Article
Gastroenterology & Hepatology
Zhaoyun Yang, Kang He, Taiwei Wang, Yan Gao, Mengmeng Chen, Kai Wang, Zeyu Wang, Hao Wu, Shuang Zhang, Lijing Zhao
Summary: This study found that mechanical dilation leads to the expression of COX-2 in colonic smooth muscle cells, causing motility dysfunction in obstructive bowel disorders. Inhibition of PKCs and PKD can improve this dysfunction by preventing the expression of COX-2.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biochemistry & Molecular Biology
Siwen Lyu, Qi Yang, Ting Li, Xuehui Duan, Jingbo Liu, Fengguang Pan, Yiding Yu, Ting Zhang
Summary: This research investigates the protective function of fermented egg-milk peptides (FEMPs) in inflammatory diseases and analyzes the potential targets and pathways regulated by digested FEMPs (dFEMPs). The results show that FEMPs can alleviate inflammatory symptoms, repair inflammation damage, and decrease pro-inflammatory cytokine levels. In silico experiments reveal that dFEMPs can influence multiple inflammation-related targets and signaling pathways. Molecular docking results indicate the importance of hydrogen-bonding and salt bridges in dFEMP-target interactions.
Article
Microbiology
Yanpeng Ma, Yi Zhang, Ruize Qu, Xin Zhou, Lulu Sun, Kai Wang, Changtao Jiang, Zhipeng Zhang, Wei Fu
Summary: Colorectal cancer is closely related to microbiota and bile acids. This study found that mucosal microbiota in cancerous tissues showed alterations, with increased levels of certain genera and higher production of deoxycholic acid (DCA). The downregulation of FXR was observed in cancer cell lines, which played an important role in CRC development. These findings have implications for potential therapeutic targets for CRC prevention.
Article
Gastroenterology & Hepatology
Yuka Azuma, Kazuhiko Uchiyama, Takeshi Sugaya, Takeshi Yasuda, Hikaru Hashimoto, Mariko Kajiwara-Kubota, Satoshi Sugino, Hiroaki Kitae, Takashi Torii, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yuji Naito, Yoshito Itoh
Summary: The study revealed that the expression of TGR5 was decreased in the colonic epithelium of mice with DSS-induced colitis and UC patients, and DCA can delay wound healing in YAMC cells. Inhibiting the AKT signaling pathway can prevent the wound healing delay induced by DCA.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Bo Young Jeong, Kyung Hwa Cho, Kang Jin Jeong, Su Jin Cho, Minho Won, Seung Hwa Kim, Nam Hoon Cho, Gang Min Hur, Se-Hee Yoon, Hwan-Woo Park, Gordon B. Mills, Hoi Young Lee
Summary: Cancer-associated fibroblasts (CAFs) enhance their invasiveness by secreting more amphiregulin (AREG), which is induced by lysophosphatidic acid (LPA). LPA induces AREG expression in CAFs through the Yes-associated protein (YAP) and Zinc finger E-box binding homeobox 1 (Zeb1) signaling pathways, and this process can be inhibited by metformin, reducing cancer cell invasiveness.
Article
Integrative & Complementary Medicine
Park Jeong-Bae, Kim Do-Wan, Lim Kye-Taek, Oh Sejong, Lee Sei-Jung
Summary: The study demonstrates that the phytoglycoprotein extracted from Cudrania tricuspidata can promote cell proliferation in human colon epithelial cells by activating PKC, JNK, and NF-kappa B. This suggests that CTB glycoprotein has the potential to prevent and alleviate inflammatory bowel disease by regulating cell proliferation signaling events in the colon epithelium.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Oncology
Patricia Dias Carvalho, Flavia Martins, Susana Mendonca, Andreia Ribeiro, Ana Luisa Machado, Joana Carvalho, Maria Jose Oliveira, Sergia Velho
Summary: This study reveals the role of mutant KRAS in modulating cell fate through autonomous and nonautonomous signaling mechanisms in colorectal cancer cells. Mutant KRAS autonomously controls processes such as proliferation and cell-cell aggregation, while cancer cell invasion depends on the cooperation between fibroblast-derived HGF and mutant KRAS regulation of C-MET expression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Cell Biology
Rui Lin, Xunxia Bao, Hui Wang, Sibo Zhu, Zhongyan Liu, Quanning Chen, Kaixing Ai, Baomin Shi
