Article
Multidisciplinary Sciences
N. Tavernier, Y. Thomas, S. Vigneron, P. Maisonneuve, S. Orlicky, P. Mader, S. G. Regmi, L. Van Hove, N. M. Levinson, G. Gasmi-Seabrook, N. Joly, M. Poteau, G. Velez-Aguilera, O. Gavet, A. Castro, M. Dasso, T. Lorca, F. Sicheri, L. Pintard
Summary: The research uncovers the activation mechanism of AURKA crucial for mitotic entry, showing that phosphorylated Bora directly activates AURKA kinase activity. Through specific amino acid regions, Bora binds AURKA and substitutes for a key phospho-regulatory site, highlighting the importance of this mechanism for timely mitotic entry in Xenopus and human cells.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Helena Silva Cascales, Kamila Burdova, Anna Middleton, Vladislav Kuzin, Erik Mullers, Henriette Stoy, Laura Baranello, Libor Macurek, Arne Lindqvist
Summary: Cyclin A2 plays a key role in regulating the cell cycle and activating mitotic kinases. A change in localization of Cyclin A2 from nuclear to both nuclear and cytoplasmic at the S/G2 border is associated with its ability to activate PLK1 through phosphorylation of Bora. Cytoplasmic presence of Cyclin A2 functions as a trigger for mitotic kinase activation at the S/G2 transition.
LIFE SCIENCE ALLIANCE
(2021)
Article
Cell Biology
Wen-Long Lei, Yuan-Yuan Li, Tie-Gang Meng, Yan Ning, Si-Min Sun, Chun-Hui Zhang, Yaoting Gui, Zhen-Bo Wang, Wei-Ping Qian, Qing-Yuan Sun
Summary: The study revealed a novel function of PPP6C in male germ cell survival and differentiation by regulating cell-cell communication through dephosphorylation of beta-catenin at S552.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Shi Pan, Maria Secrier
Summary: H&E stained slides are widely used in disease diagnosis, and deep learning enables the detection of complex molecular patterns for automated decision-making. HistoMIL is a Python package designed to streamline the implementation and training process of MIL-based algorithms, achieving up to 85% AUROC performance on breast cancer histology slides.
Article
Green & Sustainable Science & Technology
Nicola Blasuttigh, Stefano Pastore, Mariangela Scorrano, Romeo Danielis, Alessandro Massi Pavan
Summary: This study investigates the implementation of vehicle-to-grid (V2G) technology and the development of an MPC-based energy management system (EMS) in a ski resort. The results show that photovoltaic power generation has a significant impact on cost and environmental aspects, leading to a about 7% reduction in total expenditure and CO2 emissions. However, the use of V2G technology for energy arbitrage does not result in significant cost and CO2 reductions in future scenarios, but different charging strategies improve self-consumption by approximately 100%. A sensitivity analysis reveals that an increase in PV production and the number of EVs, as well as a higher energy price gap, can significantly reduce total costs.
SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS
(2023)
Article
Cell Biology
Shuji Wakatsuki, Yoko Takahashi, Megumi Shibata, Naoki Adachi, Tadahiro Numakawa, Hiroshi Kunugi, Toshiyuki Araki
Summary: The study reveals a novel role of vtRNA in synaptogenesis, demonstrating its promotion of synapse formation by modulating the MAPK signaling pathway. mvtRNA, as part of the vault complex, is transported to the distal region of neurites and released from the complex by phosphorylation of MVP, activating MEK1-mediated ERK activation in neurites. These findings suggest a regulatory mechanism of the MAPK signaling pathway by vtRNAs as a new molecular basis for synapse formation.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Sanjana Sundararajan, Hyewon Park, Shinji Kawano, Marnie Johansson, Bunu Lama, Tomoko Saito-Fujita, Noriko Saitoh, Alexei Arnaoutov, Mary Dasso, Zhengqiang Wang, Daniel Keifenheim, Duncan J. Clarke, Yoshiaki Azuma
Summary: DNA Topoisomerase IIa is essential for the segregation of sister chromatids in mitosis, and its C-terminal domain interacts with methylated nucleosomes to ensure high-fidelity chromosome segregation.
