Article
Plant Sciences
Siya Wu, Jian Liu, Ya Zhang, Jianxi Song, Zhongshan Zhang, Yue Yang, Mingjiang Wu, Haibin Tong
Summary: This study determined the structural characteristics of SFF-32, a fucoidan fraction from S. fusiforme, and its antagonistic effect against P-selectin mediated function. It was found that SFF-32 inhibited P-selectin-mediated function by blocking the interaction between P-selectin and its physiological ligand PSGL-1, suggesting its potential as an anti-inflammatory lead compound.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Hematology
Patrick C. Hines, Michael U. Callaghan, Ahmar U. Zaidi, Xiufeng Gao, Ke Liu, Jennell White, Michael Tarasev
Summary: The study found that adhesion of blood cells to P-selectin and VCAM1 is significantly increased on VOC days in patients with SCD. By establishing optimal cutoff values and a multimarker risk score, a better ability to identify VOC risk was demonstrated.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sherwin K. B. Sy, Chiaki Tanaka, Kai Grosch
Summary: The study developed a population pharmacokinetic (PK) and pharmacodynamic (PD) model for crizanlizumab, a monoclonal antibody for sickle cell disease. The results showed that crizanlizumab exhibited nonlinear PK and factors such as renal and hepatic impairments, concomitant hydroxyurea usage, and anti-drug antibody did not impact its exposure. The model can be used to extrapolate PK to pediatric population and evaluate alternative regimens and routes of administration.
CLINICAL PHARMACOKINETICS
(2023)
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Arduino A. Mangoni
Summary: Statins can effectively decrease circulating levels of cell adhesion molecules, including P-selectin, L-selectin, and E-selectin, which are involved in the pathogenesis of atherosclerosis. Research indicates that statins have a significant impact on reducing these selectins independently of baseline lipid profiles and other patient characteristics, potentially contributing to cardiovascular risk reduction.
Article
Cell Biology
Fangyuan Zhou, Fang Zhang, Veronika Zarnitsyna, Larissa Doudy, Zhou Yuan, Kaitao Li, Rodger P. McEver, Hang Lu, Cheng Zhu
Summary: Selectins and integrins play crucial roles in recruiting leukocytes to inflamed tissues. Studies have found that E- and P-selectins have different effects on the activation of α(L)β(2), with varying responses observed at different temperatures.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Zhi Cai, Yishu Yan, Juan Zhou, Yang Yang, Yan Zhang, Jinghua Chen
Summary: Novel brush-like glycopolymers (BGPs) were synthesized with BGP-SFH showing the highest anti-metastasis ability similar to heparin. In vitro assays demonstrated the efficacy of these glycopolymers in inhibiting cancer cell metastasis.
Article
Biochemistry & Molecular Biology
Kou-Gi Shyu, Bao-Wei Wang, Wei-Jen Fang, Chun-Ming Pan, Chiu-Mei Lin
Summary: The expression of macrophage-derived exosomal MALAT1 is increased by high glucose levels, which in turn suppresses the expression of miR-150-5p and promotes resistin expression in macrophages. Additionally, macrophage-derived exosomal MALAT1 may serve as a potential therapeutic target for vascular disease in diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tianyang Li, Yang Yang, Yongqi Li, Zhengmin Wang, Faxiang Ma, Runqi Luo, Xiaoming Xu, Guo Zhou, Jianhua Wang, Junqi Niu, Guoyue Lv, Ian N. Crispe, Zhengkun Tu
Summary: Infection with SARS-CoV-2 can lead to COVID-19, which ranges from mild to moderate disease but carries the risk of morbidity and mortality. Severe cases of COVID-19 are associated with hemostasis disorders, monocyte activation, and a cytokine storm, but the connection between these manifestations is not fully understood. This study reveals that the spike protein of SARS-CoV-2 interacts with P-selectin/PGSL-1 and CD40L/CD40, leading to proinflammatory cytokine production by monocytes. These findings provide an explanation for the correlation between hypercoagulation, monocyte activation, and a cytokine storm in severely affected COVID-19 patients, and suggest a potential target for therapeutic intervention.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Qi Xu, Ming Shi, Lu Ding, Yu Xia, Liang Luo, Xiaofang Lu, Xiaoying Zhang, David Y. B. Deng
Summary: This study found that P-selectin induces the formation of NETs through the PSGL-1 and downstream Syk/Ca2+/PAD4 signaling pathway, playing an important role in acute pancreatitis. Inhibiting the P-selectin pathway may be a promising strategy for the treatment of AP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Danfeng Zhang, Lingjuan Liu, Yuxing Yuan, Tiewei Lv, Xupei Huang, Jie Tian
Summary: Sera from KD patients stimulate OXPHOS levels and enhance E-selectin expression in HCAECs, contributing to the development of CAL in KD patients.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Jean Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Kee Ryeon Kang, Hye Jung Kim
Summary: This study investigated the mechanisms involved in oxLDL-induced endothelial permeability and monocyte diapedesis under high glucose (HG) conditions and the potential effects of rosmarinic acid. It was found that oxLDL increased the expression of adhesion molecules and enhanced monocyte-EC adhesion in ECs under HG conditions. These effects were dependent on the ROS/p38 MAPK/FOXO1/TXNIP signaling pathway. Additionally, oxLDL induced increased endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer. This study also demonstrated that rosmarinic acid could reverse these oxLDL-mediated effects in a dose-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Hematology
Zixiang Leonardo Liu, Christopher Bresette, Cyrus K. Aidun, David N. Ku
Summary: This study elucidates the biophysics of shear-induced platelet aggregation (SIPA) using a multiscale in silico model and a thrombosis-on-a-chip device. The findings show that SIPA begins with the elongation of von Willebrand factor (VWF), followed by agglomeration of platelets in the flow mediated by soluble VWF entanglement, and eventually captured by immobilized VWF. Increasing soluble VWF concentration leads to higher SIPA rates, and the morphology of mural aggregates is controlled by VWF molecular weight.
