Article
Immunology
Dipasree Hajra, Abhilash Vijay Nair, Atish Roy Chowdhury, Soumyadeep Mukherjee, Ritika Chatterjee, Dipshikha Chakravortty
Summary: This study reveals a novel role of U32 peptidase YdcP in Salmonella Typhimurium by protecting the bacteria from oxidative stress. The knockout of YdcP leads to attenuated intracellular proliferation of Salmonella and increased susceptibility to in vitro oxidative stress.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Hasnaa Maksouri, Dounia Darif, Jerome Estaquier, Myriam Riyad, Christophe Desterke, Meryem Lemrani, Pham My-Chan Dang, Khadija Akarid
Summary: This study evaluated the impact of Moroccan strains of L. major and L. tropica on PMNs. The results showed that L. tropica inhibited O-2(-) production, while L. major did not. Additionally, Leishmania soluble antigens from both species inhibited O-2(-) induction.
Article
Chemistry, Medicinal
Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Ahmed M. Sayed, Eman K. Rashwan, Abdel-Gawad S. Shalkami, Ayman M. Mahmoud
Summary: The study showed that the natural NADPH oxidase inhibitor acetovanillone (AV) can protect rats from acute lung injury (ALI) induced by cyclophosphamide (CP) by attenuating oxidative stress and enhancing Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Article
Neurosciences
Gajendra Singh, Anjali Singh, Sanjay Mishra, Devendra Singh, Alok Kumar
Summary: This study investigates the changes in iron transporter and iron storage proteins, as well as inflammatory and oxidative stress-mediated signaling, in Japanese encephalitis (JE) viral infection. The results show that iron storage protein ferritin significantly increases post-JE viral infection, leading to iron accumulation in cortical tissue. Inflammatory markers such as TNF-a, IL-6, and the regulator TLR4 increase, while the anti-inflammatory regulator SOCS1 decreases with increased oxidative stress markers. The study also found imbalances in the hepcidin-ferroportin regulation after JE viral infection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
German Higuera-Martinez, Ivonne Maciel Arciniega-Martinez, Rosa Adriana Jarillo-Luna, Luz Maria Cardenas-Jaramillo, David Levaro-Loquio, Maritza Velasquez-Torres, Edgar Abarca-Rojano, Aldo Arturo Resendiz-Albor, Judith Pacheco-Yepez
Summary: Amebiasis is an intestinal infection caused by Entamoeba histolytica. Amebic liver abscess (ALA) is the most common extraintestinal complication of amebiasis. Neutrophils play a key role in the initial phase of ALA through reactive oxygen species (ROS) and the enzyme NADPH oxidase (NOX2). Apocynin, a natural inhibitor of NOX, reduces ALA progression by decreasing NOX activity and damaging amoebae in vitro.
Article
Cell Biology
Ahmed Kouki, Wafa Ferjani, Pham My-Chan Dang, Neziha Ghanem-Boughanmi, Abdelaziz Souli, Mossadok Ben-Attia, Jamel El-Benna
Summary: This study demonstrates the preventive effect of apocynin on acetic acid-induced ulcerative colitis in rats. Apocynin reduces pro-oxidant markers, preserves colonic cytoarchitecture, and decreases systemic inflammatory markers. These findings suggest that apocynin could be a promising therapeutic option for the prevention of ulcerative colitis.
Article
Biochemistry & Molecular Biology
Ahmed Kouki, Wafa Ferjani, Neziha Ghanem-Boughanmi, Mossadok Ben-Attia, Pham My-Chan Dang, Abdelaziz Souli, Jamel El-Benna
Summary: Inflammation is the body's response to insults, such as lung inflammation caused by pollutants or pathogens. This study investigated the effects of two NADPH oxidase inhibitors on LPS-induced lung inflammation in rats. The results showed that the inhibitors reduced lung damage, edema, and oxidative stress markers, suggesting that NADPH oxidase inhibition could be a new therapeutic strategy for inflammatory lung diseases.
