Review
Cell Biology
Abudu I. Bello, Rituparna Goswami, Shelby L. Brown, Kara Costanzo, Taylor Shores, Shefaa Allan, Revan Odah, Ryan D. Mohan
Summary: This article provides a brief overview of the role of DUBs in neurodegeneration and their potential as therapeutic targets.
Article
Neurosciences
Meaghan Morris, Abhay Moghekar, Haidan Guo, Olga Pletnikova, Javier Redding-Ochoa, Marilyn Albert, Susan M. Resnick, Liam Chen
Summary: This article presents a rare case of a neurodegenerative pathology mimicking Parkinson's disease, characterized by ubiquitin-positive astrogliopathy without significant neuronal loss in the substantia nigra, and not containing known pathogenic proteins.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mustafa. T. T. Ardah, Nada Radwan, Engila Khan, Tohru Kitada, M. Emdadul Haque
Summary: The loss of the E3 ligase Parkin is believed to cause the failure of mitochondrial polyubiquitination and subsequent mitophagy induction, leading to abnormal mitochondrial accumulation in familial Parkinson's disease. However, this has not been confirmed in autopsy cases or animal models. The recent discovery of Parkin's role as a redox molecule has drawn much attention. Overexpression of Parkin in cell culture systems showed that it self-aggregated with or without self-ubiquitination on the inner and outer mitochondrial membranes, suggesting that polyubiquitination of Parkin substrates is not necessary for mitophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jessica A. Lawrence, Patricia Aguilar-Calvo, Daniel Ojeda-Juarez, Helen Khuu, Katrin Soldau, Donald P. Pizzo, Jin Wang, Adela Malik, Timothy F. Shay, Erin E. Sullivan, Brent Aulston, Seung Min Song, Julia A. Callender, Henry Sanchez, Michael D. Geschwind, Subhojit Roy, Robert A. Rissman, JoAnn Trejo, Nobuyuki Tanaka, Chengbiao Wu, Xu Chen, Gentry N. Patrick, Christina J. Sigurdson
Summary: Endolysosomal defects, including the reduction of Hrs and STAM1, exacerbate synaptic derangements and accelerate neurodegeneration in prion-infected brains. Depletion of neuronal Hrs leads to increased surface levels of PrPC, contributing to the rapidly advancing disease through neurotoxic signaling. The findings highlight the importance of proteostatic pathways and synaptic integrity in prion diseases.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Niklas Lonnemann, Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A. Dinarello, Martin Korte
Summary: IL-37 has immunomodulatory effects in the central nervous system, protecting neuronal structure and function, inhibiting microglial activation, enhancing long-term potentiation, and exerting anti-inflammatory effects in chronic neuroinflammatory conditions like Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Omur Gulsum Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Suleyman Kaplan, Abdu Adem
Summary: The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. In this study, the impact of short-term adrenalectomy on hippocampal neuronal populations in Wistar rats was investigated using stereological technique and ultrastructural examination. The levels of insulin-like growth factor-1 (IGF-1) and beta-nerve growth factor (beta-NGF) were measured to understand the underlying mechanisms of degeneration in these neurons. The cognitive behavior of Wistar rats after short-term adrenalectomy was also examined.
Review
Biochemistry & Molecular Biology
Sabyasachi Maity, Kayla Farrell, Shaghayegh Navabpour, Sareesh Naduvil Narayanan, Timothy J. Jarome
Summary: Epigenetic mechanisms play a crucial role in regulating activity-dependent changes in gene transcription and are widely implicated in synaptic plasticity and memory formation in the brain. Dysregulation of these mechanisms is associated with memory decline in the aged brain and in neurodegenerative disorders, including Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Uroos Akber, Heeji Jo, Seungje Jeon, Seung-Joo Yang, Sunhwa Bong, Sungsu Lim, Yun Kyung Kim, Zee-Yong Park, Chul-Seung Park
Summary: Protein aggregation-induced neurotoxicity in neurodegenerative disorders can be mitigated by the protective role of molecular chaperones, while the substrate-recruiting subunit CRBN of cullin4-RING-E3-ligase can influence phosphorylation and aggregation of tau protein through ubiquitin-mediated degradation, reducing pathological tau accumulation in the brain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Sangh Jyoti Singh, Ankit Tandon, Phoolmala, Tulika Srivastava, Nivedita Singh, Shweta Goyal, Smriti Priya, Rajnish Kumar Chaturvedi
Summary: This study found that bisphenol-A (BPA) negatively affects the proliferation and differentiation of neural stem cells, leading to neurological disorders during brain development. BPA impairs the ubiquitin-proteasome system (UPS) by reducing its activity in neural stem cells, resulting in disrupted neuronal differentiation. However, UPS activation with a bioactive triterpenoid 18 alpha-glycyrrhetinic acid (18 alpha GA) can alleviate BPA-induced neurotoxicity and provide neuroprotection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Summary: This study investigates the formation of the epichaperome in traumatic brain injury (TBI) and suggests that this mechanism may contribute to protein misfolding, degradation, aggregation, and transport. Further understanding of this pathological mechanism can provide insights into the connection between TBI and increased risk of neurodegenerative diseases, as well as potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Aaron Lam, Carla Haroutonian, Lucy Grummitt, Catriona Ireland, Ronald R. Grunstein, Shantel Duffy, Angela D'Rozario, Sharon L. Naismith
Summary: The study found that there was no significant difference in SDMC between MCI patients and controls, but there was a significant decrease in SDMC in those with multiple domain MCI. Impaired SDMC in MCI was correlated with hippocampal atrophy, shorter sleep spindle duration, and worse daytime episodic memory, while in controls, poorer SDMC was associated with higher AHI.
