Review
Environmental Sciences
Ewa Mulkiewicz, Daniel Wolecki, Klaudia Swiacka, Jolanta Kumirska, Piotr Stepnowski, Magda Caban
Summary: This review presents the current state of knowledge on the metabolic pathways of NSAIDs in organisms at various levels of biological organisation. The study found similarities in NSAIDs metabolism to that in mammals, as well as differences such as newly detected metabolites and phase III metabolism in plants. Some metabolites were found to exhibit higher toxicity than their parent forms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Takeshi Tenno, Kohki Kataoka, Natsuko Goda, Hidekazu Hiroaki
Summary: The article discusses the potential application of select non-steroidal anti-inflammatory drugs as tight junction modulators by regulating the PDZ domain of zonula occludens-1. This can lead to decreased epithelial barrier function and improved paracellular absorption of drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Mohd Sajid Ali, Hamad A. Al-Lohedan
Summary: The non-covalent molecular interaction between lysozyme and two important non-steroidal anti-inflammatory drugs (paracetamol and ibuprofen) was studied using fluorescence, UV-visible, circular dichroism spectroscopies, and molecular docking simulations. The results showed that both drugs had a good interaction with lysozyme, with ibuprofen having a slightly stronger interaction than paracetamol. The binding of the drugs with lysozyme involved hydrophobic forces and hydrogen bonding in the case of paracetamol, while hydrophobic interactions dominated in the lysozyme-ibuprofen interaction. Both drugs induced changes in the secondary structure of lysozyme, increasing its alpha-helicity. The results obtained from molecular docking simulations were in excellent agreement with the experimental studies.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Gustavo Marinho Miranda, Vitoria Ohana Ramos e Santos, Jonatas Reis Bessa, Yanna C. F. Teles, Setondji Cocou Modeste Alexandre Yahouedehou, Marilda Souza Goncalves, Jaime Ribeiro-Filho
Summary: The incorporation of drugs into cyclodextrins has shown promising results in improving the pharmacological and biopharmaceutical properties of non-steroidal anti-inflammatory drugs. This systematic review identified 24 different NSAIDs, 12 types of CDs, and 60 distinct inclusion complexes, with meloxicam and beta-CD being the most studied combination.
Review
Pharmacology & Pharmacy
Hongjin Lai, Yi Liu, Juan Wu, Jie Cai, Hui Jie, Yuyang Xu, Senyi Deng
Summary: Inflammatory processes play a crucial role in innate immunity and tumor development in various malignancies. Targeting inflammation with pharmacotherapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), has the potential to reduce the risk of carcinogenesis and enhance the effectiveness of anti-cancer treatments. However, the pharmacogenomic variability of NSAIDs can greatly impact their pharmacokinetics and therapeutic outcomes in cancer patients. Thus, a comprehensive understanding of the pharmacogenomic characteristics of NSAIDs and cancer-related inflammation is important for developing new strategies in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Soumita Ghosh
Summary: Metabolomics is a valuable tool in understanding the side effects of NSAIDs and has the potential to identify drug targets for side effects mitigation. Researchers focus on metabolomics techniques, bio sample handling, and review of metabolomics studies in different biofluids and tissues related to NSAIDs. The altered pathways highlighted in the analysis, such as TCA cycle and amino acid metabolism, provide insights into the disease progression and pathogenesis influenced by NSAIDs.
