Article
Biochemistry & Molecular Biology
Sara Catalini, Diego R. Perinelli, Paola Sassi, Lucia Comez, Giovanni F. Palmieri, Assunta Morresi, Giulia Bonacucina, Paolo Foggi, Stefania Pucciarelli, Marco Paolantoni
Summary: A method for quickly forming protein hydrogels has been designed based on the self-assembly of highly concentrated lysozyme solutions in acidic conditions, with properties easily modulated by selecting the curing temperature. Molecular insights from in situ FTIR spectroscopy, calorimetric, and rheological results have provided a consistent picture on structure-property correlations, showing formation of interconnected amyloid oligomers.
Article
Chemistry, Multidisciplinary
Yangyang Han, Yiping Cao, Jiangtao Zhou, Yang Yao, Xiaodong Wu, Sreenath Bolisetty, Michael Diener, Stephan Handschin, Canhui Lu, Raffaele Mezzenga
Summary: A facile and general method for fabricating amyloid films via electrostatic self-assembly is introduced, allowing for the construction of multifunctional films and smart devices. The films exhibit tunable properties and have been successfully used in the preparation of a magnetically oriented soft robotic swimmer and a smart magnetic sensor.
Article
Chemistry, Multidisciplinary
Junjun Wu, Lin Zhou, Hu Peng, Zhaojun Wang, Zhaoshi Wang, Jay D. Keasling, Shike Liu, Guanghong Zhou, Shijie Ding, Qiong Wang, Xuejian Wang, Xinxiu Chen, Yifei Lang, Mo Xia, Xin Guan, Mingsheng Dong, Jingwen Zhou, Jian Chen
Summary: This study introduces an easy-to-implement and tunable self-assembling strategy using Ure2 amyloidogenic peptide to induce any target proteins to assemble into supramolecular hydrogels with notable compositional control. The nanoscale interactions among amyloid nanofibrils and partially disordered elastomeric polypeptides lead to the emergence of useful macroscopic material properties. Few pure protein-based materials could meet such seemingly mutually exclusive properties simultaneously. The versatility of this novel supramolecular nanomaterial makes it a next-generation functional protein-based material.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Sara Catalini, Viviane Lutz-Bueno, Mattia Usuelli, Michael Diener, Andrea Taschin, Paolo Bartolini, Paolo Foggi, Marco Paolantoni, Raffaele Mezzenga, Renato Torre
Summary: This study focuses on the formation of amyloid oligomers in crowded lysozyme solutions under acidic conditions. It is found that amyloid oligomers form at high protein concentration and low pH. Multi-length scale structural analysis reveals the thermal history of amyloid oligomers and highlights the impact of hierarchical self-assembly of biological macromolecules on functional properties.
Article
Chemistry, Physical
Nico Kummer, Caroline E. Giacomin, Peter Fischer, Silvia Campioni, Gustav Nystrom
Summary: Amyloid fibrils from inexpensive food proteins and nanocellulose have diverse applications and their hybrid materials have improved mechanical properties due to electrostatic interactions. These interactions increase the elasticity of the amyloid network by cross-linking individual fibrils. The combination of nanocellulose morphology contributes differently to the elasticity, with cellulose nanocrystals inducing bundling and network formation, and cellulose nanofibrils forming a second network. The gained knowledge on colloidal interactions provides a basis for designing functional biohybrid materials.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Yi Lai, Fenglin Li, Zhifeng Zou, Madiha Saeed, Zhiai Xu, Haijun Yu
Summary: This article explores the development and applications of amyloid polypeptide-based nanostructures in biotechnological applications. It emphasizes the importance of thermodynamic and kinetic factors in self-assembly and summarizes cutting-edge advances and challenges in engineering amyloid peptide nanomaterials.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Multidisciplinary
Te-Haw Wu, Rai-Hua Lai, Chun-Nien Yao, Jyh-Lyh Juang, Shu-Yi Lin
Summary: A non-equilibrium state of interaction between supramolecular lipopolysaccharide (LPS) and A beta 42 was identified, which triggers cellular response to clear extracellular A beta 42 deposits, potentially serving as a promising target for developing Alzheimer's disease therapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ana M. Garcia, Michele Melchionna, Ottavia Bellotto, Slavko Kralj, Sabrina Semeraro, Evelina Parisi, Daniel Iglesias, Paola D'Andrea, Rita De Zorzi, Attilio V. Vargiu, Silvia Marchesan
Summary: Self-assembling peptides with proline as a beta-breaker and diphenylalanine motif were studied for their ability to form diverse nanostructures. The stereo-configuration of amino acids played a crucial role in directing these peptides to assemble into nanoparticles, nanotapes, or fibrils. Additionally, the study found that heterochirality could strategically interfere with pathological processes, potentially offering future therapeutic applications with resistance to degradation and biocompatibility.
