Article
Gastroenterology & Hepatology
Xin Luo, Sheng-Zheng Luo, Zi-Xin Xu, Cui Zhou, Zheng-Hong Li, Xiao-Yan Zhou, Ming-Yi Xu
Summary: miR-1297 is overexpressed in exosomes derived from lipotoxic hepatocytes, promoting the activation and proliferation of hepatic stellate cells through the PTEN/PI3K/AKT signaling pathway, accelerating the progression of MAFLD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, Research & Experimental
Zongze He, Meixiong Cheng, Junting Hu, Lingtong Liu, Ping Liu, Longyi Chen, Deqian Cao, Jian Tang
Summary: ADM expression is upregulated in TMZ-resistant glioma samples. Knocking down ADM enhances the suppressive effects of TMZ on glioma cell viability, promotes cell apoptosis, and inhibits mitochondrial membrane potential. Moreover, ADM knockdown also enhances TMZ effects on Bax/Bcl-2, Akt phosphorylation, and Erk1/2 phosphorylation. miR-1297 directly targets ADM and inhibits ADM expression. miR-1297 overexpression exerts similar effects to ADM knockdown on TMZ-treated glioma cells. Inhibition of miR-1297 attenuates TMZ treatment on glioma cells, and ADM knockdown partially attenuates the effects of miR-1297 inhibition on TMZ-treated glioma cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The study revealed that miR-1297 can inhibit proliferation and tumor growth in osteosarcoma by directly targeting CCND2. Overexpression of miR-1297 significantly suppressed CCND2 protein expression and resulted in similar phenotypic effects as CCND2 downregulation. Therefore, miR-1297 may represent a novel therapeutic target for osteosarcoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Pan Jiang, Lianghao Mao, Xuan Lei, Chunshan Luo, Yiming Zhang, Xinyu Zhong, Zhenyu Yin, Xiaofeng Xu, Dapeng Li, Qiping Zheng
Summary: The present study demonstrated that miR-1297 inhibited proliferation and tumor growth in osteosarcoma by directly targeting CCND2.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiazhan Mei, Guiju Liu, Ruijun Li, Peng Xiao, Dan Yang, Hua Bai, Yibin Hao
Summary: The study revealed that lncRNA SNHG6 has inhibitory effects on DDP resistance and progression of GC by sponging miR-1297 and regulating BCL-2 expression.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Yuebin Zheng, Lifu Duan, Yirong Yang, Dengyao Luo, Bincheng Yan
Summary: The study found that circ_0023028 was highly expressed in laryngeal squamous cell carcinoma (LSCC) tissues and cells. Silencing circ_0023028 inhibited cancer cell proliferation and metastasis, induced apoptosis, and hindered tumor growth. Circ_0023028 may regulate LASP1 expression by sponging miR-486-3p, impacting the malignant behaviors of LSCC cells.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Yu Shuang, Jing Liu, Juntao Niu, Wenyu Guo, Chao Li
Summary: Abnormal expression of the novel circRNA circPPFIA1 was found to promote the progression of laryngeal squamous cell carcinoma (LSCC) by enhancing cell proliferation, migration, and invasion. This effect was mediated through the miR-340-3p/ELK1 signaling axis, highlighting circPPFIA1 as a potential prognostic or therapeutic target for LSCC.
Article
Multidisciplinary Sciences
Wenjie Yu, Xiaoling He, Chunming Zhang, Fuhui Huang
Summary: This study found that circSLC7A11 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and is associated with tumor stage and patient survival time. Functional studies showed that circSLC7A11 knockdown reduced cell proliferation, migration, invasion, stemness characteristics, and enhanced cell apoptosis in LSCC. Mechanistic study revealed that circSLC7A11 accelerates LSCC through the miR-877-5p/LASP1 pathway.
Article
Urology & Nephrology
Shujuan Wang, Kun Sun, Honglei Hu, Xingqian Jin, Zhenzhen Wang, Hongmei Zhang, Xiaodong Zhao
Summary: The study indicates that miR-1297 protects HK-2 cells from HG-induced damage by suppressing inflammatory pathways through targeting COL1A2. This provides a novel therapeutic strategy for suppressing DN progression.
Article
Immunology
Jin-ya Wang, Xiaoyan Dong, Zhiwei Yu, Lei Ge, Lu Lu, Ling Ding, Weihua Gan
Summary: The study demonstrated that borneol alleviated asthma in mice by downregulating miR-26a and miR-142-3p, which reduced CD4+ T cells infiltration, thereby attenuating disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Qian Li, Lei Fu, Lili Han, Shuai Li, Yanling Zhang, Jufeng Wang
Summary: The expression of GAS5 is significantly increased in cholangiocarcinoma (CCA) tissues and cells, with high GAS5 expression associated with lymph node metastasis and advanced clinical stage. GAS5 acts as an endogenous sponge to downregulate hsa-miR-1297, promoting CCA cell proliferation and invasion.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Multidisciplinary Sciences
Zaibo Zhang, Yong Li, Liqiao Fan, Bingyu Wang, Wenbo Liu, Jiaxiang Cui, Bibo Tan
Summary: This study found that elevated levels of THUMPD3-AS1 in gastric cancer (GC) were associated with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and induced tumor growth in vivo. It exerts its regulatory function on BCAT1 through competitive binding with miR-1297.
Article
Cell Biology
Yongqiang Zhou, Ruoqi Wu, Huafang Su, Kejie Li, Chun Chen, Raoying Xie
Summary: miR-18a improves insulin sensitivity by downregulating PTEN, making it a potentially useful target for the treatment of diabetes mellitus.
Article
Multidisciplinary Sciences
Zaibo Zhang, Yong Li, Liqiao Fan, Bingyu Wang, Wenbo Liu, Jiaxiang Cui, Bibo Tan
Summary: This study found that THUMPD3-AS1 is upregulated in gastric cancer and is significantly correlated with poor prognosis. Functionally, THUMPD3-AS1 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of gastric cancer cells and induces tumor growth in vivo. THUMPD3-AS1 exerts its regulatory function on BCAT1 through competitive binding with miR-1297.
Article
Cell Biology
Daqing Fan, Youhua Zhu
Summary: The aim of this study was to investigate the role and mechanism of circular RNA 0120175 (circ_0120175) in the development of laryngeal squamous cell carcinoma (LSCC). The study found that circ_0120175 abundance was increased in LSCC and was associated with advanced tumor staging, lymph node metastasis, and poor prognosis. Circ_0120175 acted as a sponge for miR-330-3p and increased the expression of SLC7A11, promoting cell proliferation, migration, and invasion while inhibiting apoptosis in LSCC cells.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)