Article
Biochemistry & Molecular Biology
Leena Haataja, Anoop Arunagiri, Anis Hassan, Kaitlin Regan, Billy Tsai, Balamurugan Dhayalan, Michael A. Weiss, Ming Liu, Peter Arvan
Summary: Efficient export of proinsulin from the endoplasmic reticulum requires the formation of specific disulfide bonds, while disrupting certain pairings may improve trafficking in some mutants. Mutations causing Mutant INS gene-induced Diabetes of Youth (MIDY) often result in perturbed proinsulin disulfide bond formation, with potential for allele-specific pharmacological targeting in the future.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Liwei Wang, Catherine E. Hall, Emiko Uchikawa, Dailu Chen, Eunhee Choi, Xuewu Zhang, Xiao-chen Bai
Summary: The researchers characterized insulin fibrils using cryo-EM and solved the structure of one fibril form. They designed several insulin mutants that can reduce fibrillation while maintaining the activity of insulin signaling, which may lead to more effective therapeutics for type 1 diabetes.
Article
Chemistry, Multidisciplinary
Yingying Zhang, Yongchun Liu, Yonggang Liu, Ping Zuo, Shuting Miao, Bowen Hu, Yu Kang, Wei Liu, Qingmin Yang, Hao Ren, Peng Yang
Summary: Proteins can form robust bioadhesive materials through an α-helix-mediated interfacial adhesion model. Reduction of disulfide bonds in proteins leads to the gathering of α-helices at the solid/liquid interface, exposing hydrophobic residues and disrupting the hydration layer. This model provides a unique strategy for preparing protein nanofilms with well-defined layering, exhibiting strong adhesion and resistance to various conditions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Jinchuang Rong, Jiang Zhong, Wanlong Yan, Maochen Liu, Yalei Zhang, Yongluo Qiao, Changqing Fu, Fei Gao, Liang Shen, Haifeng He
Summary: The novel self-healable waterborne polyurethanes with synergistic reversible units of aliphatic disulfide bonds and quadruple hydrogen bonding have been successfully prepared, showing superior mechanical properties and self-repairing efficiency.
Article
Polymer Science
Wencong Zhang, Minhui Wang, Jiahui Zhou, Yeming Sheng, Min Xu, Xiaolin Jiang, Yuanhao Ma, Xun Lu
Summary: By synthesizing thermoplastic polyurethanes with multiple dynamic bonds, self-healing elastomers with high strength and efficiency were successfully prepared. The self-healing mechanism can be explained from the perspective of aggregate structure, degree of microphase separation, and molecular dynamics.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Jiarong Huang, Zhou Gong, Yukun Chen
Summary: This paper investigates a shape memory assisted self-healing (SMASH) material, where polylactide (PLA) and disulfide bonds are introduced into epoxidized natural rubber (ENR). The SMASH elastomer achieved automatic closure and healing of cracks through intrinsic shape memory and the exchange reaction of disulfide bonds. The dynamic feature of disulfide bonds endowed the material with recyclability. Moreover, the feasibility of this strategy was verified in designing PLA/ENR thermoplastic vulcanizate with SMASH behavior, expanding the research scope of self-healing elastomers and dynamic vulcanization.
Article
Polymer Science
Dan Liu, Cheng-Jie Fan, Yi Xiao, Ke-Ke Yang, Yu-Zhong Wang
Summary: In this study, a self-healing polyurethane elastomer (PPG-UPy-SS) was developed with desirable mechanical performance and excellent self-healing capacity by incorporating multiple dynamic interactions. The introduction of UPy motif and APDS in multiphase contributed to the improvement of mechanical strength and self-healing efficiency, respectively.
Article
Chemistry, Multidisciplinary
Huijuan Zhang, Li An, Xue Wang, Chao Niu, Xinjuan Hou
Summary: In this study, a colorless and transparent polyurethane elastomer (PUE) with high strength, excellent chemical resistance, and adhesive performance was designed. The resulting PUE showed remarkable transparency, good chemical resistance, and strong adhesion to metal substrates. This research provides an effective method for fabricating advanced protecting films and offers molecular insights into the adhesion mechanism of PUE and metals.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Polymer Science
Kaiming Zhang, Zhe Wang, Junhao Zhang, Yuetao Liu, Chenzhengzhe Yan, Tongxi Hu, Chuanhui Gao, Yumin Wu
Summary: In this study, hyperbranched organosilicon polymers (HPSi) with multiple hydrogen bonds and dynamic disulfide bonds were synthesized. The material showed excellent stretchability and autonomous self-healing properties at room temperature, with a repair efficiency of 96.9% and an elongation at break of 3463%. This muscle-like elastomer has great potential applications in soft robotics, electronic devices, and coatings.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Multidisciplinary Sciences
Shay Laps, Fatima Atamleh, Guy Kamnesky, Hao Sun, Ashraf Brik
Summary: This study presents a general synthetic strategy for the rapid formation of two and three disulfide bonds in peptides and proteins, which has been applied to prepare several therapeutically important peptides.
