期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 392, 期 4, 页码 505-509出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.01.053
关键词
TSE; Prion; Blood plasma; Detection; ELISA; Aggregation; Multimers; Monomer; Antibody
资金
- HSRF [NF82090]
- TAMOP [4.4.2-08-1-5]
- Kyungwon University Research Funds
- GRRC program of Gyeonggi province
- Sungmin Kang from PeopleBio Inc.
This communication describes the application of a modified sandwich enzyme-linked immunosorbent assay (ELISA), termed Multimer Detection System (MDS) for the detection of disease-associated multimeric forms of the prion protein (PrPd) in hamster blood. PrPd was detected in plasma of prion-affected hamsters while MDS revealed no PrPd in identically-treated plasma of healthy animals. This is the first report of a single ELISA- based immune detection of PrPd from blood samples. (C) 2010 Elsevier Inc. All rights reserved.
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