Article
Immunology
Jing Zhang, Hongguang Sheng, Xiaoyi Tang, Panpan Xia, Zhangwang Li, Minxuan Xu, Jianyong Ma, Yunfeng Shen, Peng Yu, Xiao Liu
Summary: According to a post-hoc analysis from the ORCHID trial, the use of non-steroidal anti-inflammatory drugs (NSAIDs) in hospitalized American adult COVID-19 patients is not associated with worse clinical outcomes, including 28-day mortality or hospital discharge. Furthermore, a meta-analysis of 14 studies involving 48,788 COVID-19 patients showed that NSAID use had a survival benefit and decreased the risk of severe COVID-19.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Hugo Ribeiro, Ines Rodrigues, Leonardo Napoleao, Luis Lira, Denise Marques, Manuel Verissimo, Jose Paulo Andrade, Marilia Dourado
Summary: This narrative review examines the safest NSAIDs to use in the elderly based on the best available evidence. Understanding patient characteristics and basic pharmacology can improve treatment safety and adherence.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Zhao-Xuan Lu, Bing-Qing Dong, Heng-Le Wei, Liang Chen
Summary: This study aims to investigate potential predictors of non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in migraine therapy and their influence on efficacy. The results showed that migraine-related and psychiatric parameters play a critical role in predicting the outcomes of acute migraine treatment. Additionally, the models based on predictors can optimize drug selection and improve treatment benefits.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nuha Wazzan
Summary: This study presented the first available simulation of the interactions between four NSAIDs and a nanographene surface, revealing that the DIC@NG system had the largest binding energy, in agreement with experimental findings. The calculated results showed that the DIC@NG system had the most stable adsorption and highest removal rate, with the most negative free energy change.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Medicine, General & Internal
Nattawat Klomjit, Patompong Ungprasert
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed drugs that inhibit COX enzyme, affecting prostaglandin production and causing various renal complications. AKI from NSAIDs is usually reversible after discontinuation, emphasizing the importance of avoiding NSAIDs in high-risk patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Environmental Sciences
Anna Michalaki, Konstantinos Grintzalis
Summary: This study assessed the impact of two commonly prescribed non-steroidal anti-inflammatory drugs on Daphnia magna, a species commonly found in freshwater ecosystems. It found that exposure to these drugs affected feeding behavior and key enzyme activities in the daphnids, and the effects were more pronounced in the transgenerational exposures. The study suggests that combining molecular and phenotypic markers of physiology in transgenerational studies is an effective way to understand the impact of pharmaceutical stressors.
Review
Environmental Sciences
Nguyen Chi Huynh, Thuy Thi Thanh Nguyen, Duyen Thi Cam Nguyen, Thuan Van Tran
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used pharmaceuticals that enter water sources and cause adverse effects on aquatic organisms and humans. High concentrations of NSAIDs have been detected in wastewater, leading to genotoxicity, endocrine disruption, and other harmful effects. Metal-organic frameworks and advanced porous carbons have shown promise in effectively removing NSAIDs from water.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Chunjiang Wang, Weijin Fang, Liying Song, Zhenzhen Deng, Zuojun Li, Linli Sun
Summary: This study investigated the clinical features of Kounis syndrome induced by non-steroidal anti-inflammatory drugs (NSAIDs). The most frequently involved NSAIDs were diclofenac, metamizole, and aspirin. Kounis syndrome mainly occurred within 30 minutes after administration, with a maximum latency of 1 month. Chest pain, dyspnea, and allergic reactions were the most common clinical manifestations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angelos G. Kalampounias, Sotiris K. Hadjikakou
Summary: The low water solubility of aspirin has led to the development of new water-soluble formulations, such as SLS@ASPH micelle. The inhibitory activity of SLS@ASPH against LOX is 3.5-fold stronger than that of free SLS. The toxicity of SLS@ASPH was tested on HaCaT cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Allergy
Tomoharu Yokooji, Hitomi Nouma, Ryohei Ogino, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo
ALLERGOLOGY INTERNATIONAL
(2019)
Article
Allergy
Tomoko Furuta, Kajiyo Tanaka, Kazunori Tagami, Teruaki Matsui, Shiro Sugiura, Naoyuki Kando, Yuuki Kanie, Michihiro Naito, Hidehiko Izumi, Akira Tanaka, Sigrid Sjolander, Tomoharu Yokooji, Hiroaki Matsuo, Komei Ito
Article
Allergy
Ryohei Ogino, Yuko Chinuki, Tomoharu Yokooji, Daigo Takizawa, Hiroaki Matsuo, Eishin Morita
Summary: The study identified peroxidase-1 and beta-glucosidase as specific wheat allergens for grass pollen-related wheat allergy, showcasing the high specificity of these tests in differentiating this unique phenotype from other types of wheat-induced food allergies.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Tatsuo Kataoka, Hiroshi Sakurashita, Kazuya Kajikawa, Yasuyuki Saeki, Takanori Taogoshi, Hiroaki Matsuo
Summary: This retrospective study of 74 patients found that low serum albumin level and type of cancer are associated with delayed methotrexate elimination in high-dose methotrexate monotherapy. Low albumin was identified as a risk factor that may require pharmacokinetic analysis for dosage adjustment in patients undergoing HD-MTX therapy with low albumin levels.