NATURE COMMUNICATIONS
(2021)
Article
Agricultural Engineering
Nan Sun, Zhaofeng Wang, Xi Ma, Kaixin Zhang, Zeyu Wang, Zhenyu Guo, Yun Chen, Lihao Sun, Wang Lu, Yang Liu, Mingwei Di
Summary: A facile strategy to prepare lignin-containing polyurethane elastomers based on hydrogen and disulfide bonds with good self-healing properties and tensile strength is reported. The study explores the role of lignin and the introduction order of disulfide bonds on the properties of polyurethane elastomers, and elaborates on the self-healing mechanism of dynamic hydrogen and disulfide bonds.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Weijun Yang, Yanlin Zhu, Tianxi Liu, Debora Puglia, Jose M. Kenny, Pengwu Xu, Rui Zhang, Piming Ma
Summary: A novel amorphous and transparent polyurethane/nanocellulose elastomer with excellent self-healing, self-reinforcing and toughening performance is obtained by implementing a dual dynamic crosslinking strategy through multiple hydrogen and disulfide bonds. The elastomer can fully self-heal within 4.0 h at 50 degrees C and exhibits significantly increased tensile strength and toughness after multiple hot-pressing. The self-strength and self-toughening effects are attributed to the reconstruction of dual dynamic networks and the presence of multiple hydrogen bonds.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Polymer Science
Hong Gao, Yingchun Sun, Miaomiao Wang, Bo Wu, Guoqiang Han, Ling Jin, Kui Zhang, Youyi Xia
Summary: This article introduces a novel acrylate-based elastomer with exchangeable disulfide crosslinks for self-healing and reprocessing capabilities. The use of a base system as a catalyst proves to be highly efficient, enabling the material to quickly restore over 90% of its mechanical properties within 5 hours, showing promising application potential as recoverable adhesives.
Article
Polymer Science
Jumpei Kida, Daisuke Aoki, Hideyuki Otsuka
Summary: This study reports the mechanochemical strengthening of cross-linked elastomers using macrocyclic mechanophores containing a dynamic covalent disulfide bond, successfully imparting the polymers with self-strengthening functionality without the need for any additives such as monomers and modifiers.
Article
Chemistry, Multidisciplinary
Zhiran Zheng, Jiawei Li, Kailun Wei, Ning Tang, Min-Hui Li, Jun Hu
Summary: This study develops an integrated auxetic elastomer (IAE) that can exhibit transverse expansion while being axially stretched. By using high-modulus cross-linked poly(urethane-urea) as a skeleton and low-modulus non-cross-linked poly(urethane-urea) as a complementary-shape matrix, along with the dual dynamic interfacial healing promoted by disulfide bonds and hydrogen bonds, the resulting IAE possesses flat, void-free, and sharp soft-to-hard interface-free characteristics. Moreover, the fracture strength and elongation at the break of the IAE are significantly improved compared to those of the corrugated re-entrant skeleton alone, while maintaining the negative Poisson's ratio (NPR) within a certain strain range. Finite element analysis further confirms the advantageous mechanical and auxetic properties of this elastomer.
ADVANCED MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Xue-Jing Li, Qing-Lan Li, Lin-Gao Ju, Chen Zhao, Lan-Shen Zhao, Jia-Wen Du, Yan Wang, Ling Zheng, Bao-Liang Song, Lian-Yun Li, Li Li, Min Wu
Summary: The study demonstrates that Setd2 deficiency can trigger spontaneous HCC by modulating DNA damage response and lipid metabolism in the liver. High-fat diet enhances lipid accumulation and promotes the development of HCC in Setd2-deficient mice.
Article
Biochemistry & Molecular Biology
Jiao Wang, Yushuo Xiao, Chengyu Liu, Yixue Huang, Robert B. Petersen, Ling Zheng, Kun Huang
Summary: MeCP2 plays a crucial role in both neurological and non-neurological disorders, including causing Rett syndrome in the former and cardiac dysfunction, liver injury, respiratory disorders, and other conditions in the latter. Research suggests that MeCP2 can influence various physiological and pathological processes in a DNA methylation-dependent or independent manner.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Meng-Jie Zhao, Xiao Yao, Ping Wei, Chen Zhao, Meng Cheng, Dong Zhang, Wen Xue, Wen-Tian He, Weili Xue, Xinxin Zuo, Lei-Lei Jiang, Zhiyuan Luo, Jiaqi Song, Wen-Jie Shu, Han-Ye Yuan, Yi Liang, Hui Sun, Yan Zhou, Yu Zhou, Ling Zheng, Hong-Yu Hu, Jiwu Wang, Hai-Ning Du
Summary: Research has shown that O-GlcNAc transferase OGT-mediated O-GlcNAcylation of TDP-43 can suppress ALS-related proteinopathies and enhance TDP-43's splicing function. This study further demonstrates the importance of TDP-43 O-GlcNAcylation in maintaining neuronal health and function.
