Article
Cell & Tissue Engineering
Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang
Summary: The loss of NFIX gene affects endochondral ossification and mineralization in bone, with NFIX inducing osteoblast differentiation and impairing adipocyte formation by regulating HMGA1 expression. HMGA1 plays a role in osteoblast commitment and mediates NFIX function by activating canonical Wnt signaling pathways.
Article
Biotechnology & Applied Microbiology
Youhua Chen, Yan Mei, Lu Yang, Weibin Li, Yu Zhou, Surong He, Jie Liang
Summary: This study reveals the potential of Taxifolin (TXL) in the treatment of asthma. TXL increases cell viability and suppresses inflammation, mucus formation, and apoptosis in TNF-alpha-induced BEAS-2B cells. Furthermore, TXL blocks the Wnt/beta-catenin pathway by inhibiting MMP10 expression. This study provides new insights into the treatment of asthma.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Immunology
Yuxuan Li, Lutian Yao, Jing Lu
Summary: IL-35 inhibits adipogenesis by regulating the proliferation, cytotoxicity, and differentiation of adipocytes. It suppresses the expression of PPAR gamma and C/EBP alpha, and also influences the Wnt/beta-actin pathway through the regulation of Axin2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dermatology
Sophie Frech, Agnes Forsthuber, Ana Korosec, Katharina Lipp, Viktor Kozumov, Beate M. Lichtenberger
Summary: Patients with large scars, such as burn victims, face not only aesthetic challenges but also ongoing itching or pain that significantly reduces their quality of life. The regeneration of skin appendages, such as hair follicles, is a major objective for regenerative medicine as their lack limits scarless wound healing. In this study, the researchers found that Hedgehog signaling plays different roles in two distinct developmental lineages of dermal fibroblasts, promoting wound repair and inducing de novo hair follicle formation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell & Tissue Engineering
Guopan Liu, Ying Wang, Yilin Pan, Li Tian, Ming Ho Choi, Li Wang, Jin Young Kim, Jian Zhang, Shuk Han Cheng, Liang Zhang
Summary: Hypertonicity induces dedifferentiation of adipocytes through the release of mitochondrial EVs and activation of TNF-α and Wnt/β-catenin signaling pathways.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kayla M. Scott, D. Joshua Cohen, Barbara D. Boyan, Zvi Schwartz
Summary: The study reveals that IL-1β and TNF-α induce cartilage destruction and progression of osteoarthritis, which can be prevented by miR-122. Conversely, miR-451 exacerbates these effects. Furthermore, the WNT/β-catenin signaling pathway also influences the actions of IL-1β and TNF-α.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Cell & Tissue Engineering
Xiaoli Shi, Yunzhu Cen, Liying Shan, Lijie Tian, Endong Zhu, Hairui Yuan, Xiaoxia Li, Ying Liu, Baoli Wang
Summary: The study revealed that NDRG1 negatively regulated cell growth and modulated the differentiation of marrow stromal progenitor cells towards adipocytes, impacting the osteoblast differentiation. NDRG1 interacted with LRP6 and inactivated the canonical Wnt/beta-catenin signaling cascade in stromal progenitor cells. In vivo transfection of Ndrg1 siRNA prevented inactivation of Wnt signaling and improved osteoblasts reduction and fat accumulation in ovariectomized mice.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jinhai Luo, Zhiling Yu, Juscelino Tovar, Anne Nilsson, Baojun Xu
Summary: Phytochemicals inhibit adipogenesis and lipid accumulation by activating the Wnt/β-catenin signaling pathway, potentially serving as anti-obesity drugs.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Shengchao Xu, Chengke Luo, Dikang Chen, Lu Tang, Quan Cheng, Ling Chen, Zhixiong Liu
Summary: The study aimed to elucidate the role and mechanism of circMMD in tumor treating fields (TTF) treatment of glioblastoma (GBM). The results showed that circMMD expression was elevated in GBM and high expression was associated with poor prognosis. TTF intervention reduced circMMD synthesis, suppressing GBM proliferation and increasing TTF-mediated apoptosis. The reduction of circMMD promoted the interaction between FUBP1 and FIR, leading to decreased DVL1 transcription. Additionally, decreased circMMD enhanced miR-15b-5p activity to degrade FZD6. Ultimately, the diminished expression of DVL1 and FZD6 suppressed the activation of Wnt/beta-catenin pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Review
