Article
Biochemistry & Molecular Biology
Yuanyuan Zhang, Weidong Fei, Huiwen Zhang, Yi Zhou, Li Tian, Jing Hao, Yuhan Yuan, Wenlong Li, Yunjun Liu
Summary: The iridium (III) complex [Ir(bzq)(2)(PYIP)](PF6) showed significant cytotoxic activity on BEL-7402 cells, with the liposomes inducing apoptosis through intrinsic mitochondrial pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jing Chen, Haimei Liu, Yichuan Chen, Huiyan Hu, Chunxia Huang, Yi Wang, Lijuan Liang, Yunjun Liu
Summary: In this article, two new iridium(III) complexes were synthesized and their anti-cancer activity was investigated. The results showed that these complexes induced apoptosis in BEL-7402 cells through ROS-mediated mitochondrial dysfunction and inhibition of the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Oncology
Quan Lin, Yan Jia, Duo Zhang, Hongjuan Jin
Summary: The study reveals that NCK1-AS1 is overexpressed in melanoma cell lines, and its knockdown inhibits the proliferation and migration of melanoma cells. Additionally, miR-526b-5p binds to NCK1-AS1 in melanoma, with ADAM15 validated as its downstream target.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Yun-Qiong Gu, Yu-Jun Zhong, Mei-Qi Hu, Huan-Qing Li, Kun Yang, Qi Dong, Hong Liang, Zhen-Feng Chen
Summary: The four copper complexes showed higher cytotoxic activity against various cancer cell lines, especially BEL-7402 cells, with low toxicity to normal human liver cells. Mechanistic studies revealed that they induced apoptosis by inducing G0/G1 arrest and altering the expression of cell cycle-related proteins.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Michael Chute, Preetinder K. Aujla, Yingxi Li, Sayantan Jana, Pavel Zhabyeyev, Jaslyn Rasmuson, Caroline A. Owen, Thomas Abraham, Gavin Y. Oudit, Zamaneh Kassiri
Summary: ADAM15 plays an important role in heart disease, and its deficiency can lead to impaired scar formation after myocardial infarction, potentially related to collagen cross-linking and kinase expression.
Article
Biochemistry & Molecular Biology
Xiang Wang, Sen Zhang, Keyan Han, Lisheng Wang, Xu Liu
Summary: This study investigates the antiproliferative and apoptosis-inducing effects of matrine derivatives, particularly ZS17, on hepatocellular carcinoma cells. ZS17 showed strong antiproliferative activity and induced apoptosis and ROS production in vitro. Mechanistic studies revealed that ZS17 activates the ROS-JNK-P53 pathway and inhibits tumor cell migration and growth in vivo. These findings suggest that ZS17 could be a promising chemotherapeutic agent for the treatment of hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Beryl Laplace-Builhe, Audrey Barthelaix, Said Assou, Candice Bohaud, Marine Pratlong, Dany Severac, Gautier Tejedor, Patricia Luz-Crawford, Mai Nguyen-Chi, Marc Mathieu, Christian Jorgensen, Farida Djouad
Summary: This study utilized single-cell RNA sequencing to characterize the cells involved in blastema formation and fin regeneration in zebrafish, highlighting the role of neural crest cells in orchestrating regeneration through the NRG1/ErbB axis. The presence of foxd3-positive neural crest-derived cells was identified to be crucial in regulating macrophage recruitment and polarization during blastema formation and caudal fin regeneration. The findings underscore the critical function of the NRG1/ErbB pathway in controlling the communication between macrophages and neural crest-derived cells during fish fin regeneration.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Dongmei Tang, Yitong Lu, Na Zuo, Renchun Yan, Cheng Wu, Lijuan Wu, Shaofeng Liu, Yingzi He
Summary: This study demonstrates the important role of Kdm6b in the development of the zebrafish hearing organ, regulating the migration of primordium and deposition of neuromasts through mediating the gene expression of chemokines and Wnt and Fgf signaling pathways. Targeting Kdm6b may present as a novel therapeutic regimen for hearing disorders.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Krzysztof Bartlomiej Piotrowski, Laia Puig Blasco, Jacob Samsoe-Petersen, Rikke Lovendahl Eefsen, Martin Illemann, Victor Oginga Oria, Karla Iveth Aguilera Campos, Alexia Melanie Lopresti, Reidar Albrechtsen, Claus Storgaard Sorensen, Xiao-Feng Sun, Marie Kveiborg, Sebastian Gnosa
Summary: Radiotherapy is a common cancer treatment, but some patients require high doses to respond. Personalizing therapy is important to avoid unnecessary burden on cancer patients. ADAM12 is upregulated in cancers and correlates with poor survival and chemoresistance. ADAM12 expression is upregulated in response to irradiation and correlates with disease stage and treatment response in rectal cancer patients. Depletion of ADAM12 reduces tumor growth in irradiated cancer cells and alters tumor vascularity. ADAM12 can be a prognostic factor and targeting it with radiotherapy may improve treatment response.
