi, Dwaipayan Bhattacharya, Kalyani Rajesh Sakhare, Kumar Pranav Narayan, Srilakshmi Patri
Summary: Cimetidine, acting as a hydrophilic domain in cationic lipids, can target genes to the gastric system through in vitro transfection. Tocopherol-based lipids showed better transfection efficacy in colon cancer cell lines.
Article
Chemistry, Medicinal
Zhenwei Zhang, Shan Zhao, Jiying Pei, Linghui Hou, Shenglin Luan, Hongguang Deng, Dan Liu, Min Huang, Linxiang Zhao
Summary: Direct activation of BAX, a pro-apoptotic protein, is a potential therapeutic strategy for inducing apoptosis in cancer. In this study, structural optimization of BTSA1, a BAX trigger site activator, led to the development of pyrazolone derivatives, with compound 6d exhibiting enhanced antiproliferative effects and apoptosis induction compared to BTSA1. Mechanism of action studies revealed that compound 6d could activate the BAX cascade, leading to mitochondrial membrane insertion, MOMP activation, cytochrome c release, and apoptosis. Furthermore, 6d showed improved stability and CYPs profile compared to BTSA1. This work may pave the way for the development of potent BAX trigger site activators for BAX-expressing malignancies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Minkyeong Lee, Changwon Yang, Sunwoo Park, Gwonhwa Song, Whasun Lim
Summary: Fraxetin is a natural compound with anticancer properties, capable of inhibiting colon cancer cell growth and inducing apoptosis through various mechanisms. Additionally, it shows synergistic effects with 5-fluorouracil or irinotecan in targeting colon cancer cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Hongshan Zhao, Zeyan Zhang
Article
Biochemical Research Methods
Di Wen, Zhi Chen, Zeyan Zhang, Qiangqiang Jia
PROTEIN EXPRESSION AND PURIFICATION
(2020)
Correction
Nanoscience & Nanotechnology
Jingrui Guan, Shengxuan Xia, Zeyan Zhang, Jing Wu, Haiyu Meng, Jing Yue, Xiang Zhai, Lingling Wang, Shuangchun Wen
NANOSCALE RESEARCH LETTERS
(2020)
Article
Nanoscience & Nanotechnology
Jingrui Guan, Shengxuan Xia, Zeyan Zhang, Jing Wu, Haiyu Meng, Jing Yue, Xiang Zhai, Lingling Wang, Shuangchun Wen
NANOSCALE RESEARCH LETTERS
(2020)
Article
Cell Biology
Zeyan Zhang, Qianfu Gao, Shanchao Wang
Summary: The study found that GSK3 beta suppresses the progression of CRC through the FTO-regulated MZF1/c-Myc axis, providing a new possible pathway for CRC treatment.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shanchao Wang, Zeyan Zhang, Qianfu Gao
Summary: In this study, it was found that cancer cell-derived extracellular vesicles (EVs) promoted colorectal cancer (CRC) progression by delivering miR-25, which targeted SIRT6. SIRT6, in turn, inhibited NRP-1 through downregulation of Lin28b. Tumor-bearing nude mouse experiments confirmed that EVs transferred miR-25 to facilitate tumor formation and metastasis by inhibiting SIRT6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Qianfu Gao, Shanchao Wang, Zeyan Zhang
Summary: This study reveals the antitumor activity of SMURF2 in colorectal cancer (CRC) and the mechanism associated with the degradation of YY1 and the downregulation of SENP1/c-myc.
Article
Cell Biology
Shang-Ze Li, Ze-Yan Zhang, Jie Chen, Ming-You Dong, Xue-Hua Du, Jie Gao, Qi-Peng Shu, Chao Li, Xin-Yi Liang, Zhi-Hao Ding, Run-Lei Du, Junli Wang, Xiao-Dong Zhang
Summary: Nemo-like kinase (NLK) phosphorylates SRF at Ser101/103, enhancing its association with ELK and antagonizing the SRF/MKL pathway, thus regulating muscle development.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Xiaoyi Xu, Xin He, Zeyan Zhang, Yanyi Chen, Junyu Li, Shanshan Ma, Qiaoying Huang, Mingtao Li
Summary: This study identified that the inactivation of CREB and decreased expression of NURR1 are associated with nigral dopaminergic neurodegeneration in Parkinson's disease (PD). The mechanism underlying CREB inactivation involves the interaction between HDAC1/PP1y complex and CREB, and disrupting this interaction can restore CREB activity and protect dopaminergic neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Jie Yang, Qianghu Wang, Ze-Yan Zhang, Lihong Long, Ravesanker Ezhilarasan, Jerome M. Karp, Aristotelis Tsirigos, Matija Snuderl, Benedikt Wiestler, Wolfgang Wick, Yinsen Miao, Jason T. Huse, Erik P. Sulman
Summary: Molecular classification has improved diagnosis and treatment for patients with malignant gliomas. This study proposes using DNA methylation as a clinical diagnostic platform to classify gliomas and provide subtype characteristics, showing accurate prediction and improvement over existing classifiers. The developed Unified Diagnostic Pipeline (UniD) is rapid and cost-effective, and can be applied to other malignancies.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Aram S. Modrek, Eskil Eskilsson, Ravesanker Ezhilarasan, Qianghu Wang, Lindsey D. Goodman, Yingwen Ding, Ze-Yan Zhang, Krishna P. L. Bhat, Thanh-Thuy T. Le, Floris P. Barthel, Ming Tang, Jie Yang, Lihong Long, Joy Gumin, Frederick F. Lang, Roel G. W. Verhaak, Kenneth D. Aldape, Erik P. Sulman
Summary: This study demonstrates that PDPN expression is associated with prognosis and treatment resistance in gliomas. Knockdown of PDPN sensitizes glioma cells to radiation therapy and improves overall survival in a mouse model. Therefore, PDPN may serve as a novel therapeutic target for gliomas.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Aram S. Modrek, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G. W. Verhaak, Erik P. Sulman
Summary: CAPTURE is a single-cell barcoding approach that comprehensively traces clonal dynamics and captures resistant cells for in-depth analysis and exploration. The study finds that resistance in BRAF(V600E) melanoma is dominated by heterogeneous clones and drug-tolerant persister cells, and uncovers various resistance mechanisms. The findings provide new therapeutic insights and a platform for studying treatment resistance in other cancers.
Article
Optics
Zhao Hongshan, Zhang Zeyan
ACTA OPTICA SINICA
(2020)
Meeting Abstract
Oncology
Ze-yan Zhang, Ravesanker Ezhilarasan, Yingwen Ding, Qianghu Wang, Jie Yang, Lihong Long, Roel G. Verhaak, Erik P. Sulman
Meeting Abstract
Oncology
Soon Young Park, Yuji Piao, Emmanuel Martinez-Ledesma, Jianwen Dong, Sabbir Khan, Sandeep Mittal, Ze-yan Zhang, Erik P. Sulman, Veerakumar Balasubramaniyan, John F. de Groot
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