Oncology
Kaiting Wang, Xinyao Qiu, Yan Zhao, Hongyang Wang, Lei Chen
Summary: The Wnt/beta-catenin signaling pathway plays a crucial role in regulating interactions among different components of the TME in hepatocellular carcinoma. Utilizing Wnt/beta-catenin mutations as a biomarker to predict resistance in immunotherapy holds significant clinical implications.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Shuwen Qian, Yan Tang, Qi-Qun Tang
Summary: Adipose tissues, including different types such as white, beige, and brown adipose tissue, are highly dynamic and undergo profound changes during development and regeneration. Bone morphogenetic proteins (BMPs), with their pleiotropic functions, play a crucial role in regulating the differentiation of adipocytes and macrophages in adipose tissues.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Young-Dan Cho, Woo-Jin Kim, Sungtae Kim, Young Ku, Hyun-Mo Ryoo
Summary: The study found that the surface roughness of titanium implants affects their osteogenic potential, with sandblasted/large-grit/acid-etched (SLA) surfaces showing superior osteogenic response compared to machined surfaces, likely due to a different epigenetic landscape, particularly DNA methylation of the Alp gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bong-Soo Kim, Hye-Rim Shin, Hyun-Jung Kim, Heein Yoon, Young-Dan Cho, Kang-Young Choi, Je-Yong Choi, Woo-Jin Kim, Hyun-Mo Ryoo
Summary: Midface hypoplasia in Apert syndrome is associated with abnormal nasal septum cartilage. Surgical correction of the nasal septum cartilage may improve the prognosis of patients with midface hypoplasia and respiratory problems in Apert syndrome.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Young-Dan Cho, Woo-Jin Kim, Hyun-Mo Ryoo, Hong-Gee Kim, Kyoung-Hwa Kim, Young Ku, Yang-Jo Seol
Summary: The ENCODE project has increased our understanding of functional elements in the genome and epigenome. Current research trends focus on the link between epigenetics and periodontal diseases, with a growing interest in oral health and systemic health. Advances in sequencing technology have expanded the scope of epigenetic studies from specific genes to genome-wide analyses, providing crucial information for comprehensive dental medicine.
CLINICAL EPIGENETICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Young-Dan Cho, Woo-Jin Kim, Hyun-Mo Ryoo, Young Ku
Summary: This study evaluated the current status of patents on dental implants and found that the technology is in the decline stage. The United States holds the largest number of patents, and profit-oriented companies are the main contributors to development.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Maria Akhtar, Kyung Mi Woo, Muhammad Tahir, Wenhui Wu, Jeevithan Elango, Munazza R. Mirza, Maryam Khan, Saba Shamim, Praveen R. Arany, Saeed Ur Rahman
Summary: The study demonstrated that LiCl-incorporated nanofiber scaffolds can enhance osteoblast differentiation by promoting cell proliferation and increasing expression of proteins associated with osteogenesis.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Cell Biology
Hye-Rim Shin, Bong-Soo Kim, Hyun-Jung Kim, Heein Yoon, Woo-Jin Kim, Je-Yong Choi, Hyun-Mo Ryoo
Summary: This study finds that the main cause of limb shortening in Apert syndrome resulting from FGFR2 gene mutations is the excessive expression of RANKL, which leads to an imbalance in osteoblast and osteoclast coupling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Abdul S. Qadir, Jean Philippe Guegan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoue, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter
Summary: The apoptosis inducing receptor CD95/Fas has tumorigenic activities and its expression in tumor cells can suppress NK cell immunity, providing a new target for immune therapy.
