期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 427, 期 3, 页码 618-622出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.09.108
关键词
Cereblon; Proteasome subunit beta type 4; Binding protein; Proteasome activity
资金
- National Research Foundation [2012-0000760, 2011-0028665]
- Ministry of Education, Science, and Technology of Korea
- National Research Foundation of Korea [2011-0028665] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In humans, mutations in the gene encoding cereblon (CRBN) are associated with mental retardation. Although CRBN has been investigated in several cellular contexts, its function remains unclear. Here, we demonstrate that CRBN plays a role in regulating the ubiquitin-proteasome system (UPS). Heterologous expression of CRBN inhibited proteasome activity in a human neuroblastoma cell line. Furthermore, proteasome subunit beta type 4 (PSMB4), the beta 7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN. These findings suggest that CRBN may modulate proteasome activity by directly interacting with the beta 7 subunit. (C) 2012 Elsevier Inc. All rights reserved.
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