Article
Biochemistry & Molecular Biology
Claudia Sepulveda-Quinenao, Juan M. Rodriguez, Francisco Diaz-Castro, Andrea del Campo, Roberto Bravo-Sagua, Rodrigo Troncoso
Summary: The study investigates the impact of glucocorticoid receptor beta on glucose uptake and storage in hepatocytes, showing that GR beta overexpression inhibits the induction of gluconeogenic genes by dexamethasone and has insulin-like actions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Kyle E. Harvey, Shiqi Tang, Emily K. LaVigne, Evan P. S. Pratt, Gregory H. Hockerman
Summary: In this study, the researchers found that RyR2 is required for the regulation of insulin content and glucose-stimulated insulin secretion in INS-1 cells, partly through its interaction with IRBIT. The experiments showed that the absence of RyR2 led to a decrease in store-operated Ca2+ entry and PLC activity, as well as an increase in cellular PIP2 levels. Furthermore, RyR2 was found to regulate beta-cell electrical activity by controlling Ca-v current density and SK channel activation.
Article
Multidisciplinary Sciences
Kyle E. Harvey, Emily K. LaVigne, Mohd Saleem Dar, Amy E. Salyer, Evan P. S. Pratt, Paxton A. Sample, Uma Aryal, Humaira Gowher, Gregory H. Hockerman
Summary: The role of RyR2 in pancreatic beta-cell function involves regulation of IRBIT levels and activity, maintenance of insulin content and secretion, and modulation of the proteome possibly through DNA methylation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
H. Sho, K. Fukui, S. Yoneda, S. Toyoda, H. Ozawa, C. Ishibashi, Y. Fujita, H. Eguchi, J. Kozawa, I Shimomura
Summary: Insulinoma is associated with reduced expression of GLUT2 and GLPIR in non-tumor area islets, possibly due to high levels of insulin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Muhammad S. Aldhshan, Gursagar Jhanji, Nicole J. Poritsanos, Tooru M. Mizuno
Summary: This study found that increased local glucose concentration stimulates GDNF expression and inhibits MANF expression in microglia, leading to suppressed appetite. Furthermore, this regulation is associated with GLUT5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Minami Kosuda, Midori Yamana, Akiko Nagasawa, Aya Tanaka, Kentaro Watanabe, Hisamitsu Ishihara
Summary: This study revealed that mitochondrial CA VB and cytosolic CA XIII are significantly increased in highly glucose-responsive insulin-secreting cells, while cytosolic CA XI is decreased. Overexpression of CA VB increases insulin secretion, while overexpression of CA XIII and CA XI has no effect on insulin secretion.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Christopher M. Carmean, Lidan Zhao, Michael Landeche, Bijoy Chellan, Robert M. Sargis
Summary: Short-term exposure to DMSO enhances insulin secretion in MIN6-K8 cells, without affecting basal secretion or potassium responsiveness. Furthermore, DMSO's mechanism of action may be upstream of calcium-dependent insulin granule exocytosis.
HISTOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Kentaro Sakaki, Takaaki Murakami, Hiroyuki Fujimoto, Yoichi Shimizu, Kanae Kawai Miyake, Daisuke Otani, Sakura Kiyobayashi, Takuya Okada, Masakazu Fujimoto, Takuro Hakata, Ichiro Yamauchi, Kotaro Shimada, Hironori Shimizu, Kazuyuki Nagai, Yuji Nakamoto, Nobuya Inagaki
Summary: F-18-exendin-4 PET/CT is a noninvasive diagnostic technique that can help localize insulinomas, and it is crucial for curative surgical resection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tobias M. Backes, Daniel S. Langfermann, Andrea Lesch, Oliver G. Rossler, Matthias W. Laschke, Charles Vinson, Gerald Thiel
Summary: The study revealed that activation of the Ca(v)1.2 calcium channel connects gene transcription in pancreatic beta-cells through the kinase c-Jun N-terminal protein kinase and transcription factor AP-1.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Neurosciences
Yinyi Xiong, Chae-Seok Lim
Summary: CBD, a non-psychoactive phytocannabinoid, shows potential for reversing cognitive deficits, reducing Aβ accumulation and tau hyperphosphorylation in Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Ayse Karatug Kacar
Summary: This study investigates the effects of DB on pancreatic beta cell tumors and finds that DB can induce cell death in INS-1 cells via the ERK signaling pathway, while stimulating insulin secretion by decreasing K+ channels and increasing Ca+2 levels. Additionally, DB promotes cell proliferation through the JNK signaling pathway.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Akinobu Nakamura
Summary: SGLT2 inhibitors not only lower blood glucose levels but also have protective effects on organs such as the heart and kidneys. These inhibitors prevent beta-cell dysfunction by reducing glucose overload, leading to increased beta-cell proliferation and decreased apoptosis. Clinical and preclinical data support the protective effect of SGLT2 inhibitors on beta-cell mass and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lidan Zhao, Christopher M. Carmean, Michael Landeche, Bijoy Chellan, Robert M. Sargis
Summary: The study found that selenium supplementation as selenomethionine enhanced insulin secretion and altered the expression of selenoproteins such as Gpx3 and SelP, affecting insulin release. These results support a potential role for selenium and selenoproteins in regulating insulin secretion, glucose homeostasis, and diabetes risk.
