Article
Biochemistry & Molecular Biology
Tobias Puengel, Hanyang Liu, Adrien Guillot, Felix Heymann, Frank Tacke, Moritz Peiseler
Summary: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are chronic liver diseases that can lead to end-stage liver disease and hepatocellular carcinoma (HCC) worldwide. The metabolic syndrome is closely linked to NAFLD, and comorbidities such as type 2 diabetes, obesity, and insulin resistance worsen liver disease, while NAFLD increases cardiovascular risk in affected patients. Therapeutic strategies targeting multiple drug targets or drugs with multiple mechanisms of actions are needed for effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Valentina Bordano, Gemma K. Kinsella, Stefania Cannito, Chiara Dianzani, Casimiro Luca Gigliotti, John C. Stephens, Chiara Monge, Claudia Bocca, Arianna C. Rosa, Gianluca Miglio, Umberto Dianzani, John B. C. Findlay, Elisa Benetti
Summary: This study evaluated the role of GPR21 in human macrophages, finding its involvement in cell migration and cytokine release, and the inhibition of its activity by the drug GRA2. GRA2 reduced the release of inflammatory cytokines from M1 macrophages and promoted the migration of M2 macrophages. Thus, pharmacological inhibition of GPR21 may be important in pathological conditions characterized by low-grade chronic inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Immunology
Marco Orecchioni, Hiroaki Matsunami, Klaus Ley
Summary: Olfactory receptors in macrophages play a significant role in inflammation regulation and pathological processes. By triggering specific receptors and their ligand binding, the formation of inflammasomes and the release of inflammatory mediators can be induced.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ulrich Stifel, Giorgio Caratti, Jan Tuckermann
Summary: In this review, the authors discuss the regulatory role of nuclear receptors (NRs) in cellular metabolism of immune cells, particularly macrophages, during the resolution of inflammation. The recent developments in understanding the mechanisms and implications of NRs in immune responses and anti-inflammatory drug design are highlighted.
Article
Biochemistry & Molecular Biology
Polina Vishnyakova, Anastasiya Poltavets, Maria Nikitina, Konstantin Midiber, Liudmila Mikhaleva, Kamilla Muminova, Alena Potapova, Zulfiya Khodzhaeva, Alexey Pyregov, Andrey Elchaninov, Timur Fatkhudinov, Gennady Sukhikh
Summary: Preeclampsia is a gestational hypertensive syndrome associated with systemic failure and innate immunity. This study compared pro-inflammatory and anti-inflammatory markers in decidual macrophages between normal pregnancy and early- and late-onset preeclampsia. Downregulation of estrogen receptor alpha, HGF and CD206 may contribute to the pathogenesis of preeclampsia.
Article
Biochemistry & Molecular Biology
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
Summary: In this study, the effects of sex steroids on the expression of inflammatory mediators in human-derived adipocytes were evaluated. The results showed that non-aromatizable androgen DHT and the aromatase inhibitor anastrozole in combination with testosterone significantly enhanced the expression of inflammatory cytokines induced by LPS. These results confirm the involvement of sex hormones in adipose tissue inflammation and suggest a specific role for non-aromatizable androgens as amplificatory sex hormones of the inflammatory response.
Article
Biochemistry & Molecular Biology
Pinyi Liu, Yan Chen, Zhi Zhang, Zengqiang Yuan, Jian-Guang Sun, Shengnan Xia, Xiang Cao, Jian Chen, Cun-Jin Zhang, Yanting Chen, Hui Zhan, Yuexinzi Jin, Xinyu Bao, Yue Gu, Meijuan Zhang, Yun Xu
Summary: Microglia-mediated neuroinflammation is involved in various neurological diseases, and this study explores the endogenous mechanisms by which the transcription factor NR4A1 restricts inflammation. The researchers found that cytoplasmic NR4A1 functions as an RNA-binding protein that directly binds and destabilizes Tnf mRNA, thereby regulating its expression. The conditional deletion of Nr4a1 in microglia leads to elevated Tnf expression and worsened outcomes in a mouse model of ischemic stroke.