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Adam J. Kanack, Michael D. Olp, Oliver J. Newsom, Jamie B. Scaglione, David M. Gooden, Kevin McMahon, Brian C. Smith, K. Matthew Scaglione
Summary: The ubiquitin ligase CHIP plays an important role in proteostasis, but few small molecules that regulate its activity have been developed. In this study, we identified a compound called MS.001 that inhibits the chaperone binding and ubiquitin ligase activity of CHIP. Our data also reveal a potential binding site for MS.001 on the linker domain of CHIP.
Article
Neurosciences
Ribhav Mishra, Anurag Bansal, Amit Mishra
Summary: Ribosomes synthesize proteins according to cellular demands, but defects in the process can lead to non-functional proteins. Cells rely on quality control mechanisms like LISTERIN to eliminate abnormal proteins. LISTERIN's role in regulating protein quality is crucial for brain health and development, with implications for neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Rekha K. Narasimhamurthy, Kamalesh D. Mumbrekar, B. S. Satish Rao
Summary: Advancements in radio diagnostic imaging tools and techniques have greatly improved the diagnosis of various pathophysiological conditions, but the effects of low dose radiation on the biological system remain unclear. Current research suggests that low dose radiation may have neurological effects on the central nervous system and further investigation is needed to understand the risks and benefits.
Article
Neurosciences
Hideki Miwa, Ken Kobayashi, Shinobu Hirai, Mitsuhiko Yamada, Masahiko Watanabe, Haruo Okado, Yuchio Yanagawa
Summary: The study reveals the critical role of GABA in establishing connections between basket cells and Purkinje cells in the cerebellum, and its association with motor coordination in mice.
Article
Cell Biology
Anussara Kamnate, Juthathip Sirisin, Masahiko Watanabe, Hisatake Kondo, Wiphawi Hipkaeo, Surang Chomphoo
Summary: The study found that cannabinoid receptor type 1 (CB1) is localized on mitochondrial membranes in ovarian interstitial gland cells of adult mice, potentially modulating the synthetic process of progesterone through CB1.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2022)
Article
Neurosciences
Ken Matsuura, Shizuka Kobayashi, Kohtarou Konno, Miwako Yamasaki, Takahiro Horiuchi, Takao Senda, Tomoatsu Hayashi, Kiyotoshi Satoh, Fumiko Arima-Yoshida, Kei Iwasaki, Lumi Negishi, Naomi Yasui-Shimizu, Kazuyoshi Kohu, Shigenori Kawahara, Yutaka Kirino, Tsutomu Nakamura, Masahiko Watanabe, Tadashi Yamamoto, Toshiya Manabe, Tetsu Akiyama
Summary: The study reveals that SIPA1L1 is mainly localized to submembranous regions in neurons, and its deficiency may be associated with neuropsychiatric disorders related to dysregulated GPCR signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Czarina Ramos, Stefano Lutzu, Miwako Yamasaki, Yuchio Yanagawa, Kenji Sakimura, Susumu Tomita, Masahiko Watanabe, Pablo E. Castillo
Summary: This study provides the first direct evidence of functional extrasynaptic kainate receptors (KARs) on mossy cells (MCs) in the hippocampus. These KARs are mainly located extrasynaptically and play a critical role in the activity of MCs. Increases in ambient glutamate can activate the KARs on MCs.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mayuko Hashimoto, Masaki Fujimoto, Kohtarou Konno, Ming-Liang Lee, Yui Yamada, Koya Yamashita, Chitoku Toda, Michio Tomura, Masahiko Watanabe, Osamu Inanami, Hiroshi Kitamura
Summary: This study reveals that hypothalamic USP2 regulates blood glucose levels through the ROS-AMPK-sympathetic nerve axis. Inhibition of USP2 leads to mitochondrial dysfunction and AMPK phosphorylation, resulting in increased blood glucose and norepinephrine levels.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Eriko Miura, Masahiko Watanabe
Summary: This study investigated the expression of calcineurin (CN) in the mouse brain and found that CNA alpha, CNA, and CNB1 were predominantly expressed. The protein localization experiments revealed that CNB1 and CNA were co-distributed in various cerebellar neurons and glia, while CNA alpha was exclusive to granule cell elements. These findings provide anatomical evidence for the regulatory roles of CN in long-term depression and transmitter release function at synapses.