Article
Multidisciplinary Sciences
Janna Luessing, Chituru C. Okowa, Emer Brennan, Muriel Voisin, Noel F. Lowndes
Summary: This study reveals a cell cycle-specific role of ATR in abscission, which is important for genome stability. ATR and ATRIP localize to the midbody during late cytokinesis and regulate abscission independently of RPA or detectable ssDNA. The regulation of abscission by ATR requires the presence of CHMP4C, CDC7 kinase, and ETAA1.
Article
Biochemistry & Molecular Biology
Monika Raab, Yves Matthess, Christopher A. Raab, Niklas Gutfreund, Volker Doetsch, Sven Becker, Mourad Sanhaji, Klaus Strebhardt
Summary: PLK1 activation during the G2 phase is controlled by dimerization supported by Bora and dissociation triggered by Aurora-A phosphorylation, allowing timely entry into mitosis. Interfering with this dimer/monomer switch affects PLK1's nuclear shuttling and localization during the G2-M transition, suggesting potential for novel PLK1 inhibitors.
Review
Chemistry, Physical
Priya, Shalini Jaswal, Ghanshyam Das Gupta, Sant Kumar Verma
Summary: Aurora kinase family plays a critical role in cell division and the cell cycle, and overexpression of AURKA and AURKB has been linked to the development of various carcinomas. The synthesis and development of Aurora Kinase inhibitors offer new opportunities for anticancer therapy.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Multidisciplinary Sciences
Roberto Quadr, Giuseppe Rotondo, Sarah Sertic, Sara Pozzi, Maria Chiara dell'Oca, Luisa Guerrini, Marco Muzi-Falconi
Summary: This article reports a new role for Haspin in mitosis, where it regulates the spindle orientation by modulating Rho-ROCK activity, thus supporting the establishment of tissue morphology.
Article
Cell Biology
Xiaoling Zhang, Xianling Cong, Xiangting Jin, Yu'e Liu, Tong Zhang, Xinyuan Fan, Xiyao Shi, Xiaoying Zhang, Xue Wang, Yong-Guang Yang, Xiangpeng Dai
Summary: The transcription factor MYCN is frequently amplified and overexpressed in various cancers, and is considered undruggable. In this study, BRCA1-associated protein-1 (BAP1) is identified as an upstream regulator that stabilizes MYCN through direct binding. Depletion of BAP1 inhibits neuroblastoma tumor cell growth and migration, and confers cellular resistance to BET protein inhibitor JQ1 and Aurora A kinase inhibitor Alisertib. Our findings suggest that BAP1 could be a potential therapeutic target for MYCN-amplified neuroblastoma.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Jin-Gyeong Park, Hanul Jeon, Sangchul Shin, Chiman Song, Hyomin Lee, Nak-Kyoon Kim, Eunice EunKyeong Kim, Kwang Yeon Hwang, Bong-Jin Lee, In-Gyun Lee
Summary: This study identified a conserved region of CEP192 that interacts with AURKA and revealed the structural basis for CEP192-mediated regulation of AURKA at the centrosome. This regulation is distinct from TPX2-mediated regulation on the spindle microtubule.
Article
Multidisciplinary Sciences
Ryuzaburo Yuki, Yuki Ikeda, Ryuji Yasutake, Youhei Saito, Yuji Nakayama
Summary: SH2D4A is a newly identified mitotic regulator that promotes centrosome maturation and microtubule formation by inhibiting PP1 phosphatase. It accelerates spindle formation and supports mitotic progression.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Ilaria Gori, Roger George, Andrew G. Purkiss, Stephanie Strohbuecker, Rebecca A. Randall, Roksana Ogrodowicz, Virginie Carmignac, Laurence Faivre, Dhira Joshi, Svend Kjaer, Caroline S. Hill
Summary: Shprintzen-Goldberg syndrome (SGS) is associated with mutations in the transcriptional co-repressor SKI, leading to attenuation of TGF-beta-induced transcriptional responses.
