Article
Infectious Diseases
Basma Abdi, Sidonie Lambert-Niclot, Marc Wirden, Aude Jary, Elisa Teyssou, Sophie Sayon, Romain Palich, Roland Tubiana, Anne Simon, Marc-Antoine Valantin, Christine Katlama, Laurence Morand-Joubert, Vincent Calvez, Anne-Genevieve Marcelin, Cathia Soulie
Summary: The study reveals an association between virological and clinical factors and APOBEC3 editing activity, with G-to-A mutations and stop codons in the reverse transcriptase gene as markers of HIV-1 diversity among virologically suppressed patients. A higher prevalence of hypermutated sequences was found in the APOBEC+ group, while the total cell-associated HIV-1 DNA level was lower in this group compared to the APOBEC- group.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Guangdi Li, Yali Wang, Erik De Clercq
Summary: This article provides a comprehensive review of HIV reverse transcriptase inhibitors approved in the past decade, including their drug discovery, pharmacology, and clinical efficacy. New inhibitors are also highlighted, and future development may focus on novel antiretroviral inhibitors with improved characteristics.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Physiology
Nancy S. Krieger, David A. Bushinsky
Summary: The study revealed that regulation of regulator of G protein signaling 16 (RGS16) and G protein signaling in osteoblasts plays a crucial role in modulating the response of osteoblastic ovarian cancer G protein-coupled receptor 1 (OGR1) to metabolic acidosis and subsequent stimulation of osteoclastic bone resorption. Further investigations into the regulation of OGR1 in metabolic acidosis-induced bone resorption will aid in understanding bone loss in acidotic patients with chronic kidney disease.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Gongsheng Yuan, Shuying Yang
Summary: This review summarizes the role of RGS proteins in bone homeostasis and diseases, focusing on their regulation of osteoblasts, chondrocytes, and osteoclasts. The impacts of RGS proteins on bone development and related diseases are highlighted, suggesting their potential as drug targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zodwa Dlamini, Mzwandile Mbele, Tshepiso J. Makhafola, Rodney Hull, Rahaba Marima
Summary: Globally, HIV/AIDS and cancer are significant public health problems, with sub-Saharan Africa bearing the largest burden. While AIDS-defining cancers are decreasing, non-AIDS defining cancers are on the rise in HIV-positive individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Karolina Jurkowska, Beata Szymanska, Brygida Knysz, Amadeusz Kuzniarski, Agnieszka Piwowar
Summary: Sirtuins, a family of enzymes, regulate various processes in the body by splitting the acetyl group. Little is known about their role in the course of HIV infection, but they may play a significant role in the development of comorbidities associated with HIV infection.
Article
Multidisciplinary Sciences
Hanna Brattgard, Per Bjoerkman, Piotr Nowak, Carl Johan Treutiger, Magnus Gisslen, Olof Elvstam
Summary: Among Swedish PWH, low-level viremia (LLV) during antiretroviral therapy (ART) was associated with markers of HIV disease severity before starting ART, male sex, injecting drug use, and use of protease inhibitor (PI)-based or non-standard ART regimens.
Review
Biochemistry & Molecular Biology
Laura Macca, Vittoria Moscatt, Manuela Ceccarelli, Ylenia Ingrasciotta, Giuseppe Nunnari, Claudio Guarneri
Summary: Hidradenitis suppurativa (HS) is associated with human immunodeficiency virus (HIV), and HIV-infected individuals are more susceptible to developing HS, particularly in atypical sites due to HIV-related immunosuppression.
