Article
Biochemistry & Molecular Biology
Criselda Mendoza-Milla, Fernanda Isabel Macias Macias, Kimberly Abigail Velazquez Delgado, Manuel Alejandro Herrera Rodriguez, Zaira Colin-Val, Maria del Pilar Ramos-Godinez, Agustina Cano-Martinez, Anita Vega-Miranda, Diana Xochiquetzal Robledo-Cadena, Norma Laura Delgado-Buenrostro, Yolanda Irasema Chirino, Jose Ocotlan Flores-Flores, Rebeca Lopez-Marure
Summary: Zinc oxide nanoparticles are widely used in the cosmetic industry due to their antimicrobial properties. This study found that ZnO NPs are toxic to cardiac cells, potentially causing heart damage and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tsendsuren Tungalag, Kye Won Park, Dong Kwon Yang
Summary: Oxidative stress plays a significant role in the pathogenesis of heart diseases, and butein exhibits potential antioxidant effects in cardiomyocytes, providing protection against oxidative damage and suggesting its therapeutic potential for cardiac diseases.
Article
Cell Biology
Iraselia Garcia, Fredy Calderon, Patrick De la Torre, Shaynah St Vallier, Cristobal Rodriguez, Divya Agarwala, Megan Keniry, Wendy Innis-Whitehouse, Robert Gilkerson
Summary: This study found that in cardiomyoblasts, differentiation to a cardiac-like phenotype via treatment with retinoic acid results in robust cleavage and degradation of long OPA1 isoforms (L-OPA1) under loss of mitochondrial transmembrane potential, suggesting a novel developmental regulatory mechanism for OPA1 cleavage.
Article
Cell Biology
Imen Saadaoui, Touria Bounnit, Fatima Mraiche, Jensa M. Joseph, Maroua Cherif, Hareb Al-Jabri
Summary: Oxidative stress is a significant factor in cardiovascular diseases, and finding effective antioxidant molecules is crucial for disease prevention. This study evaluated the potential of microalgae bioactive compounds in protecting H9c2 cardiomyoblasts from H2O2-induced oxidative stress. Four microalgal species were tested for their antioxidant capacity, and the hexanoic extracts showed high antioxidant activity. Among them, Asterarcys quadricellulare exhibited the highest antioxidant capacity and protected against H2O2-induced oxidative stress similar to N-Acetylcysteine. The extract also showed anti-apoptotic properties. These findings suggest that A. quadricellulare could be a natural and efficient antioxidant for preventing cardiovascular diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Plant Sciences
Sarmina Dangol, Nam Khoa Nguyen, Raksha Singh, Yafei Chen, Juan Wang, Hyeon-Gu Lee, Byung KooK Hwang, Nam-Soo Jwa
Summary: This study demonstrates the involvement of rice MAP kinase signaling cascades in iron- and ROS-dependent ferroptotic cell death responses to M. oryzae infection. OsMPK1 interacts with the WRKY90 transcription factor in the nucleus, and overexpression of OsMEK2 and OsMPK1 induces ferroptotic cell death in response to M. oryzae. These findings highlight the regulatory role of OsMEK2 and OsMPK1 in iron- and ROS-dependent cell death pathways in rice-M. oryzae interactions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Zaira Colin-Val, Carlos Daniel Vera-Marquez, Manuel Alejandro Herrera-Rodriguez, Maria del Pilar Ramos-Godinez, Alejandro Lopez-Saavedra, Agustina Cano-Martinez, Diana Xochiquetzal Robledo-Cadena, Sara Rodriguez-Enriquez, Francisco Correa, Norma Laura Delgado-Buenrostro, Yolanda I. Chirino, Rebeca Lopez-Marure
Summary: Cardiovascular diseases are the leading cause of death worldwide. Food-grade TiO2 (E171) has been found to be toxic to cardiac cells and may contribute to the development of heart diseases.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Biochemistry & Molecular Biology
Rukhsana Gul, Nouf Alsalman, Assim A. Alfadda
Summary: This study reveals that blocking eNOS, an enzyme that produces nitric oxide, attenuates the beneficial effects of nebivolol on Ang II-induced signaling in heart muscle cells. The rise in nitric oxide bioavailability caused by nebivolol is key for its anti-inflammatory and antioxidant properties, but not for its ability to prevent hypertrophy in response to Ang II stimulation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Eddie Tam, Hye Kyoung Sung, Nhat Hung Lam, Sally You, Sungji Cho, Saher M. M. Ahmed, Ali A. A. Abdul-Sater, Gary Sweeney
Summary: Iron overload leads to cardiovascular diseases, including heart failure. This study showed that iron overload triggers cell death in H9c2 cells by promoting intracellular and mitochondrial iron accumulation and ROS production. The use of iron-binding fluorescent reporters and antioxidants reduced these effects, and decreased apoptosis and lytic cell death. Overexpression of the mitochondrial membrane protein MitoNEET lowered iron and ROS accumulation in the mitochondria, leading to reduced cell death in response to iron overload.
