期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 430, 期 2, 页码 505-511出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.12.006
关键词
Angiogenesis; Colon cancer; c-Myc; HIF-1 alpha; VEGF
资金
- foundation of 973 Program [2009CB521802]
- National Natural Science foundation [30872472, 30973496, 81172512]
Angiogenesis plays a pivotal role in tumor growth. The hypoxia-inducible factor 1, alpha subunit (HIF-1 alpha)/vascular endothelial growth factor pathway is the most important pathway for regulating angiogenesis in the tumor microenvironment. c-Myc is an important oncogene that has many biological functions. In this study, we investigated the role of c-Myc in tumor angiogenesis. We found that the overexpression of c-Myc in colon cancer cells could promote the expression of HIF-1 alpha and that of vascular endothelial growth factor. Moreover, we found that c-Myc regulated HIF-1 alpha at the post-transcriptional level. The results revealed c-Myc-dependent regulation of HIF-1 alpha instead of HIF-1 alpha-dependent c-Myc regulation for the first time. They also showed that c-Myc was essential to regulate colon cancer cell-mediated angiogenesis and contributed to tumor growth. This research provides the theoretical basis for clinical trials of new therapeutic targets of c-Myc and HIF-1 alpha in colon cancer cells. (C) 2012 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据