Article
Cell Biology
Angela D. Morris, Sarah Kucenas
Summary: Injecting lysolecithin into zebrafish larvae allows for visualization of key features of lysolecithin-induced demyelination, similar to mammalian models, providing a new approach to study the temporal dynamics of such damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Shuxin Liu, Wei Zhang, Lin Yang, Fan Zhou, Peng Liu, Yaping Wang
Summary: The study showed that BMP7 has neuroprotective effects on rats with SCI, reducing demyelination and promoting functional recovery. BMP7 partially reversed oligodendrocyte loss, helping to maintain the normal structure of myelin, increase the number of axons, and improve scores. The protective effects of BMP7 may involve the induction of p-Smad1/5/9 and p-STAT3 in oligodendrocytes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Neurosciences
Simon Hametner, Sara Silvaieh, Majda Thurnher, Assunta Dal-Bianco, Hakan Cetin, Markus Ponleitner, Karin Zebenholzer, Berthold Pemp, Siegfried Trattnig, Karl Roessler, Thomas Berger, Hans Lassmann, Johannes A. Hainfellner, Gabriel Bsteh
Summary: In this case report, a 22-year-old woman presented with acute dizziness, gait dysbalance, and blurred vision. Magnetic resonance imaging revealed a lesion in the white matter affecting the right optic radiation. Ophthalmologic examination showed mild quadrantanopia, but no signs of optic neuropathy. Biopsy and neuropathological evaluation revealed a demyelinating lesion with unique cellular changes. Multiple sclerosis was excluded, but the exact etiology of the lesion remains unknown.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jacopo Angelini, Davide Marangon, Stefano Raffaele, Davide Lecca, Maria P. Abbracchio
Summary: The study identified a significant increase of GPR17-expressing cells in multiple sclerosis (MS) patients, mainly accumulating in the normal appearing white matter (NAWM) with moderate inflammation. Additionally, two distinct subpopulations of GPR17-expressing oligodendroglial cells were found in the white matter of healthy controls and MS patients, characterized by different morphologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
R. Moreno-Luna, P. F. Esteban, B. Paniagua-Torija, A. Arevalo-Martin, D. Garcia-Ovejero, E. Molina-Holgado
Summary: Regional differences exist in some components of the endocannabinoid system between oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes (OLs) derived from the spinal cord and cerebral cortex, which need to be taken into consideration in therapeutic strategies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Elham Gholami, Mohammad Reza Gholami, Asadollah Tavakoli, Mahdie Ahmadi, Jafar Rezaian, Maryam Alipour, Farzaneh Chehelcheraghi, Mojtaba Khaksarian
Summary: In this study, the effect of fluoxetine treatment on a demyelination model was examined. The results showed that fluoxetine reduces inflammation and enhances endogenous remyelination. Further studies are needed to determine the detailed mechanisms.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Neuroimaging
Simon Schading, Gergely David, Tim Max Emmenegger, Cristian Achim, Alan Thompson, Nikolaus Weiskopf, Armin Curt, Patrick Freund
Summary: This study tracks the spatiotemporal dynamics of remote anterograde and retrograde spinal tract degeneration in the upper cervical cord following SCI over two years utilizing quantitative MRI. The findings show ongoing structural changes, indicative of myelin reductions and atrophy within 2 years after SCI, providing potential biomarkers for regenerative and remyelinating therapies along entire spinal pathways.
NEUROIMAGE-CLINICAL
(2023)
Article
Cell & Tissue Engineering
Katarzyna Pieczonka, Hiroaki Nakashima, Narihito Nagoshi, Kazuya Yokota, James Hong, Anna Badner, Jonathon C. T. Chio, Shinsuke Shibata, Mohamad Khazaei, Michael G. Fehlings
Summary: Traumatic spinal cord injury (SCI) causes the loss of neurons and glial cells. Current interventions for SCI lack regenerative solutions. Neural stem/progenitor cell (NPC) transplantation is a promising strategy for regeneration but inconsistent differentiation hinders functional recovery. This study generated oligodendrogenically biased NPCs (oNPCs) from human induced pluripotent stem cells (hiPSCs) and demonstrated their effectiveness in a rodent model of cervical SCI, showing enhanced tissue preservation, remyelination, and functional recovery without adverse effects. These findings highlight the therapeutic potential of oNPCs in cervical SCI and call for further investigation to optimize this approach.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jennifer Enrich-Bengoa, Gemma Manich, Irene R. Degano, Alex Peralvarez-Marin
Summary: This study identified molecules associated with demyelinating disorders and multiple sclerosis through transcriptomic analysis, and discovered the interaction and related genes between microglia and oligodendrocyte progenitor cells. This research provides clues for further study on the treatment of demyelinating disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Weihong Du, Yongbing Deng, Rong Jiang, Luyao Tong, Ruixue Li, Xue Jiang
Summary: Recent evidence suggests that demyelination and axonal degeneration occur in spinal cord injury during the secondary injury phase. Treatment with clemastine, an FDA-approved drug, was shown to preserve myelin integrity, decrease axonal loss, and improve functional recovery in a rat SCI model. This indicates that myelination-enhancing strategies could potentially be a therapeutic approach for functional recovery in SCI.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Hengri Cong, Mengru Liang, Yupeng Wang, Haoxiao Chang, Li Du, Xinghu Zhang, Linlin Yin
Summary: Icariin treatment can alleviate CPZ-induced demyelination in mice by preserving MBP and BDNF proteins and modulating the numbers of Ols, microglia, and astrocytes in the brain.