Article
Oncology
Shumei Kato, Robert Porter, Ryosuke Okamura, Suzanna Lee, Ori Zelichov, Gabi Tarcic, Michael Vidne, Razelle Kurzrock
Summary: The study found that patients with tumors harboring RAS alterations with high MAPK activity had significantly longer median progression-free survival (PFS) and overall survival when treated with MEK inhibitors. This correlation between RAS-mutant cancers with greater MAPK signaling and PFS suggests potential clinical benefit of MEK inhibitor treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Fisheries
Yuanlan Wu, Xuelin Zhao, Yangxi Xiang, Ming Guo, Chenghua Li
Summary: In this study, the echinoderm MAPK family was identified and analyzed, revealing insights into its evolutionary history and immune function.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Allergy
Johanna Theodorou, Elisabeth Nowak, Andreas Boeck, Michael Salvermoser, Claudia Beerweiler, Kathrin Zeber, Paulina Kulig, Miranda S. Tsang, Chun-Kwok Wong, Gary W. K. Wong, Marjut Roponen, Joerg Kumbrink, Fahd Alhamdan, Florian Michel, Holger Garn, Vinko Tosevski, Bianca Schaub, Omer Kalayci
Summary: The study found that children with asthma have lower levels of DUSP1, but after exposure to farm dust stimulation, their DUSP1 expression is upregulated, and inflammatory MAPK is downregulated at the gene and protein level. The farm environment regulates inflammatory MAPK in various immune cell types, contributing to anti-inflammatory characteristics.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Takayuki Matsumoto, Tomoki Katome, Mihoka Kojima, Keisuke Takayanagi, Kumiko Taguchi, Tsuneo Kobayashi
Summary: This study demonstrated that methylglyoxal may enhance uridine diphosphate-induced contraction in rat carotid arteries, potentially through the activation of p38 MAPK and protein kinase C, and increased oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Ester Diaz-Mora, Diego Gonzalez-Romero, Marta Meireles-da-Silva, Juan Jose Sanz-Ezquerro, Ana Cuenda
Summary: Mitogen- and Stress-activated Kinase (MSK) 1 is a nuclear protein that modulates the production of certain cytokines in macrophages, and it is activated by p38 alpha Mitogen-Activated Kinase (MAPK) and extracellular signal-regulated kinase (ERK1/2). Our study shows that p38 delta, another p38MAPK, is also involved in the phosphorylation and activation of MSK in LPS-stimulated macrophages. The activation of MSK by p38 delta is crucial for the expression of various inflammatory molecules involved in immune innate response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Peiran Feng, Quanli Yang, Liang Luo, Yadong Sun, Wenkai Lv, Shuo Wan, Zerong Guan, Zhiqiang Xiao, Feng Liu, Zehua Li, Zhongjun Dong, Meixiang Yang
Summary: The study revealed the crucial role of PDK1 in Treg cell homeostasis and function, with its deficiency leading to autoimmune disorders and disruption of iron ion balance. Modulation of certain pathways could partially rescue the survival of PDK1-deficient Treg cells.
