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Gastroenterology & Hepatology
Sai Wang, Rilu Feng, Shan Shan Wang, Hui Liu, Chen Shao, Yujia Li, Frederik Link, Stefan Munker, Roman Liebe, Christoph Meyer, Elke Burgermeister, Matthias Ebert, Steven Dooley, Huiguo Ding, Honglei Weng
Summary: This study investigates the transcriptional regulation of multidrug resistance protein 2 (MRP2) under different pathophysiological conditions and identifies FOXA2 as a potential replacement for FXR in maintaining MRP2 expression in patients with acute liver failure (ALF). The findings suggest that by regulating the expression of FOXA2, it may be possible to prevent hyperbilirubinemia in ALF patients with sepsis.
Article
Biotechnology & Applied Microbiology
Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen
Summary: This study revealed that 4-PBA could alleviate RFP-induced cholestatic liver injury by inhibiting ER stress and ubiquitination degradation of MRP2, leading to a decrease in serum total bilirubin concentration. These findings provide important insights into the treatment mechanism of 4-PBA in RFP-induced cholestasis and liver damage.
Article
Pharmacology & Pharmacy
Xing Wang, Wenqiang Xiong, Xin Wang, Liying Qin, Maolian Zhong, Yan Liu, Yuqing Xiong, Xiaoyi Yi, Xiaosong Wang, Hong Zhang
Summary: Ursolic acid (UA) has various pharmacological actions and can prevent cholestatic liver injury. The study found that UA exerts its effects by regulating the expression of uridine diphosphate glucuronosyltransferase 2B7 and bile salt export pump/multidrug resistance-associated protein 2 through the nuclear factor E2-related factor 2 (NRF2) pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Dong Xiang, Yanan Liu, Yue Zu, Jinyu Yang, Wenxi He, Chengliang Zhang, Dong Liu
Summary: CBS alleviates EIC-induced hepatic and intestinal injury through regulating inflammation, oxidative stress, apoptosis, and bile acid profiles.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Steffen Landerer, Sandra Kalthoff, Christian P. Strassburg
Summary: The study found that coffee exerts a protective effect in cholestasis-induced liver fibrosis by activating UGT1A enzymes, reducing collagen deposition, oxidative stress, and the expression of profibrotic markers. The inductive effect of coffee on UGT1A genes plays a key role in hepatic protection and antioxidative effects.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Naser-Aldin Lashgari, Danial Khayatan, Nazanin Momeni Roudsari, Saeideh Momtaz, Ahmad Reza Dehpour, Amir Hossein Abdolghaffari
Summary: This study summarizes the role of neutrophils and nitric oxide in the pathogenesis of cholestatic liver diseases. It found that certain natural products and chemicals can attenuate nitric oxide production and inflammation, suggesting that suppression of nitric oxide and its related pathways could be a therapeutic option for preventing or treating cholestatic liver diseases.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pablo Muriel, Pedro Lopez-Sanchez, Erika Ramos-Tovar
Summary: Chronic diseases, particularly metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), are major health challenges globally, with fructose overconsumption playing a significant role in their development. Fructose-induced inflammation, fibrosis, and oncogenic signaling pathways contribute to the progression of NAFLD, leading to serious liver complications such as NASH and ultimately liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Atsushi Kawase, Momoko Hatanaka, Naoya Matsuda, Hiroaki Shimada, Masahiro Iwaki
Summary: This study demonstrates the alterations in Slc25a39/40 expression in mice with cholestasis-associated renal injury and LPS-induced inflammation, providing insights into the regulation of this protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Soraya Salas-Silva, Jocelyn Lopez-Ramirez, Jonatan Barrera-Chimal, Roberto Lazzarini-Lechuga, Arturo Simoni-Nieves, Veronica Souza, Roxana U. Miranda-Labra, Felipe Masso, Marcelo G. Roma, Maria Concepcion Gutierrez-Ruiz, Leticia E. Bucio-Ortiz, Luis Gomez-Quiroz
Summary: This study demonstrates that HGF protects the kidney from damage caused by ANIT-induced cholestasis through its antioxidant properties. It reverses renal damage, decreases tubular cast formation, and controls renal oxidative stress.