Article
Cell Biology
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong
Summary: Obesity-induced hypoxic stress in white adipose tissue leads to inflammation and interferon-y (IFN-y) production by natural killer (NK) cells. This study reveals that hypoxia promotes glutamate excretion and CXCL12 expression in white adipocytes, recruiting CXCR4+ NK cells. The spatial proximity between adipocytes and NK cells induces IFN-y production by stimulating metabotropic glutamate receptor 5 (mGluR5), which triggers inflammatory activation of macrophages and increases xCT and CXCL12 expression in adipocytes. Inhibition of xCT, mGluR5, or IFN-y receptor in adipocytes or NK cells alleviates obesity-related metabolic disorders in mice and elevated glutamate/mGluR5 and CXCL12/CXCR4 levels are observed in obese patients, suggesting a potential therapeutic target for obesity-related metabolic disorders.
Article
Immunology
Laura D. Manzanares-Meza, Claudia Gutierrez-Roman, Albertana Jimenez-Pineda, Felipe Castro-Martinez, Genaro Patino-Lopez, Eunice Rodriguez-Arellano, Ricardo Valle-Rios, Vianney F. Ortiz-Navarrete, Oscar Medina-Contreras
Summary: Mucosal innate immunity is the first line of defense against pathogens. IL-1 cytokines are important regulators in inflamed mucosa. The secretion of IL-1 cytokines is regulated by unconventional pathways. Mouse macrophages experiments indicate IL-36 gamma is mainly secreted through membrane pores formed by P2X7R and Gasdermin D.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Review
Cardiac & Cardiovascular Systems
Saif Ali, Roshan Alam, Haseeb Ahsan, Saba Khan
Summary: This article summarizes the roles of two adipokines - omentin and visfatin - in coronary artery disease (CAD). Omentin has anti-inflammatory and anti-atherogenic effects, regulating cardiovascular functions, while visfatin is a factor that promotes vascular inflammation and atherosclerosis.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Hematology
Juliana M. Navia-Pelaez, Colin Agatisa-Boyle, Soo-Ho Choi, Yi Sak Kim, Shenglin Li, Elena Alekseeva, Kimberly Weldy, Yury I. Miller
Summary: The plasma membrane of macrophages in atherosclerotic lesions may undergo reprogramming to maintain inflammarafts, which serve as platforms for assembling inflammatory receptor complexes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Priscila R. Nunes, Ricardo C. Cavalli, Vanessa A. Belo, Valeria C. Sandrim, Marcelo R. Luizon
Summary: This study conducted the first longitudinal study of plasma visfatin levels in healthy pregnant women, finding that visfatin levels were significantly higher in the third trimester compared to the second trimester, and significantly reduced in the postpartum period. These findings suggest the potential of visfatin as a biomarker for pregnancy complications.
REPRODUCTIVE SCIENCES
(2023)
Article
Cell Biology
Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, Xian Liu, Dong-Xu Li, Yang Xiao, Xu Chen, Ya-Ting Li, Yi-Qun Zhan, Shen-Si Xiang, Hui Chen, Hui-Ying Gao, Ke Zhao, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Zhi-Qiang Ge, Xiao-Ming Yang, Rong-Hua Yin
Summary: This study investigated the pathophysiological role of BRISC in acute liver failure. The expression of BRISC components was found to increase in kupffer cells (KCs) upon LPS treatment, and the deficiency of BRISC significantly attenuated liver damage and inflammation response. The study demonstrated that BRISC is involved in NF-kappa B-mediated proinflammatory cytokines production in LPS-treated KCs. This research opens the possibility for the development of new strategies to inhibit KCs-driven inflammation in liver diseases.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Saskia Rauber, Maximilian Fischer, Denise Messerer, Vanessa Wimmler, Kumaraswami Konda, Andrei Todica, Michael Lorenz, Anna Titova, Christian Schulz, Tobias Weinberger
Summary: The reduction of Rxr alpha levels in monocytes and macrophages negatively impacts cardiac remodeling after myocardial infarction, leading to increased myocardial defects and worsened cardiac function.