Summary: The mechanism of TRPM2 in pancreatic cancer involves the activation of PKC/MAPK pathways, leading to enhanced proliferation, migration, and invasion abilities of PA cells. TRPM2 is negatively correlated with overall survival and progression-free survival time in PA patients, while its expression increases with tumor stage. Inhibitors of PKC/MEK significantly inhibit PA cell growth, suggesting a potential therapeutic target for pancreatic cancer.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Yiwei Shi, Rui Jiang, Xiaojiang Qin, Anqi Gao, Xiaomin Hou, Liangjing Chen, Xinrong Xu, Yunting Guo, Lina Chai, Liangyuan Zhao, Xuefeng Du, Furong Wu
Summary: This study investigated the role of nPKC in mediating PASMCs proliferation in PH. The findings revealed that hypoxia promoted PASMCs proliferation, with the most significant effect observed after 72 hours of treatment. The upregulation of PKC8 and PKC? expression under hypoxia led to PASMCs proliferation via the upregulation of AKT and ERK phosphorylation. These results suggest potential novel targets for molecular therapy of pulmonary hypertension.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhishi Xu, Yu Hou, Jiang Sun, Lin Zhu, Qibin Zhang, Wenjie Yao, Xudong Fan, Ke Zhang, Ji-gang Piao, Yinghui Wei
Summary: In this study, a combination therapy strategy using DCS-Lips and EMO-IGE effectively alleviated renal fibrosis. The DCS-Lips improved the oral bioavailability of EMO, while the EMO-IGE restored gut microbiota and enhanced the therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Qiuyan Zhao, Zhonglin Zhu, Wenqin Xiao, Guanzhao Zong, Chuanyang Wang, Weiliang Jiang, Kai Li, Jie Shen, Xingya Guo, Jianhua Cui, Lihong Guo, Rong Wan
Summary: This research reveals that the hypoxic conditions within pancreatic tumors promote the production of a circular RNA molecule called circRNF13, which is associated with aggressive tumor growth. High levels of circRNF13 are linked to a poor prognosis and it modulates downstream targets that contribute to tumor progression, providing new targets for drug development.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dan Li, Jiefei Zhou, Lingyu Wang, Zizhen Gong, Huijuan Le, Ye Huang, Congfeng Xu, Chunyan Tian, Wei Cai, Jin Wu
Summary: DCA promotes the differentiation of CD4+ T cells into pathogenic Th17 lineage by stimulating cholesterol biosynthesis through upregulation of CYP51. Modulation of bile acid level or targeting cholesterol metabolic pathway may be potential therapeutic measurements for HFD-related colitis.
CELL AND BIOSCIENCE
(2023)
Editorial Material
Hematology
Jan A. Burger
Summary: The study reveals that MARCKS protein is differentially expressed in patients with chronic lymphocytic leukemia based on the mutation status of IGHV, and its expression and phosphorylation are linked to CLL cell migration through key signaling pathways. The findings were also confirmed in samples from patients treated with the BTK inhibitor acalabrutinib.
Article
Oncology
Topi A. Tervonen, Shishir M. Pant, Denis Belitskin, Johanna Englund, Katja Narhi, Caj Haglund, Panu E. Kovanen, Emmy W. Verschuren, Juha Klefstrom
Summary: The study reveals that Ras proteins promote cancer growth and invasion by activating hepsin, a member of the serine protease family, through the Raf-MEK-ERK signaling pathway. In Ras-transformed culture, ablation of hepsin restored cell-cell junctions and basement membrane integrity, suggesting a critical role of hepsin in early tumor dissemination.
Article
Multidisciplinary Sciences
Xinyue Wang, Songyi Qian, Siyi Wang, Sheng Jia, Nishang Zheng, Qing Yao, Jian Gao
Summary: The combination of vitamin C and lenvatinib has synergistic antitumor activities against HCC cells, providing a promising therapeutic strategy to improve the prognosis of HCC patients.
Article
Medicine, General & Internal
Yinhong Zhang, Jing He, Yunqian Zhang, Li Li, Xinhua Tang, Lei Wang, Jingjing Guo, Chanchan Jin, Sean Tighe, Yuan Zhang, Yingting Zhu, Baosheng Zhu
Article
Ophthalmology
Can Zhao, Qing Cun, Yi-Jin Tao, Wen-Yan Yang, Hua Zhong, Feng-Jie Li, Sean Tighe, Ying-Ting Zhu, Ting Wang
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Medicine, General & Internal
Can Zhao, Jiao Li, Qing Cun, Yijin Tao, Wenyan Yang, Sean Tighe, Yingting Zhu, Hua Zhong
Summary: The study found that the main factors affecting quality of life in glaucoma patients were the negative correlation between binocular integrated visual field index (BVFI) and GQL-15 scores. Mild to moderate binocular VF defects had a minor impact on quality of life, while severe and uncompensated VF loss significantly affected glaucoma patients' quality of life.
