期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 396, 期 2, 页码 182-186出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.04.061
关键词
Hydrogen sulfide; Atherosclerosis; Proliferation; Hyperhomocysteinemia; Calcification; Inflammation
资金
- National Natural Science Foundation of China [30630031, 30821001, 30801251]
- Major Basic Research Development Program of People's Republic of China [2006CB503807]
Atherosclerosis is a chronic, complex, and progressive pathological process in large and medium sized arteries. The exact mechanism of this process remains unclear. Hydrogen sulfide (H2S), a novel gasotransmitter, was confirmed as playing a major role in the pathogenesis of many cardiovascular diseases. It plays a role in vascular smooth muscle cell (VSMC) proliferation and apoptosis, participates in the progress of hyperhomocysteinemia (HHCY), inhibits atherogenic modification of LDL, interferes with vascular calcification, intervenes with platelet function, and there are interactions between H2S and inflammatory processes. The role of H2S in atherosclerotic pathogenesis highlights the mysteries of atherosclerosis and inspires the search for innovative therapeutic strategies. Here, we review the studies to date that have considered the role of H2S in atherosclerosis. (C) 2010 Elsevier Inc. All rights reserved.
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