Review
Pharmacology & Pharmacy
Mandeep Kaur, Sakshi Misra, Priyanka Swarnkar, Preeti Patel, Balak Das Kurmi, Ghanshyam Das Gupta, Amrita Singh
Summary: Diabetic neuropathy is a common neuro-degenerative disorder affecting peripheral nerves in patients with diabetes, with potential consequences such as sensory loss, discomfort, foot ulceration, and even amputation. The underlying pathophysiology involves multiple signaling pathways, and early detection remains a challenge. Traditional analgesics and opioids are not the first-line treatment, with anticonvulsants and antidepressants being the common approach. Occupational therapy, along with palliative therapy, plays a crucial role in preventing and alleviating neuropathic symptoms, supporting wellness, and preventing disability.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Education, Scientific Disciplines
Shubhangi Pawar, Aman Upaganlawar, Chandrashekhar Upasani
Summary: Syringic acid and sinapic acid have been shown to have antihyperglycemic, antioxidant, and neuroprotective effects in the treatment of diabetic neuropathy, as supported by various experimental data in this study.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Article
Environmental Sciences
Navpreet Kaur, Lalit Kishore, Shah Asma Farooq, Anu Kajal, Randhir Singh, Rohini Agrawal, Ashi Mannan, Thakur Gurjeet Singh
Summary: The potential of Cucurbita pepo in attenuating diabetic neuropathy was investigated in this study. The results showed that C. pepo extracts significantly reduced pain and abnormal motor nerve conduction velocity associated with diabetic neuropathy, as well as alleviated oxidative stress and inflammation. Therefore, C. pepo may improve the progression of diabetic neuropathy by modulating chronic hyperglycemia and could be a potential therapeutic option for diabetic neuropathic pain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jonathan Enders, Daniel Elliott, Douglas E. Wright
Summary: Diabetic peripheral neuropathy (DPN) is a complication of metabolic syndrome and diabetes, causing sensory changes such as slow nerve conduction, nerve degeneration, loss of sensation, pain, and gait abnormalities. Nonpharmacologic approaches, including dietary interventions and exercise, show promise in treating DPN. These lifestyle interventions have the potential to provide meaningful relief for patients and identify new therapeutic targets.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, General & Internal
Hua Xu, Qi Wang, Qian Wang, Xuan Qiang Che, Xue Liu, Shumiao Zhao, Shitao Wang
Summary: The study showed that serum apelin levels were higher in diabetic patients compared to healthy controls, and even higher in patients with DPN compared to those without DPN. After treatment, apelin levels decreased and were significantly lower in the DPN-B group, while some nerve conduction velocity values increased in this group. Apelin was negatively correlated with some nerve conduction velocity values and positively correlated with TNF-alpha and fasting blood glucose.
Article
Anesthesiology
Puneet Rinwa, Laura Calvo-Enrique, Ming-Dong Zhang, Jens Randel Nyengaard, Pall Karlsson, Patrik Ernfors
Summary: Recent findings suggest that nociceptive nerves terminate in a specialized end-organ in mice, consisting of nociceptive nerves and specialized Schwann cells. Similarly, human skin contains nociceptive Schwann cells that contribute to neuropathy and pain hypersensitivity. Ablation of nociceptive Schwann cells in mice results in nerve retraction and hypersensitivity to mechanical, cold, and heat stimuli, while ablating the nociceptive nerves leads to changes in Schwann cell morphology and hypersensitivity. These results highlight the interdependence between nerves and nociceptive Schwann cells.
Article
Environmental Sciences
Shrey Kumar Bhargava, Thakur Gurjeet Singh, Ashi Mannan, Shareen Singh, Manjinder Singh, Saurabh Gupta
Summary: The study demonstrates the neuroprotective efficacy of Thuja occidentalis in treating diabetic neuropathy. It effectively corrects the levels of inflammatory markers and oxidative stress caused by hyperglycemia, leading to the restoration of neuronal functions. The hypoglycemic, antioxidant, anti-hyperalgesia, and anti-inflammatory properties of Thuja occidentalis are responsible for its neuroprotective benefit.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Polymer Science
Anamika Singh, Parvaiz Ahmad Shiekh, Irfan Qayoom, Ekta Srivastava, Ashok Kumar
Summary: This study developed a therapeutic approach for treating traumatic peripheral nerve injuries after diabetic neuropathy by utilizing nerve guiding scaffold and stem cell-derived exosomes. Both in vitro and in vivo experiments demonstrated significant improvement in nerve injuries after diabetic peripheral neuropathy, suggesting the potential clinical application of this approach.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Medicine, General & Internal
Lin Lin, Jingjing Li, Jingshan Lin, Shiheng Tang, Yuxia Li
Summary: This study aims to evaluate the effectiveness and safety of LLLT for DPN through a systematic review and meta-analysis, comparing it with sham LLLT, no (specific) treatment, or active conventional medical treatments.
SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
Dalal Y. Al-Bazz, Andrew J. Nelson, Jamie Burgess, Ioannis N. Petropoulos, Jael Nizza, Anne Marshall, Emily Brown, Daniel J. Cuthbertson, Andrew G. Marshall, Rayaz A. Malik, Uazman Alam
Summary: There is currently no FDA-approved disease-modifying therapy for diabetic peripheral neuropathy (DPN). This study found significant variability in the change and direction of change in nerve conduction velocity (NCV) in the placebo group, as well as variability influenced by the anatomical site of neurophysiological measurement. A critical re-evaluation of efficacy trials should consider placebo-adjusted effects and present the placebo-subtracted change in NCV.
Article
Endocrinology & Metabolism
Yuru Wu, Qin Wan, Yong Xu, Jia Li, Ke Li, Zhihong Zhang, Qian Tang, Ying Miao, Pijun Yan
Summary: This study explored the possible correlation between visceral fat area (VFA) and diabetic peripheral neuropathy (DPN) in a Chinese population. It found that lower VFA level may be associated with an increased risk of DPN in patients with type 2 diabetes mellitus (T2DM).
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Qingwei Xiang, Yu Liu, Li Chen
Summary: This study found that Saikosaponin d (SSD) can alleviate diabetic peripheral neuropathy (DPN) induced by STZ/HFD in rats by inhibiting the AQP1/RhoA/ROCK signaling pathway. SSD has multiple pharmacological activities and can increase body weight, decrease blood glucose levels, attenuate mechanical and thermal hyperalgesia, enhance nerve conductive velocity (NCV), and reduce proinflammatory cytokine levels. AQP1 showed high expression in DPN rats and SSD treatment can suppress the expression of AQP1. SSD can also enhance the protective effect of AQP1 knockdown on the pathological changes of DPN and suppress the activation of the RhoA/ROCK signaling pathway in DPN rats.
ACTA DIABETOLOGICA
(2023)
Article
Cell Biology
Bo Pang, Ling Qiao, Shaoxin Wang, Xin Guo, Yun Xie, Liping Han
Summary: MiR-214-3p alleviated diabetes-induced nerve injury, pathological lesions, cell apoptosis, and inflammation in DRG through regulating Nav1.3 and TLR4 in STZ-induced rats. These findings suggest novel therapeutic targets for clinical treatment of diabetic neuropathy.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Lin Lin, Yi Chen, Yuxia Li, Ke Cheng, Haiping Deng, Jianping Lu, Ling Zhao, Xueyong Shen
Summary: This study aims to compare the efficacy of 10.6μm laser moxibustion (LM) combined with medical treatment versus sham LM. LM may help alleviate symptoms, improve quality of life, and reduce medication dosage without causing serious side effects.
Article
Health Care Sciences & Services
Simeon C. C. Daeschler, Anna Pennekamp, Dimitrios Tsilingiris, Catalina Bursacovschi, Martin Aman, Amr Eisa, Arne Boecker, Felix Klimitz, Annette Stolle, Stefan Kopf, Daniel Schwarz, Martin Bendszus, Ulrich Kneser, Zoltan Kender, Julia Szendroedi, Leila Harhaus
Summary: This study aims to quantify the therapeutic effect of targeted lower extremity nerve decompression surgery on pain intensity, sensory function, motor function, and neural signal conduction in patients with preexisting painful sensorimotor diabetic neuropathy and nerve entrapment. The results indicate that surgical decompression can alleviate external strain on the affected nerve and improve symptoms, including pain and sensory dysfunction. This research is of great significance for screening and providing proper treatment to diabetic neuropathy patients with lower extremity nerve entrapment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)