Article
Oncology
Christopher Berlin, Felicie Cottard, Dominica Willmann, Sylvia Urban, Stephan M. Tirier, Lisa Marx, Karsten Rippe, Mark Schmitt, Valentina Petrocelli, Florian R. Greten, Stefan Fichtner-Feigl, Rebecca Kesselring, Eric Metzger, Roland Schuele
Summary: This study identifies lysine methyltransferase 9 (KMT9) as an important regulator in colorectal tumorigenesis. KMT9 alpha and KMT9 beta are overexpressed in colorectal cancer and colocalize with H4K12me1 at promoters of proliferation-related target genes. Ablation of KMT9 alpha significantly reduces colorectal tumorigenesis and prevents the growth of tumor organoids. Loss of KMT9 alpha impairs the maintenance and function of colorectal cancer stem/initiating cells and induces apoptosis specifically in this cellular compartment. These findings suggest that KMT9 could be a promising therapeutic target for colorectal cancer treatment.
Review
Immunology
Saerok Shim, Siyoung Lee, Yasmin Hisham, Sinae Kim, Tam T. Nguyen, Afeisha S. Taitt, Jihyeong Hwang, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Su Cheong Yeom, Sang-Yeob Kim, Yong-Gil Kim, Soohyun Kim
Summary: IL-32 plays a contradictory role in cancer development, with its high expression typically associated with tumor proliferation and progression. However, different isoforms of IL-32 may have different effects in cancer, such as IL-32 beta promoting cancer expansion and IL-32 theta inhibiting epithelial-mesenchymal transition. Further research is needed to understand the role of IL-32 in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhan Qu, Ke-Da Yang, Bai-Hua Luo, Fan Zhang
Summary: CAF-derived exosomal cricN4BP2L2 promoted CRC cell stemness and oxaliplatin resistance through the EIF4A3/PI3K/AKT/mTOR pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Yoshitoshi Ichikawa, Hidekazu Takahashi, Yoshinao Chinen, Asami Arita, Yuki Sekido, Tsuyoshi Hata, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: The histone methyltransferase G9a is related to prognosis in colorectal cancer, with high G9a expression associated with better overall survival and relapse-free survival. G9a can affect cancer stemness and chemosensitivity by suppressing IL-8 expression.
Article
Biochemistry & Molecular Biology
Shinan Li, Thi Thinh Nguyen, Trong Thuan Ung, Dhiraj Kumar Sah, Seon Young Park, Vinoth-Kumar Lakshmanan, Young Do Jung
Summary: The study demonstrated that piperine blocked LCA-induced IL-8 expression by inhibiting Src and EGFR in human CRC HCT-116 cells, leading to a significant reduction in tube formation of endothelial EA.hy926 cells.
Review
Biochemistry & Molecular Biology
Jingwei Shi, Xujun Song, Benno Traub, Michael Luxenhofer, Marko Kornmann
Summary: IL-4 and IL-13 are pleiotropic Th2 cytokines involved in immune responses and have been found to play a role in oncogenesis and tumor progression. Their effects on tumor cells are mediated through specific receptors, with IL-4R alpha/IL-13R alpha 1 being the main target in tumors. Understanding the implications of these cytokines and their receptors in pancreatic cancer helps in developing potential new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xujun Song, Benno Traub, Jingwei Shi, Marko Kornmann
Summary: IL-4 and IL-13 are structurally and functionally related cytokines that regulate immune responses and are involved in the pathogenesis of various human neoplasms. They can mediate tumor cell proliferation, survival, and metastasis in solid tumors through different receptors. This review summarizes their role in gastric and colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Guanglin Cui, Aping Yuan, Zhigang Pang, Jon Florholmen
Summary: Using quantitative real-time PCR, this study explored the role of host immune surveillance in colorectal cancer (CRC). It was found that the expression levels of certain immunological factors were significantly higher in adenoma tissues compared to adjacent tissues. Furthermore, the increase in COX2 expression was associated with the degree of dysplasia in adenoma patients, indicating its potential as a biomarker. Overall, the difference in immunological factor levels between tumor and tumor-free sites reflects the balance of pro- and anti-tumor forces and is implicated in CRC initiation and invasion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Jorge Barriuso, Raghavendar T. Nagaraju, Shreya Belgamwar, Bipasha Chakrabarty, George J. Burghel, Helene Schlecht, Lucy Foster, Elaine Kilgour, Andrew J. Wallace, Michael Braun, Caroline Dive, D. Gareth Evans, Robert G. Bristow, Mark P. Saunders, Sarah T. O'Dwyer, Omer Aziz
Summary: The study identified gene dysregulation in peritoneal metastasis that enhances tumor resistance and inflammatory changes. After adjusting for age, gender, and stage, the gene signature showed significant prognostic value for both overall survival and disease-free survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G. Wise, Brett David Hambly, Kun Tao, Shi-San Bao
Summary: The expression of IL-31, IL-32, and IL-33 is lower in gastric cancer patients and correlates with clinicopathological parameters, suggesting their potential as biomarkers for gastric cancer detection. Further exploration of the mechanisms underlying the actions of IL-31, IL-32, and IL-33 in gastric cancer is warranted.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Oncology
Celia Lopez-Menendez, Alberto Vazquez-Naharro, Vanesa Santos, Pierre Dubus, Patricia G. Santamaria, Angel Martinez-Ramirez, Francisco Portillo, Gema Moreno-Bueno, Marisa M. Faraldo, Amparo Cano
Summary: This study identifies the crucial role of E2A factors in breast cancer cell sternness, metastasis, and drug resistance, suggesting the potential therapeutic vulnerability of targeting E2A proteins in breast cancer.