Article
Agriculture, Multidisciplinary
Arunaksharan Narayanankutty, Devika Mukundan Palliyil, Kezia Kuruvilla, Achuthan C. Raghavamenon
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2018)
Article
Spectroscopy
Arunaksharan Narayanankutty, Midhun K. Gopinath, Muneera Vakayil, Smitha K. Ramavarma, Thekkekara Devassy Babu, Achuthan C. Raghavamenon
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2018)
Review
Food Science & Technology
Arunaksharan Narayanankutty, Soorya Parathodi Illam, Achuthan C. Raghavamenon
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Arunaksharan Narayanankutty, Anu Anil, Soorya Parathodi Illam, Sruthi Panniyan Kandiyil, Achuthan C. Raghavamenon
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2018)
Article
Toxicology
D. L. Sheela, A. Narayanankutty, P. A. Nazeem, A. C. Raghavamenon, S. R. Muthangaparambil
HUMAN & EXPERIMENTAL TOXICOLOGY
(2019)
Article
Oncology
Arunaksharan Narayanankutty, Anusree Nair, Soorya Parathodi Illam, Aman Upaganlawar, Achuthan C. Raghavamenon
Summary: The study suggests that curcumin-enriched virgin coconut oil has the potential to act as a chemopreventive agent against skin papilloma by promoting antioxidant status and improving anticarcinogenic potential. Further research is needed to confirm the enhancement of curcumin bioavailability.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Arunaksharan Narayanankutty, Soorya Parathodi Illam, Varsha Rao, Sabah Shehabudheen, Achuthan C. Raghavamenon
Summary: This study compared the phenolic content and nephroprotective effect of hot-processed virgin coconut oil (HPVCO) and fermentation-processed virgin coconut oil (FPVCO). The results showed that HPVCO had higher polyphenol content and greater antioxidant activity, and provided better protection against cisplatin-induced nephrotoxicity.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Soorya P. Illam, Sruthi P. Kandiyil, Achuthan C. Raghavamenon
Summary: Epigenetic mechanisms, such as DNA methylation and histone modifications, regulate gene expression and play important roles in normal growth and metabolism. Aberrant histone modifications are linked to pathological conditions and have been a focus of research. Nutri-epigenetics explores the influence of dietary compounds on epigenetics.
CURRENT DRUG TARGETS
(2021)
Article
Nutrition & Dietetics
Arunaksharan Narayanankutty, Balu T. Kuzhivelil, Achuthan C. Raghavamenon
Summary: This study evaluated the effects of high-sugar diet and thermally oxidized oils on rat colon mucosa. The findings showed that high-fructose diet led to hyperglycemia and insulin resistance, and the intake of thermally oxidized oils exacerbated oxidative and inflammatory damage in the colon epithelium.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Food Science & Technology
Soorya Parathodi Illam, Arunaksharan Narayanankutty, Sruthi Panniyan Kandiyil, Achuthan Chathrattil Raghavamenon
Summary: Virgin coconut oil (VCO) prepared by traditional method (HVCO) showed greater anti-inflammatory efficacy compared to VCO prepared by simple fermentation process (FVCO). This difference in efficacy is attributed to variations in phenolic profile revealed by LC-MS analysis. HVCO is suggested as a potential food supplement to reduce the incidence of degenerative diseases.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Soorya Parathodi Illam, Sruthi Panniyan Kandiyil, Arunaksharan Narayanankutty, Soumya Valappan Veetil, Thekkekara Devassy Babu, Rao M. Uppu, Achuthan C. Raghavamenon
Summary: The study found that pretreatment with VCOP was effective in mitigating fluoride-induced cell death compared to VCO and VCOF. Additionally, supplementation of VCOP significantly reduced intracellular ROS levels, and oral administration of VCO reversed hepatic oxidative stress in fluoride intoxicated mice.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Devaki Girija, Kizhakkeettil Deepa, Thomas Chubicka, P. R. Shidhi, Safna Hussan, Achuthan Chathrattil Raghavamenon, Thekkekara Devassy Babu
Summary: Parasporin from the KAU41 Bt isolate exhibited specific toxicity to cancer cells, with a cleaved peptide showing cytotoxicity to HeLa cells. The protein is predicted to belong to the Aerolysin superfamily and interacts with caspase 3, indicating its role in activating the intrinsic pathway of apoptosis in cancer cells.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2023)
Article
Chemistry, Medicinal
Madhuri Menon, Soumya Raj, Achuthan C. Raghavamenon, Leyon Varghese
Summary: This study evaluated the antitumor potential of Pleurolobus gangeticus plant parts and found that ethanol extract demonstrated significant cytotoxicity and apoptosis induction in vitro and in vivo models. Ethanol extract also reduced tumor burden in mice models and showed the presence of pharmacologically important molecules.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Toxicology
Soorya Parathodi Illam, Ashif Hussain, Anu Elizabeth, Arunaksharan Narayanankutty, Achuthan C. Raghavamenon
TOXICOLOGY REPORTS
(2019)
Article
Toxicology
Neethu Cyril, James Baben George, Laigi Joseph, A. C. Raghavamenon, V. P. Sylas
TOXICOLOGY RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)