BRAIN RESEARCH BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Zawadzka, Marine Yeghiazaryan, Sylwia Niedziolka, Krzysztof Miazga, Anna Kwasniewska, Marek Bekisz, Urszula Slawinska
Summary: Enhanced remyelination plays an important role in the recovery of motor and sensory functions in spinal cord injuries. The injection of ethidium bromide induced multifocal demyelination, leading to increased oligodendrocyte progenitor cells after 14 days. In double-EB-injected rats, most axons were remyelinated by Schwann cells and went beyond the injury epicenter into distant spinal cord segments, while some serotoninergic fibers grew caudally through the injury site. Behavioral tests confirmed significant improvement in locomotor function recovery, which was impaired by the blockade of serotonin receptors, emphasizing the important role of restored serotonergic fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nicole Pukos, Christina M. Marion, W. David Arnold, Benjamin T. Noble, Phillip G. Popovich, Dana M. McTigue
Summary: Our previous study found that a large number of new oligodendrocytes (OLs) are generated in the injured spinal cord of mice, with peak oligodendrogenesis occurring between 4 and 7 weeks post-injury. We also observed new myelin formation up to 2 months post-injury. Our current research expands on these findings, quantifying new myelin formation up to 6 months post-injury and investigating indices of demyelination. We discovered that remyelination reaches its peak during the third month post-injury and continues for at least 6 months. Additionally, we observed chronic demyelination through the expression of Nav1.2 and nodal protein disorganization. Our study also revealed a potential mechanism for initiating post-injury myelination, showing that oligodendrocyte progenitor cells (OPCs) make contact with glutamatergic axons in an activity-dependent manner. Increasing OPC/axon contacts through chemogenetic activation of axons may serve as a therapeutic target for enhancing post-spinal cord injury myelin repair.
Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Summary: MS is a chronic inflammatory and degenerative disease of the central nervous system commonly affecting the cerebellum. FGFs and FGFRs are involved in demyelinating pathologies such as MS. Recent research shows that cell-specific deletion of FGFR1 has anti-inflammatory and neuroprotective effects in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Lucile Ben Haim, Lucas Schirmer, Amel Zulji, Khalida Sabeur, Brice Tiret, Matthieu Ribon, Sandra Chang, Wouter H. Lamers, Severine Boillee, Myriam M. Chaumeil, David H. Rowitch
Summary: The study suggests that GS is expressed in myelinating oligodendrocytes in the ventral spinal cord of mice and humans, but not in oligodendrocyte progenitor cells.
Article
Engineering, Biomedical
Y. Jeong, Y. K. Son, Y. -S. Lee, C. H. Hwang, K. -i. Koo
Article
Medicine, General & Internal
Hea Nam Hong, Ju Hee Shim, You Jin Won, Jong Yoon Yoo, Chang Ho Hwang
Article
Multidisciplinary Sciences
Kyo-in Koo, Dae Kwon Park, Yoon Seok Youm, Sung Do Cho, Chang Ho Hwang
SCIENTIFIC REPORTS
(2018)
Article
Rehabilitation
JaYoung Kim, Dae Yul Kim, Min Ho Chun, Seong Woo Kim, Ha Ra Jeon, Chang Ho Hwang, Jong Kyoung Choi, Suhwan Bae
CLINICAL REHABILITATION
(2019)
Article
Engineering, Biomedical
S. Lee, J. S. Lee, J. P. Kim, K. Kim, C. H. Hwang, K. -I Koo
Article
Chemistry, Multidisciplinary
Huu Lam Phan, Jong Pal Kim, Kwangsoo Kim, Chang Ho Hwang, Kyo-in Koo
APPLIED SCIENCES-BASEL
(2019)
Review
Medicine, General & Internal
Chang Ho Hwang
WORLD JOURNAL OF CLINICAL CASES
(2019)
Article
Multidisciplinary Sciences
Kyo-in Koo, Myoung-Hwan Ko, Yongkwan Lee, Hye Won Son, Suwon Lee, Chang Ho Hwang
Article
Medicine, General & Internal
Chanh Trung Nguyen, Chung Reen Kim, Thi Huong Le, Kyo-in Koo, Chang Ho Hwang
Review
Nanoscience & Nanotechnology
Chang Ho Hwang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Multidisciplinary Sciences
Kyo-in Koo, Chang Ho Hwang
Article
Chemistry, Multidisciplinary
Huu Lam Phan, Thi Huong Le, Jung Min Lim, Chang Ho Hwang, Kyo-in Koo
Summary: Augmented reality (AR)-based rehabilitation has the potential to improve upper and lower limb function in stroke patients. Studies have shown that AR has a significant impact on both upper and lower limb function, increasing treatment intensity and promoting motor recovery after a stroke.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Thi Huong Le, Chanh Trung Nguyen, Kyo-in Koo, Chang Ho Hwang
Summary: This study confirms the feasibility of EPO-nanobots (ENBs) as therapeutic tools for neuroprotection. The results show that ENBs can control the release of EPO after preconditioning sonication and have similar neuroprotective effects to EPO.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Van Thuy Duong, Thi Thao Dang, Chang Ho Hwang, Sung Hoon Back, Kyo-in Koo
Article
Cell & Tissue Engineering
V-T. Duong, T-T. Dang, J. P. Kim, K. Kim, H. Ko, C. H. Hwang, K-I. Koo
EUROPEAN CELLS & MATERIALS
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)