Article
Biochemistry & Molecular Biology
Banlanjo Abdulaziz Umaru, Yoshiteru Kagawa, Yuki Ohsaki, Yijun Pan, Chuck T. Chen, Daniel K. Chen, Toshiaki Abe, Subrata Kumar Shil, Hirofumi Miyazaki, Shuhei Kobayashi, Motoko Maekawa, Yui Yamamoto, Tunyanat Wannakul, Shuhan Yang, Richard P. Bazinet, Yuji Owada
Summary: This study demonstrates that the interaction between fatty acid-binding protein 7 (FABP7) and its ligand oleic acid (OA) enhances tumor cell proliferation by modulating nuclear lipid droplet formation and increasing transcription of proliferation-regulating genes.
Article
Medicine, General & Internal
An Cheng, Wenbin Jia, Ichiro Kawahata, Kohji Fukunaga
Summary: The study demonstrated that MF 6 has potential therapeutic effects in multiple sclerosis by reducing myelin loss and clinical symptoms, as well as decreasing oxidative stress levels and specific cell types in the spinal cord. Additionally, MF 6 showed protective functions for mitochondria in oligodendrocytes through FABP5 inhibition, suggesting a promising role in immune inhibition and oligodendrocyte protection in MS therapy.
Review
Biochemistry & Molecular Biology
Rong Jin, Jiaqing Hao, Yanmei Yi, Edward Sauter, Bing Li
Summary: Macrophages play crucial roles in maintaining tissue homeostasis and can exhibit heterogeneous phenotypes and functions depending on their activation states, influenced by various environmental stimuli. Fatty acid binding proteins, particularly A-FABP and E-FABP, are key players in integrating metabolic and inflammatory pathways in different subsets of activated macrophages, contributing to their functional diversity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Medicine, General & Internal
Julia Nowowiejska, Anna Baran, Justyna Magdalena Hermanowicz, Beata Sieklucka, Julita Anna Krahel, Paulina Kiluk, Dariusz Pawlak, Iwona Flisiak
Summary: This study found that the concentration of FABP-7 and NFL, which are present in the brain, was significantly higher in psoriasis patients compared to controls before treatment, but decreased after treatment. GA concentration did not differ significantly between patients and controls, but showed a negative correlation with CRP. The duration of psoriasis does not seem to directly affect the risk of neurodegeneration, but does affect the severity of the disease. Elevated FABP-7 and NFL may be potential indicators of neurodegenerative diseases development in psoriatics, and GA may correspond with neuroinflammation in psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Nobuhiro Okada, Chihiro Ueki, Masahiro Shimazaki, Goki Tsujimoto, Susumu Kohno, Hayato Muranaka, Kiyotsugu Yoshikawa, Chiaki Takahashi
Summary: The NFYAv1 splice variant promotes malignant behavior of triple negative breast cancer cells by upregulating the transcription of ACACA and FASN, essential lipogenic enzymes. The NFYAv1-lipogenesis axis is crucial for triple-negative breast cancer and targeting NFYAv1 may be a safe therapeutic approach. NFYAv1-deficient mice showed no developmental abnormalities, suggesting that NFYAv1 could be a potential therapeutic target for TNBC without causing adverse effects.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: This study discusses the role of fatty-acid-binding proteins (FABPs) in psoriasis and their potential as markers. Due to the different expressions and functions of FABPs in various tissues, they may be associated with psoriasis and its comorbidities.
Article
Chemistry, Multidisciplinary
An Cheng, Yi-Fei Wang, Yasuharu Shinoda, Ichiro Kawahata, Tetsunori Yamamoto, Wen-Bin Jia, Hanae Yamamoto, Tomohiro Mizobata, Yasushi Kawata, Kohji Fukunaga
Summary: The study demonstrates that FABP7 triggers alpha-synuclein oligomerization through oxidative stress, while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation, thereby rescuing glial cells and oligodendrocytes from cell death.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Chemistry, Multidisciplinary
Xia Xu, Yixiong Wang, Won-Shik Choi, Xuejun Sun, Roseline Godbout
Summary: The study highlights the role of brain fatty acid binding protein FABP7 in promoting glioblastoma cell migration, which can be reversed in medium supplemented with DHA. Super-resolution imaging shows the significance of FABP7 and its fatty acid ligands in mitigating GBM cell migration, suggesting a link between cell migration, membrane lipid order, and FABP7 nanoscale domains.