Article
Chemistry, Analytical
Ondrej Krivosudsky, Daniel Havelka, Djamel Eddine Chafai, Michal Cifra
Summary: A novel method for monitoring tubulin self-assembly states using microwave lab-on-a-chip technology was proposed and validated experimentally, demonstrating the effectiveness of this approach in detecting the assembly of tubulin proteins into microtubules.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Applied
Ting Li, Li Wang, Xinxia Zhang, Han Geng, Wei Xue, Zhengxing Chen
Summary: The study found that cowpea protein had the highest ability to form amyloid fibrils. During heating, the legume proteins underwent partial denaturation and elongation of fibrils over time. The restructuring of ordered structure led to an increase in protein particle size.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Multidisciplinary
Peter Faller, Christelle Hureau
Summary: Controlling protein and peptide aggregation in vitro and obtaining reproducible results poses a challenge, which is scarcely reported and discussed in the literature, potentially hindering progress in the field and misleading newcomers.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Shuai Zhang, Jiajun Chen, Jianli Liu, Harley Pyles, David Baker, Chun-Long Chen, James J. De Yoreo
Summary: Biomolecular self-assembly is a fundamental process used by life to create functional materials, but progress in engineering self-assembly at solid-liquid interfaces lags behind that in bulk solutions. Recent research has focused on programming self-assembly of peptides, proteins, and peptoids at solid-liquid interfaces, as well as advancing physical understandings of self-assembly pathways using in situ atomic force microscopy. These developments are leading to novel strategies for designing biomaterials organized at and interfaced with inorganic surfaces.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ankush Garg, Sharmistha Sinha
Summary: Dihydromethanopterin reductase (DmrB) is a naturally occurring cage protein with high thermal stability, mediated by the cofactor FMN. This study provides valuable insights into the assembly principles and significance of DmrB, which could have important implications for its downstream applications in nanobiotechnology.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Xiaohui Wu, Feihe Ma, Bin-Bin Pan, Yanli Zhang, Lin Zhu, Fei Deng, Linlin Xu, Yu Zhao, Xu Yin, Haihong Niu, Xun-Cheng Su, Linqi Shi
Summary: The development of a nanochaperone (α-S-nChap) tailored for alpha-synuclein regulation shows promise in preventing neurodegenerative diseases by controlling protein misassembly. This nanochaperone has the ability to specifically recognize, capture, and stabilize the monomeric form of alpha-synuclein, ultimately impeding its oligomerization. The strategy of using nanochaperones to regulate aberrant protein assembly provides important insights into potential therapeutic interventions for Parkinson's disease.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Takayasu Kawasaki, Yuusuke Yamaguchi, Hideaki Kitahara, Akinori Irizawa, Masahiko Tani
Summary: Far-infrared radiation has potential applications in regulating the conformation of biomaterials.
Article
Chemistry, Multidisciplinary
Yan Zhang, Qi Li, Haoran Wu, Yancheng Wang, Yan Wang, Sigal Rencus-Lazar, Yurong Zhao, Jiqian Wang, Deqing Mei, Hai Xu, Ehud Gazit, Kai Tao
Summary: Amino acids are bio-building blocks that play various roles in metabolic activities. Supramolecular structures formed by amino acids exhibit amyloid-like characteristics, which are driven by hydrogen bonds and play critical roles in the properties and applications of amino acid assemblies. Tyrosine-based superstructures have diverse properties and functions, making them promising next-generation biomaterials for biomedical applications. However, modulating the energetically stable supramolecular structures of tyrosine-based organizations is challenging. By assembling L-Y and D-Y, the secondary structures of the supramolecular assemblies can be modulated, leading to distinct organization kinetics and modulation of physicochemical properties.