Article
Physiology
Samuel D. Walton, John Henry Dasinger, Emily C. Burns, Mary Cherian-Shaw, Justine M. Abais-Battad, David L. Mattson
Summary: Infiltrating T cells in the kidney amplify salt-sensitive hypertension and renal damage, and reactive oxygen species produced by NOX2 in T cells play a key role in this process.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Arturo Simoni-Nieves, Denise Clavijo-Cornejo, Soraya Salas-Silva, Alejandro Escobedo-Calvario, Leticia Bucio, Veronica Souza, Maria Concepcion Gutierrez-Ruiz, Roxana U. Miranda-Labra, Luis E. Gomez-Quiroz
Summary: This study investigated the regulation of p22(phox) by HGF and its receptor c-Met in primary mouse hepatocytes, revealing that HGF exerts regulation of NADPH oxidase through a variety of molecular mechanisms. NADPH oxidase-derived reactive oxygen species regulated by HGF/c-Met represent a key signaling mechanism elicited by this growth factor.
ANNALS OF HEPATOLOGY
(2021)
Article
Neurosciences
Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study investigated the expression and regulatory mechanisms of NRROS in astrocytes under the influence of 15d-PGJ(2). The results demonstrated that 15d-PGJ(2) induced NRROS expression through the PI3K/Akt-dependent phosphorylation of FoxO1 and Sp1, as well as the Nrf2 cascade, which effectively suppressed ROS generation and IL-6 expression.
NEUROTOXICITY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Meng-Yan Deng, Khalil Ali Ahmad, Qiao-Qiao Han, Zi-Ying Wang, Rana Muhammad Shoaib, Xin-Yan Li, Yong-Xiang Wang
Summary: The study showed that thalidomide alleviates neuropathic pain by upregulating spinal microglial IL-10 and beta-endorphin expression rather than downregulating TNF alpha expression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Neurosciences
Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy
Summary: In this study, the effectiveness of a mitochondrial-targeted NADPH oxidase inhibitor in reducing oxidative stress and inflammation in rats exposed to organophosphates (OP) was examined. The inhibitor showed promising results in decreasing markers of oxidative stress and inflammation in the serum, but had limited effects in the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Celeste Santamaria-Juarez, Fausto Atonal-Flores, Alfonso Diaz, Victor E. Sarmiento-Ortega, Miguel Garcia-Gonzalez, Patricia Aguilar-Alonso, Gustavo Lopez-Lopez, Eduardo Brambila, Samuel Trevino
Summary: Metabolic changes induced by exposure to Cd lead to impaired vascular relaxation and increased oxidative stress, resulting in hypertension and endothelial injury.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Immunology
Saba Fekrvand, Samaneh Delavari, Zahra Chavoshzadeh, Roya Sherkat, Seyed Alireza Mahdaviani, Mahnaz Sadeghi Shabestari, Gholamreza Azizi, Mohammad Taghi Arzanian, Bibi Shahin Shamsian, Shabnam Eskandarzadeh, Narges Eslami, William Rae, Antonio Condino-Neto, Javad Mohammadi, Hassan Abolhassani, Reza Yazdani, Asghar Aghamohammadi
Summary: APDS is a primary immunodeficiency disease characterized by recurrent respiratory tract infections, lymphoproliferation, autoimmunity and lymphoma. APDS1 is caused by gain-of-function mutations in PIK3CD and APDS2 by loss-of-function mutations in PIK3R1. Respiratory tract infections and humoral immunodeficiency are common complications in pediatric APDS patients, with potential fatal outcomes due to chronic lung damage.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Immunology
Tabata Takahashi Franca, Lucila Akune Barreiros, Ranieri Coelho Salgado, Sarah Maria da Silva Napoleao, Lillian Nunes Gomes, Janaira Fernandes Severo Ferreira, Carolina Prando, Cristina Worm Weber, Regina Sumiko Watanabe Di Gesu, Cecilia Montenegro, Carolina Sanchez Aranda, Gisele Kuntze, Aide Tamara Staines-Boone, Edna Venegas-Montoya, Juan Carlos Aldave Becerra, Liliana Bezrodnik, Daniela Di Giovanni, Ileana Moreira, Gisela Analia Seminario, Andrea Cecilia Gomez Raccio, Mayra de Barros Dorna, Nelson Augusto Rosario-Filho, Herberto Jose Chong-Neto, Elisa de Carvalho, Milena Baptistella Grotta, Julio Cesar Orellana, Miguel Garcia Dominguez, Oscar Porras, Laura Sasia, Karina Salvucci, Emilio Garip, Luiz Fernando Bacarini Leite, Wilma Carvalho Neves Forte, Fernanda Pinto-Mariz, Ekaterini Goudouris, Maria Enriqueta Nunez Nunez, Magdalena Schelotto, Laura Berron Ruiz, Diana Ines Liberatore, Hans D. Ochs, Otavio Cabral-Marques, Antonio Condino-Neto
Summary: CD40L deficiency is a rare immune disorder with limited information about Latin American patients. This study retrospectively analyzed data from 50 Latin American patients to characterize the clinical and genetic features of CD40L deficiency. The findings provide valuable insights for the diagnosis and management of CD40L deficiency patients.