Review
Cell Biology
Jing Yang, Qiu-yi Song, Shu-xuan Niu, Hui-jing Chen, Robert B. Petersen, Yu Zhang, Kun Huang
Summary: ANGPTLs, a family of secreted glycoproteins, play key roles in lipid metabolism and inflammation. Their potential roles and mechanisms in inflammatory diseases have attracted significant attention from researchers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Food Science & Technology
Yangmian Yuan, Chengyu Liu, Xingrui Chen, Yuyan Sun, Mingrui Xiong, Yu Fan, Robert B. Petersen, Hong Chen, Kun Huang, Ling Zheng
Summary: The study suggests that Tet1 plays a crucial role in obesity by promoting lipolysis and reducing obesity. Vitamin C can treat obesity by enhancing Tet1 activity, thus decreasing hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shilin Wang, Jiaojiao Zheng, Liang Ma, Robert B. Petersen, Li Xu, Kun Huang
Summary: Protein aggregation is closely related to the development of PMDs, and inhibiting the formation of toxic protein aggregates is seen as a potential therapeutic approach. Nanomaterials have shown promise in this regard, but the precise mechanisms of interaction with amyloidogenic proteins are still not well understood. Rational design strategies must consider factors such as size, charge, concentration, surface modification, and morphology to achieve desired effects on protein aggregation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Pharmacology & Pharmacy
Yixue Huang, Yunhao Xie, Dong Yang, Mingrui Xiong, Xingrui Chen, Di Wu, Qing Wang, Hong Chen, Ling Zheng, Kun Huang
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure. Recent research suggests that the epigenetic enzyme Utx plays a key role in APAP-induced liver injury by promoting the clearance of toxic metabolites and alleviating ER stress. Additionally, overexpression of Sult2a1 can reduce APAP overdose-induced liver injury.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Yunhao Xie, Jin Li, Huan Qin, Qing Wang, Zixi Chen, Chengyu Liu, Ling Zheng, Jiangxin Wang
Summary: The study found that sonicated and alkalized paramylon (SA-Pa) effectively alleviated LPS/D-Gal-induced ALI and promoted M2 macrophage activation, reducing inflammation and cell death in the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qing Wang, Yuchen Chen, Yunhao Xie, Dong Yang, Yuyan Sun, Yangmian Yuan, Hong Chen, Yu Zhang, Kun Huang, Ling Zheng
Summary: Linker histone H1.2 plays a significant role in hepatocellular carcinoma by regulating the activation of STAT3 and participating in inflammatory response. Blocking the H1.2/STAT3 loop may be a potential strategy for the treatment of hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Hong Chen, Chong Liu, Qian Wang, Mingrui Xiong, Xia Zeng, Dong Yang, Yunhao Xie, Hua Su, Yu Zhang, Yixue Huang, Yuchen Chen, Junqiu Yue, Chengyu Liu, Shun Wang, Kun Huang, Ling Zheng
Summary: The global obesity epidemic has negative effects on human health by causing obesity-related kidney and liver diseases. The researchers found that knockout of the UTX gene inhibits lipid accumulation in the kidney and liver induced by a high-fat diet by increasing circulating serine levels. They also discovered that UTX regulates the degradation of phosphoglycerate dehydrogenase, a key enzyme in serine synthesis, which in turn affects renal and circulating serine levels. Importantly, oral administration of serine improves fatty liver and renal dysfunction induced by a high-fat diet. These findings suggest potential treatment targets for obesity-related metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Review
Nutrition & Dietetics
Chengyu Liu, Wanyao Yan, Jiajian Shi, Shun Wang, Anlin Peng, Yuchen Chen, Kun Huang
Summary: Individuals with obesity have shown worse prognosis and higher mortality in the COVID-19 pandemic. Dyslipidemia, a common condition in obese individuals, plays a major role in the severity of COVID-19. The use of statins, lipid-regulating drugs, has been associated with a reduced risk of progressing to severe illness and in-hospital death in COVID-19 patients. However, caution should be taken due to potential side effects and concerns about interference with COVID-19 vaccines. Further clinical trials are needed to fully understand the benefits, harms, and mechanisms of statin use in the context of COVID-19.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Liang Ma, Xi Li, Chengyu Liu, Wanyao Yan, Jinlu Ma, Robert B. Petersen, Anlin Peng, Kun Huang
Summary: Parkinson's disease is a common neurodegenerative disease that affects the motor system and worsens with age. Current treatment options mainly target symptoms due to limited understanding of the disease's causes and mechanisms. Various preclinical models, including C. elegans, have been developed to study the disease and test potential treatments.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Medicine, Research & Experimental
Jiao Wang, Mingrui Xiong, Yu Fan, Chengyu Liu, Qing Wang, Dong Yang, Yangmian Yuan, Yixue Huang, Shun Wang, Yu Zhang, Shuxuan Niu, Junqiu Yue, Hua Su, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang
Summary: This study reveals a protective role of Mecp2 in acute kidney injury (AKI) induced by ischemia-reperfusion, suggesting that it inhibits renal tubular damage, inflammation, and fibrosis by suppressing the Il-6/STAT3 signaling pathway.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)