Review
Chemistry, Multidisciplinary
Nikhil Bajpayee, Thangavel Vijayakanth, Sigal Rencus-Lazar, Sneha Dasgupta, Aamod V. Desai, Rahul Jain, Ehud Gazit, Rajkumar Misra
Summary: Flexible and biocompatible metal peptide frameworks (MPFs) have been developed from short and ultra-short peptides for various applications such as greenhouse gas storage, molecular recognition, and chiral transformations. Recently, specifically folded peptides have been utilized to fabricate metal helix frameworks (MHFs) that control the formation of three-dimensional (3D)-MHFs. This article describes the recent progress of metal-driven folded peptide assembly for constructing 3D porous structures with potential applications in energy storage, chiral recognition, and biomedical fields, serving as an alternative to conventional metal-organic frameworks (MOFs).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Geriatrics & Gerontology
Rony M. Sayig-Keren, Moria Dagan, Pablo Cornejo Thumm, Marina Brozgol, Eran Gazit, Brad Manor, Jeffrey M. Hausdorff
Summary: This study examines the effects of theta-tACS on dual-task walking and cognitive function in older adults. The results show that theta-tACS and tDCS have similar effects in reducing dual-task costs, suggesting that theta-tACS may influence the fronto-parietal network and improve dual-tasking.
Review
Pharmacology & Pharmacy
Vijay Bhooshan Kumar, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, Ehud Gazit
Summary: Tissue engineering is focused on restoring or replacing damaged tissues, and peptide self-assembly, particularly RGD peptides, is an effective method for developing tissue structures and functionalities. This review summarizes the progress of RGD application in tissue and organ development, examines its impact on TE efficacy in clinical and preclinical studies, and outlines recent advancements in the use of RGD functionalized biomaterials for tissue regeneration.
Article
Chemistry, Multidisciplinary
Ruth Aizen, Zohar A. Arnon, Or Berger, Antonella Ruggiero, Dor Zaguri, Noam Brown, Evgeny Shirshin, Inna Slutsky, Ehud Gazit
Summary: Nucleobase crystals have unique fluorescence properties in the visible spectrum, unlike their monomeric counterparts. Additionally, some nucleobases exhibit a red edge excitation shift, which is uncommon in the field of organic supramolecular materials and may have implications in therapeutic and materials science.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Om Shanker Tiwari, Ruth Aizen, Massimiliano Meli, Giorgio Colombo, Linda J. W. Shimon, Noam Tal, Ehud Gazit
Summary: Molecular self- and co-assembly have the ability to form diverse and well-defined supramolecular structures with notable physical properties. By exploring the co-assembly of L-His with different aromatic amino acids, including Phe, Tyr, and Trp, we expanded the structural space of amino acid nanomaterials. The best seamless co-assembly was observed between L-His and L-Phe, resulting in the formation of single crystals.
Article
Chemistry, Multidisciplinary
Anna Yucknovsky, Yaniv Shlosberg, Noam Adir, Nadav Amdursky
Summary: Light is commonly used as an energy source in sustainable technologies for generating photocurrent. We introduced a new mechanism for photocurrent generation based on excited state proton transfer of photoacids and photobases. We demonstrated that the formed ions can serve as electron donors or acceptors, or modify mass transport kinetics, resulting in photocurrent generation. By switching the irradiation between the photoacid and the photobase, control of current polarity can be achieved. Our study represents a new approach in photoelectrochemistry and can be utilized in light-responsive energy production or storage.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Ziyu Yang, Amit Kumar Sarkar, Nadav Amdursky
Summary: Biopolymers, primarily proteins and polysaccharides, are attractive environmentally friendly alternatives to synthetic polymers. In this study, a new platform for combining the advantages of proteins and polysaccharides is introduced, using a glycosylated protein, mucin, as a starting point. Different chemical strategies are used to crosslink the glycoproteins and introduce proton conductivity properties, resulting in a free-standing proton-conductive soft biopolymer with potential applications in soft bioelectronic devices.
