Article
Oncology
Julie Cremer, Laura Brohee, Laura Dupont, Camille Lefevre, Raphael Peiffer, Alicia M. Saarinen, Olivier Peulen, Laure Bindels, Jun Liu, Alain Colige, Christophe F. Deroanne
Summary: Bidirectional interactions between cancer cells and adipocytes in the microenvironment play a critical role in tumor progression. Acidification of the extracellular medium induced by cancer cells promotes preadipocyte lipolysis, which affects the phenotype of cancer cells and their response to chemotherapy. G0S2 is identified as the main regulator of cancer-induced lipolysis, and its adipocyte-specific overexpression inhibits mammary tumor growth and lung metastasis.
Article
Biology
Francesca Copperi, Inna Schleis, Martin Roumain, Giulio G. Muccioli, Stefano Casola, Martin Klingenspor, Alexander Pfeifer, Thorsten Gnad
Summary: The study identifies GPR183/EBI2 as the most highly expressed inhibitory G-protein-coupled receptor in brown adipose tissue, which decreases energy expenditure. Loss of Ebi2 in mice results in increased brown adipocyte energy expenditure in response to cold exposure, providing potential insights into modulating energy expenditure in humans.
COMMUNICATIONS BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Summary: We explore different potential sources of UCP1-independent thermogenesis and identify a futile ATP-consuming triglyceride/fatty acid cycle as the main contributor to cellular heat production in brown adipocytes lacking UCP1. We uncover the mechanism on a molecular level and pinpoint the key enzymes involved using pharmacological and genetic interference.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
Summary: This study investigates the intricate interplay between angiogenic regulation and the browning of white adipocytes. The findings reveal that concurrent activation of angiogenesis is necessary for inducing browning of white adipocytes. The study also highlights the role of Vascular endothelial growth factor (VEGF) in promoting angiogenesis and triggering the browning process through the activation of Estrogen receptor alpha (ER alpha) signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2024)
Article
Biochemistry & Molecular Biology
Jun-ichi Morishige, Kazuaki Yoshioka, Hiroki Nakata, Kazuhiro Ishimaru, Naoto Nagata, Tamotsu Tanaka, Yoh Takuwa, Hitoshi Ando
Summary: This study revealed a significant role of SphK1 in lysosomal integrity, which is crucial for energy consumption in brown adipose tissue. It further elucidates the mechanism underlying the association between S1P and brown adipose tissue.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Fisheries
Xiufei Cao, Wei Fang, Jiamin Li, Wencong Lai, Kangsen Mai, Qinghui Ai
Summary: This study reveals the involvement of antisense lncRNA LTCONS_00091578 and atgl in hepatic lipolysis in rainbow trout. The function of lncRNA in fish lipid metabolism needs further investigation.
Article
Endocrinology & Metabolism
Chiara Scaffidi, Annie Srdic, Daniel Konrad, Stephan Wueest
Summary: IL-27 increases glucose uptake and triglyceride deposition in white adipocytes.
Article
Multidisciplinary Sciences
Ji Seul Han, Yong Geun Jeon, Minsik Oh, Gung Lee, Hahn Nahmgoong, Sang Mun Han, Jeehye Choi, Ye Young Kim, Kyung Cheul Shin, Jiwon Kim, Kyuri Jo, Sung Sik Choe, Eun Jung Park, Sun Kim, Jae Bum Kim
Summary: “The study demonstrates that HIF alpha plays a key role in regulating thermogenic function in response to cold and re-warming. Specifically, HIF2 alpha suppresses PKA activity by inducing miR-3085-3p expression, leading to downregulation of PKA C alpha. Ablation of adipocyte HIF2 alpha stimulates retention of beige adipocytes during re-warming after cold stimuli. Moreover, administration of miR-3085-3p promotes beige-to-white transition via downregulation of PKA C alpha and mitochondrial abundance in adipocyte HIF2 alpha deficient mice. These findings highlight the importance of HIF2 alpha-dependent PKA regulation in dynamic remodeling of beige adipocytes as thermostats.”
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Kai Huang, Yong Wang, Jiangjiang Zhu, Yan Xiong, Yaqiu Lin
Summary: This study demonstrates that FGF9 interacts with FGFR2 to inhibit goat intramuscular adipocyte differentiation by regulating PPARγ and Pref1, providing data support for subsequent pathway research.
ANIMAL SCIENCE JOURNAL
(2021)
Article
Chemistry, Medicinal
Thanet Laolob, Nuntavan Bunyapraphatsara, Neti Waranuch, Sutatip Pongcharoen, Wikorn Punyain, Sirirat Chancharunee, Krisada Sakchaisri, Jaturong Pratuangdejkul, Sumet Chongruchiroj, Filip Kielar, Uthai Wichai
Summary: The study demonstrates that nitroarene capsaicinoid analogs significantly promote lipolysis by interacting with TRPV1 receptors, leading to decreased lipid accumulation and triglyceride content.
NATURAL PRODUCT COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Xiangming Hu, Xingchen Dong, Guo Li, Yanheng Chen, Jinjing Chen, Xiaoxin He, Hao Sun, Dong-Hyun Kim, Jongsook Kim Kemper, Lin-Feng Chen
Summary: This study reveals that Brd4 plays a crucial role in obesity-related inflammation and insulin resistance, affecting lipolysis and lipid metabolism by regulating Gdf3 expression in adipose tissue. The findings suggest that Brd4 could be a potential therapeutic target for obesity and insulin resistance, highlighting its importance in modulating lipid metabolism.
Article
Multidisciplinary Sciences
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam
Summary: The deletion of the multifunctional protein E4F1 is protective against diet-induced obesity in mice, and E4F1 regulates adipocyte lipid metabolism through p53. The interaction between E4F1 and p53 plays a crucial role in controlling lipid metabolism in adipocytes, and this crosstalk is relevant to obesity and insulin resistance.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yi Yan, Ming-Huan Jia, Zhi-Jun Le, Kang-Kang Xu, Can Li, Wen-Jia Yang
Summary: The four LsPGRP genes play important and distinct regulatory roles in the antibacterial defense response of Lasioderma serricorne, and they are significant for pest control and immune response.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Hongyan Peng, Dezheng Guo, Wenlu Shan, Zhenguo Liu, Hongfang Wang, Lanting Ma, Baohua Xu, Xingqi Guo
Summary: This study reports the cloning and functional analysis of A. cerana cerana CDK1 (AccCDK1) protein, and determines its distribution profile in different developmental stages and tissues. The results show that AccCDK1 distribution is affected by various stress conditions and may play an important role in honey bee resistance to stress. Furthermore, silencing AccCDK1 affects the expression of antioxidant genes and the activity of relevant enzymes, which can influence the bee's resistance to oxidative stress.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yusuke Nakatsu, Tomoichiro Asano
Summary: Pin1 regulates thermogenesis in brown adipose tissue and lipolysis in white adipose tissue through interactions with PRDM16 and ATGL. Adipocyte-specific Pin1 knockout mice show lower body weight and improved glucose metabolism on a high fat diet.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)