Review
Oncology
Ignacio Campillo-Marcos, Raul Garcia-Gonzalez, Elena Navarro-Carrasco, Pedro A. Lazo
Summary: VRK1 is a nuclear Ser-Thr chromatin kinase that is not mutated in cancer, but is overexpressed in many types of tumors and linked to poor prognosis. It plays crucial roles in regulating cell proliferation and DNA damage response pathways, having both pro-tumorigenic effects and protective anti-tumor roles depending on the cellular context.
Review
Cell Biology
Nhat-Tu Le
Summary: ERK5, a member of the MAPK family, has distinct activation mechanisms and catalytic-independent functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Agata Gluszek-Kustusz, Benjamin Craske, Thibault Legal, Toni McHugh, Julie P. Welburn
Summary: During mitosis, the microtubule crosslinker protein PRC1 recruits motor proteins CENP-E and Kif4A to the central spindle to coordinate chromosome segregation and cytokinesis. This recruitment is mediated by a conserved hydrophobic motif and is spatially and temporally regulated by CENP-E. The interaction between PRC1 and microtubule motor proteins is essential for controlling chromosome partitioning, maintaining central spindle integrity, and ensuring cytokinesis during anaphase.
Article
Chemistry, Medicinal
Duncan C. Miller, Suzannah J. Harnor, Mathew P. Martin, Richard A. Noble, Stephen R. Wedge, Celine Cano
Summary: This Miniperspective summarizes the evidence for using the extracellular signal-regulated kinase 5 (ERK5) signaling pathway as a drug target in cancer chemotherapy. It discusses the structure of ERK5 and the evolution of structurally distinct chemotypes of ERK5 kinase domain inhibitors. The complexities of ERK5 pharmacology, including paradoxical ERK5 activation by small molecule inhibitors, are also explored.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Debanjan Bhattacharjee, Sreeram Kaveti, Nishant Jain
Summary: STAT3, an oncogene associated with poor prognosis, can be ubiquitinated by APC/C CDH1 during mitosis, resulting in long-lasting anti-tumor responses. Inhibiting phosphatases can decrease STAT3 ubiquitination. Targeting mitosis may be a potential therapeutic window for treating STAT3-activated cancers.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Oncology
Yi Xiao, Yuanhong Chen, Aimin Peng, Jixin Dong
Summary: CTDSPL2, phosphorylated by CDK1 in mitosis, plays a crucial role in regulating cell mitosis, proliferation, and motility in pancreatic cancer. Depletion of CTDSPL2 or using a phosphorylation-deficient mutant hindered tumor growth in xenograft models. Downstream regulators of CTDSPL2, p21 and p27, were identified, providing an alternative molecular target for pancreatic cancer treatment.
Article
Oncology
Adrian Sanchez-Fdez, Maria Florencia Re-Louhau, Pablo Rodriguez-Nunez, Dolores Ludena, Sofia Matilla-Almazan, Atanasio Pandiella, Azucena Esparis-Ogando
Summary: Lung cancer remains a common and deadly tumor, with studies showing the importance of the MEK5/ERK5 MAPK pathway in its pathogenesis. Targeting this pathway may present a new therapeutic option for lung cancer treatment.
NPJ PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Stier, Samuel Gilberto, Weaam Mohamed, Lars N. Royall, Jonne Helenius, Ivan Mikicic, Tatjana Sajic, Petra Beli, Daniel J. Mueller, Sebastian Jessberger, Matthias Peter
Summary: CUL4A and CUL4B are paralogs that assemble cullin-RING E3 ubiquitin ligase (CRL) complexes regulating chromatin-associated cellular functions. The unique N-terminal extension of CUL4B is heavily phosphorylated during mitosis, and this phosphorylation is disrupted in the CUL4B-P50L mutation causing X-linked intellectual disability (XLID). Phenotypic characterization and mutational analysis showed that CUL4B phosphorylation is essential for mitosis progression and controls spindle positioning and cortical tension.
Article
Multidisciplinary Sciences
Charlie Conroy, Rohan P. Naidu, Nicolas Garavito-Camargo, Gurtina Besla, Dennis Zaritsky, Ana Bonaca, Benjamin D. Johnson
Summary: Gravitational interactions between the Large Magellanic Cloud and the Milky Way halo are expected to cause disequilibrium phenomena in the outer Milky Way. The detection of a local wake and northern overdensity in the Galaxy map provide important insights into this interaction. The data show that the outer halo is not in dynamical equilibrium, and the morphology and strength of the wake can be used to test the nature of dark matter and gravity.
Article
Multidisciplinary Sciences
Osama Garwain, Xiaoming Sun, Divya Ramalingam Iyer, Rui Li, Lihua Julie Zhu, Paul D. Kaufman
Summary: The depletion of Ki-67 in vertebrate mammals can cause DNA damage, particularly in mitotic cells. The C-terminal chromatin-binding domain of Ki-67 plays a crucial role in protecting cells from this damage. Simultaneous depletion of Ki-67 and p53 results in increased chromosome bridges and micronuclei, highlighting the importance of Ki-67 in maintaining genome stability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Yi Xiao, Yuanhong Chen, Jianan Chen, Jixin Dong
Summary: This study investigates the role of ASPP2 in pancreatic cancer and its phosphorylation regulation during mitosis. The findings reveal that ASPP2 is phosphorylated by CDK1 during mitosis and its depletion attenuates pancreatic cancer cell growth. Additionally, ASPP2 significantly affects the transcriptome landscape of YAP-related genes.
