Article
Cell & Tissue Engineering
Defu Kong, Apostolos Mourtzinos, Janette Heegsma, Hans Blokzijl, Vincent E. de Meijer, Klaas Nico Faber
Summary: This study reveals the role of GDF7 in liver fibrosis and suggests its potential pro-regenerative function in liver fibrosis caused by chronic liver disease.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biology
Ignacio Casanova-Maldonado, David Arancibia, Pablo Lois, Isaac Pena-Villalobos, Veronica Palma
Summary: Hyperbaric oxygen treatment (HBOT) can promote the proliferation of intestinal stem cells (ISCs) by modulating the mTORC1/S6K1 pathway without affecting the animal's oxidative metabolism. This study provides insights into the therapeutic mechanisms of HBOT and paves the way for future research.
BIOLOGICAL RESEARCH
(2023)
Article
Oncology
Zhi-Qin Xie, Hong-Xia Li, Xiao-Juan Hou, Mei-Yuan Huang, Ze-Min Zhu, Li-Xin Wei, Cai-Xi Tang
Summary: This study demonstrates that capsaicin can suppress hepatocarcinogenesis by inhibiting the stemness of HPCs via the SIRT1/SOX2 signaling pathway. Therefore, it may be a promising therapeutic candidate for liver cancer.
Article
Multidisciplinary Sciences
Hongen Meng, Yingying Yu, Enjun Xie, Qian Wu, Xiangju Yin, Bin Zhao, Junxia Min, Fudi Wang
Summary: The study reveals that HDAC3 regulates iron homeostasis and ferroptosis through the Hippo/Yap pathway, providing potential targets for reducing ferroptosis in iron-overload-related diseases.
Article
Biochemistry & Molecular Biology
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun Ping, Song Xiaoling, Weng Hao, Gu Jun
Summary: Proliferation is a significant hallmark of gallbladder cancer, a relatively rare but fatal malignancy. This study identified KIF11 as a major upregulated regulator of proliferation in gallbladder cancer, potentially promoting GBC cell proliferation through the ERBB2/PI3K/AKT signaling pathway. The findings provide insights into the mechanisms underlying GBC cancer development and may contribute to the development of novel diagnostic and therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Zhang Jiao-jiao, Li Ya-qi, Shi Mei, Wang Yu-sha, Tang Yao, Wang Xian-zhong
Summary: This study investigated the effects of cold plasma on immune chicken Sertoli cell (SC) proliferation and the regulation mechanism. The results showed that appropriate cold plasma treatment can promote SC viability, cell growth, and cell cycle progression. This effect is regulated by increasing ATP production and respiratory enzyme activity in the mitochondria, potentially through the AMPK-mTOR signaling pathway mediated by microRNA targeting regulation and intracellular reactive oxygen species homeostasis. The findings suggest that cold plasma treatment provides a safe strategy to improve SC proliferation, which is beneficial to elevating male chicken reproductive capacity.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2022)
Article
Pharmacology & Pharmacy
Wen-qian Jia, Tao-cheng Zhou, Jing-wen Dai, Zhen-ni Liu, Ya-fei Zhang, Dan-dan Zang, Xiong-wen Lv
Summary: The study reveals the role of CD73 in HSC activation and suggests that the Wnt/beta-catenin signaling pathway may be involved in this progression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Xiaoli Huang, Hongfeng Guo, Xuejun Cheng, Jinyu Zhang, Wenzheng Qu, Qianyun Ding, Qihang Sun, Qiang Shu, Xuekun Li
Summary: Nicotinamide adenine dinucleotide hydrate (NAD+) plays a crucial role in regulating adult neural stem/progenitor cells (aNSPCs) by reducing proliferation, neuronal differentiation, and inducing apoptosis. NAD+ exposure also inhibits neuronal morphological development. Mechanistically, NAD+ exposure alters transcriptome and decreases the expression of genes related to ATP metabolism and the PI3k-Akt signaling pathway.
Article
Oncology
Youqun Tang, Yanming Cao
Summary: The study confirmed that SOX10 is an oncogene in melanoma, promoting cell proliferation by activating the Notch signaling pathway. High expression of SOX10 is negatively correlated with the prognosis of melanoma patients, suggesting potential therapeutic effects by targeting the SOX10/Notch axis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yuting Xu, Lin Zhang, Qingling Wang, Maojin Zheng
Summary: MLF1IP is up-regulated in colorectal cancer and its high expression is significantly associated with clinical features and patient survival. Overexpression of MLF1IP promotes the proliferation and clonogenicity of colorectal cancer cells and tumorigenicity in mice. The study also reveals that MLF1IP promotes colorectal cancer cell proliferation and tumorigenicity through mediating the BRCA1/AKT/p27 signaling axis.
CELLULAR SIGNALLING
(2022)
Article
Cell Biology
Kensuke Kitsugi, Hidenao Noritake, Moe Matsumoto, Tomohiko Hanaoka, Masahiro Umemura, Maho Yamashita, Shingo Takatori, Jun Ito, Kazuyoshi Ohta, Takeshi Chida, Barbara Ulmasov, Brent A. Neuschwander-Tetri, Takafumi Suda, Kazuhito Kawata
Summary: This study found that CWHM12 suppresses the proliferation of activated HSCs and promotes apoptosis by blocking the Hippo signaling pathway. Furthermore, CWHM12 induces cell cycle arrest at the G1 phase. The inhibition of focal adhesion kinase (FAK) phosphorylation leads to the translocation of Yes-associated protein (YAP). These findings provide a novel drug target for the treatment of hepatic fibrosis.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Fangfang Gao, Xiaoqian Mu, Huijuan Wu, Lijuan Chen, Jie Liu, Yanqiu Zhao
Summary: Calreticulin (CALR) is aberrantly expressed in lung cancer, and its overexpression promotes proliferation of lung cancer cells, possibly through activation of the NF-kappa B signaling pathway.
Article
Multidisciplinary Sciences
Douglas G. Brownfield, Alex Diaz de Arce, Elisa Ghelfi, Astrid Gillich, Tushar J. Desai, Mark A. Krasnow
Summary: The study reveals that FGF signaling plays a critical role in initiating alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains the existence of AT2 cells throughout life.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)