Article
Chemistry, Physical
Yunxiao Wang, Qiang Geng, Yan Zhang, Lihi Adler-Abramovich, Xinyuan Fan, Deqing Mei, Ehud Gazit, Kai Tao
Summary: In this article, the mechanisms underlying the self-assembly of 9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), the preparation methodologies of Fmoc-FF hydrogels, and the properties and applications of Fmoc-FF self-assemblies are systematically summarized. The contemporary shortcomings that limit the development of Fmoc-FF self-assembly are raised, and alternative solutions and future research perspectives are proposed.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou, Yu Chen, Ehud Gazit, Phanourios Tamamis
Summary: The design of novel cancer drug nanocarriers is crucial in cancer therapeutics. Nanomaterials, especially self-assembling peptides, show great potential in drug delivery by promoting drug release and stability while reducing side effects. This review highlights the importance of metal coordination, structure stabilization, cyclization, and minimalism in the design of peptide self-assembled nanocarriers for cancer drug delivery. Future perspectives suggest that incorporating these materials into single or multicomponent systems could lead to novel classes of cancer drug delivery systems.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Computer Science, Interdisciplinary Applications
Gaelle Prigent, Kamiar Aminian, Andrea Cereatti, Francesca Salis, Tecla Bonci, Kirsty Scott, Claudia Mazza, Lisa Alcock, Silvia Del Din, Eran Gazit, Clint Hansen, Anisoara Paraschiv-Ionescu
Summary: This study aims to validate a robust walking detection algorithm using a single foot-worn inertial measurement unit (IMU) in real-life settings. Accurate walking detection was obtained, with sensitivity and specificity of 98% and 91% respectively. A validated algorithm would pave the way for assessing patient performance and gait quality in real-world conditions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Nanoscience & Nanotechnology
Ramesh Nandi, Anna Orieshyna, Nadav Amdursky
Summary: This study presents a protein-based elastomer that can bind various chromophores and prevent their aggregation. Energy transfer among five different chromophores within the protein matrix is explored, and control over blue, green, and red chromophores results in tunable emission properties and white-light generation. The affordability and simplicity of the chosen protein and molecular doping strategy make these protein elastomers attractive for investigating energy transfer in proteins and potential integration in light-emitting applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Srestha Basu, Martina Peric Bakulic, Zeljka Sanader Marsic, Vlasta Bonacic-Koutecky, Nadav Amdursky
Summary: This study demonstrates the assembly of atomically precise gold nanoclusters into large fibrillar structures that exhibit excitation-dependent luminescence and excitation-selective circularly polarized luminescence (CPL). The origin of CPL in the assembly of atomic clusters is attributed to hierarchical organization and hydrogen bonding interaction with a surfactant. The findings have implications for the rational design of materials with chiroptical properties and controlled CPL activity.
Article
Biochemistry & Molecular Biology
Anna Orieshyna, Jennifer L. Puetzer, Nadav Amdursky
Summary: Collagen, a widely studied protein, not only plays a fundamental role in our bodies but also finds extensive applications in tissue engineering scaffolds. This study reveals a new role for hydroxyproline (Hyp), an abundant component of collagen, in supporting proton transport (PT) through collagen fibrils. The researchers found that adding a methanesulfonyl group significantly enhances PT, while reverting Hyp to proline (Pro) reduces PT efficiency. Understanding the role of Hyp in PT can contribute to a better understanding of the physiological functions of collagen, and modulating conductivity in collagen is crucial in regenerative medicine.
Article
Chemistry, Multidisciplinary
Alessandro Paradisi, Marcello Berto, Matteo Di Giosia, Sara Mazzali, Marco Borsari, Tainah Dorina Marforio, Francesco Zerbetto, Matteo Calvaresi, Anna Orieshyna, Nadav Amdursky, Carlo Augusto Bortolotti, Fabio Biscarini
Summary: This study introduces a simple solution-based method for fabricating electrolyte-gated transistor (EGT) devices using stable dispersions of single-walled carbon nanotubes (SWCNTs)/bovine serum albumin (BSA) hybrids in water. The method allows the formation of a semiconducting random network of SWCNTs as the channel, enabling the fabrication of EGT devices with excellent electrical performance for biosensing applications. The method is demonstrated for the detection of cortisol in solution, showcasing its robustness and cost-effectiveness in overcoming limitations of standard SWCNTs biosensor fabrications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)