Article
Gastroenterology & Hepatology
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan
Summary: ETBF infection activates IL-8 gene and protein expression through Stat3, while the disruption of E-cadherin appears to be independent of Stat3 signaling.
Article
Oncology
Shuhai Chen, Mingyou Chen
Summary: This study identified a new mechanism of tumor-neuroglia interaction in colorectal cancer (CRC), where Schwann cells (SCs) promote migration and invasion of CRC cells by releasing the tumor-promoting factor IL-8. Co-culture of SCs and CRC cells also leads to the activation of the NF-kappa B signaling pathway in SCs. These findings enrich the understanding of the tumor-neural axis in the tumor microenvironment of CRC and provide potential targets for anti-cancer therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Wan-Hsiang Hu, Ching-Di Chang, Ting-Ting Liu, Hong-Hwa Chen, Chang-Chun Hsiao, Hong-Yo Kang, Jiin-Haur Chuang
Summary: The study revealed a significant association between sarcopenia and interleukin-23 in colorectal cancer patients, and patients with sarcopenia and high IL-23 expression had the worst survival outcomes.
CLINICAL NUTRITION
(2021)
Article
Immunology
Grazzielle Guimaraes de Matos, Ana Marina Barroso de Figueiredo, Pedro Hugo Diniz Goncalves, Lucas Luiz de Lima Silva, Aline Carvalho Bastista, Clayton Luiz Borges, Celia Maria de Almeida Soares, Leo A. B. Joosten, Fatima Ribeiro-Dias
Summary: IL-32 is highly detected in PCM lesions, its production in PBMCs is dependent on the Dectin-1 receptor, IL-15 can induce IL-32, and together IL-15 and IL-32 can increase fungicidal activity of PBMCs.
MICROBIAL PATHOGENESIS
(2021)
Article
Engineering, Biomedical
Wen-Liang Lo, Yueh Chien, Guang-Yuh Chiou, Ling-Ming Tseng, Han-Shui Hsu, Yuh-Lih Chang, Kai-Hsi Lu, Chian-Shiu Chien, Mong-Lien Wang, Yi-Wei Chen, Pin-I Huang, Fang-Wei Hu, Cheng-Chia Yu, Pen-Yuan Chu, Shih-Hwa Chiou
Article
Engineering, Biomedical
Yi-Ping Yang, Yueh Chien, Guang-Yuh Chiou, Jong-Yuh Cherng, Mong-Lien Wang, Wen-Liang Lo, Yuh-Lih Chang, Pin-I Huang, Yi-Wei Chen, Yang-Hsin Shih, Ming-Teh Chen, Shih-Hwa Chiou
Review
Cell & Tissue Engineering
Pei-Ming Chu, Hsin-I Ma, Li-Hsin Chen, Ming-Teh Chen, Pin-I Huang, Shinn-Zong Lin, Shih-Hwa Chiou
CELL TRANSPLANTATION
(2013)
Article
Cell & Tissue Engineering
Yi-Yen Lee, Yi-Ping Yang, Ming-Chao Huang, Mong-Lien Wang, Sang-Hue Yen, Pin-I Huang, Yi-Wei Chen, Shih-Hwa Chiou, Yuan-Tzu Lan, Hsin-I Ma, Yang-Hsin Shih, Ming-Teh Chen
CELL TRANSPLANTATION
(2014)
Review
Genetics & Heredity
Pin-I Huang, Wen-Liang Lo, Jong-Yuh Cherng, Yueh Chien, Guang-Yuh Chiou, Shih-Hwa Chiou
