Article
Biochemistry & Molecular Biology
Johan Paakkonen, Nina Hakulinen, Martina Andberg, Anu Koivula, Juha Rouvinen
Summary: Xylonolactonase Cc XylC from Caulobacter crescentus exhibits specific metal binding properties and the crystal structures provide insights into the mechanism of intramolecular ester bond hydrolysis. Comparison with other ester hydrolases of the beta-propeller hydrolase family suggests potential metal binding specificities that could expand our understanding of Fe2+ utilization in enzymatic reactions.
Article
Chemistry, Physical
Jorick Franceus, Jolien Lormans, Lore Cools, Matthias D'hooghe, Tom Desmet
Summary: The study demonstrates significant phosphorylase activity can be established in GH3 glycoside hydrolases through single-site substitutions and further optimized through mutational paths. These findings suggest new insights into developing phosphorylases and provide a novel approach for future research in this field.
Article
Biochemistry & Molecular Biology
Casey Crooks, Nathan J. Bechle, Franz J. St John
Summary: This study characterized a non-reducing terminal (NRT)-specific xylobiohydrolase AcXbh30A, which strictly cleaves xylobiose from the NRT with minimal other hydrolysis products under optimized reaction conditions. This new xylobiohydrolase may be useful for commercial production of industrial quantities of xylobiose.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Medicinal
Dianyi Li, Zheng Wang, Yong Yu, Huirong Li, Wei Luo, Bo Chen, Guoqing Niu, Haitao Ding
Summary: A novel GH2 beta-galactosidase from Marinomonas sp. BSi20584 was successfully expressed in E. coli and showed stable soluble form. The purified enzyme had a specific activity of 96.827 U mg(-1) at 30 degrees C using ONPG as a substrate. It had an optimum pH of 7.0 and an optimum temperature of 50 degrees C. The enzyme's activity was enhanced by some divalent cations and inhibited by EDTA. Despite being derived from a cold-adapted strain, the enzyme exhibited considerable stability against various physical and chemical elements. It also showed activity towards rare substrates. The enzyme is a promising candidate for the industrial application of beta-galactosidase.
Article
Biochemistry & Molecular Biology
Huitang Qi, Xi Jiang, Yi Ding, Tian Liu, Qing Yang
Summary: Kasugamycin, an aminoglycoside antibiotic, has been found to be a competitive inhibitor of glycoside hydrolase family 18 (GH18) chitinases in various organisms. It was discovered that the electrostatic interaction between kasugamycin and a conserved aspartate in GH18 chitinase is vital for its inhibitory activity. This research not only identifies new molecular targets of kasugamycin but also expands the understanding of GH inhibitor design by utilizing a scaffold unrelated to the substrate.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Laura Plaza-Vinuesa, Oswaldo Hernandez-Hernandez, Ana Sanchez-Arroyo, Jose M. Cumella, Nieves Corzo, Ana M. Munnoz-Labrador, F. Javier Moreno, Blanca de las Rivas, Rosario Munoz
Summary: This study confirmed the myrosinase-like activity of Lactiplantibacillus plantarum WCFS1, indicating that glucosinolates in this strain may undergo phosphorylation and the glycosidases belonging to the GH1 family are involved in the hydrolysis of phosphorylated glucosinolates.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anders Lonstrup Hansen, Johanna M. Koivisto, Signe Simonsen, Zehui Dong, Ramon Crehuet, Dennis K. Hansen, Martin Willemoes
Summary: The study identified the importance of Asp-682 and a conserved water molecule in the activation of the catalytic nucleophile in endo-alpha-N-acetylgalactosaminidase EngBF. Mutagenesis experiments showed that His-685, His-718, and the catalytic water molecule are also crucial for catalytic activity.
Article
Plant Sciences
Naoki Shinohara, Kazuhiko Nishitani
Summary: This study reveals that the non-plant origin of the XTH family is from ExoKs in Alphaproteobacteria, not licheninases in Firmicutes as previously believed, with the relevant HGT event traced back to the Cryogenian geological period, supporting the adaptation of plants and fungi to the ancient icy environment.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Shubha Singh, Jebin Ahmed, Parmeshwar Vitthal Gavande, Carlos M. G. A. Fontes, Arun Goyal
Summary: This study investigated the structure and function of family 30 glycoside hydrolase from Ruminococcus flavefaciens. The results revealed the catalytic residues and ligand binding characteristics of the enzyme. Experimental techniques were used to validate the structural features and stability of the enzyme, providing various conformational information in solution.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Biochemistry & Molecular Biology
Xi Jiang, Qing Yang
Summary: Glycoside hydrolase family 20 (GH20) and GH84 are involved in glycoprotein modification, metabolism, and degradation, with potential applications in disease treatment and plant protection. The challenges lie in designing highly selective inhibitors due to the similarity of their active sites. Understanding the catalytic mechanism and substrate binding mode of Hex and OGA provides crucial information for inhibitor design.