Correction
Multidisciplinary Sciences
Mauricio Torres, Karen Castillo, Ricardo Armisen, Andres Stutzin, Claudio Soto, Claudio Hetz
Article
Genetics & Heredity
Diego A. Rojas, Fabiola Urbina, Lucia Valenzuela-Perez, Lorenzo Leiva, Vicente J. Miralles, Edio Maldonado
Summary: This study defines the pathway of preinitiation complex formation on the fission yeast nmt1 gene promoter and identifies a functional initiator element in the promoter. The findings show that transcription initiation in this system relies on multiple transcription factors and a identified transcription cofactor TCIF. Additionally, the study demonstrates the ability of other initiators from the nmt1/hDHFR family to be transcribed in fission yeast whole-cell extracts.
Review
Medicine, General & Internal
Solange Rivas, Ricardo Armisen
Summary: Lung cancer is the leading cause of cancer death in many countries globally, and precision medicine has played a pivotal role in improving the diagnosis and treatment of this disease. Targeted therapy against driver gene mutations in lung cancer has shown significant success, but challenges such as unequal access to drugs, lack of actionable gene mutations, and therapy resistance mutations still exist on a global scale. Current research in NSCLC is focused on biomarkers, circulating DNA in plasma, measuring tumor mutational burden, and conducting clinical trials with combination targeted therapies.
REVISTA MEDICA CLINICA LAS CONDES
(2022)
Article
Genetics & Heredity
Fernanda Morales, Paola Perez, Julio C. Tapia, Lorena Lobos-Gonzalez, Jose Manuel Herranz, Francisca Guevara, Pamela Rojas de Santiago, Esteban Palacios, Rodrigo Andaur, Eduardo A. Sagredo, Katherine Marcelain, Ricardo Armisen
Summary: In triple-negative breast cancer (TNBC), ADAR1 is found to be connected with the canonical Wnt signaling pathway. ADAR1 overexpression alters the expression of key components of the Wnt pathway, promoting tumor invasion and neovascularization.
Article
Oncology
Andrea Sabina Llera, Eliana Saul Furquim Werneck Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Bettina Muller, Carlos Velazquez, Elsa B. Alcoba, Isabel Alonso, Daniela B. Alves da Quinta, Renata Binato, Alicia Ines Bravo, Natalia Camejo, Dirce Maria Carraro, Monica Castro, Juan M. Castro-Cervantes, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cisterna, Lucia Delgado, Marisa Dreyer-Breitenbach, Laura Fejerman, Elmer A. Fernandez, Jorge Fernandez, Wanda Fernandez, Ramon A. Franco-Topete, Carolina Gabay, Fancy Gaete, Adriana Garibay-Escobar, Jorge Gomez, Gonzalo Greif, Thomas G. Gross, Marisol Guerrero, Marianne K. Henderson, Miguel E. Lopez-Munoz, Alejandra Lopez-Vazquez, Silvina Maldonado, Andres J. Moran-Mendoza, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Miguel A. Ortiz-Martinez, Jael Quintero, Antonio Quintero-Ramos, Rui M. Reis, Javier Retamales, Ernesto Rivera-Claisse, Dario Rocha, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Veronica Sanchotena, Laura Segovia, Juan Martin Sendoya, Aida A. Silva-Garcia, Alejandra Trinchero, Olivia Valenzuela, Vidya Vedham, Livia Zagame, Osvaldo L. Podhajcer
Summary: This study assessed molecular features at the transcriptomic level in a multicountry Latin American breast cancer patient cohort. Hormone-related and proliferation pathways were found to be the main tumor-driving mechanisms and have prognostic power. The immune-related features seen in the most aggressive subtypes may pave the way for therapeutic approaches not yet disseminated in Latin America.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Diego A. Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado
Summary: The Pneumocystis genus is an opportunistic fungal pathogen that primarily infects AIDS patients and individuals with weakened immune systems. This study focuses on characterizing the function of a specific transcription factor called TFIIB from Pneumocystis carinii using a related model organism, Schizosaccharomyces pombe. The results show that P. carinii TFIIB is capable of replacing the essential function of S. pombe TFIIB, indicating a similar transcriptional machinery between the two organisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diego A. Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado
Summary: This study describes the effect of PC4 phosphorylation on RNAPII transcription in fission yeast, and identifies CK2 as a regulator of PC4 coactivator function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Karen Y. Orostica, Juan Saez-Hidalgo, Pamela R. de Santiago, Solange Rivas, Sebastian Contreras, Gonzalo Navarro, Juan A. Asenjo, Alvaro Olivera-Nappa, Ricardo Armisen
Summary: This study found that tumor stage is the primary feature that affects metastasis prediction in lung cancer patients, but the information from total mutational load (TML) also contributes to the classification. Combining clinical variables and TML can more accurately assess the likelihood of lung cancer patients progressing to metastatic states, highlighting the need for comprehensive diagnostic tools for metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Guillermo Valenzuela, Mauricio Burotto, Katherine Marcelain, Jaime Gonzalez-Montero
Summary: Colorectal cancer is a leading cause of death globally, with high molecular heterogeneity. Though targeted therapy for CRC has improved with the identification of mutations, there is still uncertainty in its effectiveness. The recent development of liquid biopsy may become a new standard in targeted CRC therapy decision-making.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Solange Rivas, Arnaldo Marin, Suraj Samtani, Evelin Gonzalez-Feliu, Ricardo Armisen
Summary: The MET gene plays a significant role in lung adenocarcinoma, and its driver mutations contribute to tumor cell migration, invasion, and proliferation. However, the development of drug resistance after MET targeted therapy poses a challenge to precision medicine. Evaluating the patient's MET mutational profile is crucial in devising individualized treatment plans and follow-up processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Edio Maldonado, Diego A. Rojas, Fabiola Urbina, Lucia Valenzuela-Perez, Christian Castillo, Aldo Solari
Summary: DNA polymerase beta plays an important role in Trypanosoma cruzi's life cycle by participating in kinetoplast DNA repair and replication. This study identified several phosphorylation sites on DNA polymerase beta and found that casein kinase 2 and protein kinase C-like enzymes are involved in its phosphorylation process. Additionally, the presence of multiple protein kinase C-like enzymes in T. cruzi was discovered, with TcPKC1 and TcPKC2 able to phosphorylate DNA polymerase beta in vitro.
Article
Microbiology
Diego A. Rojas, Carolina A. Ponce, Adriel Bustos, Vicente Cortes, Daniela Olivares, Sergio L. Vargas
Summary: Inflammation and mucus hypersecretion are common features of chronic respiratory diseases. Pneumocystis infection can aggravate disease by activating pathways that induce airway pathology. This study demonstrates that Pneumocystis is a co-factor for disease severity in an elastase-induced COPD model, highlighting the relevance of the STAT6 pathway in Pneumocystis pathogenesis.
Meeting Abstract
Oncology
Solange V. Rivas, Evelin Gonzalez, Alejandro Blanco, Carolina Ibanez, Alejandro Corvalan, Marcelo Garrido, Gareth Owen, Katherine Marcelain, Ricardo Armisen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Liz Maria de Almeida, Sandra Cortes, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian de Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S. Llera, Bettina Muller, Osvaldo L. Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia Bravo, Natalia Camejo, Dirce Maria Carraro, Monica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernandez, Jorge Fernandez, Wanda Fernandez, Ramon A. Franco-Topete, Fancy Gaete, Jorge Gomez, Leivy P. Gonzalez-Ramirez, Marisol Guerrero, Susan A. Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Miguez, Andres de J. Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M. Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M. Sendoya, Aida A. Silva-Garcia, Stella Vina, Livia Zagame, Beth Jones, Moyses Szklo
Summary: The molecular profile of breast cancer in Latin-American women was studied in five countries. The study described the socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes, and estimated the 60-month overall cumulative survival probabilities. Factors such as country of residence, intrinsic subtype, age, and tumor stage were found to be associated with overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