CURRENT GENE THERAPY
(2012)
Article
Biochemistry & Molecular Biology
Wen-Liang Lo, Pen-Yuan Chu, Tsung-Heng Lee, Tsann-Long Su, Yueh Chien, Yi-Wei Chen, Pin-I Huang, Ling-Ming Tseng, Pang-Hsien Tu, Shou-Yen Kao, Jeng-Fan Lo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2012)
Review
Oncology
Yu-Wen Hu, Pin-I Huang, Tai-Tong Wong, Donald Ming-Tak Ho, Kai-Ping Chang, Wan-Yuo Guo, Feng-Chi Chang, Cheng-Yin Shiau, Muh-Lii Liang, Yi-Yen Lee, Hsin-Hung Chen, Sang-Hue Yen, Yi-Wei Chen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2012)
Article
Cell Biology
Yi-Ping Yang, Yuh-Lih Chang, Pin-I Huang, Guang-Yuh Chiou, Ling-Ming Tseng, Shih-Hwa Chiou, Ming-Hsiung Chen, Ming-Teh Chen, Yang-Hsin Shih, Chin-Hong Chang, Chuan-Chih Hsu, Hsin-I Ma, Chin-Tien Wang, Lo-Lin Tsai, Cheng-Chia Yu, Charn-Jung Chang
JOURNAL OF CELLULAR PHYSIOLOGY
(2012)
Article
Chemistry, Multidisciplinary
Guang-Yuh Chiou, Jong-Yuh Cherng, Han-Shui Hsu, Mong-Lien Wang, Chun-Ming Tsai, Kai-Hsi Lu, Yueh Chien, Shih-Chieh Hung, Yi-Wei Chen, Chiang-Ing Wong, Ling-Ming Tseng, Pin-I Huang, Cheng-Chia Yu, Wen-Huh Hsu, Shih-Hwa Chiou
JOURNAL OF CONTROLLED RELEASE
(2012)
Article
Oncology
Mei-Chun Cheng, Yu-Wen Hu, Ching-Sheng Liu, Jeun-Shenn Lee, Pin-I Huang, Sang-Hue Yen, Yuh-Lin Lee, Chun-Mei Hsieh, Cheng-Ying Shiau
Article
Biochemistry & Molecular Biology
Guang-Yuh Chiou, Chian-Shiu Chien, Mong-Lien Wang, Ming-Teh Chen, Yi-Ping Yang, Yung-Luen Yu, Yueh Chien, Yun-Ching Chang, Chiung-Chyi Shen, Chung-Ching Chio, Kai-Hsi Lu, Hsin-I Ma, Kuan-Hsuan Chen, Dean-Mo Liu, Stephanie A. Miller, Yi-Wei Chen, Pin-I Huang, Yang-Hsin Shih, Mien-Chie Hung, Shih-Hwa Chiou
Article
Oncology
Pen-Yuan Chu, Fang-Wei Hu, Cheng-Chia Yu, Lo-Lin Tsai, Chuan-Hang Yu, Buor-Chang Wu, Yi-Wei Chen, Pin-I Huang, Wen-Liang Lo
Article
Critical Care Medicine
Chorng-Kuang How, Yueh Chien, Kuang-Yao Yang, Hsin-Chin Shih, Chi-Chang Juan, Yi-Ping Yang, Guang-Yuh Chiou, Pin-I Huang, Yuh-Lih Chang, Liang-Kung Chen, Chien-Ying Wang, Han-Shui Hsu, Shih-Hwa Chiou, Chen-Hsen Lee
Article
Multidisciplinary Sciences
Yau-Hua Yu, Guang-Yuh Chiou, Pin-I Huang, Wen-Liang Lo, Chien-Ying Wang, Kai-Hsi Lu, Cheng-Chia Yu, Gil Alterovitz, Wen-Chien Huang, Jeng-Fan Lo, Han-Shui Hsu, Shih-Hwa Chiou
SCIENTIFIC REPORTS
(2012)
Article
Pharmacology & Pharmacy
Ling-Ming Tseng, Pin-I Huang, Yu-Rung Chen, Yu-Chih Chen, Yueh-Ching Chou, Yi-Wei Chen, Yuh-Lih Chang, Han-Shui Hsu, Yuan-Tzu Lan, Kuan-Hsuan Chen, Chin-Wen Chi, Shih-Hwa Chiou, De-Ming Yang, Chen-Hsen Lee
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2012)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)