Article
Oncology
Ester Pagano, Tommaso Venneri, Giuseppe Lucariello, Donatella Cicia, Vincenzo Brancaleone, M. Francesca Nani, Nunzio A. Cacciola, Raffaele Capasso, Angelo A. Izzo, Francesca Borrelli, Barbara Romano
Summary: Palmitoylethanolamide (PEA) inhibits colon cancer cell proliferation via PPAR-alpha and GPR55 pathways, reduces cell migration, and has a positive impact on DNA fragmentation. Studies indicate the potential therapeutic effects of PEA in colon carcinogenesis.
Review
Biochemistry & Molecular Biology
Hideaki Kaneto, Tomohiko Kimura, Masashi Shimoda, Atsushi Obata, Junpei Sanada, Yoshiro Fushimi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku
Summary: GLP-1 is crucial in pancreatic beta-cells and its activator, GLP-1RA, shows more favorable effects in early T2DM stages; GLP-1 also plays an important role in arterial cells and GLP-1RA has more protective effects on arteriosclerosis in early T2DM stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Alexander F. Hoffman, Eun-Kyung Hwang, Carl R. Lupica
Summary: The ability of neurons to dynamically and flexibly encode synaptic inputs is crucial for learning and environmental adaptation, with both pre- and postsynaptic plasticity being necessary for optimal learning. Endogenous cannabinoids play key roles in modulating synaptic transmission, and disruptions in the endocannabinoid signaling system can lead to impairments in learned behaviors. Exposure to exogenous cannabinoids can alter the endocannabinoid signaling, resulting in widespread impairment of synaptic plasticity.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Cell Biology
Stephanie Lazo, Nicole Noren Hooten, Jamal Green, Erez Eitan, Nicolle A. Mode, Qing-Rong Liu, Alan B. Zonderman, Ngozi Ezike, Mark P. Mattson, Paritosh Ghosh, Michele K. Evans
Summary: The mitochondrial free radical theory of aging posits that oxidative damage to mitochondria and mtDNA contributes to aging. This study found a portion of ccf-mtDNA in plasma is encapsulated in EVs, and that EV mtDNA levels decrease with age. Additionally, EVs from old and young donors had differential effects on mitochondrial respiration, suggesting an age-dependent impact of EVs on mitochondrial energetics.
Article
Chemistry, Multidisciplinary
Hai-Ying Zhang, Lindsay De Biase, Ramesh Chandra, Hui Shen, Qing-Rong Liu, Eliot Gardner, Mary Kay Lobo, Zheng-Xiong Xi
Summary: Cannabinoid CB2 receptors are involved in drug reward and addiction. Repeated cocaine exposure increases CB2R expression in the brain and spleen, while repeated heroin administration leads to a dose-dependent reduction in CB2 mRNA expression in the striatum. Upregulation of CB2R mainly occurs in D-1-MSNs, not in D-2-MSNs or microglia.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pathology
Maire E. Doyle, Ashley Appleton, Qing-Rong Liu, Qin Yao, Caio H. Mazucanti, Josephine M. Egan
Summary: The study found that SARS-CoV-2 may enter the human body through infecting taste papillae cells, affecting taste receptor stem cell activity and causing taste impairment. Some patients still had not fully recovered, with disrupted taste stem cells.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Neurosciences
Agustin Zapata, Carl R. Lupica
Summary: Animal and human studies suggest that cannabis can increase cocaine seeking and is associated with impulse control deficits, possibly through involvement of the CB1 receptors. The CB1 receptors in the Lateral Habenula (LHb) play a role in impulsivity deficits, highlighting a potential therapeutic target for substance use disorders.
Article
Endocrinology & Metabolism
Qing-Rong Liu, Min Zhu, Pingbo Zhang, Caio H. Mazucanti, Nicholas S. Huang, Doyle L. Lang, Qinghua Chen, Pavan Auluck, Stefano Marenco, Jennifer F. O'Connell, Luigi Ferrucci, Chee W. Chia, Josephine M. Egan
Summary: The human insulin gene has diverged from ancestral genes millions of years ago and recent research revealed novel isoforms and protein products. A new peptide segment named Cα-peptide was found, distinct from the conventional C-peptide. The ratio of a 74-amino acid proinsulin to proconvertase-processed Cα-peptide was significantly increased in type 2 diabetes mellitus autopsy donors, suggesting potential clinical relevance.
