Article
Microbiology
Saikat De, Prabhudutta Mamidi, Soumyajit Ghosh, Supriya Suman Keshry, Chandan Mahish, Sweta Smita Pani, Eshna Laha, Amrita Ray, Ankita Datey, Sanchari Chatterjee, Sharad Singh, Tathagata Mukherjee, Somlata Khamaru, Subhasis Chattopadhyay, Bharat Bhusan Subudhi, Soma Chattopadhyay
Summary: Telmisartan inhibits CHIKV infection and inflammation through modulation of host factors and viral replication, making it a potential candidate for CHIKV repurposing.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Berna Guven, Arzu Onay-Besikci
Summary: This review focuses on the role of beta arrestins in mediating metabolic modulation, particularly in relation to insulin signaling. It is suggested that beta arrestins play a regulatory role in insulin secretion and action, making them potential targets for therapeutic intervention in metabolic disorders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Lebin Weng, Ting-Hsu Chen, Qingyan Zheng, Wei-Hao Weng, Liyue Huang, Dong Lai, Yaw-Syan Fu, Ching-Feng Weng
Summary: The study demonstrated that syringaldehyde can lower blood glucose levels in diabetic mice by enhancing intestinal contractility and reducing glucose absorption, suggesting its potential therapeutic benefits.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Safaa A. Faheem, Yasser M. Moustafa, Noha M. Saeed, Reem M. Hazem, Norhan M. El-Sayed
Summary: The aim of this study was to investigate whether pyrvinium pamoate (PP) could protect against cyclosporin A (CsA)-induced hepatotoxicity. The results showed that PP has antioxidant, anti-inflammatory, and antiapoptotic properties, which can reduce CsA-induced liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Nevertyty M. Mahmoud, Shimaa M. Elshazly, Samar Rezq
Summary: This study found that geraniol has a dose-dependent protective effect against CsA-induced renal damage, and its effects are comparable or superior to the PPAR gamma agonist pioglitazone. Geraniol exerts its renoprotective potential by modulating the Wnt/beta-catenin and PPAR gamma signaling pathways.
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Xiaoyun Zhao, Liang Li, Hongxiang Sun, Xiaoli Jiang, Wenjuan Bai, Ningbo Wu, Jing Wang, Bing Su
Summary: We reported a novel Rspo1-tdTomato gene reporter mouse line that specifically labels mouse alveolar macrophages (AMs) and visualizes their dynamics and differentiation processes. Insertion of the tdTomato cassette in the Rspo1 locus increased the accessibility of a PPARE motif, potentially regulating AM differentiation via the transcription factor PPAR-γ. Comparative transcriptomic analysis showed similar gene expression profiles between AMs from Rspo1-tdTomato mice and wild type mice, confirming the unaffected cell identity and function of AMs. This study provides an alternative tool for specific labeling of AMs in vivo and in vitro and can serve as an indicator for PPAR-γ activity in drug development.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rosaria Scandiffio, Sara Bonzano, Erika Cottone, Sujata Shrestha, Simone Bossi, Silvia De Marchis, Massimo E. Maffei, Patrizia Bovolin
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease without approved pharmacological therapy. The study investigated the effects of (E)-beta-caryophyllene (BCP), a phytocannabinoid, on HepG2 steatotic hepatocytes. BCP was found to decrease lipid accumulation and change the lipid profile in steatotic conditions by reducing saturated fatty acids. The action of BCP was mediated by CB2 cannabinoid receptor, peroxisome proliferator-activated receptor alpha (PPAR alpha), and gamma (PPAR gamma). The results suggest potential applications of BCP in the treatment of NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Wenkun Dou, Manpreet Malhi, Teng Cui, Minyao Wang, Tiancong Wang, Guanqiao Shan, Junhui Law, Zheyuan Gong, Julia Plakhotnik, Tobin Filleter, Renke Li, Craig A. Simmons, Jason T. Maynes, Yu Sun
Summary: In this study, a biosensing platform was developed using carbon-based nanomaterials for on-chip and simultaneous measurement of contractility and electrophysiology of cardiomyocytes. The platform was validated for disease modeling and drug testing through evaluation of cardiac functional properties and establishment of an in vitro model of drug-induced cardiac arrhythmia.