Article
Gastroenterology & Hepatology
Sarra Smati, Arnaud Polizzi, Anne Fougerat, Sandrine Ellero-Simatos, Yuna Blum, Yannick Lippi, Marion Regnier, Alexia Laroyenne, Marine Huillet, Muhammad Arif, Cheng Zhang, Frederic Lasserre, Alain Marrot, Talal Al Saati, JingHong Wan, Caroline Sommer, Claire Naylies, Aurelie Batut, Celine Lukowicz, Tiffany Fougeray, Blandine Tramunt, Patricia Dubot, Lorraine Smith, Justine Bertrand-Michel, Nathalie Hennuyer, Jean-Philippe Pradere, Bart Staels, Remy Burcelin, Francoise Lenfant, Jean-Francois Arnal, Thierry Levade, Laurence Gamet-Payrastre, Sandrine Lagarrigue, Nicolas Loiseau, Sophie Lotersztajn, Catherine Postic, Walter Wahli, Christophe Bureau, Maeva Guillaume, Adil Mardinoglu, Alexandra Montagner, Pierre Gourdy, Herve Guillou
Summary: The study found that different diets induced more severe NAFLD in male mice, characterized by lipid accumulation and inflammation/fibrosis. Sex-biased hepatic gene signatures showed different responses to various dietary challenges, with Peroxisome proliferator-activated receptor alpha (PPAR alpha) playing a key role in gender-specific and NAFLD pathophysiology.
Article
Biochemistry & Molecular Biology
Laura Vila, Nuria Cabedo, Carlos Villarroel-Vicente, Ainhoa Garcia, Alvaro Bernabeu, Nathalie Hennuyer, Bart Staels, Xavier Franck, Bruno Figadere, Maria-Jesus Sanz, Diego Cortes
Summary: The study synthesized three new series of prenylated benzopyrans containing different numbers of isoprenoid units and explored their hPPAR transactivation activity and structure activity relationships. The results demonstrated that 2-prenylated benzopyrans with seven-carbon and nine-carbon side chains are good lead compounds for preventing cardiovascular diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Paolo Zanoni, Grigorios Panteloglou, Alaa Othman, Joel T. Haas, Roger Meier, Antoine Rimbert, Marta Futema, Yara Abou Khalil, Simon F. Norrelykke, Andrzej J. Rzepiela, Szymon Stoma, Michael Stebler, Freerk van Dijk, Melinde Wijers, Justina C. Wolters, Nawar Dalila, Nicolette C. A. Huijkman, Marieke Smit, Antonio Gallo, Valerie Carreau, Anne Philippi, Jean-Pierre Rabes, Catherine Boileau, Michele Visentin, Luisa Vonghia, Jonas Weyler, Sven Francque, An Verrijken, Ann Verhaegen, Luc Van Gaal, Adriaan van der Graaf, Belle V. van Rosmalen, Jerome Robert, Srividya Velagapudi, Mustafa Yalcinkaya, Michaela Keel, Silvija Radosavljevic, Andreas Geier, Anne Tybjaerg-Hansen, Mathilde Varret, Lucia Rohrer, Steve E. Humphries, Bart Staels, Bart van de Sluis, Jan Albert Kuivenhoven, Arnold von Eckardstein
Summary: This study identified a novel mechanism of posttranscriptional regulation of LDLR activity in humans and found associations of genetic variants of RBM25 with LDL-cholesterol levels.
CIRCULATION RESEARCH
(2022)
Letter
Endocrinology & Metabolism
Alhassane Diallo, Matthieu Pichelin, Matthieu Wargny, Pierre Gourdy, Jean-Baptiste Bonnet, Samy Hadjadj, Bertrand Cariou, Ariane Sultan, Florence Galtier
DIABETES OBESITY & METABOLISM
(2022)
Article
Oncology
Segolene Hescot, Matthieu Faron, Manal Kordahi, Christine Do Cao, Annabelle Naman, Livia Lamartina, Julien Hadoux, Sophie Leboulleux, Francois Pattou, Sebastien Aubert, Jean-Yves Scoazec, Abir Al Ghuzlan, Eric Baudin
Summary: The aim of this study was to identify and prioritize potential prognostic parameters in metastatic ACC. The study found P53 and PDxK to be independent prognostic markers of metastatic adrenocortical carcinoma, highlighting the importance of adjusting biomarkers to validated prognostic factors.
Article
Nutrition & Dietetics
Justine Gillard, Corinne Picalausa, Christoph Ullmer, Luciano Adorini, Bart Staels, Anne Tailleux, Isabelle A. Leclercq
Summary: Activation of TGR5 has beneficial effects on glucose tolerance and MAFLD, particularly when activated in the enterohepatic system.
Article
Medicine, Research & Experimental
Alexis Boulinguiez, Christian Duhem, Alicia Mayeuf-Louchart, Benoit Pourcet, Yasmine Sebti, Kateryna Kondratska, Valerie Montel, Stephane Delhaye, Quentin Thorel, Justine Beauchamp, Aurore Hebras, Marion Gimenez, Marie Couvelaere, Mathilde Zecchin, Lise Ferri, Natalia Prevarskaya, Anne Forand, Christel Gentil, Jessica Ohana, France Pietri-Rouxel, Bruno Bastide, Bart Staels, Helene Duez, Steve Lancel
Summary: The study shows that NR1D1 plays a crucial role in regulating skeletal muscle SR calcium homeostasis by repressing the expression of the SERCA inhibitor myoregulin. Lower NR1D1 expression is observed in patients with Duchenne muscular dystrophy, while pharmacological activation of NR1D1 improves calcium homeostasis and muscle structure and function.
Article
Multidisciplinary Sciences
Marie Bobowski-Gerard, Clemence Boulet, Francesco P. Zummo, Julie Dubois-Chevalier, Celine Gheeraert, Mohamed Bou Saleh, Jean-Marc Strub, Amaury Farce, Maheul Ploton, Loic Guille, Jimmy Vandel, Antonino Bongiovanni, Ninon Very, Eloise Woitrain, Audrey Deprince, Fanny Lalloyer, Eric Bauge, Lise Ferri, Line-Carolle Ntandja-Wandji, Alexia K. Cotte, Corinne Grangette, Emmanuelle Vallez, Sarah Cianferani, Violeta Raverdy, Robert Caiazzo, Viviane Gnemmi, Emmanuelle Leteurtre, Benoit Pourcet, Rejane Paumelle, Kim Ravnskjaer, Guillaume Lassailly, Joel T. Haas, Philippe Mathurin, Francois Pattou, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jerome Eeckhoute
Summary: The transcription factor Basonuclin 2 (BNC2) is found to play a key role in driving myofibroblast activation in liver fibrosis. Its expression is induced in fibrotic livers and it integrates pro-fibrotic stimuli to induce matrisome gene expression. BNC2 deficiency leads to reduced collagen deposition in the liver. Furthermore, the study identifies a potential drug target, CC-885, as a BNC2 inhibitor.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Raphael Decoin, Laura Butruille, Thomas Defrancq, Jordan Robert, Nicolas Destrait, Augustin Coisne, Samy Aghezzaf, Eloise Woitrain, Zouriatou Gouda, Sofia Schino, Cedric Klein, Patrice Maboudou, Francois Brigadeau, Didier Klug, Andre Vincentelli, David Dombrowicz, Bart Staels, David Montaigne, Sandro Ninni
Summary: This study suggests that metabolic dysfunction-associated fatty liver disease (MAFLD) and liver fibrosis severity have an impact on left atrial (LA) structure and function. MAFLD patients with a high risk of F3-F4 liver fibrosis showed abnormalities in LA low-voltage areas, peak left atrial longitudinal strain, and volume, as well as a higher rate of atrial fibrillation (AF) recurrence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Veronique Ferret-Sena, Carlos Capela, Ana Macedo, Antonio Vasco Salgado, Bruno Derudas, Bart Staels, Armando Sena
Summary: This study aimed to evaluate the effects of Fingolimod treatment on PPAR and CD36 gene expression. The results showed that Fingolimod treatment increased HDL-Cholesterol and Apolipoprotein E levels, as well as leukocyte PPAR gamma and CD36 gene expression. Additionally, the variations in PPAR gamma and CD36 were significantly correlated during therapy and in patients with stable disease.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Oncology
Gregory Baud, Arnaud Jannin, Camille Marciniak, Benjamin Chevalier, Christine Do Cao, Emmanuelle Leteurtre, Amandine Beron, Georges Lion, Samuel Boury, Sebastien Aubert, Brigitte Bouchindhomme, Marie-Christine Vantyghem, Robert Caiazzo, Francois Pattou
Summary: This study aimed to analyze the risk factors of post-thyroidectomy complications and assess the morbidity of lymph node dissection, particularly in the central neck compartment. The results showed that lymph node dissection in the central and lateral compartments increased the risk of hypoparathyroidism and recurrent laryngeal nerve injuries.
