Article
Pharmacology & Pharmacy
Baohui Yuan, He Liu, Xiaohua Pan, Xiaoliang Dong, Le-Feng Qu, Jia Sun, Li-Long Pan
Summary: LSD1 plays a crucial role in neointima formation, and its overexpression is associated with neointima formation. Knockdown of LSD1 significantly reduces neointima formation and inhibits platelet-derived growth factor-induced VSMC proliferation. Moreover, LSD1 overexpression exhibits opposite effects in vivo and in vitro.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Jingjing Wang, Zhikai Wu, Xingyi Zhu, Peixuan Li, Yiwu Fu, Xia Wang, Youpeng Sun, Ershun Zhou, Zhengtao Yang
Summary: The study demonstrates the important regulatory roles of LSD1 in LPS-induced mastitis and the inhibitory effects of GSK-LSD1 on LSD1 activity, leading to reduced inflammatory response and tissue damage. The inhibition of LSD1 results in increased histone H3K4me2 and H3K9me2 levels, and suppression of NF-kappa B signaling and cytokine production in mammary gland. These findings suggest LSD1 as a potential regulator of inflammation and provide insights into epigenetic control mechanisms in inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Xing-Jie Dai, Ying Liu, Lei-Peng Xue, Xiao-Peng Xiong, Ying Zhou, Yi-Chao Zheng, Hong-Min Liu
Summary: LSD1, a FAD-dependent monoamine oxidase, functions as a transcription coactivator or corepressor to regulate histone methylation, and has emerged as a promising epigenetic target for anticancer treatment. Numerous inhibitors targeting LSD1 have been developed, with some undergoing clinical trials for cancer therapy. Significant advances have been made in the development of reversible LSD1 inhibitors over the past decade.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Di Sun, Jiaqi An, Zixu Cui, Jiao Li, Ziwei You, Chang Lu, Yang Yang, Pengfei Gao, Xiaohong Guo, Bugao Li, Chunbo Cai, Guoqing Cao
Summary: This study identifies a novel circRNA, circCSDE1, that is highly expressed in skeletal muscle. Functional studies show that circCSDE1 promotes proliferation and inhibits myoblast differentiation, while miR-21-3p has opposite effects. Dual-luciferase reporter assay confirms that circCSDE1 targets miR-21-3p directly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Martina Menna, Francesco Fiorentino, Biagina Marrocco, Alessia Lucidi, Stefano Tomassi, Domenica Cilli, Mauro Romanenghi, Matteo Cassandri, Silvia Pomella, Michele Pezzella, Donatella Del Bufalo, Mohammad Salik Zeya Ansari, Nevena Tomasevic, Milan Mladenovic, Monica Viviano, Gianluca Sbardella, Rossella Rota, Daniela Trisciuoglio, Saverio Minucci, Andrea Mattevi, Dante Rotili, Antonello Mai
Summary: Chemical modifications of LSD1 led to highly active and selective inhibitors, which showed antiproliferative effects and gene expression regulation in leukemia cells. The inhibition of LSD1 demonstrated a crucial role in solid tumor cells, suggesting no added value for simultaneous G9a inhibition.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Catherine M. Mills, Jonathan Turner, Ivett C. Pina, Kathleen A. Garrabrant, Dirk Geerts, Andre S. Bachmann, Yuri K. Peterson, Patrick M. Woster
Summary: LSD1, an epigenetic regulator, is an oncogenic accomplice in MYCN-expressing neuroblastoma. We report 3 novel scaffolds for reversible LSD1 inhibition and found one of them to be highly potent and able to increase an important modification mark in cells. Combination treatment with bortezomib also showed a synergistic effect.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Yihui Song, Huiqing Zhang, Xiaoke Yang, Yuting Shi, Bin Yu
Summary: Lysine-specific demethylase 1 (LSD1/KDM1A) has emerged as a promising epigenetic target for disease treatment. This review provides an update on LSD1 inhibitors, including natural products, synthetic compounds, and cyclic peptides reported in 2021. The design strategies, structure-activity relationships, binding model analysis, and modes of action are discussed. Highlights include the repurposing of FDA-approved drugs as reversible LSD1 inhibitors, the identification of clinical candidates for neuro-developmental disorders, and the enhanced anti-cancer effects of dual inhibitors targeting both LSD1 and HDAC6 or tubulin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Hirofumi Uchiyama, Daisuke Muramatsu, Hideaki Higashi, Hiroshi Kida, Atsushi Iwai
Summary: Chondroitin sulfate oligosaccharides (Oligo-CS) derived from skate have higher bioactivity compared to high molecular weight CS. Oligo-CS significantly inhibits osteoclast differentiation and promotes cell viability in C2C12 cells, while high molecular weight CS does not have these effects.
