Article
Biotechnology & Applied Microbiology
Yue Wang, Qingyue Xiao, Wenjie Zhong, Chuangwei Zhang, Yuanyuan Yin, Xiang Gao, Jinlin Song
Summary: This study evaluated the regeneration potential of periodontitis tissue treated with low-intensity pulsed ultrasound (LIPUS) combined with guided tissue regeneration (GTR) technique in a beagle model of furcation involvement. The results showed that LIPUS could enhance periodontal bone formation and bone matrix maturity in furcation involvement after GTR treatment, and also had anti-inflammatory and pro-angiogenic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Kwang-Soo Lyoo, Yoon-Hwan Yeo, Sung-Geun Lee, Minjoo Yeom, Joo-Yeon Lee, Kyung-Chang Kim, Daesub Song
Summary: This study investigated the infectivity of SARS-CoV-2 and MERS-CoV in beagle dogs. The results demonstrated that dogs can be infected by both viruses, with viral shedding in nasal secretions, feces, and urine. Lung tissues of dogs inoculated with SARS-CoV-2 or MERS-CoV showed pathological changes and changes in lactate dehydrogenase levels.
Article
Polymer Science
Beiyuan Gao, Yoshitomo Honda, Yoichi Yamada, Tomonari Tanaka, Yoshihiro Takeda, Takayuki Nambu, Shunsuke Baba
Summary: The newly developed material vhEc-GS-beta showed high stability and bone-forming ability in experiments, achieved through thermal cross-linking induced in gelatin sponges by vacuum heating treatment. This insight could potentially lead to the development of novel materials with good operability and bone-forming ability in bone regenerative medicine.
Article
Cell & Tissue Engineering
Toshie Nagayasu-Tanaka, Jun Anzai, Masahide Takedachi, Masahiro Kitamura, Tatsuhiro Harada, Shinya Murakami
Summary: In this study, the combined use of fibroblast growth factor-2 (FGF-2) and carbonated apatite (CO3Ap) was found to enhance periodontal regeneration and maintain the adjacent bone in a beagle dog model of one-wall periodontal defect. This suggests that the combination of FGF-2 and CO3Ap may promote periodontal regeneration in severe bony defects of periodontitis patients.
REGENERATIVE THERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Chi-Yu Lin, Min-Shi Tsai, Po-Jan Kuo, Yu-Tang Chin, I-Tsen Weng, Yen Wu, Haw-Ming Huang, Chao-Nan Hsiung, Hung-Yun Lin, Sheng-Yang Lee
Summary: The findings of this study suggest that THSG-treated human dental pulp stem cells have significant regenerative effects in the healing of periodontal defects in rats. They promote new bone formation, increase the periodontal bone supporting ratio, enhance cell recruitment, and possibly angiogenesis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tasuku Murakami, Daisuke Matsugami, Wataru Yoshida, Kentaro Imamura, Takahiro Bizenjima, Fumi Seshima, Atsushi Saito
Summary: The combination therapy of FGF-2 and DBBM showed better healing effects on experimental periodontal defects compared to using FGF-2 alone. This combined treatment may enhance healing by promoting cell proliferation, angiogenesis, and osteogenic differentiation.
Article
Dentistry, Oral Surgery & Medicine
Tomoyuki Iwata, Noriyoshi Mizuno, Takayoshi Nagahara, Eri Kaneda-Ikeda, Mikihito Kajiya, Shinya Sasaki, Katsuhiro Takeda, Mari Kiyota, Ryoichi Yagi, Tsuyoshi Fujita, Hidemi Kurihara
Summary: This study investigated the regulatory genes induced by periodontal regenerative cytokines using MSCs, identifying miR-628-5p as a negative regulator of MSC stemness during periodontal regeneration. Periodontal regenerative cytokines act as suppressors of miR-628-5p to support periodontal regeneration, indicating the importance of selecting effective cytokines for different MSCs based on miRNA profiling in advancing regenerative therapies.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Genetics & Heredity
David M. Dolivo
Summary: Fibrosis is a pathological tissue repair process that leads to nearly half of deaths in developed countries. Current therapies targeting fibrosis are lacking, highlighting the significance of basic science research and anti-fibrotic modalities.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hideto Aoki, Takahiro Bizenjima, Fumi Seshima, Masahiro Sato, Daisuke Irokawa, Kouki Yoshikawa, Wataru Yoshida, Kentaro Imamura, Daisuke Matsugami, Yurie Kitamura, Daichi Kita, Hiroki Sugito, Sachiyo Tomita, Atsushi Saito
Summary: The study compared the outcomes of rhFGF-2 + DBBM therapy and rhFGF-2 alone in treating intrabony defects, showing that both treatments were equally effective in improving clinical attachment level (CAL) at 2 years, but the test treatment achieved significantly greater radiographic bone fill (RBF). Favorable clinical, radiographic, and patient-reported outcomes were sustained for at least 2 years in both treatments.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Engineering, Biomedical
Gyeongjin Joo, Myeongki Park, Seong-su Park, Garima Tripathi, Byong-Taek Lee
Summary: An alginate-tasted polycaprolactone-gelatin-beta-tricalcium phosphate dual membrane was fabricated to enhance new bone formation under guided bone regeneration (GBR) process. The dual layered membrane exhibited compatibility with cells and suppressed fibrous tissue infiltration while promoting bone growth.
BIOMEDICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Junrong Li, Alain Wuethrich, Abu A. I. Sina, Han-Hao Cheng, Yuling Wang, Andreas Behren, Paul N. Mainwaring, Matt Trau
Summary: The study develops a digital nanopillar SERS platform for real-time single cytokine counting and dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment. By predicting cytokine concentrations, the platform demonstrates capability to identify patients at higher risk for developing severe immune toxicities.
NATURE COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yohei Nakayama, Hideo Matsuda, Shoichi Itoh, Yasunobu Iwai, Hideki Takai, Masaru Mezawa, Shoichi Yoshino, Yorimasa Ogata
Summary: Modified papilla preservation technique (mPPT) and autogenous bone grafts (AG) act as powerful adjunctive effects on rhFGF-2 therapy, significantly improving probing depth (PD), clinical attachment level (CAL), and bone defects. The combination of mPPT and AG shows positive correlations with improvements in radiographic bone fill, highlighting the importance of these adjunctive procedures in periodontal tissue regeneration. More studies are needed to confirm these findings through randomized clinical trials.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ahmed E. Zarrough, Hatice Hasturk, Danielle N. Stephens, Thomas E. Van Dyke, Alpdogan Kantarci
Summary: The study found that RvD1 has a significant impact on wound healing and proliferation, receptor expression, and cytokine expression and release in PDLFs. RvD1 can reverse the inhibitory effects of IL-1beta, promote wound healing and proliferation in PDLFs, and inhibit inflammatory reactions.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Shu Hua, Peter Mark Bartold, Karan Gulati, Corey Stephen Moran, Saso Ivanovski, Pingping Han
Summary: This review discusses the biogenesis of extracellular vesicles (EVs), particularly small EVs (sEVs) derived from periodontal and dental pulp cells, and their therapeutic potential. The study found that these EVs have various functions in vitro and in vivo, indicating a significant potential for regenerative applications.
Article
Polymer Science
Sin Ting Ngo, Wei-Fang Lee, Yi-Fan Wu, Eisner Salamanca, Lwin Moe Aung, Yan-Qiao Chao, Ting-Chia Tsao, Hao-Wen Hseuh, Yi-Huan Lee, Ching-Chiung Wang, Wei-Jen Chang
Summary: Manufacturing 3D objects with polymers/bioceramic composite materials has been explored recently. This study focused on creating and assessing a solvent-free polycaprolactone (PCL) and beta-tricalcium phosphate (b-TCP) composite fiber as a scaffold material for 3D printing. Different ratios of b-TCP mixed with PCL were investigated to determine the optimal feedstock material for 3D printing. The addition of 20% b-TCP significantly improved the mechanical properties, biocompatibility, and osteogenic ability of the PCL/b-TCP mixture. These findings suggest that the solvent-free PCL-20 and PCL-30 fibers are promising materials for 3D printing customized bone scaffolds promptly, sustainably, and cost-effectively.
Article
Dentistry, Oral Surgery & Medicine
Toshie Nagayasu-Tanaka, Takenori Nozaki, Koji Miki, Keigo Sawada, Masahiro Kitamura, Shinya Murakami
CLINICAL ORAL IMPLANTS RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
S. Miyauchi, J. Kitagaki, R. Masumoto, A. Imai, K. Kobayashi, A. Nakaya, S. Kawai, C. Fujihara, Y. Asano, M. Yamashita, M. Yanagita, S. Yamada, M. Kitamura, S. Murakami
JOURNAL OF DENTAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
M. Takedachi, M. Iyama, K. Sawada, K. Mori, S. Yamamoto, C. Morimoto, M. Yanagita, S. Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Shinji Kawai, Ikumi Michikami, Jirouta Kitagaki, Kenji Hata, Hiroshi Kiyonari, Takaya Abe, Atsuo Amano, Satoshi Wakisaka
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