Article
Biochemistry & Molecular Biology
Alexandre Vallee
Summary: Schizophrenia is a complex syndrome characterized by widespread brain multi-dysconnectivity. Recent studies suggest that inflammation and immune dysfunction in the central nervous system (CNS) may play a role in the development of schizophrenia. The dysregulation of the WNT/beta-catenin pathway is associated with neuroinflammation in schizophrenia, and there is a positive interaction between neuroinflammation and oxidative stress. These findings suggest a metabolic-inflammatory imbalance in this disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Chiara Bartolucci, Mohamadamin Forouzandehmehr, Stefano Severi, Michelangelo Paci
Summary: In this study, a novel mathematical model of human ventricular cardiomyocytes electromechanics, BPSLand, is proposed. The model successfully reproduces realistic human active tension and its potential abnormalities, as well as captures the transmural heterogeneity in both electrophysiology and contractility. The model also demonstrates capabilities in simulating various contraction abnormalities. The mechanical results of the model are validated against previous experimental and in silico studies.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Immunology
Samantha M. Yeligar, Ashish J. Mehta, Frank L. Harris, Lou Ann S. Brown, C. Michael Hart
Summary: Alcohol use disorders impair alveolar macrophage immune function and increase susceptibility to respiratory infections. Alcohol induces oxidative stress in alveolar macrophages, affecting their phagocytic capacity. Pharmacologic activation of PPAR gamma can mitigate alcohol-induced dysfunction in alveolar macrophages.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jia Duan, Heng Liu, Fenghui Zhao, Qingning Yuan, Yujie Ji, Xiaoqing Cai, Xinheng He, Xinzhu Li, Junrui Li, Kai Wu, Tianyu Gao, Shengnan Zhu, Shi Lin, Ming-Wei Wang, Xi Cheng, Wanchao Yin, Yi Jiang, Dehua Yang, H. Eric Xu
Summary: Phosphorylation of G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) regulates G-protein and arrestin signalling, which can be modulated by biased ligands. However, the molecular assembly of GRKs on GPCRs and the mechanisms of GRK-mediated biased signalling are not well understood. This study presents the complex structure of neurotensin receptor 1 (NTSR1) bound to GRK2, Ga-q, and the arrestin-biased ligand SBI-553. The structure provides insights into the details of GPCR-GRK interactions and the mechanisms underlying GRK2-mediated biased signalling.
Article
Biochemistry & Molecular Biology
Firdos Ahmad, Dhanendra Tomar, Smriti A. C. Aryal, Adel B. Elmoselhi, Manfred Thomas, John W. Elrod, Douglas G. Tilley, Thomas Force
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Article
Cell Biology
Harika Vemulapalli, Samara Albayati, Viren C. Patwa, Douglas G. Tilley, Alexander Y. Tsygankov, Elisabetta Liverani
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2020)
Article
Cardiac & Cardiovascular Systems
Melissa Lieu, Christopher J. Traynham, Claudio de Lucia, Jessica Pfleger, Michela Piedepalumbo, Rajika Roy, Jennifer Petovic, Gavin Landesberg, Steven J. Forrester, Matthew Hoffman, Laurel A. Grisanti, Ancai Yuan, Erhe Gao, Konstantinos Drosatos, Satoru Eguchi, Rosario Scalia, Douglas G. Tilley, Walter J. Koch
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Review
Physiology
Ama Dedo Okyere, Douglas G. Tilley
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Mikhail A. Kolpakov, Xinji Guo, Khadija Rafiq, Liudmila Vlasenko, Bahman Hooshdaran, Rachid Seqqat, Tao Wang, Xiaoxuan Fan, Douglas G. Tilley, John C. Kostyak, Satya P. Kunapuli, Steven R. Houser, Abdelkarim Sabri
Article
Cardiac & Cardiovascular Systems
Claudio de Lucia, Laurel A. Grisanti, Giulia Borghetti, Michela Piedepalumbo, Jessica Ibetti, Anna Maria Lucchese, Eric W. Barr, Rajika Roy, Ama Dedo Okyere, Haley Christine Murphy, Erhe Gao, Giuseppe Rengo, Steven R. Houser, Douglas G. Tilley, Walter J. Koch
Summary: This study found that myocyte GRK5 has a crucial role in regulating leukocyte infiltration, cardiac function, and survival post-MI in a murine model of ischemic heart failure.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cell Biology
Viren Patwa, Shuchi Guo, Rhonda L. Carter, Lindsay Kraus, Jeanette Einspahr, David Teplitsky, Abdelkarim Sabri, Douglas G. Tilley
Summary: The proximal region of the JMD of EGFR is responsible for its association with beta 1AR, and disruption of this interaction prevents beta 1AR-mediated transactivation, providing a new tool for studying the functional consequences of disrupting beta 1AR-EGFR downstream signaling.