Article
Multidisciplinary Sciences
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao
Summary: This study reveals the catalytic-independent role of LSD1 in regulating gene expression and cellular differentiation, demonstrating that the loss of LSD1 protein globally de-represses enhancers and impairs cell fate transition. The researchers found that the increase of H3K27ac catalyzed by P300/CBP, rather than the loss of CoREST complex components from chromatin, contributes to the transcription de-repression of LSD1 targets and differentiation defects caused by LSD1 loss.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Georgia Papadopoulou, Stavroula Petroulia, Eirini Karamichali, Alexios Dimitriadis, Dimitrios Marousis, Elisavet Ioannidou, Panagiota Papazafiri, John Koskinas, Pelagia Foka, Urania Georgopoulou
Summary: Hepatitis C virus (HCV) alters gene expression epigenetically to rearrange the cellular microenvironment in a beneficial way for its life cycle. Lysine-specific demethylase 1 (LSD1) is an epigenetic controller of critical cellular functions that are essential for HCV propagation. This study investigates the role of LSD1 in HCV infection and shows that LSD1 overexpression inhibits HCV replication, while inhibition of LSD1 increases viral replication. The study also suggests that LSD1 participates in an antiviral mechanism by activating IFITM3 via demethylation, leading to degradation of HCV virions.
Article
Multidisciplinary Sciences
Yi-Xuan Li, Chun-Hung Hsiao, Yung-Fu Chang
Summary: This study aimed to investigate the effect of NAC on arecoline-inhibited myoblast differentiation and its underlying mechanisms. The results showed that NAC attenuated the inhibition of myoblast differentiation caused by arecoline and this effect was mediated by the activation/phosphorylation of ERK1/2.
Article
Cell Biology
Tzu-Ling Shao, Ruei-Teng Ting, Ming -Chia Lee
Summary: This study investigates the interaction between Lsd1 and lncRNAs and its role in ovarian development and cell differentiation using fly ovaries as a model.
Review
Cell Biology
Carlos Martinez-Gamero, Sandhya Malla, Francesca Aguilo
Summary: This review summarizes the current knowledge about LSD1 and its molecular mechanism in influencing the stem cell state, including the regulatory circuitry underlying self-renewal and pluripotency.
Article
Multidisciplinary Sciences
Mattie J. Casey, Alexandra M. Call, Annika V. Thorpe, Cicely A. Jette, Michael E. Engel, Rodney A. Stewart
Summary: Lsd1/Kdm1a functions as both a histone demethylase enzyme and a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression during embryogenesis. Our analysis of zebrafish lsd1/kdm1a mutants reveals that Lsd1's scaffolding function, mediated by its SNAG-binding domain, is required for repression of gene expression, including gfi1 and snai1/2, through a negative feedback loop.
Article
Genetics & Heredity
Natalia Leciejewska, Ewa Pruszynska-Oszmalek, Karolina Mielnik, Maciej Glowacki, Tomasz P. Lehmann, Maciej Sassek, Bartosz Gaweda, Dawid Szczepankiewicz, Krzysztof W. Nowak, Pawel A. Kolodziejski
Summary: SPX and its receptors, GalR2 and GalR3, have significant effects on the metabolism, proliferation, and differentiation of skeletal muscle cells. Through modulation of protein expression and cell signaling pathways, SPX promotes the proliferation and differentiation of C2C12 cells, as well as myoblast fusion into myotubules. Additionally, exercise stimulates the expression of SPX and GalR2, leading to an increase in SPX concentration in the blood serum.