R. Masumoto, J. Kitagaki, M. Matsumoto, S. Miyauchi, C. Fujihara, M. Yamashita, S. Yamada, M. Kitamura, S. Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Yorimasa Ogata, Yohei Nakayama, Junichi Tatsumi, Takehiko Kubota, Shuichi Sato, Tetsuya Nishida, Yasuo Takeuchi, Tokuya Onitsuka, Ryuji Sakagami, Takenori Nozaki, Shinya Murakami, Naritoshi Matsubara, Maki Tanaka, Toshiaki Yoshino, Junya Ota, Taneaki Nakagawa, Yuichi Ishihara, Taichi Ito, Atsushi Saito, Keiko Yamaki, Etsuko Matsuzaki, Toshirou Hidaka, Daisuke Sasaki, Takashi Yaegashi, Tadashi Yasuda, Toshiaki Shibutani, Kazuyuki Noguchi, Hisao Araki, Noriharu Ikumi, Yukihiko Aoyama, Hideki Kogai, Kenji Nemoto, Shinji Deguchi, Takashi Takiguchi, Matsuo Yamamoto, Keita Inokuchi, Takatoshi Ito, Takashi Kado, Yasushi Furuichi, Mikimoto Kanazashi, Kazuhiro Gomi, Yukie Takagi, Keita Kubokawa, Nobuo Yoshinari, Yoshiaki Hasegawa, Tetsushi Hirose, Toshinaga Sase, Hirokazu Arita, Toshiro Kodama, Kitetsu Shin, Yuichi Izumi, Hiromasa Yoshie
JOURNAL OF ORAL SCIENCE
(2017)
Article
Dentistry, Oral Surgery & Medicine
Keisuke Handa, Syouta Abe, V. Venkata Suresh, Yoshiyasu Fujieda, Masaki Ishikawa, Ai Orimoto, Yoko Kobayashi, Satoru Yamada, Satoko Yamaba, Shinya Murakami, Masahiro Saito
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Shinya Murakami, Brian L. Mealey, Angelo Mariotti, Iain L. C. Chapple
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Iain L. C. Chapple, Brian L. Mealey, Thomas E. Van Dyke, P. Mark Bartold, Henrik Dommisch, Peter Eickholz, Maria L. Geisinger, Robert J. Genco, Michael Glogauer, Moshe Goldstein, Terrence J. Griffin, Palle Holmstrup, Georgia K. Johnson, Yvonne Kapila, Niklaus P. Lang, Joerg Meyle, Shinya Murakami, Jacqueline Plemons, Giuseppe A. Romito, Lior Shapira, Dimitris N. Tatakis, Wim Teughels, Leonardo Trombelli, Clemens Walter, Gernot Wimmer, Pinelopi Xenoudi, Hiromasa Yoshie
JOURNAL OF CLINICAL PERIODONTOLOGY
(2018)
Article
Multidisciplinary Sciences
Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Taturo Ishizaki, Yasumichi Arai, Hiroki Inagaki, Takeshi Nakagawa, Mai Kabayama, Hirochika Ryuno, Hitomi Okubo, Hajime Takeshita, Chisato Inomata, Yuko Kurushima, Yusuke Mihara, Kohdai Hatta, Motoyoshi Fukutake, Kaori Enoki, Taiji Ogawa, Ken-ichi Matsuda, Ken Sugimoto, Ryosuke Oguro, Yoichi Takami, Norihisa Itoh, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi, Shinya Murakami, Masahiro Kitamura, Yoshinobu Maeda
Article
Geriatrics & Gerontology
Kodai Hatta, Kazunori Ikebe, Yasuyuki Gondo, Kei Kamide, Yukie Masui, Hiroki Inagaki, Takeshi Nakagawa, Ken-ichi Matsuda, Taiji Ogawa, Chisato Inomata, Hajime Takeshita, Yusuke Mihara, Motoyoshi Fukutake, Masahiro Kitamura, Shinya Murakami, Mai Kabayama, Tatsuro Ishizaki, Yasumichi Arai, Ken Sugimoto, Hiromi Rakugi, Yoshinobu Maeda
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Cell Biology
Chiharu Fujihara, Yu Kanai, Risa Masumoto, Jirouta Kitagaki, Masahiro Matsumoto, Satoru Yamada, Tetsuhiro Kajikawa, Shinya Murakami
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Dentistry, Oral Surgery & Medicine
Risa Masumoto, Jirouta Kitagaki, Chiharu Fujihara, Masahiro Matsumoto, Shizuka Miyauchi, Yoshihiro Asano, Atsuko Imai, Kaori Kobayashi, Akihiro Nakaya, Motozo Yamashita, Satoru Yamada, Masahiro Kitamura, Shinya Murakami
JOURNAL OF PERIODONTAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Venkata Suresh Venkataiah, Keisuke Handa, Mary M. Njuguna, Tatsuya Hasegawa, Kentaro Maruyama, Eiji Nemoto, Satoru Yamada, Shunji Sugawara, Lu Lu, Masahide Takedachi, Shinya Murakami, Hanayuki Okura, Akifumi Matsuyama, Masahiro Saito
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Tomoaki Iwayama, Tomoko Okada, Tsugumi Ueda, Kiwako Tomita, Shuji Matsumoto, Masahide Takedachi, Satoshi Wakisaka, Takeshi Noda, Taku Ogura, Tomomichi Okano, Peter Fratzl, Toshihiko Ogura, Shinya Murakami
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)