期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 404, 期 4, 页码 1060-1064出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.12.110
关键词
Adiponectin; AdipoR1; LTBR; Yeast two-hybrid screen; NF-kappa B
资金
- Natural Science Foundation of China [30971187]
- Zhejiang Provincial Natural Science Foundation of China [Y2091198]
- Hangzhou Science and Technology Development Program [20090833B01]
Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown. In this study, we identified the lymphotoxin (LT)-beta receptor (LTBR) as an interacting partner of human AdipoR1 by using a yeast two-hybrid screening. The interaction between LTBR and AdipoR1 was confirmed by co-immunoprecipitation and co-localization analysis. Furthermore, adiponectin incubation inhibited lymphotoxin-induced NF-kappa B activation and the expression of adhesion molecules in human umbilical vein endothelial cells. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappa B pathway. (C) 2010 Elsevier Inc. All rights reserved.
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