ANNALS OF PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Shiori Akimoto, Tomoharu Yokooji, Ryohei Ogino, Yuko Chinuki, Takanori Taogoshi, Atsuko Adachi, Eishin Morita, Hiroaki Matsuo
Summary: This study identified P75 homologue and fructose 1,6-bisphosphate aldolase (FBPA) as IgE-binding allergens for shrimp-FDEIA, which could be valuable for the development of diagnostic tools and desensitization therapy for these patients.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Yuuka Shibata, Hideki Itoh, Hiroaki Matsuo, Kazue Nakajima
Summary: The study investigates the impact of pharmacist medication reviews on medication optimization and prevention of adverse drug events (ADE) in elderly patients. Pharmacists' interventions, primarily based on medication history or clinical symptoms, were found to be more frequent in elderly patients, highlighting the importance of pharmacist involvement in optimizing medication therapy for the elderly.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Allergy
Yuki Koga, Tomoharu Yokooji, Ryohei Ogino, Takanori Taogoshi, Shunsuke Takahagi, Kaori Ishii, Yuko Chinuki, Eishin Morita, Michihiro Hide, Hiroaki Matsuo
Summary: This study developed a new method using Alpha to detect functional anti-Fc epsilon RI alpha and anti-IgE autoantibodies in the sera of aiCSU patients. This simple and practical assay method may serve as a diagnostic tool for urticaria patients.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Food Science & Technology
Yukinori Yamada, Tomoharu Yokooji, Kyohei Kunimoto, Koki Inoguchi, Ryohei Ogino, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo
Summary: This study found that the early consecutive ingestion of 1BS-18H wheat can induce oral tolerance to gluten and omega 5-gliadin, thus preventing wheat allergy.
Letter
Allergy
Eishin Morita, Yuko Chinuki, Kunie Kohno, Hiroaki Matsuo
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Food Science & Technology
Eishin Morita, Hiroaki Matsuo, Kunie Kohno, Tomoharu Yokooji, Hiroyuki Yano, Takashi Endo
Summary: This study outlines the current status of hypoallergenic wheat products and highlights the difficulties faced in creating completely safe products for patients allergic to wheat. Various approaches, such as genetic modification and enzymatic treatment, have been used to reduce allergenicity, but there are still challenges to overcome.
Article
Pharmacology & Pharmacy
Yuuka Ushio, Hiroshi Yoshikawa, Tetsuya Murase, Tatsuo Kataoka, Shohei Miyamoto, Kazunari Maruko, Shoko Okamoto, Yuuka Shibata, Ryotaro Toda, Yoshiaki Kiuchi, Hiroaki Matsuo
Summary: This study retrospectively investigated the incidence of postoperative infections in trabeculectomy patients who received or did not receive CEZ injection. The results showed no significant difference in the incidence of postoperative endophthalmitis between the CEZ and non-CEZ groups, suggesting a decreased need for CEZ injections before trabeculectomy.
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yuuka Shibata, Takanori Taogoshi, Hiroaki Matsuo
Summary: This article reviews case reports and animal experiments to classify the severity of extravasation injury by noncytotoxic agents, providing appropriate warning of possible injury severity and helping medical personnel understand and prevent tissue damage during extravasation.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Pharmacology & Pharmacy
Takanori Taogoshi, Yuuka Shibata, Hiromi Uno, Tomoharu Yokooji, Maiko Tanaka, Michihiro Hide, Hiroaki Matsuo
Summary: In this study, skin injuries caused by extravasation of noncytotoxic electrolyte solutions and infusions were evaluated using a rat model. The severity of skin injury was classified into three categories based on the composition of the solutions. The findings from this study provide basic information for the development of guidelines for the treatment of extravasation.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Soichiro Ishii, Hiroshi Sakurashita, Emiko Mashida, Yasuyuki Saeki, Hiroaki Matsuo
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Yukinori Yamada, Tomoharu Yokooji, Naoki Ninomiya, Takanori Taogoshi, Eishin Morita, Hiroaki Matsuo
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)