Review
Immunology
Farooq Rashid, Silvere D. Zaongo, Fangzhou Song, Yaokai Chen
Summary: Despite progress in managing and treating HIV/AIDS-related disease, understanding of HIV infection and the roles of miRNAs in HIV pathogenesis requires further investigation. miRNAs can be either beneficial or harmful to the host, depending on the genes they target. This review discusses the roles of miRNAs in viral pathogenesis, their mechanisms in regulating HIV-1 infection, their predictive roles in the viral life cycle, and their involvement in antiretroviral therapeutics. The therapeutic potential of miRNAs, particularly miR-34a, in promoting HIV-1 pathogenesis is also explored, along with future perspectives and controversies regarding miRNA expression by HIV-1.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Diana Barger, Mojgan Hessamfar, Didier Neau, Sophie Farbos, Olivier Leleux, Charles Cazanave, Nicolas Rouanes, Pierre Duffau, Estibaliz Lazaro, Patrick Rispal, Francois Dabis, Linda Wittkop, Fabrice Bonnet
Summary: This study evaluated the quality of life of people living with HIV and found that multimorbidity, HIV-related stigma, and social determinants were associated with poorer quality of life.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Dmitriy Y. Ryazantsev, Mikhail Yu. Myshkin, Vera A. Alferova, Vladimir B. Tsvetkov, Elena Y. Shustova, Polina N. Kamzeeva, Polina V. Kovalets, Elvira R. Zaitseva, Nadezhda S. Baleeva, Timofei S. Zatsepin, Zakhar O. Shenkarev, Mikhail S. Baranov, Liubov I. Kozlovskaya, Andrey V. Aralov
Summary: This study investigated the potential of GFP chromophore-based compounds as anti-HIV drug candidates, identifying some promising hits that exhibited high stabilization of the LTR-III G4. The SAR analysis allowed for the identification of structural fragments important for G4 binding, and synthetic compounds developed based on this analysis showed moderate activity against HIV-I in vitro. However, this activity was accompanied by notable cytotoxicity.
Article
Biochemistry & Molecular Biology
Samir Amrane, Chloe Jaubert, Amina Bedrat, Tiffany Rundstadler, Patricia Recordon-Pinson, Cindy Aknin, Aurore Guedin, Aurore De Rache, Laura Bartolucci, Ibra Diene, Frederic Lemoine, Olivier Gascuel, Genevieve Pratviel, Jean-Louis Mergny, Marie-Line Andreola
Summary: The formation of G-quadruplex structures during HIV-1 infection plays a crucial role in viral replication and processing of viral RNA genome. The use of G4-binders has shown to efficiently inhibit HIV-1 infectivity.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Microbiology
Daniela Roxana Matasariu, Mircea Onofriescu, Elena Mihalceanu, Carmina Mihaiela Schaas, Iuliana Elena Bujor, Alexandra Maria Tibeica, Alexandra Elena Cristofor, Alexandra Ursache
Summary: HIV infection and ART have a combined effect on the anthropometric parameters of infants, resulting in lower birth weight and smaller body size.
Editorial Material
Medicine, General & Internal
Francesca Ambrogio, Alexandre Raphael Meduri, Giovanni Infante, Melita Anna Poli, Paolo Romita, Domenico Bonamonte, Raffaele Filotico, Giuseppe Ingravallo, Gerardo Cazzato, Carmelo Laface, Aurora De Marco, Caterina Foti
Summary: Healing viral warts in immunocompromised patients is difficult, but immunocompetent patients can be treated with various methods like topical ointments, cryotherapy, laser therapy, imiquimod, and photodynamic therapy (PDT). PDT has been found to be a valid option for immunocompromised patients, who are at a higher risk of relapse.
Article
Dentistry, Oral Surgery & Medicine
Lucio Souza Goncalves, Dennis de Carvalho Ferreira, Fabio Vidal, Rodrigo Carvalho Souza, Cristiane Goncalves, Priscila Pavan, Florence Carrouel, Denis Bourgeois, Gregory J. Seymour
Summary: This retrospective cross-sectional study aimed to assess the impact of HIV-1 infection under highly active antiretroviral treatment (HAART) on periodontitis clinical parameters. The results showed a direct association of HIV-1 infection with bleeding on probing (BOP), but no association with periodontal probing depth (PPD). Age and visible supragingival biofilm (VSB) also had significant associations with BOP outcome.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Endocrinology & Metabolism
Christine A. Cabelka, Cory W. Baumann, Angus Lindsay, Andrew Norton, Nick C. Blixt, Gengyun Le, Gordon L. Warren, Kim C. Mansky, Susan A. Novotny, Dawn A. Lowe
Summary: The tissue-selective effects of Bazedoxifene (BZA) on musculoskeletal system in Ovariectomized (OVX) female mice indicate that BZA may act as an estrogen receptor agonist in skeletal muscle, as it has been seen in bone, providing minor benefits to the musculoskeletal system.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ismael Y. Karkache, Jeyaram R. Damodaran, David H. H. Molstad, Kim C. Mansky, Elizabeth W. Bradley
Summary: Phlpp1 deficiency within myeloid lineage cells enhances bone mass by limiting bone resorption, repressing osteoclastogenesis, and controlling responses to M-CSF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Nicholas G. Fischer, Xi Chen, Kristina Astleford-Hopper, Jiahe He, Alex F. Mullikin, Kim C. Mansky, Conrado Aparicio
Summary: The study successfully synthesized a multi-functional, dynamic coating on titanium by co-immobilizing GL13K antimicrobial peptide and an MMP-9 responsive peptide secreted by bone-remodeling osteoclasts. The co-immobilized peptide surface demonstrated potent anti-biofilm activity, promoted osteoblast and fibroblast proliferation, and showed stability against mechanical challenge. This dynamic surface has potential to reduce infection rates and enhance tissue regeneration in percutaneous bone-anchored devices by temporal synchronization between biomaterial cues and tissue responses.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Endocrinology & Metabolism
Carina Mello Guimaraes Meyers, Samuel D. Burciaga, Bora Faulkner, Parandis Kazemi, Jacob M. Cohn, Kim C. Mansky, Eric D. Jensen
Summary: The PRKD/HDAC5 axis plays a crucial role in osteoclast formation and regulation of skeletal dynamics.
Article
Multidisciplinary Sciences
Andrew Norton, Kathleen Thieu, Cory W. Baumann, Dawn A. Lowe, Kim C. Mansky
Summary: Osteoporosis and sarcopenia are more prevalent in women as they age. Recent research has shown that estrogen signaling has an impact on the chemical communication between bone and muscle cells, and a deficiency in estrogen can lead to increased expression of myokines, which further accelerates bone loss in women.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E. Ball, Jason C. Maynard, Alma L. Burlingame, Hu Zeng, Kim C. Mansky, Hai-Bin Ruan
Summary: In mammals, the interaction between bone marrow stroma and hematopoietic progenitors contributes to bone-BM homeostasis, but the mechanisms and interactions between the development of skeletal and hematopoietic systems are largely unknown. This study reveals that the intracellular O-GlcNAc modification plays a role in dictating the fate and function of early BM stromal cells (BMSCs). O-GlcNAcylation promotes osteogenic differentiation of BMSCs and supports lymphopoiesis, while inhibiting adipogenesis and myelopoiesis. Impaired bone formation and defective hematopoiesis were observed when O-GlcNAc transferase (OGT) was ablated in BMSCs.
Article
Biochemistry & Molecular Biology
Ravi Maisuria, Andrew Norton, Cynthia Shao, Elizabeth W. Bradley, Kim Mansky
Summary: This study aims to determine the role of MEF2C in osteoclast differentiation and analyze the skeletal phenotype of Mef2c-cKO mice. The results suggest that MEF2C is critical for osteoclastogenesis and its dysregulation leads to a sex-specific osteopenic phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Isha Mutreja, Dhiraj Kumar, Kami Hogan, Emily Campbell, Kim Mansky, Conrado Aparicio
Summary: Developing multifunctional nanostructures incorporating high levels of strontium in mesoporous bioactive silicate nanostructures can prevent infection and promote bone regeneration.
BIOMATERIALS ADVANCES
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ismael Karkache, David Molstad, Andrew Norton, Kim Mansky, Elizabeth Bradley
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ismael Karkache, Jeyaram Damodaran, David Molstad, Elizabeth Bradley, Kim Mansky
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ismael Karkache, David Molstad, Andrew Norton, Kim Mansky, Elizabeth Bradley
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Kristina Astleford-Hopper, Kim Mansky
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Mark Banovetz, Kim Mansky, Elizabeth Bradley
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ismael Karkache, Jeyaram Damodaran, David Molstad, Elizabeth Bradley, Kim Mansky
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Medicine, General & Internal
Georgios S. Chatzopoulos, Massimo Costalonga, Kim C. Mansky, Larry F. Wolff
Summary: This study aimed to investigate the total amount of Sclerostin and WNT-5a in different periodontal conditions, finding that the WNT-5a levels in GCF depend on the stage of periodontitis sites. SOST trended higher in the GCF of gingivitis sites but similar in chronic periodontitis and healthy sites. WNT-5a and SOST play a crucial role in periodontal tissue remodeling and depend on the inflammatory and osteoclastogenic activities.
MEDICINA-LITHUANIA
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)