Article
Biochemistry & Molecular Biology
Yongqi Zhang, Jia Man, Jiali Wang, Jianing Liu, Xinzhong Song, Xiaohan Yu, Jianyong Li, Ruijian Li, Yinghua Qiu, Jianfeng Li, Yuguo Chen
Summary: This study developed heparinized surfaces on PVC substrates using plasma treatment technology and chemical grafting method. The heparinized surfaces not only reduced thrombosis but also decreased side effects of anticoagulants. Sodium alginate and carboxymethyl chitosan interlayers significantly increased the graft density of heparin, improving its anticoagulant effects and hemocompatibility. The CCS/low-molecular-weight heparin surface showed the best anticoagulant properties. The heparinized surfaces prepared in this study have great potential in anticoagulant treatment for medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Meihan Fang, Jialu Wang, Sheng Fang, Xiaobo Zuo
Summary: Gliadin-carboxymethyl chitosan composite nanoparticles (GC NPs) co-encapsulated with natamycin (Nata) and theaflavins (TFs) were added to carboxymethyl chitosan (CMCS) films as an antioxidant, antifungal, and structural enhancer. The stability of GC NPs dispersion was maintained by electrostatic repulsion. Coencapsulation of TFs improved the photostability of Nata and the antioxidant activity of the NPs dispersion. The addition of Nata/TFs-GC NPs improved the properties and activities of CMCS films.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li
Summary: This study generated chitosan nanoparticles and examined their effects on dendritic cells, finding that 200kDa NO-CMC-HACC nanoparticles showed strong potential as immunological adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Renjie Yi, Xiaodong Shi, Yan Tang, Yongqiang Yang, Peng Zhou, Bingan Lu, Jiang Zhou
Summary: A cross-linked gel (Zn-CMCS) based on carboxymethyl chitosan is proposed as an artificial electrolyte interphase for zinc anode. The coating formed by crosslinking closely adheres to the surface of the zinc foil, providing toughness, ductility, and ideal electrochemical kinetics. By introducing adsorptive activated carbon on the cathode, the Zn-CMCS/AC-CFC battery exhibits greatly improved reversibility under long-cycling conditions.
Article
Materials Science, Composites
K. Meera, Manammel Thankappan Ramesan
Summary: Biopolymer nanocomposites derived from carboxymethyl chitosan and boehmite were prepared via an environmentally friendly method. The nanocomposites showed improved thermal, mechanical, electric, and dielectric properties, making them a potential green alternative for flexible electronic and charge storage devices.
POLYMER COMPOSITES
(2023)
Article
Chemistry, Physical
Maria E. Fortuna, Elena Ungureanu, Carmen D. Jitareanu
Summary: New hybrid materials consisting of precipitated calcium carbonate (PCC) and carboxymethyl chitosan (CMC) were prepared for papermaking in this study. The PCC-CMC material improved the mechanical and optical properties of the paper compared to unmodified PCC at similar levels of content, as evidenced by higher breaking length, brightness, and opacity.
Article
Biochemistry & Molecular Biology
Qun Liu, Bo Li, Yan Li, Xiaodeng Yang, Congde Qiao, Wei Hu, Mingxia Liu
Summary: pH-sensitive and amphiphilic chitosan derivatives were synthesized and studied for their rheological properties, showing that high degree of substitution and pH near the isoelectric points corresponded to low viscosity and viscoelasticity. Strong networks formed at high concentrations, and the role of Ca2+ varied depending on concentration levels. Molecular dynamics simulations were also used to examine intermolecular hydrogen bonds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Zhao Wang, Junfeng Su, Amjad Ali, Wenshuo Yang, Ruijie Zhang, Yifei Li, Lingfei Zhang, Jiawei Li
Summary: This research evaluates chitosan and carboxymethyl chitosan as polysaccharides that mimic the role of bacterial extracellular polymeric substance in biomineralization. Carboxymethyl chitosan demonstrated higher calcium precipitation efficiency and the nucleation of calcium carbonate was triggered by the binding of different functional groups on the polysaccharides. The study also conducted experiments on polysaccharide-mediated biomineralization, showing improved calcium precipitation efficiency with the addition of carboxymethyl chitosan. The findings provide insights into the biomineralization mechanism and strategies for enhancing MICP technology.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Guozhu Chang, Qifeng Dang, Chengsheng Liu, Xiaoyu Wang, Hao Song, Hong Gao, Hantian Sun, Bonian Zhang, Dongsu Cha
Summary: A new dual drug delivery system CMCSH was designed to promote diabetic wound healing effectively. This system improved drug availability, promoted cell proliferation, and reduced inflammation.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Sarinthip Thanakkasaranee, Kittisak Jantanasakulwong, Yuthana Phimolsiripol, Noppol Leksawasdi, Phisit Seesuriyachan, Thanongsak Chaiyaso, Pensak Jantrawut, Warintorn Ruksiriwanich, Sarana Rose Sommano, Winita Punyodom, Alissara Reungsang, Thi Minh Phuong Ngo, Parichat Thipchai, Wirongrong Tongdeesoontorn, Pornchai Rachtanapun
Summary: This study found that using chitosan powder with smaller particle sizes can significantly improve the water solubility of the CMCh powders and films. Additionally, as the particle size of chitosan decreased, the mechanical properties of the CMCh films also increased.
Article
Polymer Science
Karol K. Klosinski, Radoslaw A. Wach, Malgorzata K. Girek-Bak, Bozena Rokita, Damian Kolat, Zaneta Kaluzinska-Kolat, Barbara Klosinska, Lukasz Duda, Zbigniew W. Pasieka
Summary: Hydrogels formed from CMCS and crosslinking agent via electron beam irradiation showed potential as wound dressings. The gel's elasticity was influenced by component concentrations and irradiation dose. The hydrogels exhibited biocompatibility and could stimulate cell growth. Ionizing radiation proved to be a suitable tool for synthesis and sterilization of CMCS hydrogels.
Article
Engineering, Chemical
Shun-yi Yao, Si-peng Chen, Ruo-xun Wang, Kai Zhang, Xiao-xuan Lin, Sui Mai
Summary: An antibacterial adhesive was developed by adding carboxymethyl chitosan (CMC) to prevent secondary caries on the bonding surface while ensuring bonding performance. Incorporating polyelectrolyte into the adhesive system provided a new idea for the development of antibacterial adhesives. The results showed that the adhesive containing CMC significantly reduced the amount of adherent Streptococcus mutans, and the inhibitory effect was more significant with higher CMC concentration.
INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES
(2022)
Article
Chemistry, Applied
Yuhan Shen, Zhaoliang Wang, Yongchao Wang, Zhiyuan Meng, Zheng Zhao
Summary: A self-healing hydrogel with fluorescent bioprobes was developed for glucose detection, showing high sensitivity and a linear detection range covering the level of glucose in clinical detection. Additionally, the hydrogel exhibited good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Lianlian Yang, Junhong Ling, Nan Wang, Yongjun Jiang, Yuqing Lu, Li-Ye Yang, Xiao-kun Ouyang
Summary: GMA was used to modify CMCS to prepare nanogels for targeted delivery of DOX. The experimental results showed that GCMCS-FA-DOX had high glutathione and pH responsiveness, exhibited excellent inhibitory effect on tumor cell proliferation, and improved drug uptake efficiency.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Yilin Jie, Fusheng Chen, Tingwei Zhu, Dingyang Lv
Summary: The ability of carboxymethyl chitosan (CMCS) to stabilize high internal phase emulsions (HIPEs) was investigated. CMCS formed a multi-layered network structure to stabilize the emulsions and improve their stability.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)