Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation

Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase

(2014) A Hamacher-Brady et al.   CELL DEATH AND DIFFERENTIATION

Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage

(2013) Jiao Zhang et al.   Nature Communications

Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML

(2012) Thanh-Trang Vo et al.   CELL

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

(2012) Joshua J Sims et al.   NATURE METHODS

Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes

(2012) Yulia Kushnareva et al.   PLOS BIOLOGY

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

(2011) Christian Frezza et al.   PLoS One

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

(2011) T. N. Chonghaile et al.   SCIENCE

BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

XIAP impairs Smac release from the mitochondria during apoptosis

(2010) L Flanagan et al.   Cell Death & Disease

Spatial and Temporal Dynamics of Mitochondrial Membrane Permeability Waves during Apoptosis

(2009) Patrick D. Bhola et al.   BIOPHYSICAL JOURNAL

Role for X-linked Inhibitor of Apoptosis Protein Upstream of Mitochondrial Permeabilization

(2009) Thomas W. Owens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

(2009) Naotada Ishihara et al.   NATURE CELL BIOLOGY

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

Quantitative Analysis of Pathways Controlling Extrinsic Apoptosis in Single Cells

(2008) John G. Albeck et al.   MOLECULAR CELL

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY