期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 426, 期 1, 页码 122-128出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.08.049
关键词
Distinct AU-rich RNA; C/EBP beta 3 ' UTR; Tumor suppression; HuR; Competitive binding
资金
- State Natural Science Foundation of China [30970585, 31170722]
- State Key Laboratory of Molecular Biology
AU-rich elements are functional motifs in the 3'untranslated region of mRNA and are binding sites for the RNA binding protein HuR, an mRNA stabilizer and translation enhancer implicated in carcinogenesis. It is not clear whether, and, if so, how the AU-rich elements function in cells when they are separated from their mRNA and form an independent RNA species. Here, we show that a short RNA with AU-rich elements derived from C/EBP beta 3'UTR suppressed growth in a human liver cancer cell line. It specifically bound HuR, and it competed with C/EBP beta mRNA in order to bind to HuR. Our results provide evidence that the cancer cell growth suppression by this 62nt RNA containing AU-rich elements may be due to competitive binding to HuR. This work may open new options for the development of novel anti-cancer drugs. (C) 2012 Elsevier Inc. All rights reserved.
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