期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 392, 期 3, 页码 247-251出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.12.115
关键词
Notch signaling; Pancreatic endocrine cell; Diabetes
资金
- Intramural Research Program of NIA/NIH
Recent studies have improved our understanding of the physiological function of Notch signaling pathway and now there is compelling evidence demonstrating that Notch is a key regulator of embryonic development and tissue homeostasis. Although further extensive studies are necessary to illustrate the molecular mechanisms. new insights into the role of Notch signaling in pancreas development and diabetes have been achieved Importantly, the ability to regulate Notch signaling intensity both positively and negatively may hive therapeutic relevance for diabetes Thus, this paper reviews the current knowledge of the roles of Notch signaling in the pancreatic endocrine cell system Published by Elsevier Inc
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