BIOORGANIC CHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Laure Ayme, Agnes Hebert, Bernard Henrissat, Vincent Lombard, Nathalie Franche, Stephanie Perret, Etienne Jourdier, Senta Heiss-Blanquet
Summary: The study identified six GH9 enzymes from a compost metagenome and characterized three of them, revealing their diverse structures and functional characteristics. These enzymes play a crucial role in bacterial biomass deconstruction.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biochemistry & Molecular Biology
Emma De Beul, Alana Jongbloet, Jorick Franceus, Tom Desmet
Summary: The study focuses on the sequence diversity of Glycoside Hydrolase Family 65 (GH65) and identified specificity-determining positions through in-silico analysis of correlated mutations. By searching for amino acid motifs that differ from previously characterized enzymes, several new clades with potential new functions were identified. Three new enzymes were expressed in E. coli, with one enzyme showing high specificity in hydrolyzing specific substrates.
Article
Biochemistry & Molecular Biology
Yan An, Phuong Lan Tran, Min-Jee Yoo, Hyung-Nam Song, Kwang-Hyun Park, Tae-Jip Kim, Jong-Tae Park, Eui-Jeon Woo
Summary: The crystal structure of MalS, a periplasmic alpha-amylase from Escherichia coli, was revealed to have unique features of circularly permutated domains and a possible CBM69. The enzyme interacts with a 6-glucosyl unit at the non-reducing end of the cleavage site, and shows a higher affinity for polysaccharides such as glycogen and amylopectin. The structural analysis provides new insights into the evolution and catalytic function of GH13 subfamily 19 enzymes, and offers a molecular basis for understanding substrate binding of MalS.
Article
Agriculture, Multidisciplinary
Zhen Qin, Sainan Yu, Kemin Zhang, Xiasen Wei, Junjie Li, Zheyi Zhang, Sibao Wan, Haiyan Gao
Summary: In this study, a GH family 157 endo-beta-1,3-glucanase (BsGlc157A) was identified and characterized from Bacteroides sp. M27. It was found to have applications in fields such as food processing, plant protection, and breweries. The study also revealed its catalytic properties and antifungal activity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Zhen Qin, Sainan Yu, Kemin Zhang, Xiasen Wei, Junjie Li, Zheyi Zhang, Sibao Wan, Haiyan Gao
Summary: In this study, a β-1,3-glucanase named BsGlc157A was identified from Bacteroides sp. M27. It exhibited optimal catalytic activity at pH 6.0 and 40 degrees C. BsGlc157A adopted a classic (beta/alpha)(8) TIM-barrel structure and two catalytic residues were confirmed. Moreover, BsGlc157A showed inhibitory effects on the hyphal growth of fruit pathogenic fungi, highlighting its potential as a biocontrol agent.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Genetics & Heredity
Duleepa Pathiraja, June Wee, Kijong Cho, In-Geol Choi
Summary: This study determined the microbiota composition of laboratory-maintained Collembola and found that it is influenced by the soil microbial community. The results demonstrate that the bacterial community of adult Collembola can serve as an indicator to evaluate the soil ecosystem.
ENVIRONMENTAL MICROBIOME
(2022)
Article
Microbiology
Chul-Hwan Kim, Yeonjae Yoo, Dongjun Kim, Jong Seong Khim, Duleepa Pathiraja, Bogun Kim, In-Geol Choi, Jae-Jin Kim
Summary: A new species of bacterium, Aurantiacibacter sediminis JGD-13T, was isolated from a tidal flat in South Korea. It has distinctive characteristics and shows similarities with related strains.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Food Science & Technology
Duleepa Pathiraja, Junghwan Cho, Junsung Kim, In-Geol Choi
Summary: This study applied eDNA metabarcoding to analyze the DNA signatures of bacteria, plants, and honey bees in 48 commercial honey products from different geographical origins. The results showed that the bacterial DNA composition varied among samples from different regions, while the floral DNA signatures could identify the source of the honey. Additionally, the DNA sequences from honey bees could trace the geographical origin of the honey.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Microbiology
Yeonjae Yoo, Hanbyul Lee, Jong Seong Khim, Xiaoyue Xu, Bogun Kim, In-Geol Choi, Jae-Jin Kim
Summary: A novel halotolerant bacterium, Halomonas getboli, was isolated from saltern sediment in Yongyu- do, Republic of Korea. It showed high salt and pH tolerance.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Duleepa Pathiraja, Junghwan Cho, Peter Stougaard, In-Geol Choi
Summary: Researchers developed an enzymatic process to obtain β-neocarrabiose and 3,6-anhydro-D-galactose from kappa-carrageenan, which are important bioactive substances with potential applications in functional foods and drugs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Jungyeon Kim, Yong-Su Jin, Kyoung Heon Kim
Summary: L-fucose is an important metabolite in human-gut microbiome interactions. It is continuously produced by humans and delivered to the gut, where gut microorganisms metabolize it and produce short-chain fatty acids. Recent studies have shown that the carbon flux in L-fucose metabolism by gut microorganisms is different from other sugar metabolisms due to cofactor imbalance and low energy synthesis efficiency. The large amounts of short-chain fatty acids produced during microbial L-fucose metabolism are used by epithelial cells to recover the energy used up during L-fucose synthesis. This review provides an overview of microbial L-fucose metabolism and discusses the potential use of genetically engineered probiotics for disease treatment and prevention by modulating fucose metabolism.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Sun-Hee Lee, Eun Ju Yun, Na Ree Han, Inho Jung, Jeffrey G. Pelton, Jae-Eun Lee, Nam Joo Kang, Yong-Su Jin, Kyoung Heon Kim
Summary: This study synthesized ethyl-agarobioside (ethyl-AB) through acid-catalyzed alcoholysis of agarose, which exhibited higher thermal and pH stability than AB, with similar skin-moisturizing activity. Ethyl-AB is a novel cosmetic ingredient with potential due to its high chemical stability.
Article
Engineering, Electrical & Electronic
Heon Ick Park, Tae Jin Cho, In-Geol Choi, Min Suk Rhee, Youngsu Cha
Summary: In this study, smart finger devices (SFDs) were proposed for object classification using unimodal temperature sensors. Each SFD consisted of a module with a flexible thermoelectric device (TED) and a resistance temperature detector (RTD) sensor embedded in a silicone finger cot on a robot gripper. The Peltier heat stored on the TED was transferred to the object when gripped by the robot. The RTD sensor data, processed through a one-dimensional convolutional neural network (1D-CNN), accurately distinguished materials with similar thermal conductivities. The designed classifier identified ten selected objects using the preprocessed sensor data, enabling real-time recognition with unimodal temperature sensors.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Biochemical Research Methods
Duleepa Pathiraja, Byeonghyeok Park, Bogun Kim, Peter Stougaard, In-Geol Choi
Summary: Marine red algal biomass is a potential feedstock for sustainable production of value-added chemicals. In this study, the marine heterotrophic bacterium Pseudoalteromonas atlantica T6c was used as a metabolic chassis to produce valuable chemicals from low-cost red algal galactans or industrial waste agaropectin.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Eun Ju Yun, Sora Yu, Dong Hyun Kim, Na Jung Park, Jing-Jing Liu, Yong-Su Jin, Kyoung Heon Kim
Summary: A new metabolic pathway of 3,6-anhydro-l-galactose (l-AHG) in red macroalgae was discovered, and the enantiomeric nature of 2-keto-3-deoxy-galactonate (KDGal), a product of l-AHG catabolism, was identified. The study also demonstrated the utilization of l-KDGal by Escherichia coli. These findings have implications in determining the absolute configuration of compounds and constructing engineered microbial platforms for utilizing l-AHG or l-KDGal as substrates.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Young Seo Jang, Jungwoo Yang, Jae Kyun Kim, Tae In Kim, Yong-Cheol Park, In Jung Kim, Kyoung Heon Kim
Summary: In this study, isobutanol-tolerant mutants were isolated from two E. coli parental strains, E. coli BL21(DE3) and MG1655(DE3), through adaptive laboratory evolution (ALE) under high isobutanol concentrations. Subsequently, 16 putative genes responsible for isobutanol tolerance were identified by transcriptomic analysis. Overexpression of four genes (fadB, dppC, acs, and csiD) in E. coli conferred isobutanol tolerance and improved isobutanol titers. These findings are important for understanding microbial isobutanol tolerance and facilitating industrial isobutanol production.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Nutrition & Dietetics
Sun-Hee Lee, Tae-Joong Lim, Eun Ju Yun, Kyoung Heon Kim, Sanghyun Lim
Summary: This study investigated the effects of a combination of soybean germ extract and a probiotic on menopausal conditions and found that they can improve body weight, uterine and bone health, lipid profile, liver function, vascular markers, and neurotransmitter levels.
Article
Microbiology
Jungyeon Kim, Christine Atkinson, Michael J. Miller, Kyoung Heon Kim, Yong-Su Jin
Summary: Our study identified changes in the microbiome by administering wild-type S. boulardii in mice based on long-read sequencing and demonstrated the ability of engineered S. boulardii to secrete a recombinant protein that alters the microbiome. These findings provide valuable insights for the development of therapeutics using engineered S. boulardii that can modify the gut microbiome and host physiology.
MICROBIOLOGY SPECTRUM
(2023)
Article
Agriculture, Dairy & Animal Science
Bogun Kim, Ziayo Meng, Xiaoyue Xu, Seungwoo Baek, Duleepa Pathiraja, In-Geol Choi, Sejong Oh
Summary: Lactic acid bacteria (LAB) have important applications in milk fermentation, industrial lactic acid fermentation, and health and medicine. Limosilactobacillus fermentum, isolated from fermented dairy and food products, is considered safe and has beneficial effects on the intestinal microbiota, host immune system, and feed digestibility.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Ye-Gi Lee, Hae-Yong Jo, Do-Haeng Lee, Jong-Won Yoon, Young-Ha Song, Dae-Hyuk Kweon, Kyoung Heon Kim, Yong-Cheol Park, Jin-Ho Seo
Summary: 2'-Fucosyllactose (2'-FL), a human milk oligosaccharide, was successfully synthesized using engineered Corynebacterium glutamicum. The optimized fed-batch cultivation strategy significantly increased the production and productivity of 2'-FL.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