Article
Cell Biology
Antonino Asaro, Rishabhdev Sinha, Magda Bakun, Oleksandra Kalnytska, Anne-Sophie Carlo-Spiewok, Tymon Rubel, Annemieke Rozeboom, Michal Dadlez, Bozena Kaminska, Eleonora Aronica, Anna R. Malik, Thomas E. Willnow
Summary: Sortilin is a neuronal receptor for apoE that plays a crucial role in anti-inflammatory gene expression in the brain. The presence of apoE4 disrupts the interaction between Sortilin and FABP7, leading to impaired lipid signaling and loss of neuroprotective lipid metabolism. This study provides a mechanistic explanation for the impact of these interactions on neuronal lipid homeostasis in Alzheimer's disease.
JOURNAL OF CELL SCIENCE
(2021)
Article
Nutrition & Dietetics
Guojun Wu, Hiba R. Tawfeeq, Atreju I. Lackey, Yinxiu Zhou, Zoe Sifnakis, Sophia M. Zacharisen, Heli Xu, Justine M. Doran, Harini Sampath, Liping Zhao, Yan Y. Lam, Judith Storch
Summary: This study investigated the effects of LFABP and IFABP deficiency on the gut microbiota in mice, and found that these changes were associated with phenotypic changes induced by a high-fat diet.
Article
Cell Biology
Liang-Ti Huang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants characterized by interrupted alveologenesis and alveolar simplification due to oxygen therapy. The study found that the FABP4 inhibitor BMS309403 can regulate pulmonary fibrotic processes in newborn rats exposed to hyperoxia, reducing lung fibrosis and expression of TGF-beta 1. The inhibition of FABP4 showed potential clinical and therapeutic applications in attenuating hyperoxia-induced lung impairments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Pan Li, Ruoyu Zhang, Meng Wang, Yuwei Chen, Zhiwei Chen, Xiumei Ke, Ling Zuo, Jianwei Wang
Summary: Baicalein (BAL), a compound extracted from Traditional Chinese Medicine, has potential therapeutic effects for liver diseases. The study found that BAL improved fructose-induced hepatic steatosis by regulating fatty acid synthesis, elongation, and oxidation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Feng Jiang, Fei Luo, Ni Zeng, Yan Mao, Xinfang Tang, Jimei Wang, Yifang Hu, Chuyan Wu
Summary: This study examines the involvement of fatty acid metabolism in glioma and develops a prognostic signature for predicting glioma outcome. Higher-risk individuals are more susceptible to certain drugs and exhibit specific immune features in the tumor microenvironment. The study also identifies a critical regulatory role of gene CCNA2 in glioma proliferation and invasion.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shirin Farheen, Swalih P. Ahmed, Mubeena P. M. Mariyath, Tasneem Kausar, Md. Fakhrul Hoda, Sayeedul H. Arif, Shahid M. Nayeem, Asif Ali, Kunzang Chosdol, Mehdi H. Shahi
Summary: This study explored the potential interaction and regulation of Sonic hedgehog (Shh)-Gli1 cell signaling with Pax6 and IDH2 in glioma. It was found that Gli1 had differential dynamic interactions with IDH2 and Pax6, and Gli1 knockdown resulted in downregulation of Pax6 and upregulation of IDH2 expression. Additionally, the knockdown of Pax6 gene in glioma cells downregulated the expression of Gli1 and IDH2 and promoted cell proliferation. The study also showed that the combination of Gli1 inhibitor and an anti-cancer drug had a higher efficacy in treating glioma cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Psychiatry
Minori Koga, Shin Nakagawa, Asumi Sato, Matsuhiko Oka, Keisuke Makikhara, Yuri Sakai, Atsuhito Toyomaki, Mayumi Sato, Marie Matsui, Hiroyuki Toda, Ichiro Kusumi
Summary: The study found that plasma FABP7 concentrations were correlated with PANSS scores but not with other symptom assessment scales. In the analysis, the severity of depression/anxiety, cognition, and positive symptoms were significantly correlated with plasma FABP7 concentrations, indicating that FABP7 may be a biological indicator reflecting the pathogenesis of schizophrenia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
The Minh Vo, Rebecca Burchett, Miranda Brun, Elizabeth A. Monckton, Ho-Yin Poon, Roseline Godbout
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Oncology
Rong-Zong Liu, The M. Vo, Saket Jain, Won-Shik Choi, Elizabeth Garcia, Elizabeth A. Monckton, John R. Mackey, Roseline Godbout
JOURNAL OF PATHOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jasdeep Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Helene Lemieux, Ing Swie Goping
Article
Oncology
Rong-Zong Liu, Won-Shik Choi, Saket Jain, Deepak Dinakaran, Xia Xu, Woo Hyun Han, Xiao-Hong Yang, Darryl D. Glubrecht, Ronald B. Moore, Helene Lemieux, Roseline Godbout
MOLECULAR ONCOLOGY
(2020)
Review
Oncology
Rong-Zong Liu, Roseline Godbout
Article
Oncology
Alamelu G. Bharadwaj, Margaret L. Dahn, Rong-Zong Liu, Patricia Colp, Lynn N. Thomas, Ryan W. Holloway, Paola A. Marignani, Catherine K. L. Too, Penelope J. Barnes, Rosaline Godbout, Paola Marcato, David M. Waisman
Article
Nutrition & Dietetics
Won-Shik Choi, Xia Xu, Susan Goruk, Yixiong Wang, Samir Patel, Michael Chow, Catherine J. Field, Roseline Godbout
Summary: GBM neural stem-like cells express high levels of FABP7, and increasing DHA content can reduce their migration ability, potentially offering therapeutic value.