Article
Cell Biology
Jinyuan Duan, Wenzhu Li, Xin Shu, Bing Yang, Xiangwei He, Xing Guo
Summary: A highly conserved phosphorylation was identified on the unassembled alpha 5 subunit of the proteasome, specifically during mitosis. Blocking this phosphorylation site resulted in growth defects and cell cycle arrest. The phosphorylation of alpha 5-Ser16 plays an important role in regulating PLK1 and mitosis.
Article
Microbiology
Francisco Alejandro Lagunas-Rangel, Janet Yee, Rosa Maria Bermudez-Cruz
Summary: Giardia duodenalis, a flagellated protozoan responsible for diarrheal disease worldwide, has a complex microtubule cytoskeleton and must coordinate cell division to ensure successful infection through duplication and partitioning of cell structures.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Oncology
Elena Arconada-Luque, Jaime Jimenez-Suarez, Raquel Pascual-Serra, Syong Hyun Nam-Cha, Teresa Moline, Francisco J. Cimas, German Fliquete, Marta Ortega-Muelas, Olga Roche, Diego M. Fernandez-Aroca, Raul Munoz Velasco, Natalia Garcia-Flores, Cristina Garnes-Garcia, Adrian Sanchez-Fdez, Sofia Matilla-Almazan, Victor J. Sanchez-Arevalo Lobo, Javier Hernandez-Losa, Borja Belandia, Atanasio Pandiella, Azucena Esparis-Ogando, Santiago Ramon y Cajal, Luis del Peso, Ricardo Sanchez-Prieto, Maria Jose Ruiz-Hidalgo
Summary: ERK5 plays a critical role in the biology of soft tissue sarcoma, as shown in both mouse models and human sarcomas. Transcriptome analysis reveals the important role of KLF2 in the biological effects of ERK5. These findings open new avenues for the diagnosis and therapy of soft tissue sarcomas.
Article
Multidisciplinary Sciences
Jean Claude Labbe, Suzanne Vigneron, Francisca Mechali, Perle Robert, Sylvain Roque, Cindy Genoud, Perrine Goguet-Rubio, Phillipe Barthe, Gilles Labesse, Martin Cohen-Gonsaud, Anna Castro, Thierry Lorca
Summary: Arpp19 is a potent inhibitor of PP2A-B55 that plays a regulatory role in stable phosphorylation of mitotic/meiotic substrates. Phosphorylation states of Ser67 and Ser109 of Arpp19 create a double feedback loop that coordinates Arpp19-dependent inhibition of PP2A-B55 and Cyclin B activation during cell cycle progression.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Lucia Privitera, Lorenzo More, Daniel D. Cooper, Philippa Richardson, Marianthi Tsogka, Daniel Hebenstreit, J. Simon C. Arthur, Bruno G. Frenguelli
JOURNAL OF NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Michael J. Pattison, Rangeetha Jayaprakash Naik, Kathleen M. S. E. Reyskens, J. Simon C. Arthur
BIOSCIENCE REPORTS
(2020)
Article
Neurosciences
Oladiran I. Olateju, Lorenzo More, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Neurogenesis in the adult hippocampus can be stimulated by exposure to an enriched environment, leading to increased production of neurons and benefits for health and cognition. MSK1 plays a negative regulatory role post-enrichment by influencing the number of cells destined to become neurons, thereby potentially serving as a homeostatic control on the integration of new neurons into the dentate gyrus.
Article
Biochemistry & Molecular Biology
Nicola J. Darling, J. Simon C. Arthur, Philip Cohen
Summary: The study demonstrates the essential roles of salt-inducible kinases (SIKs) in producing inflammatory mediators in response to IL-33 stimulation, which play a critical role in regulating airway inflammation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Judit Remenyi, Rangeetha Jayaprakash Naik, Jinhua Wang, Momchil Razsolkov, Alyssa Verano, Quan Cai, Li Tan, Rachel Toth, Samantha Raggett, Carla Baillie, Ryan Traynor, C. James Hastie, Nathanael S. Gray, J. Simon C. Arthur
Summary: JAK3 has been proposed as an ideal drug target for immune disorders due to its restricted expression in the immune system and requirement for cytokine signaling. Mutating the cysteine residue to serine in JAK3 increases the IC50 for covalent inhibitors. Mice with the Cys905Ser mutation in the JAK3 gene provide a chemical-genetic model to study JAK3 function.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Naveed Akbar, Calum Forteath, Muhammad S. Hussain, Kathleen Reyskens, Jill J. F. Belch, Chim C. Lang, Ify Mordi, U. Bhalraam, J. Simon C. Arthur, Faisel Khan
Summary: In this study, it was found that mitogen and stress kinase 1/2 (MSK1/2) play a significant role in the development of endothelial dysfunction in myocardial infarction patients and mouse models. Genetic deficiency of MSK1/2 increased plasma levels of pro-inflammatory cytokines and promoted endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Meriam Nefla, Nicola J. Darling, Manuel van Gijsel Bonnello, Philip Cohen, J. Simon C. Arthur
Summary: Salt Inducible Kinases 2 (SIK2) and 3 (SIK3) play important roles in thymic T cell development, with their loss leading to decreased numbers of peripheral T cells and defects in negative and/or positive selection in the thymus.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Emma L. Robinson, Faye M. Drawnel, Saher Mehdi, Caroline R. Archer, Wei Liu, Hanneke Okkenhaug, Kanar Alkass, Jan Magnus Aronsen, Chandan K. Nagaraju, Ivar Sjaastad, Karin R. Sipido, Olaf Bergmann, J. Simon C. Arthur, Xin Wang, H. Llewelyn Roderick
Summary: This study demonstrates the importance of MAPK pathways in regulating gene expression during cardiac hypertrophy and provides mechanistic insights into the coupling of MAPK stimulation and IEG induction through MSK-mediated phosphorylation of histone H3, which recruits Brg1 to initiate gene expression.