CELLULAR SIGNALLING
(2021)
Article
Cardiac & Cardiovascular Systems
Shuchi Guo, Ama Dedo Okyere, Erin McEachern, Joshua L. Strong, Rhonda L. Carter, Viren C. Patwa, Toby P. Thomas, Melissa Landy, Jianliang Song, Ana Maria Lucchese, Thomas G. Martin, Erhe Gao, Sudarsan Rajan, Jonathan A. Kirk, Walter J. Koch, Joseph Y. Cheung, Douglas G. Tilley
Summary: This study demonstrates the importance of EGFR in maintaining contractile homeostasis in the adult heart under physiological conditions, highlighting the role of PR72 expression regulation in this process.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Cell Biology
Ama Dedo Okyere, Douglas G. Tilley
Summary: Recent research has identified a natural negative allosteric modulator that attenuates the development of chronic inflammatory vascular disease abdominal aortic aneurysm.
Review
Cardiac & Cardiovascular Systems
Heli Xu, Douglas G. Tilley
Summary: Pepducins are small-lipidated peptides derived from the intracellular loops of G protein-coupled receptors (GPCRs) that modulate GPCR activity in an allosteric manner. Changes in amino acid sequence greatly impact the effects and selectivity of pepducins at their cognate receptors. Pepducins designed from various GPCRs have shown therapeutic potential for cardiovascular diseases and other pathological conditions.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Jeanette M. Einspahr, Douglas G. Tilley
Summary: Adhesion GPCRs, as the second-largest family of GPCRs, have not yet been targeted for clinical treatment despite increasing evidence of their physiological and pathological functions. They are associated with a variety of diseases, including cancer, central nervous system disorders, immunity, and inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ama D. Okyere, Tapas K. Nayak, Viren Patwa, David Teplitsky, Erin McEachern, Rhonda L. Carter, Heli Xu, Erhe Gao, Yan Zhou, Douglas G. Tilley
Summary: Myeloid cell-specific EGFR deletion leads to an accelerated decline in cardiac function, increased cardiomyocyte hypertrophy, and decreased capillary density following acute ischemic injury.
Review
Physiology
Tapas K. Nayak, Douglas G. Tilley
Summary: The response of leukocytes after acute cardiac injury is influenced by chemokine receptors, while other GPCR classes have been found to regulate this response. Understanding and modulating these receptors is important for mitigating inflammation and promoting repair processes.
CURRENT OPINION IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xinji Guo, Mikhail A. Kolpakov, Bahman Hooshdaran, William Schappell, Tao Wang, Satoru Eguchi, Katherine J. Elliott, Douglas G. Tilley, A. Koneti Rao, Patricia Andrade-Gordon, Matthew Bunce, Chintala Madhu, Steven R. Houser, Abdelkarim Sabri
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)
Article
Medicine, Research & Experimental
Martina S. Burczyk, Martin D. Burkhalter, Teresa Casar Tena, Laurel A. Grisanti, Michael Kauk, Sabrina Matysik, Cornelia Donow, Monika Kustermann, Melanie Rothe, Yinghong Cui, Farah Raad, Svenja Laue, Allessandra Moretti, Wolfram-H Zimmermann, Jurgen Wess, Michael Kuehl, Carsten Hoffmann, Douglas G. Tilley, Melanie Philipp
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)