Article
Biochemistry & Molecular Biology
Woo-Ram Park, Da Jung Lim, Hyunkyu Sang, Eunae Kim, Jae-Hak Moon, Hueng-Sik Choi, In Seon Kim, Don-Kyu Kim
Summary: The aphid estrogen-related receptor (ERR) plays a crucial role in the fecundity and glycolytic control of aphids. Research on MpERR revealed that it modulates aphid fecundity by regulating glycolytic gene expression, providing insights into the growth and development mechanisms of aphids.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Immunology
Julien C. Marie, Edith Bonnelye
Summary: This review summarizes the impacts of estrogens on bone immune cells and their consequences on bone homeostasis, metastasis settlement into the bone, and tumor progression. The role of an orphan nuclear receptor ERRalpha on macrophages and T lymphocytes is also addressed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Nuria Lara-Castillo
Summary: Estrogen plays important roles in bone homeostasis, affecting bone growth, healing, and mechanical adaptation. Abrupt loss of estrogen can lead to osteoporosis. Understanding the mechanisms of estrogen action is crucial for bone health.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue
Summary: Estrogens play an important role in the female reproductive system and also regulate physiological processes associated with learning and memory in the brain. They have neuroprotective effects in the pathogenesis of Alzheimer's disease (AD), which has a higher incidence in older and postmenopausal women. Estrogens bind to estrogen receptors (ERs) and activate transcriptional machineries, and also stimulate signal transduction through membrane ERs (mERs). Estrogen-related receptors (ERRs), which lack estrogen-binding capabilities, are expressed in the human brain and implicated in AD pathogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andre Fischer, Ferhat Bardakci, Manuel Sellner, Markus A. Lill, Martin Smiesko
Summary: ERR alpha, ERR beta, and ERR gamma are nuclear receptors that regulate metabolic processes in various tissues. They have been implicated as drug targets for important indications. This study used molecular dynamics and metadynamics simulations to investigate the ligand pathways of these receptors, revealing their distribution and their role in ligand translocation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Emmanuelle Noirrit-Esclassan, Marie-Cecile Valera, Florence Tremollieres, Jean-Francois Arnal, Francoise Lenfant, Coralie Fontaine, Alexia Vinel
Summary: Bone is a versatile tissue that is regulated by estrogens, with estrogen deficiency being a major cause of postmenopausal osteoporosis. The effects of estrogens on bone are dependent on bone type, tissue, cell types involved, and gender. New ongoing strategies are being discussed to optimize the benefits and risks of hormonal treatment for menopause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Alina Kurylowicz
Summary: Menopausal decline in estrogen levels leads to changes in adipose tissue distribution and increased obesity prevalence in women. Hormone replacement therapy can partially restore these effects, indicating the significant role of estrogen in adipocyte regulation. Preclinical studies have shown involvement of estrogen in adipose tissue development, metabolism, and inflammation. However, the relationship between estrogen and obesity is bidirectional, as estrogen deficiency leads to fat accumulation and impairs adipocyte function, while obese individuals have altered expression of estrogen receptors and key enzymes involved in their synthesis. This narrative review provides an overview of estrogen's role in adipose tissue development, physiology, and obesity-related dysfunction, as well as discussing potential therapeutic applications in obesity treatment.
Article
Genetics & Heredity
Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo
Summary: This study confirmed the important role of PGRN in regulating the estrogen signal, maintaining bone homeostasis. Our findings may provide a new strategy for the treatment of osteoporosis and maintaining bone homeostasis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Cell Biology
Mariya Stavnichuk, Svetlana Komarova
Summary: Multiple studies have shown reciprocal communications between bone marrow hematopoiesis and bone remodeling processes, with megakaryocytes playing a role in bone homeostasis. The effects of megakaryocytes on bone cells are influenced by the age and sex of animals, and they stimulate osteoblast proliferation while having variable effects on osteoclast proliferation and activity through soluble factors and direct cell-cell communications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Engineering, Environmental
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Yung Hyun Choi, Sang Rul Park, Chang-Min Lee, Gi-Young Kim
Summary: This study reveals that BPA inhibits osteoblast differentiation and bone formation by activating ROR alpha, potentially causing bone-resorptive diseases such as osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Kiminori Ohta, Asako Kaise, Takumi Ogawa, Yasuyuki Endo
Summary: In this study, a novel estrogen receptor modulator Az-01 was developed as an alternative to tamoxifen for breast cancer treatment. Az-01 exhibited similar estrogen receptor binding affinity to tamoxifen, but acted as a partial agonist and showed potent anti-estrogenic activity in the presence of estrogen. Furthermore, Az-01 demonstrated specific cell proliferation and inhibition activities in ER-expressing cells without affecting other cell proliferation signals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Harmit S. Ranhotra
Summary: In this article, we review the latest research on the influence of ERR alpha on host metabolism and biology, particularly cancer. This receptor plays a crucial role in energy metabolism and gene regulation, interacts with numerous transcription factors and signaling pathways, and has significant regulatory effects on health and disease.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Byungyoon Choi, Woo -Ram Park, Yu-Ji Kim, Seulgi Mun, Su-Jin Park, Jae-Ho Jeong, Hueng-Sik Choi, Don-Kyu Kim
Summary: The study reveals that Tribolium castaneum estrogen-related receptor (TcERR) plays a crucial role in transcriptional regulation of antimicrobial peptides (AMPs) during the host innate immune response against Escherichia coli infection. Knockdown of TcERR leads to decreased resistance to E. coli infection in larvae, resulting in higher bacterial load and lower survival rate.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chun Feng, Zhaowei Xu, Xiaojie Tang, Haifei Cao, Guilong Zhang, Jiangwei Tan
Summary: This review summarizes the regulatory effect of the orphan nuclear receptor estrogen-related receptor (ERRα) on bone homeostasis and bone metastasis. The defined function of ERRα in bone is currently inconsistent and controversial, but it has the potential to become a target for clinical therapy.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)