Article
Multidisciplinary Sciences
Yuan Zhang, Scheffer C. G. Tseng, Ying-Ting Zhu
Summary: The study showed that culturing trabecular meshwork (TM) cells under different matrix conditions resulted in varying phenotypes, with 3D Matrigel assisting in maintaining the TM phenotype and being regulated by TGF-beta. Abnormal matrices may contribute to perpetuating pathological TM phenotypes in glaucoma patients with elevated levels of TGF-beta 2.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Chao-Xu Qian, Qin Chen, Qing Cun, Yi-Jin Tao, Wen-Yan Yang, Yue Yang, Zhong-Yin Hu, Ying-Ting Zhu, Hua Zhong
Summary: The study compared visual field defects using SITA Fast and SITA Faster strategies, showing that SITA Faster has a shorter test duration without compromising test quality compared to SITA Fast. There was a high correlation between the two strategies in terms of MD and VFI.
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ying-Ting Zhu, Sean Tighe, Shuang-Ling Chen, Yuan Zhang, Szu-Yu Chen, Winston W. Y. Kao, Scheffer C. G. Tseng
Summary: A regenerative strategy using knockdown with p120 and Kaiso siRNAs can be used to manufacture HCEC grafts with normal phenotype, morphology, and pump function following prolonged storage and shipping.
Review
Medicine, General & Internal
Qin Zhu, Xuejun Cao, Yuan Zhang, Yuan Zhou, Jieying Zhang, Xiaofan Zhang, Yingting Zhu, Liping Xue
Summary: Repeated low-level red-light therapy (RLRL) has emerged as a novel scientific approach for treating myopia by enhancing cellular metabolism and promoting repair processes. RLRL therapy, regulated by cytochrome c oxidase and dopamine-enhanced release of nitric oxide, can inhibit myopia progression and improve visual impairments without adverse effects. Targeting neuronal energy metabolism may be a major strategy for neurotherapeutics of myopia, and RLRL therapy holds great potential in controlling myopia.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Jun Hu, Nan Xiang, Gui Gang Li, Ban Luo, Yuan Zhang, Yingting Zhu, Rong Liu
Summary: This study analyzed the anatomical parameters of normal lacrimal puncta and vertical canaliculus, as well as the OCT imaging features of punctal lesions, providing a basis for clinical diagnosis and treatment. Results demonstrated that OCT can accurately measure anatomical parameters in vivo and detect punctal lesions, offering an objective basis for clinical diagnosis and treatment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Szu-Yu Chen, Yingting Zhu, Yuan Zhang, David Hsu, Scheffer C. G. Tseng
Summary: Pax6 gene plays a crucial role in supporting self-renewal of LEPC and HC-HA/PTX3 can revert senescent LNC to neural crest progenitors, supporting LEPC self-renewal. This reversion is linked to early cell aggregation mediated by CXCR4 signaling and downstream BMP signaling.
Review
Medicine, General & Internal
Qin Zhu, Shuyuan Xiao, Zhijuan Hua, Dongmei Yang, Min Hu, Ying-Ting Zhu, Hua Zhong
Summary: Near infrared (NIR) light therapy, also known as photobiomodulation therapy (PBMT), has gained significant attention as a novel therapeutic approach in ophthalmology in recent years. It has been shown to increase cytochrome oxidase and superoxide dismutase activities, inducing metabolic and antioxidant effects, as well as boost cerebral blood flow and cognitive functions without adverse effects. The scientific evidence supports the use of NIR therapy for treatment of visual and neurological conditions, focusing on molecular and cellular mechanisms in eye diseases.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Juan Sheng, Hong Sung, Fu-Bing Yu, Bo Li, Yuan Zhang, Ying-Ting Zhu
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Yijin Tao, Qin Chen, Can Zhao, Xiao Yang, Qing Cun, Wenyan Yang, Yuan Zhang, Yingting Zhu, Hua Zhong
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Wei Wang, Shen Li, Lingjuan Xu, Menglin Jiang, Xinyu Li, Yuan Zhang, Sean Tighe, Yingting Zhu, Guigang Li
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Qin Zhu, Yang Tang, Liyun Guo, Sean Tighe, Yuan Zhou, Xiaofan Zhang, Jieying Zhang, Yingting Zhu, Min Hu
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Ophthalmology
Ying-Ting Zhu, Fu Li, Yuan Zhang, Szu-Yu Chen, Sean Tighe, Shin-Ying Lin, Scheffer C. G. Tseng
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)