期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 412, 期 4, 页码 728-731出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.08.041
关键词
ATP6V1H; Diabetic complications; Longitudinal study; Type 2 diabetes; Vacuolar ATPase
资金
- National Center on Minority Health and Health Disparities (NCMHD) [MD000170 P20]
- National Center for Research Resources (NCRR) [1U54RR023417-01]
- University of Texas at Austin
- University of Texas School of Public Health
Objective: Previous studies in mice and humans observed down-regulation of the gene expression of ATP6V1H associated with type 2 diabetes. This study identified prospectively changes in ATP6V1H expression before and after overt diabetes. Methods: Expression of ATP6V1H in peripheral blood was compared pre and post development of diabetes in nine individuals. Results: Considerable variation of ATP6V1H mRNA levels was observed between different individuals. However, within each individual the decrease in expression of ATP6V1H with the development of diabetes was highly statistically significant. Conclusions: ATP6V1H may represent a critical molecular mechanism involved in the development of type 2 diabetes and its compilations through its important regulatory effect on vacuolar-ATPase activity. (C) 2011 Elsevier Inc. All rights reserved.
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