NEUROSCIENCE RESEARCH
(2022)
Article
Cell Biology
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, Masahiko Watanabe, Kenji Sakimura, Masayoshi Mishina, Katsuhiko Tabuchi
Summary: This study found that the presynaptic cell adhesion molecules NRXNs play a crucial role in the survival of cerebellar granule cells and synapse formation. They not only maintain cell survival, but also promote the formation of presynaptic protein clusters and the secretion of neurotrophic factors.
Article
Neurosciences
Keita Mori, Michinori Koebis, Kazuki Nakao, Shizuka Kobayashi, Yuji Kiyama, Masahiko Watanabe, Toshiya Manabe, Yuichi Iino, Atsu Aiba
Summary: This study investigates the function of Calsyntenins (CLSTNs) by generating triple knockout (TKO) mice lacking all CLSTN paralogs. The mutant mice exhibited freezing behavior in novel environments and hypersensitivity to stress. Glucose levels under stress were significantly higher in the mutant mice than in the wild-type controls. Phenotypes such as decreased motivation, which had not been reported in single Clstn knockout mice, were newly discovered. The TKO mice generated in this study serve as an important mouse model for further understanding the function of CLSTN.
Article
Neurosciences
Qin Zhao, Tetsufumi Ito, Chika Soko, Yoshie Hori, Takafumi Furuyama, Hiroyuki Hioki, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Satoshi Ohtsuka, Munenori Ono, Nobuo Kato, Ryo Yamamoto
Summary: This study investigates the histochemical features of DA(DR-PAG) neurons projecting to the central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BNST) in mice. Two subpopulations of these neurons were identified, TH1/VIP- and TH-/VIP1, with the latter being non-DA noncanonical DAT neurons. Both subpopulations innervate the same regions, and the TH-/VIP1 subpopulation was found to be VGlut2-positive neurons.
Article
Rheumatology
Nobuya Abe, Masato Tarumi, Yuichiro Fujieda, Nobuhiko Takahashi, Kohei Karino, Mona Uchida, Michihito Kono, Yuki Tanaka, Rie Hasebe, Masaru Kato, Olga Amengual, Yoshiyuki Arinuma, Kenji Oku, Wakiro Sato, Khin Khin Tha, Miwako Yamasaki, Masahiko Watanabe, Tatsuya Atsumi, Masaaki Murakami
Summary: The study investigates the effects of stress on the pathophysiology of neuropsychiatric lupus (NPSLE) in systemic lupus erythematosus (SLE) using lupus-prone mice and patient data.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Multidisciplinary Sciences
Tadashi Tanioku, Masayuki Nishibata, Yasuyuki Tokinaga, Kohtaro Konno, Masahiko Watanabe, Hiroaki Hemmi, Yuri Fukuda-Ohta, Tsuneyasu Kaisho, Hidemasa Furue, Tomoyuki Kawamata
Summary: This study demonstrates the essential role of Tmem45b in inflammation- and tissue injury-induced mechanical pain hypersensitivity, highlighting it as a potential therapeutic target for future treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Amy Cheung, Kotaro Konno, Yuka Imamura, Aya Matsui, Manabu Abe, Kenji Sakimura, Toshikuni Sasaoka, Takeshi Uemura, Masahiko Watanabe, Kensuke Futai, Nils Brose
Summary: The study reveals the involvement of Nrxn genes in the modulation of 5-HT transmission and behavior, suggesting a potential link between Nrxn mutations and ASD.
Article
Biology
Kieran A. Boyle, Erika Polgar, Maria Gutierrez-Mecinas, Allen C. Dickie, Andrew H. Cooper, Andrew M. Bell, Evelline Jumolea, Adrian Casas-Benito, Masahiko Watanabe, David I. Hughes, Gregory A. Weir, John S. Riddell, Andrew J. Todd
Summary: This study investigates the role of interneurons that continue to express neuropeptide Y (NPY-INs) in the adult mouse spinal cord. The findings suggest that activation of NPY-INs reduces acute pain and pruritogen-evoked itch, while silencing them causes exaggerated itch responses. Silencing another population of inhibitory interneurons also increases itch, but to a lesser extent.
Article
Multidisciplinary Sciences
Kohtarou Konno, Miwako Yamasaki, Taisuke Miyazaki, Masahiko Watanabe
Summary: The gold-standard fixative for immunohistochemistry is 4% formaldehyde; however, it limits antibody access to buried target molecules. To solve this problem, we used glyoxal as a fixative, which greatly improved antibody penetration, uncovering signals for buried molecules. Glyoxal also enhanced immunosignals of most other molecules, including the controversial synaptic adhesion molecule Neuroligin 1.
Article
Multidisciplinary Sciences
Hitomi Sasamori, Toshiaki Asakura, Chiaki Sugiura, Youcef Bouchekioua, Naoya Nishitani, Masaaki Sato, Takayuki Yoshida, Miwako Yamasaki, Akira Terao, Masahiko Watanabe, Yu Ohmura, Mitsuhiro Yoshioka
Summary: This study examined the role of dopamine D-5 receptors in impulse control and found that they are not necessary for impulse control. The results highlight the importance of time series analysis and detailed analysis of the learning process in understanding the behavioral functions of D-5 receptors.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)