Article
Peripheral Vascular Disease
Junni Wang, Wanyun Nie, Xishao Xie, Mengqiu Bai, Yanhong Ma, Lini Jin, Liang Xiao, Peng Shi, Yi Yang, Pedro A. Jose, Ines Armando, Jianghua Chen, Weiqiang Lin, Fei Han
Summary: The study identified the role of microRNA-874-3p/ADAM19 in mediating renal fibrosis after acute kidney injury by increasing macrophage infiltration via the Notch1/CCL2 pathway. Modulating the levels of microRNA-874-3p or ADAM19 could potentially slow down the process of renal fibrosis.
Article
Pharmacology & Pharmacy
Yejin Yang, Sugyeong Ha, Somi Jeong, Chae Won Jang, Jeongwon Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: This study compared two reliable toxin-induced mouse kidney fibrosis models in terms of fibrosis and inflammation. The adenine diet-induced kidney fibrosis model exhibited higher inflammatory response with increased fibrosis compared to the folic acid-induced kidney fibrosis model.
Article
Biochemistry & Molecular Biology
Minjung Son, Ga Young Kim, Yejin Yang, Sugyeong Ha, Jeongwon Kim, Doyeon Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Summary: The PPAR pan agonist MHY2013 effectively prevents renal fibrosis in both in vitro and in vivo models, suggesting its therapeutic potential against chronic kidney diseases. MHY2013 inhibits fibroblast activation and reduces inflammation through PPAR gamma and beta activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Immunology
Yi Wen, Hong-Ru Yan, Bin Wang, Bi-Cheng Liu
Summary: Kidney macrophages play crucial roles in the pathogenesis of kidney diseases, with diverse functions ranging from clearing pathogens to promoting fibrosis. Their origins and proliferation are key factors in the accumulation of macrophages after kidney injury. Understanding the mechanisms driving macrophage heterogeneity and function changes could help in the development of targeted therapies for kidney diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hui Chen, Na Liu, Shougang Zhuang
Summary: Macrophages play a crucial role in kidney injury, and targeting their activation mechanisms can significantly improve the outcomes of AKI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Article
Biochemistry & Molecular Biology
Yi-Hsin Lo, Shun-Fa Yang, Ching-Chang Cheng, Kuo-Chiang Hsu, Yu-Syuan Chen, Yu-Ya Chen, Chun-Wei Wang, Siao-Syun Guan, Cheng-Tien Wu
Summary: This study demonstrated the beneficial effects of Nobiletin in improving the progression of chronic kidney disease. Nobiletin was found to alleviate kidney fibrosis, oxidative stress, and inflammatory response. It may serve as a potential therapeutic candidate for the treatment of progressive chronic kidney disease.
Review
Biochemistry & Molecular Biology
Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Chun-Liang Lin
Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease, characterized by glomerular hyperfiltration, progressive albuminuria, and declining estimated glomerular filtration rate leading to kidney failure. Metabolic changes and programmed epigenetic modifications resulting from hyperglycemia are believed to play a role in the development of DKD, although the detailed mechanisms are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Hai-Bo Tan, Yan-Qiu Zheng, Yu-Pei Zhuang
Summary: IL-17A plays a role in DKD that is not only negative; it can alleviate inflammation and fibrosis caused by DKD by regulating autophagy or macrophage phenotype, and contradictory expression of IL-17A has been observed in human DKD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Physiology
Li Feng, Hua-Pan Shu, Lu-Lu Sun, Yu-Chi Tu, Qian-Qian Liao, Li-Jun Yao
Summary: SLIT ligand and its receptor ROBO were initially recognized for their role in axon guidance in central nervous system development. In recent years, the role of the SLIT-ROBO signaling pathway has expanded to cell migration, tumor development, angiogenesis, and bone metabolism. This article reviews the advances in the study of the SLIT-ROBO pathway in various renal pathophysiological and kidney disorders and proposes new directions for further research in this field.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Poonam Dhillon, Jihwan Park, Carmen Hurtado del Pozo, Lingzhi Li, Tomohito Doke, Shizheng Huang, Juanjuan Zhao, Hyun Mi Kang, Rojesh Shrestra, Michael S. Balzer, Shatakshee Chatterjee, Patricia Prado, Seung Yub Han, Hongbo Liu, Xin Sheng, Pieterjan Dierickx, Kirill Batmanov, Juan P. Romero, Felipe Prosper, Mingyao Li, Liming Pei, Junhyong Kim, Nuria Montserrat, Katalin Susztak
Summary: This study utilized single-cell RNA sequencing to investigate cellular diversity and gene expression changes in kidney disease, identifying proximal tubule cells as a key vulnerable cell type with significant impact on disease development. The study revealed a strong association between metabolism (fatty acid oxidation and oxidative phosphorylation) and proximal tubule cell differentiation and disease progression, regulated by nuclear receptors.