Article
Oncology
Jiesi Zhou, Yan Shu Kong, Krista M. Vincent, Dylan Dieters-Castator, Amirali B. Bukhari, Darryl Glubrecht, Rong-Zong Liu, Douglas Quilty, Scott D. Findlay, Xiaowei Huang, Zhihua Xu, Rui Zhe Yang, Lanyue Zhang, Emily Tang, Gilles Lajoie, David D. Eisenstat, Armin M. Gamper, Richard Fahlman, Roseline Godbout, Lynne-Marie Postovit, YangXin Fu
Summary: This study reveals that the elevated expression of NSUN5 is strongly associated with poor survival in GBM patients. It functions by promoting protein synthesis and its knockdown reduces cell proliferation, sphere formation, migration, and temozolomide resistance in GBM cells. In vivo experiments also show that NSUN5 knockdown extends survival in mice with U251 tumors. These findings suggest that NSUN5 could be a potential target for GBM treatment.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Rong-Zong Liu, Won-Shik Choi, Saket Jain, Xia Xu, Marwa E. Elsherbiny, Darryl D. Glubrecht, Anthony G. Tessier, Jacob C. Easaw, B. Gino Fallone, Roseline Godbout
Summary: This study reveals that infiltrative progression in GBM is driven by migratory GSCs through activation of a PUFA-FABP7-RXRα neurogenic pathway.
Article
Oncology
Quinn T. Storozynsky, Xuefei Han, Shae Komant, Kate C. Agopsowicz, Kyle G. Potts, Armin M. Gamper, Roseline Godbout, David H. Evans, Mary M. Hitt
Summary: Researchers found that cellular senescence induced by radiotherapy may impact the therapeutic potential of vaccinia virus (VACV)-based oncolytic viruses (OV) in treating glioblastoma (GBM). Both a VACV mutant, increment F4L & UDelta;J2R, and the wild-type VACV exhibited attenuated oncolytic properties towards GBM cells under irradiated senescence-enriched conditions, suggesting the presence of senescence-associated antiviral activity.
Article
Medicine, Research & Experimental
Xiaoyun Tang, Christopher R. Cromwell, Rongzong Liu, Roseline Godbout, Basil P. Hubbard, Todd P. W. McMullen, David N. Brindley
Summary: LPP2 expression is elevated in various malignancies, including breast tumors, hepatocellular carcinoma, pancreatic adenocarcinoma, and melanomas, and is associated with poorer survival. Knocking out LPP2 in breast cancer cells inhibits cell growth by affecting the cell cycle regulators and decreases the expression of c-Myc. Targeting LPP2 may provide a new strategy for reducing c-Myc expression and tumor growth.
Article
Chemistry, Multidisciplinary
Xia Xu, Yixiong Wang, Won-Shik Choi, Xuejun Sun, Roseline Godbout
Summary: The study highlights the role of brain fatty acid binding protein FABP7 in promoting glioblastoma cell migration, which can be reversed in medium supplemented with DHA. Super-resolution imaging shows the significance of FABP7 and its fatty acid ligands in mitigating GBM cell migration, suggesting a link between cell migration, membrane lipid order, and FABP7 nanoscale domains.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)