期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 410, 期 4, 页码 872-877出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.06.081
关键词
GPCR; Novel bioactive peptide; Drosophila; Neuropeptide Y
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology
- University of Miyazaki
- Ministry of Education, Science, Sports, and Culture, Japan
- Program for Promotion of Basic Research Activities for Innovative Bioscience (PROBRAIN)
- Suzuken Memorial Foundation
- Shimadzu Scientific Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [22390170, 22126003, 21591189, 23780297, 22126002, 23659422, 22790892, 22300132] Funding Source: KAKEN
A number of bioactive peptides are involved in regulating a wide range of animal behaviors, including food consumption. Vertebrate neuropeptide Y (NPY) is a potent stimulator of appetitive behavior. Recently, Drosophila neuropeptide F (dNPF) and short NPF (sNPF), the Drosophila homologs of the vertebrate NPY, were identified to characterize the functions of NPFs in the feeding behaviors of this insect. Dm-NPFR1 and NPFR76F are the receptors for dNPF and sNPF, respectively; both receptors are G protein-coupled receptors (GPCRs). Another GPCR (CG5811; NepYR) was indentified in Drosophila as a neuropeptide Y-like receptor. Here, we identified 2 ligands of CG5811, dRYamide-1 and dRYamide-2. Both peptides are derived from the same precursor (CG40733) and have no significant structural similarities to known bioactive peptides. The C-terminal sequence RYamide of dRYamides is identical to that of NPY family peptides; on the other hand, dNPF and sNPF have C-terminal RFamide. When administered to blowflies, dRYamide-1 suppressed feeding motivation. We propose that dRYamides are related to the NPY family in vertebrates, similar to dNPF and sNPF. (C) 2011 Elsevier Inc. All rights reserved.
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