Article
Biochemistry & Molecular Biology
Maria D. Sanchez-Nino, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Summary: The interaction between diabetes and Fabry disease may increase the severity of kidney damage by modulating the Gb3 synthesis pathway and downregulating kidney protective genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Pedro Rojas-Morales, Juan Carlos Leon-Contreras, Monica Sanchez-Tapia, Alejandro Silva-Palacios, Agustina Cano-Martinez, Susana Gonzalez-Reyes, Angelica Sarai Jimenez-Osorio, Rogelio Hernandez-Pando, Horacio Osorio-Alonso, Laura Gabriela Sanchez-Lozada, Armando R. Tovar, Jose Pedraza-Chaverri, Edilia Tapia
Summary: This study found that short-term ketogenic diet can increase tolerance to experimental kidney ischemia, reduce kidney injury and inflammation, and enhance antioxidant defenses. This finding opens up possibilities for future therapeutic strategies.
Article
Physiology
Roberto Palacios-Ramirez, Ixchel Lima-Posada, Benjamin Bonnard, Marie Genty, Amaya Fernandez-Celis, Judith Hartleib-Geschwindner, Fabienne Foufelle, Natalia Lopez-Andres, Krister Bamberg, Frederic Jaisser
Summary: Obesity and metabolic diseases are linked to chronic kidney disease, and mineralocorticoid receptor antagonists have shown potential in treating non-diabetic chronic kidney disease associated with metabolic diseases. This study used a mouse model to demonstrate the beneficial effects of the mineralocorticoid receptor antagonist canrenoate in improving metabolic function and reducing proteinuria in chronic kidney disease mice, while also preventing the detrimental effects of a high fat diet on renal fibrosis and inflammation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Rheumatology
William F. Jiemy, Anqi Zhang, Annemieke M. H. Boots, Peter Heeringa, Maria Sandovici, Arjan Diepstra, Sandra Hein, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis S. M. van der Geest
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Antine W. Flikweert, Anneke C. Muller Kobold, Simone van der Sar-van der Brugge, Peter Heeringa, Izabela A. Rodenhuis-Zybert, Johan Bijzet, Adriana Tami, Bernardina T. F. van der Gun, Karin I. Wold, Anke Huckriede, Hildegard Franke, Judith M. A. Emmen, Marloes Emous, Marco J. J. H. Grootenboers, Matijs van Meurs, Peter H. J. van der Voort, Jill Moser
Summary: This study investigated the association between plasma adipokines and COVID-19 severity, systemic inflammation, clinical parameters, and outcome of COVID-19 patients. The results showed that circulating adipokine levels are associated with COVID-19 hospitalization, i.e., the need for oxygen support (general ward) or the need for mechanical ventilation and other organ support in the ICU.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Allergy