Article
Multidisciplinary Sciences
Dylan G. Ryan, Elena Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A. J. O'Neill, Christian Frezza, Angus Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Summary: Cells have evolved cytoprotective protein networks controlled by Nrf2 and Keap1 to overcome oxidative, inflammatory, and metabolic stress. Activation of Nrf2 facilitates metabolic reprogramming and mitochondrial adaptation, and fine-tunes the innate immune response in macrophages.
Article
Biochemistry & Molecular Biology
Manuel van Gijsel-Bonnello, Nicola J. Darling, Takashi Tanaka, Samuele Di Carmine, Francesco Marchesi, Sarah Thomson, Kristopher Clark, Mariola Kurowska-Stolarska, Henry J. McSorley, Philip Cohen, J. Simon C. Arthur
Summary: The study shows that nintedanib, a tyrosine kinase inhibitor used for treating idiopathic pulmonary fibrosis, also inhibits salt-inducible kinase 2, which may contribute to its effectiveness in treating lung fibrosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Neurosciences
Lorenzo More, Lucia Privitera, Philippa Perrett, Daniel D. Cooper, Manuel Van Gijsel Bonnello, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: The transcription factor CREB plays a crucial role in regulating physiological functions in the central nervous system. Recent research has focused on the phosphorylation of the S133 residue in CREB, which is required for its transcriptional activation. Previous studies using molecular genetic techniques have resulted in conflicting results, possibly due to the manipulation of endogenous CREB. In this study, the researchers generated a postnatal and forebrain-specific mutant of CREB S133A to avoid potential complications. The findings show that CREB S133 is necessary for spatial cognitive flexibility, basal synaptic transmission, and long-term potentiation in the hippocampus, highlighting its importance in neuronal function, synaptic plasticity, and cognition.
Article
Biochemistry & Molecular Biology
Laura Boccuni, Elke Podgorschek, Moritz Schmiedeberg, Ekaterini Platanitis, Peter Traxler, Philipp Fischer, Alessia Schirripa, Philipp Novoszel, Angel R. Nebreda, J. Simon C. Arthur, Nikolaus Fortelny, Matthias Farlik, Veronika Sexl, Christoph Bock, Maria Sibilia, Pavel Kovarik, Mathias Mueller, Thomas Decker
Summary: This study reveals the synergistic effect of cell stress-induced p38 MAPK signaling and IFN-stimulated signal transduction, and the impact of this synergy on ISG expression and macrophage infection ability.
Review
Cardiac & Cardiovascular Systems
Zhen Hui Peh, Adel Dihoum, Dana Hutton, J. Simon C. Arthur, Graham Rena, Faisel Khan, Chim C. C. Lang, Ify R. Mordi
Summary: HFpEF is a type of heart failure that accounts for around half of all cases and may become the dominant type in the future. Compared to heart failure with reduced ejection fraction, there are limited evidence-based treatment strategies available for HFpEF. Inflammation is believed to play a key role in the pathophysiology of HFpEF and could be a potential therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Lorenzo More, Lucia Privitera, Daniel D. Cooper, Marianthi Tsogka, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Positive experiences, such as social interaction, cognitive training, and physical exercise, can improve cognitive abilities and synaptic plasticity associated with ageing. However, the mechanisms through which the environment influences neuronal response and adaptation to these positive sensory experiences remain unclear.
Article
Biochemical Research Methods
Christa P. Baker, Iain R. Phair, Alejandro J. Brenes, Abdelmadjid Atrih, Dylan G. Ryan, Roland Bruderer, Albena T. Dinkova-Kostova, Douglas J. Lamont, J. Simon C. Arthur, Andrew J. M. Howden
Summary: Here, an optimized protocol for analyzing murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics is described. The protocol includes sample preparation utilizing the S-Trap method, mass spectrometry data acquisition, and data analysis approaches. The single-shot DIA protocol achieves comparable proteomic depth with data-dependent MS approaches, making it suitable for large sample numbers with high experimental reproducibility.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