Review
Pharmacology & Pharmacy
Qing-Rong Liu, Kanikkai Raja Aseer, Qin Yao, Xiaoming Zhong, Paritosh Ghosh, Jennifer F. O'Connell, Josephine M. Egan
Summary: CB2R may play important roles in autoimmune diabetes by regulating inflammasomes, intracellular autophagy, and extracellular vesicle release, which in turn regulate the function of pancreatic islets.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Ana Canseco-Alba, Branden Sanabria, Mariam Hammouda, Rollanda Bernadin, Marizel Mina, Qing-Rong Liu, Emmanuel S. Onaivi
Summary: DAT-Cnr2 cKO mice, which do not express CB2R in midbrain dopamine neurons, exhibit reduced hyperactivity phenotype and decreased anxiety-like behavior, but increased impulsivity and risky behavior. They also show deficient response in delay decision making and perform similarly to WT mice in attention tests. The study suggests that DAT-Cnr2 cKO mice may serve as a possible model for studying the neurobiological basis of ADHD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Kshitij S. Jadhav, Aurelien P. Bernheim, Lea Aeschlimann, Guylene Kirschmann, Isabelle Decosterd, Alexander F. Hoffman, Carl R. Lupica, Benjamin Boutrel
Summary: The development of self-regulatory competencies during adolescence depends on normative brain maturation. Adolescent rats show impulsive and compulsive-like behaviors, which are associated with underdeveloped anterior insula cortex (AIC) function. In the AIC of adolescent rats, pyramidal neurons are hypoexcitable and receive fewer glutamatergic synaptic inputs compared to adults. Activation of the AIC can attenuate compulsive traits in adolescent rats, suggesting that an immature integration of sensory and cognitive information in the AIC leads to inflexible behaviors in specific reward conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Clara I. C. Wolfe, Eun-Kyung Hwang, Elfrieda C. Ijomor, Agustin Zapata, Alexander F. Hoffman, Carl R. Lupica
Summary: The lateral habenula (LHb) balances reward and aversion by opposing activation of brain reward nuclei and is involved in the inhibition of responding for cocaine in a model of impulsive behavior. Activation of cholinergic signal to LHb and M(2)Rs is critical for the inhibition of responding for cocaine, and the cellular mechanisms underlying this effect have been defined.
JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Fereshteh S. Nugent, Alfredo Kirkwood, Carl R. Lupica, P. Jesper Sjostrom
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Marco Niello, Spyridon Sideromenos, Ralph Gradisch, Ronan O'Shea, Jakob Schwazer, Julian Maier, Nina Kastner, Walter Sandtner, Kathrin Jantsch, Carl R. Lupica, Alexander F. Hoffman, Gert Lubec, Claus J. Loland, Thomas Stockner, Daniela D. Pollak, Michael H. Baumann, Harald H. Sitte
Summary: By using various in vitro, computational, and in vivo approaches, we found that the drug-binding kinetics of S-enantiomers of pyrovalerone analogs at DAT correlate with the time-course of in vivo psychostimulant action in mice. In particular, the slow dissociation (i.e., slow koff) of S-enantiomers of pyrovalerone analogs from DAT can predict their more persistent in vivo effects compared to cocaine and methylphenidate. Overall, our findings highlight the critical importance of drug-binding kinetics at DAT in determining the in vivo profile of effects produced by psychostimulant drugs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Qing-Rong Liu, Min Zhu, Qinghua Chen, Maja Mustapic, Dimitrios Kapogiannis, Josephine M. Egan
Summary: This study uncovered novel peptides associated with human-specific IAPP isoforms, which could serve as blood-based biomarkers for early Alzheimer's disease and be developed as peptide-based anti-amyloid medicine.
Article
Behavioral Sciences
Berhanu Geresu Kibret, Aaliyah Roberts, Adam Kneebone, Shymaa Embaby, Justin Fernandez, Qing-Rong Liu, Emmanuel S. Onaivi
Summary: The endocannabinoid system (ECS) plays an important role in modulating alcohol-induced neuroinflammation and behavioral impairments. The cannabinoid type 2 receptors (CB2Rs) have been found to be involved in regulating behavior and neuroinflammation, suggesting their potential as therapeutic targets for alcohol use disorder.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Caio Henrique Mazucanti, Vernon Kennedy, Hasitha U. Premathilake, Maire E. Doyle, Jane Tian, Qing-Rong Liu, Jennifer O'Connell, Simonetta Camandola, Josephine M. Egan
Summary: The choroid plexus is an important source of insulin in the central nervous system, and its secretion is regulated by Htr2c-mediated signaling. Modulating insulin expression in the choroid plexus affects food intake, anxiety behavior, and synaptic processes in the hypothalamus. Additionally, CP-derived insulin directly acts on the hypothalamus through Gq signaling.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)