Jana Koers, Rocco Sciarrillo, Ninotska I. L. Derksen, Esther M. Vletter, Yvonne E. Fillie-Grijpma, Elisabeth Raveling-Eelsing, Nuno A. G. Graca, Thiemo Leijser, Hendri H. Pas, L. Laura van Nijen-Vos, Maaike V. J. Braham, Anne-Marie Buisman, Jan de Jong, Angela I. Schriek, Anne P. Tio-Gillen, Y. K. Onno Teng, Maurice Steenhuis, Francis H. Swaneveld, Steven W. de Taeye, Marit J. van Gils, Jan J. G. M. Verschuuren, Bram Rutgers, Peter Heeringa, Barbara Horvath, Bart C. Jacobs, Karina de Leeuw, Casper F. M. Franssen, Agnes Veyradier, Paul Coppo, Kyra A. Gelderman, D. h S. Marieke van Ham, Cecile A. C. M. van Els, Diane van der Woude, Ruth Huizinga, Maartje G. Huijbers, Taco W. Kuijpers, Rene E. M. Toes, Nicolaas A. Bos, Theo Rispens
Summary: This study investigated the levels of Fab glycosylation on autoantibodies associated with various B cell-mediated autoimmune diseases and found that elevated Fab glycosylation is present in chronic autoimmune diseases. The increased Fab glycosylation was not limited to a specific subclass of IgG and was not caused by chronic antigen-stimulation. These findings suggest that disease-specific autoantibodies in chronic autoimmune diseases are enriched with Fab glycans.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Ziad A. Massy, Oriane Lambert, Marie Metzger, Mohammed Sedki, Adeline Chaubet, Benjamin Breuil, Acil Jaafer, Ivan Tack, Thao Nguyen-Khoa, Melinda Alves, Justyna Siwy, Harald Mischak, Francis Verbeke, Griet Glorieux, Yves-Edouard Herpe, Joost P. Schanstra, Benedicte Stengel, Julie Klein
Summary: The urinary peptidome (UP) analysis can classify patients with chronic kidney disease (CKD) and improve kidney failure (KF) risk prediction. The study found that the UP can predict KF with high accuracy, comparable to the currently used KF risk equation (KFRE).
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cell Biology
Femmy C. Stempels, Muwei Jiang, Harry M. Warner, Magda-Lena Moser, Maaike H. Janssens, Sjors Maassen, Iris H. Nelen, Rinse de Boer, William F. Jiemy, David Knight, Julian Selley, Ronan O'Cualain, Maksim V. Baranov, Thomas C. Q. Burgers, Roberto Sansevrino, Dragomir Milovanovic, Peter Heeringa, Matthew C. Jones, Rifka Vlijm, Martin ter Beest, Geert van den Bogaart
Summary: Stempels et al. discovered large ESCRT structures in migratory cell types that wrap around clusters of integrins lacking actin. These structures are involved in membrane repair and extracellular vesicle formation. The ESCRT structures are tightly connected to the cellular support and are left behind by the cells with surrounding patches of membrane. The presence of ESCRT structures indicates membrane damage and extracellular shedding.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Rheumatology
Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Munoz-Elias, Eric J. Tarcha, Shawn P. Iadonato, Abraham Rutgers, Peter Heeringa, Wayel H. Abdulahad
Summary: This study aimed to provide a new treatment strategy for GPA by modulating the activity of CD4(+)T(EM) cells using the specific peptide inhibitor, ShK-186. The results showed that ShK-186 reduced the expression levels of IFN gamma, TNF alpha, IL-4, IL-17, and IL-21 in CD4(+)T(H) cells from patients with GPA.