Article
Biochemistry & Molecular Biology
Ke Fu, Shu Dai, Yanzhi Li, Cheng Ma, Xinyan Xue, Shenglin Zhang, Cheng Wang, Honglin Zhou, Yafang Zhang, Yunxia Li
Summary: FTA has a significant hepatoprotective effect on cholestatic liver injury, reversing the decrease in viability of bile duct cells, the decrease in antioxidant enzymes, and cell apoptosis. FTA also protects against liver injury, abnormal biochemical indexes, bile duct hyperplasia, and inflammation in mice. Additionally, FTA alleviates liver fibrosis by inhibiting collagen deposition and HSC activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Pharmacology & Pharmacy
Bernard Nsengimana, Edozie Samuel Okpara, Wanqing Hou, Chuyun Yan, Shuxin Han
Summary: Prolonged use of cyclosporine can lead to adverse effects such as nephrotoxicity, hepatotoxicity, and cholestasis, which are associated with overproduction of oxidative stress. Cyclosporine exerts adverse effects on liver function and redox balance, potentially inducing oxidative stress through various mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad Mehdi Ommati, Ali Mobasheri, Yanqin Ma, Dongmei Xu, Zhongwei Tang, Ram Kumar Manthari, Narges Abdoli, Negar Azarpira, Yu Lu, Issa Sadeghian, Abolghasem Mousavifaraz, Ali Nadgaran, Ahmad Nikoozadeh, Sahra Mazloomi, Pooria Sayar Mehrabani, Mohammad Rezaei, Hu Xin, Yang Mingyu, Hossein Niknahad, Reza Heidari
Summary: This study evaluated the role of taurine in cholestasis-related lung injury. The results showed that taurine could attenuate inflammation, alleviate oxidative stress, and improve lung histopathological changes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Akang Dan, Yushi Chen, Yongqi Tian, Shaoyun Wang
Summary: The study aimed to explore the potential of the fungus Paecilomyces hepiali as a foodborne antioxidant and anti-aging agent. The n-butanol extract from rice cultures showed significant antioxidant activity and prolonged the lifespan of Drosophila on a high-fat diet. Further research revealed the presence of dimerumic acid as the major antioxidant compound in PHE.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Xin Yan, Yu Wang, Xue-Yang Ren, Xiao-Yun Liu, Jia-Mu Ma, Ruo-Lan Song, Xiu-Huan Wang, Ying Dong, A-Xiang Yu, Qi-Qi Fan, Jing Wei, Gai-Mei She
Summary: The study showed that Thymus quinquecostatus Celak extract has hepatoprotective effects against ALD by improving gut barrier function, modulating gut microbiota, suppressing inflammatory response, and reducing ROS production in the liver.
Article
Medicine, Research & Experimental
Jie Wang, Zihang Yuan, Haoran Zhang, Qipeng Wu, Yingying Miao, Yunxia Xu, Qinwei Yu, Xiaofei Huang, Ziling Zhang, Xinliang Huang, Qianhui Tang, Luyong Zhang, Zhenzhou Jiang
Summary: The study revealed that OCA induced overexpression of OPN in the liver of BDL mice, exacerbating ductular reaction, fibrosis, and liver inflammation, while reducing hepatocyte proliferation. This mechanism helps explain the risk of liver damage associated with OCA.
Article
Gastroenterology & Hepatology
Takafumi Nakano, Shuichi Sekine, Kousei Ito, Toshiharu Horie
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2013)
Article
Public, Environmental & Occupational Health
Enoche F. Oga, Shuichi Sekine, Yoshihisa Shitara, Toshiharu Horie
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2012)
Article
Biochemistry & Molecular Biology
Eiichiro Ogimura, Shuichi Sekine, Toshiharu Horie
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Pharmacology & Pharmacy
Kentaro Yano, Shuichi Sekine, Kanako Nemoto, Toru Fuwa, Toshiharu Horie
BIOCHEMICAL PHARMACOLOGY
(2010)
Article
Pharmacology & Pharmacy
Junjiro Saeki, Shuichi Sekine, Toshiharu Horie
BIOCHEMICAL PHARMACOLOGY
(2011)
Article
Pharmacology & Pharmacy
Shuichi Sekine, Tomoe Kimura, Midori Motoyama, Yoshihisa Shitara, Hiroshi Wakazono, Hiroji Oida, Toshiharu Horie
BIOCHEMICAL PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Shuichi Sekine, Kousei Ito, Junjiro Saeki, Toshiharu Horie
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2011)
Article
Biochemistry & Molecular Biology
Shuichi Sekine, Kaori Mitsuki, Kousei Ito, Satoe Kugioka, Toshiharu Horie
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2012)
Article
Oncology
Tomoko Maeda, Yuko Miyazono, Kousei Ito, Kazuma Hamada, Shuichi Sekine, Toshiharu Horie
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2010)
Article
Oncology
Kazuma Hamada, Yoshihisa Shitara, Shuichi Sekine, Toshiharu Horie
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2010)
Article
Oncology
Kazuma Hamada, Naoko Kakigawa, Shuichi Sekine, Yoshihisa Shitara, Toshiharu Horie
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2013)
Article
Pharmacology & Pharmacy
Enoche Florence Oga, Shuichi Sekine, Toshiharu Horie
DRUG METABOLISM AND PHARMACOKINETICS
(2013)
Article
Plant Sciences
Enoche F. Oga, Shuichi Sekine, Yoshihisa Shitara, Toshiharu Horie
JOURNAL OF ETHNOPHARMACOLOGY
(2012)
Article
Medicine, Research & Experimental
Keisuke Ueda, Kenjirou Higashi, Waree Limwikrant, Shuichi Sekine, Toshiharu Horie, Keiji Yamamoto, Kunikazu Moribe
MOLECULAR PHARMACEUTICS
(2012)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)