Article
Urology & Nephrology
Sarah Cormican, Neema Negi, Serika D. D. Naicker, Md Nahidul Islam, Barbara Fazekas, Rachael Power, Tomas P. Griffin, M. Conall Dennedy, Briain MacNeill, Andrew F. F. Malone, Matthew D. D. Griffin
Summary: Cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) is associated with increased levels of intermediate monocytes (IMs). Dysregulation of monocyte maturation and function may contribute to cardiovascular complications in CKD. In this study, the authors examined monocyte subpopulations and found that HLA-DRhi IMs were increased in individuals with CKD. These IMs produced higher levels of proinflammatory cytokines and showed increased migration and adhesion to endothelial cells compared to other monocyte populations. Dysregulated monocyte maturation and function may be targeted to reduce accelerated CVD in CKD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Hematology
Preeti Maurya, Sara K. Ture, Chen Li, Kristin M. Scheible, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelet transfusions are commonly used in preterm neonates with thrombocytopenia to reduce the risk of bleeding, but there is limited clinical evidence to support this practice. This study found that adult and neonatal platelets have differential effects on monocyte immune functions, which may affect neonatal immune function and transfusion complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Cristina Ana Mocanu, Elena Valeria Fuior, Geanina Voicu, Daniela Rebleanu, Florentina Safciuc, Mariana Deleanu, Ioana Madalina Fenyo, Virginie Escriou, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Summary: The newly developed Psel-lipo/shRAGE lipoplexes reduce the inflammatory processes associated with RAGE signaling and the progression of atherosclerosis in ApoE-deficient mice. Downregulation of RAGE employing these lipoplexes may represent a promising new targeted therapy to block atherosclerosis progression.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Analytical
Caroline G. Sanz, Andreea C. Mihaila, Alexandru Evanghelidis, Victor C. Diculescu, Elena Butoi, Madalina M. Barsan
Summary: The present study introduces a new 2D model for human heart valve in tissue engineering, which incorporates valvular interstitial cells (VIC) encapsulated in gold covered electrospun polycaprolactone (PCL/Au) fibers. The model also serves as an electrochemical sensor for monitoring oxygen levels in cellular media. The biocompatibility of the materials with VIC was evaluated, and electrochemical techniques were used to investigate the effect of cell encapsulation and quantify dissolved oxygen levels. The study provides advancements in the field of heart valve tissue engineering.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mihaela Vadana, Sergiu Cecoltan, Letitia Ciortan, Razvan D. Macarie, Andreea C. Mihaila, Monica M. Tucureanu, Ana-Maria Gan, Maya Simionescu, Ileana Manduteanu, Ionel Droc, Elena Butoi
Summary: This study found that parathyroid hormone (PTH) can cause dysfunction of human valvular endothelial cells (VEC), which in turn affects the transformation of valvular interstitial cells (VIC) into osteoblast-like cells. These findings shed light on the mechanisms of PTH involvement in valvular calcification pathology and suggest that PTH and treatment of hyperparathyroidism can be a therapeutic strategy to reduce valvular calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Summary: This study designed and obtained targeted lipid-enveloped polyplexes (V-LPP/shRunx2) suitable for systemic administration and targeted delivery of shRunx2 to osteoblast-differentiated VIC cells. The lipopolyplexes were shown to be cyto- and hemo-compatible, and specifically taken up by osteoblast-differentiated VIC cells. They successfully downregulated the expression of osteogenic molecules and could be a potential nanomedicine approach for blocking the progression of CAVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Cristina Ana Mocanu, Mihaela Loredana Vlad, Ioana Madalina Fenyo, Agneta Simionescu, Dan Teodor Simionescu, Ileana Manduteanu, Adriana Georgescu
Summary: The number and function of endothelial progenitor cells (EPCs) are reduced in diabetes. Genetically modified EPCs can be a safe treatment option for dyslipidemia and diabetes, preserving aortic valve function.