Article
Biochemistry & Molecular Biology
Federica Mescia, Shaghayegh Bayati, Elisabeth Brouwer, Peter Heeringa, Erik J. M. Toonen, Marijke Beenes, Miriam J. Ball, Andrew J. Rees, Renate Kain, Paul A. Lyons, Peter Nilsson, Elisa Pin
Summary: This study aimed to analyze the autoantibody repertoire of AAV patients using antigen arrays and identified previously unreported antibodies linked to the disease and observed possible associations between anti-kinesin antibodies and clinically relevant features within AAV patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jacoba C. Graver, William F. Jiemy, Dania H. A. Altulea, Yannick van Sleen, Shuang Xu, Kornelis S. M. van der Geest, Gwenny M. P. J. Verstappen, Peter Heeringa, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Maria Sandovici
Summary: In patients with giant cell arteritis (GCA), B cells in the inflamed arteries are capable of producing cytokines and steering macrophages towards a pro-inflammatory phenotype. This study provides evidence for a cytokine-mediated role of B cells in GCA and suggests the potential of B-cell targeted therapy.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Transplantation
Emmanouil Mavrogeorgis, Tianlin He, Harald Mischak, Agnieszka Latosinska, Antonia Vlahou, Joost P. Schanstra, Lorenzo Catanese, Kerstin Amann, Tobias B. Huber, Joachim Beige, Harald D. Rupprecht, Justyna Siwy
Summary: Specific urinary peptides combined with artificial intelligence can differentiate various CKD etiologies effectively. The developed models achieved high predictive accuracies in binary and multiclass classifications, demonstrating the potential for non-invasive assessment of CKD etiology.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Ana Amaya-Garrido, Manon Brunet, Benedicte Buffin-Meyer, Alexis Piedrafita, Lucile Grzesiak, Ezechiel Agbegbo, Arnaud Del Bello, Ines Ferrandiz, Serban Ardeleanu, Marcelino Bermudez-Lopez, Camille Fedou, Mylene Camus, Odile Burlet-Schiltz, Jean Massines, Marie Buleon, Guylene Feuillet, Melinda Alves, Eric Neau, Audrey Casemayou, Benjamin Breuil, Jean-Sebastien Saulnier-Blache, Colette Denis, Jakob Voelkl, Griet Glorieux, Sam Hobson, Samsul Arefin, Awahan Rahman, Karolina Kublickiene, Peter Stenvinkel, Jean-Loup Bascands, Stanislas Faguer, Jose M. Valdivielso, Joost P. Schanstra, Julie Klein
Summary: Vascular calcification is a significant risk factor for cardiovascular mortality in patients with chronic kidney disease. A study found that circulating calprotectin is independently associated with calcification, cardiovascular outcomes, and mortality in CKD patients. Inhibition of calprotectin may be a promising strategy to prevent vascular calcification in these patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Jill Moser, Marloes Emous, Peter Heeringa, Izabela A. Rodenhuis-Zybert
Summary: Obesity is an independent risk factor for severe COVID-19, and the mechanisms underlying this relationship are still unclear. There is a hypothesis that suggests SARS-CoV-2 disrupts adipose tissue function through direct infection or indirect mechanisms. Recent studies have shed light on the important role of adipose tissue during the acute phase of infection and its potential for long-term consequences.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Immunology
Rosanne D. Reitsema, Bernd-Cornel Hesselink, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Elisabeth Brouwer, Peter Heeringa, Yannick van Sleen
Summary: This study found differential phenotypes of antigen-presenting cells (APCs) in the peripheral blood of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) patients. The proportions of plasmacytoid DCs (pDCs) and CD141+ conventional DCs (cDC1) were lower in GCA/PMR, while the proportion of CD1c+ conventional DCs (cDC2) was negatively correlated with CRP. Additionally, single cell RNA sequencing identified differentially expressed genes related to inflammation and metabolism in GCA patients' APCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Iwona Wojcik, Manfred Wuhrer, Peter Heeringa, Coen A. Stegeman, Abraham Rutgers, David Falck
Summary: This study found that the glycosylation changes of IgG are associated with disease flares in patients with ANCA-associated vasculitis. In addition, among the glycosylation changes, alterations in Fc bisection and fucosylation levels of IgG are correlated with long-term treatment outcome and impending relapse.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Biochemistry & Molecular Biology
Lucile Grzesiak, Ana Amaya-Garrido, Guylene Feuillet, Nicole Malet, Audrey Swiader, Marie-Kerguelen Sarthou, Amandine Wahart, Damien Ramel, Stephanie Gayral, Joost Peter Schanstra, Julie Klein, Muriel Laffargue
Summary: This study identified LRG1 as a contributor to vascular calcification, suggesting its role in the development of plaque complications in patients with atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)