Article
Nutrition & Dietetics
Marion Courtalin, Helene Verkindt, Naima Oukhouya Daoud, Nassima Ramdane, Bernard Cortet, Francois Pattou, Julien Paccou
Summary: The study aimed to evaluate the implementation of the ECTS 2022 recommendations for preventing and treating osteoporosis after bariatric surgery. A retrospective cohort study was conducted on postmenopausal women and men aged 50 and older who had undergone or were undergoing bariatric surgery. Osteoporosis medication was indicated if certain criteria were met, and a fifth of the population surveyed was found to be eligible.
Article
Endocrinology & Metabolism
Stefano Rizza, Alessio Luzi, Maria Mavilio, Marta Ballanti, Arianna Massimi, Ottavia Porzio, Andrea Magrini, Juliane Hannemann, Rossella Menghini, Jonathan Cridland, Bart Staels, Peter J. Grant, Rainer H. Boger, Nikolaus Marx, Massimo Federici
Summary: This study aimed to investigate the effects of timed light therapy on rotating night shift workers. The results showed that while light therapy had no impact on inflammatory parameters or glucose tolerance, significant changes in the expression of circadian clock genes were detected in the participants' blood cells.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Carmelo Quarta, Kerstin Stemmer, Aaron Novikoff, Bin Yang, Felix Klingelhuber, Alex Harger, Mostafa Bakhti, Aimee Bastidas-Ponce, Eric Bauge, Jonathan E. Campbell, Megan Capozzi, Christoffer Clemmensen, Gustav Collden, Perla Cota, Jon Douros, Daniel J. Drucker, Barent DuBois, Annette Feuchtinger, Cristina Garcia-Caceres, Gerald Grandl, Nathalie Hennuyer, Stephan Herzig, Susanna M. Hofmann, Patrick J. Knerr, Konxhe Kulaj, Fanny Lalloyer, Heiko Lickert, Arek Liskiewicz, Daniela Liskiewicz, Gandhari Maity, Diego Perez-Tilve, Sneha Prakash, Miguel A. Sanchez-Garrido, Qian Zhang, Bart Staels, Natalie Krahmer, Richard D. DiMarchi, Matthias H. Tschoep, Brian Finan, Timo D. Mueller
Summary: A conjugate drug consisting of a GLP-1 receptor agonist and a PPAR alpha/gamma dual-agonist called tesaglitazar has been found to be more effective in treating diabetes compared to monotherapy. The drug utilizes GLP-1 receptor-dependent cellular delivery of tesaglitazar, leading to improved body weight, food intake, and glucose metabolism. It may be a promising treatment option for hyperglycemia and insulin resistance.
Article
Gastroenterology & Hepatology
Justine Gillard, Laure-Alix Clerbaux, Maxime Nachit, Christine Sempoux, Bart Staels, Laure B. Bindels, Anne Tailleux, Isabelle A. Leclercq
Summary: This study demonstrates that alterations in enterohepatic bile acids significantly contribute to the development of non-alcoholic steatohepatitis in relevant preclinical models. Experimental modulation of bile acid composition restored perturbed FXR and TGR5 signaling and prevented non-alcoholic steatohepatitis and associated metabolic disorders.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
