☆ 4.6 Article

α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

期刊

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

卷 426, 期 2, 页码 226-231

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE

DOI: 10.1016/j.bbrc.2012.08.070

关键词

Sepsis; alpha-Iso-cubebene; Inflammation; Organ failure

类别

Biochemistry & Molecular Biology Biophysics

资金

National Research Foundation of Korea (NRF)
Korean government (MEST) [2009 0093198, 35B-2011-1-E00012]
National Research Foundation of Korea [35B-2011-1-E00012] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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摘要

alpha-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, strongly enhanced survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. The mechanism involved the marked reduction of viable bacteria in the peritoneal fluid, by virtue of increased phagocytic activity and production of hydrogen peroxide. alpha-Iso-cubebene also significantly attenuated lung inflammation and widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibited the production of proinflammatory cytokines including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. The results indicate that alpha-iso-cubebene can reverse the progression of toxic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival. (C) 2012 Elsevier Inc. All rights reserved.

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