CANCER GENE THERAPY
(2023)
Article
Nanoscience & Nanotechnology
Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath, Dino Di Carlo
Summary: By developing secretion-encoded single-cell sequencing (SEC-seq) method, the authors simultaneously measured the secretion and transcriptome for thousands of cells, and found heterogeneity in the secretion of vascular endothelial growth factor A (VEGF-A) within the cell population, which is poorly correlated with the VEGFA transcript level. Enrichment of a specific cell subpopulation characterized by a unique gene expression signature enabled the identification of gene signatures linked to specific secretory states. SEC-seq facilitates mechanistic studies and the development of means to modulate cellular secretion.
NATURE NANOTECHNOLOGY
(2023)
Article
Otorhinolaryngology
Zhibin Jing, Sitong Guo, Yao Li, Zheng Liang
Summary: FOXC2 regulates the radiosensitivity of head and neck squamous cell carcinoma by targeting ADAM12. Knockdown of FOXC2 inhibits malignant behaviors and tumor growth, while overexpression of ADAM12 reverses the promotion of FOXC2 silencing on radiosensitivity. The study highlights the potential of FOXC2 and ADAM12 as therapeutic targets in HNSCC radiation therapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Medicine, Research & Experimental
Yu-Ge Zhu, Yun-Xia Lv, Chen-Yi Guo, Zhi-Min Xiao, Qun-Guang Jiang, Huang Kuang, Wen-Hua Zhang, Ping Hu
Summary: The study demonstrates that harmine significantly inhibits the proliferation and migration of U251-MG and U373-MG cells by suppressing the FAK/AKT signaling pathway. These results suggest that harmine could be a promising drug for glioblastoma therapy.
Article
Biotechnology & Applied Microbiology
Jian You, Bei Tao, Lilei Peng, Tangming Peng, Haiping He, Shan Zeng, Jizhong Han, Ligang Chen, Xiangguo Xia, Xiaobo Yang, Chuanhong Zhong
Summary: This study reveals that the transcription factor YY1 promotes the self-renewal of glioblastoma stem cells (GSCs) by upregulating the expression of SUMO enzyme SENP1, enhancing the methyltransferase activity of METTL3, and promoting the m6A modification and expression of MYC mRNA. This finding sheds light on the regulatory mechanism of GSC self-renewal and tumorigenicity.
CANCER GENE THERAPY
(2023)
Article
Neurosciences
Yamila Azul Molinari, Agustin Jesus Byrne, Maria Julia Perez, Lucas Silvestroff, Paula Gabriela Franco
Summary: Despite the extensive use of the cuprizone (CPZ) demyelination animal model, there is little evidence regarding the effects of CPZ on a cellular level. Recent studies have demonstrated that CPZ not only damages mature oligodendrocytes (OL), but also reduces neural stem cell and progenitor cell (NSC/NPC) proliferation and activates progenitor migration. These findings shed light on the direct effects of CPZ on NSC proliferation and in vitro differentiation progression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Ting Zhao, Shengfan Ye, Zimu Tang, Liwei Guo, Zhipeng Ma, Yuxi Zhang, Chun Yang, Jinrong Peng, Jun Chen
Summary: Delta 133p53 plays a protective role against cellular senescence by upregulating antioxidant genes expression, and its decreased expression in brain tissues of AD and ALS patients has been observed. The zebrafish ortholog Delta 113p53 contributes to neurogenesis and brain function maintenance, with loss of cognitive ability observed in mutants but not in wild-type fish at older ages.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)