Article
Genetics & Heredity
Eun-Young Lee, Jung Yeon Yu, A. Rome Paek, So Hee Lee, Hyonchol Jang, Soo Young Cho, June Hyuk Kim, Hyun Guy Kang, Tak Yun, Sung Eun Oh, Seog Yun Park, Hye Jin You
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Biochemistry & Molecular Biology
Seoung Min Bong, Seung-Hyun Bae, Bomin Song, HyeRan Gwak, Seung-Won Yang, Sunshin Kim, Seungyoon Nam, Krishnaraj Rajalingam, Se Jin Oh, Tae Woo Kim, SangYoun Park, Hyonchol Jang, Byung Il Lee
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Shiv Poojan, Seung-Hyun Bae, Jae-Woong Min, Eun Young Lee, Yura Song, Hee Yeon Kim, Hye Won Sim, Eun-Kyung Kang, Young-Ho Kim, Hae-Ock Lee, Yourae Hong, Woong-Yang Park, Hyonchol Jang, Kyeong-Man Hong
EXPERIMENTAL AND MOLECULAR MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Tae Hyun Park, Seung-Hyun Bae, Seoung Min Bong, Seong Eon Ryu, Hyonchol Jang, Byung Il Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Jae-Seon Lee, Su-Jin Oh, Hyun-Jung Choi, Joon Hee Kang, Seon-Hyeong Lee, Ji Sun Ha, Sang Myung Woo, Hyonchol Jang, Ho Lee, Soo-Youl Kim
Article
Oncology
Dong-Keon Kim, Bomin Song, Suji Han, Hansol Jang, Seung-Hyun Bae, Hee Yeon Kim, Seon-Hyeong Lee, Seungjin Lee, Jong Kwang Kim, Han-Seong Kim, Kyeong-Man Hong, Byung Il Lee, Hong-Duk Youn, Soo-Youl Kim, Sang Won Kang, Hyonchol Jang
Article
Cell Biology
Jae-Seon Lee, Ho Lee, Hyonchol Jang, Sang Myung Woo, Jong Bae Park, Seon-Hyeong Lee, Joon Hee Kang, Hee Yeon Kim, Jaewhan Song, Soo-Youl Kim
Article
Oncology
Eun-Ju Jang, Jee Young Sung, Ha-Eun Yoo, Hyonchol Jang, Jaegal Shim, Eok-Soo Oh, Sung-Ho Goh, Yong-Nyun Kim
Summary: FAM188B knockdown sensitizes lung cancer cells to anoikis and inhibits lung metastasis by reducing levels of tumor proteins such as EGFR and FOXM1, suggesting it may be a potential target for controlling tumor malignancies.
Article
Pharmacology & Pharmacy
Jae-Seon Lee, Jiwon Choi, Seon-Hyeong Lee, Joon Hee Kang, Ji Sun Ha, Hee Yeon Kim, Hyonchol Jang, Jong In Yook, Soo-Youl Kim
Article
Biochemistry & Molecular Biology
Hyun Ku Yeo, Tae Hyun Park, Hee Yeon Kim, Hyonchol Jang, Jueun Lee, Geum-Sook Hwang, Seong Eon Ryu, Si Hoon Park, Hyun Kyu Song, Hyun Seung Ban, Hye-Jin Yoon, Byung Il Lee
Summary: The study revealed the functions of PTPIP51 in phospholipid binding/transfer, particularly of phosphatidic acid, in cells. Depletion of PTPIP51 reduces the mitochondrial cardiolipin level, and the interaction between PTPIP51 and VAPB is mediated by specific structural motifs.
Article
Oncology
Han-Teo Lee, Il-Hwan Lee, Jae-Hwan Kim, Sangho Lee, Sojung Kwak, Min-Young Suh, In-Young Hwang, Bu-Gyeong Kang, Sun-Shin Cha, Byung-Il Lee, Sang-Eun Lee, Jinmi Choi, Jae-Seok Roe, Eun-Jung Cho, Hong-Duk Youn
Summary: OGFOD1, upregulated in various cancers, enhances tumor growth by promoting RNA polymerase II activity, which is modulated by cell cycle-dependent kinases, suggesting it as a potential target for cancer treatment.
Article
Biochemistry & Molecular Biology
Hee Yeon Kim, Sung Jin Bae, Ji-Woong Choi, Suji Han, Seung-Hyun Bae, Jae-Ho Cheong, Hyonchol Jang
Summary: The cholesterol synthesis pathway plays an important role in the distant metastasis of breast cancer cells by augmenting tumor sphere formation and invasion capacity.
Article
Medicine, Research & Experimental
Jae-Seon Lee, Ho Lee, Sang Myung Woo, Hyonchol Jang, Yoon Jeon, Hee Yeon Kim, Jaewhan Song, Woo Jin Lee, Eun Kyung Hong, Sang-Jae Park, Sung-Sik Han, Soo-Youl Kim
Summary: The activity of ALDH7A1 is upregulated in pancreatic ductal adenocarcinoma (PDAC), and its knockdown reduces tumor formation. The study investigated the role of ALDH7A1 in energy metabolism, revealing its critical function in processing fatty aldehydes from lipid peroxidation. Inhibiting ALDH7A1 and oxidative phosphorylation resulted in tumor regression in both xenograft and KPC mice models.
Article
Biochemistry & Molecular Biology
Jang-Seok Lee, Hee Yeon Kim, Bomyi Won, Sang Won Kang, Yong-Nyun Kim, Hyonchol Jang
Article
Biochemistry & Molecular Biology
Yun Jeong Lee, Eun-Young Lee, Bo Hee Choi, Hyonchol Jang, Jae-Kyung Myung, Hye Jin You
MOLECULES AND CELLS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)