Article
Biochemistry & Molecular Biology
Hyun-Jung Kim, Woo-Jin Kim, Hye-Rim Shin, Hee-In Yoon, Jae- Moon, Eunji Lee, Jin-Muk Lim, Young-Dan Cho, Mi-Hye Lee, Hong-Gee Kim, Hyun-Mo Ryoo
Summary: Cellular senescence is closely related to tissue aging, including bone. Oxidative stress caused by the accumulation of reactive oxygen species (ROS) accelerates cellular senescence and dysfunction of osteoblasts. This study identified PADI2 as a regulator of ROS-accelerated senescence of osteoblasts and provided new insights into excessive ROS-promoted cellular senescence and aging-related bone diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Abhalaxmi Singh, Sreeparna Chakraborty, Sing Wan Wong, Nicole A. Hefner, Andrew Stuart, Abdul S. Qadir, Amitabha Mukhopadhyay, Kurt Bachmaier, Jae-Won Shin, Jalees Rehman, Asrar B. Malik
Summary: This study explores the potential of mannose-targeted nanoparticles for treating lung fibrosis by delivering TGF beta-siRNA into profibrotic macrophages, inhibiting the development of fibrosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Saeed Ur Rahman, Woo-Jin Kim, Shin Hye Chung, Kyung Mi Woo
Summary: This study demonstrates that the fibrous topography of scaffolds can direct the differentiation of odontoblast-lineage cells to have the three-dimensional structure of odontoblasts. The altered responsiveness to Wnt5a on the nanofibrous substrate mediated the phosphorylation of JNK and polarity growth signaling, leading to the regeneration of tubular dentin with odontoblast processes. These findings suggest the potential application of nanofibrous scaffolds for dentin regeneration and provide evidence for the distinctive cell responsiveness to their micro-environments.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Woo Jin Kim, Young-Dan Cho, Young Ku, Hyun-Mo Ryoo
Summary: As the society ages, improving quality of life has become an important issue. With implants being accepted as a core component of oral rehabilitation treatment, competition to develop related technologies is intensifying. The analysis of 32,237 dental implant patents reveals advancements in technology, diverse geography, and a convergence towards combining various technological areas in the field. Dental implant technology has transitioned from conventional materials and surface treatments to new material technologies like zirconium and tantalum, as well as software technologies for diagnosis and prognosis. The growth of dental implant technology is expanding rapidly in East Asian countries, along with the growth of the Asian market. Overall, dental implant technology is developing by merging with different technological areas based on the local market environment.
BIOMATERIALS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jae- Moon, Woo-Jin Kim, Ki-Tae Kim, Hyun-Jung Kim, Hye-Rim Shin, Heein Yoon, Seung Gwa Park, Min-Sang Park, Young-Dan Cho, Pil-Jong Kim, Hyun-Mo Ryoo
Summary: An innovative automated image analysis method is presented in this study for precise quantification of subcellular foci within the cell nucleus. The method, called Foci-Xpress, is significantly faster and equally accurate compared to other conventional methods. Its automation eliminates biases caused by researchers and enhances experimental efficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Heein Yoon, Seung Gwa Park, Hyun-Jung Kim, Hye-Rim Shin, Ki-Tae Kim, Young-Dan Cho, Jae- Moon, Min-Sang Park, Woo-Jin Kim, Hyun-Mo Ryoo
Summary: A study found that a form of vitamin B3 called nicotinamide (NAM) can prevent or treat bone diseases related to oxidative stress by increasing the production of antioxidant enzymes. NAM enhances mitochondrial function, increases the production of antioxidant enzymes, and promotes the formation of bone-building cells called osteoblasts. NAM increases mitochondrial biogenesis and antioxidant enzyme expression through activation of the SIRT3-FOXO3A axis, enhancing osteoblast differentiation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Yoon, H. J. Kim, H. R. Shin, B. S. Kim, W. J. Kim, Y. D. Cho, H. M. Ryoo
Summary: The study demonstrates that nicotinamide improves delayed tooth eruption in Runx2(+/-) mice through the restoration of decreased osteoclastogenesis, suggesting it as a potential therapeutic drug for dental abnormalities in patients with CCD.
JOURNAL OF DENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Hyun-Jung Kim, Woo-Jin Kim, Hyun-Mo Ryoo
MOLECULES AND CELLS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)