Article
Pharmacology & Pharmacy
Gheorghe Fundueanu, Marieta Constantin, Mihaela Turtoi, Sanda-Maria Bucatariu, Bogdan Cosman, Maria Anghelache, Geanina Voicu, Manuela Calin
Summary: In this study, pH/temperature-responsive carriers were designed and characterized for the delivery of the anti-tumoral drug doxorubicin. The carriers disintegrated and released the drug under endosomal and lysosomal conditions. The results showed that the carriers were more effective in delivering the drug to hepatic carcinoma cells HepG2 compared to lung adenocarcinoma cells A549, resulting in increased cytotoxicity. Additionally, the carriers were found to be biocompatible and reduced the renal clearance of doxorubicin when administered in vivo. These findings suggest the potential importance of the newly developed carriers for the treatment of hepatic tumors.
Article
Biochemistry & Molecular Biology
Mihaela Turtoi, Maria Anghelache, Andrei A. Patrascu, Mariana Deleanu, Geanina Voicu, Mihai Raduca, Florentina Safciuc, Ileana Manduteanu, Manuela Calin, Delia-Laura Popescu
Summary: A new vanadium-based drug was developed and evaluated for its antitumor properties in a human hepatocarcinoma cell line. The compound exhibited high cytotoxicity, inducing cell death by altering the oxidative and mitochondrial status. It showed differences in cell cycle regulation compared to cisplatin, a traditional cytotoxic drug.
Article
Pharmacology & Pharmacy
Irina Florina Tudorache, Violeta Georgeta Bivol, Madalina Dumitrescu, Ioana Madalina Fenyo, Maya Simionescu, Anca Violeta Gafencu
Summary: The study found that fullerenol-based nanoparticles carrying apoE3 can limit the progression of atherosclerotic plaques by reducing plasma cholesterol levels and increasing the expression of major proteins involved in lipid metabolism.
PHARMACOLOGICAL REPORTS
(2022)
Article
Pharmacology & Pharmacy
Mirela-Fernanda Zaltariov, Mihaela Turtoi, Dragos Peptanariu, Ana-Maria Macsim, Lilia Clima, Corneliu Cojocaru, Nicoleta Vornicu, Bianca-Iulia Ciubotaru, Alexandra Bargan, Manuela Calin, Maria Cazacu
Summary: In this study, a new compound SIL-BS was synthesized by coupling 1-(3-aminopropyl) silatrane and nitro group attached to salicylaldehyde through an azomethine moiety. The results showed that SIL-BS exhibited good hydrolytic stability and cytotoxicity in vitro, increased drug permeation and residence time in tumor location, as well as antimicrobial activity and potential application in combined therapy.
Article
Biochemistry & Molecular Biology
Raluca Nicu, Diana Elena Ciolacu, Anca-Roxana Petrovici, Daniela Rusu, Mihaela Avadanei, Andreea Cristina Mihaila, Elena Butoi, Florin Ciolacu
Summary: Current trends in wound dressing development are focused on biopolymer-based materials with unique properties that are advantageous for therapy, such as non-toxicity, hydrophilicity, biocompatibility, and biodegradability. This study aims to develop hydrogels based on cellulose and dextran (CD) and investigate their anti-inflammatory performance. Plant bioactive polyphenols (PFs) were incorporated into CD hydrogels. Various assessments, including structural characteristics, morphology, swelling degree, PFs release kinetics, cytotoxicity, and anti-inflammatory properties, were conducted. The results showed that dextran improved the structure of the hydrogels, leading to decreased pore size, increased pore uniformity and interconnectivity. The swelling degree and encapsulation capacity of PFs increased with higher dextran content. The PFs release kinetics depended on the composition and morphology of the hydrogels. CD hydrogels promoted cell proliferation without cytotoxicity, and the PFs-loaded hydrogels exhibited anti-inflammatory properties. These findings provide conclusive evidence of wound healing acceleration through inhibition of the inflammation process, supporting the use of PFs encapsulated hydrogels in wound healing applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Razvan Daniel Macarie, Monica Madalina Tucureanu, Letitia Ciortan, Ana-Maria Gan, Elena Butoi, Ileana Manduteanu
Summary: This study reveals that ficolin-2 may influence plaque vulnerability by promoting a pro-inflammatory phenotype in smooth muscle cells (SMC) and enhancing monocyte transmigration through its interaction with macrophages (Mo). It elevates the expression of pro-inflammatory genes and proteins in SMC, increases the secretion of certain cytokines in Mo, and facilitates the infiltration of monocytes. These findings provide insights into previously unknown mechanisms of ficolin-2-dependent pathological inflammation in atherosclerotic plaques.
SCIENTIFIC REPORTS
(2023)
Article
Polymer Science
Irina Mihaela Pelin, Irina Popescu, Manuela Calin, Daniela Rebleanu, Geanina Voicu, Daniela Ionita, Marius-Mihai Zaharia, Marieta Constantin, Gheorghe Fundueanu
Summary: This study developed a porous biocompatible hydrogel scaffold with deposited apatite-like particles to support osteoblast proliferation. The results showed high concentration of apatite particles deposited on the pore walls of the hydrogel. The composition of the organic matrix also influenced the crystallization of calcium phosphates and the mechanical properties of the composite hydrogels.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)