JOURNAL OF CLINICAL IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Magda Massae Hata Viveiros, Claudia Aparecida Rainho, Jofer Andree Zamame Ramirez, Ramon Kaneno, Marcia Guimaraes Silva, Valdecir Farias Ximenes, Gabriel Molina de Olyveira, Pierre Basmaji, Nick Di Girolamo, Silvana Artioli Schellini
Summary: Nanoskin (R) as a potential scaffold for cell transfer therapy does not stimulate lymphocyte proliferation or induce lymphocyte death, but instead promotes elevated levels of interleukin (IL)-10 in human mesenchymal stem cells (MSCs) and lymphocytes when in contact. This suggests that Nanoskin (R) could be a promising biomaterial for cell transfer therapy as a cell carrier-scaffold.
Article
Immunology
Evangelos Andreakos, Laurent Abel, Donald C. Vinh, Elzbieta Kaja, Beth A. Drolet, Qian Zhang, Cliona O'Farrelly, Giuseppe Novelli, Carlos Rodriguez-Gallego, Filomeen Haerynck, Carolina Prando, Aurora Pujol, Helen C. Su, Jean-Laurent Casanova, Andras N. Spaan, Paul Bastard, Catherine M. Biggs, Benedetta Bigio, Bertrand Boisson, Alexandre Bolze, Anastasiia Bondarenko, Petter Brodin, Samya Chakravorty, John Christodoulou, Aurelie Cobat, Antonio Condino-Neto, Stefan N. Constantinescu, Hagit Baris Feldman, Jacques Fellay, Rabih Halwani, Emmanuelle Jouanguy, Yu-Lung Lau, Isabelle Meyts, Trine H. Mogensen, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarstrom, Anna M. Planas, Anne Puel, Lluis Quintana-Murci, Laurent Renia, Igor Resnick, Anna Sediva, Anna Shcherbina, Ondrej Slaby, Ivan Tancevski, Stuart E. Turvey, K. M. Furkan Uddin, Diederik van de Beek, Mayana Zatz, Pawel Zawadzki, Shen-Ying Zhang
Summary: SARS-CoV-2 infections can vary greatly between individuals, with some being asymptomatic while others experience life-threatening disease. While 20% of critical COVID-19 cases are due to inborn errors or autoantibodies, the genetic and immunological factors for resistance to infection itself remain unknown. Studies have shown that autosomal recessive deficiencies in certain genes or enzymes can confer resistance to diseases, suggesting a potential strategy for identifying individuals naturally resistant to SARS-CoV-2 infection.
Article
Anatomy & Morphology
Ana Ligia Pagnan, Adriano Souza Pessoa, Cintia Kazuko Tokuhara, Vanessa Svizzero Fakhoury, Gabriela Silva Neubern Oliveira, Mariana Liessa Rovis Sanches, Kelly Karina Inacio, Valdecir Farias Ximenes, Rodrigo Cardoso Oliveira
Summary: Osteosarcoma, the most common type of bone cancer, has a high metastasis rate leading to poor survival outcomes. The study on caffeic acid phenethyl ester (CAPE) and caffeic acid (CA) showed that CAPE demonstrated greater anticancer properties and selectivity compared to CA, suggesting its potential as an anticancer drug.
Article
Microbiology
Ana Paula Carvalho Reis, Giovanna Azevedo Celestrino, Mariana Villas Boas Igoa, Thais Martins Jesus, Tabata Takahashi Franca, Daniel Valerio Silva Moreira, Paula Ordonhez Rigato, Paula Keiko Sato, Antonio Condino-Neto, Irene L. Noronha, Luciane Alarcao Dias-Melicio, Pritesh Jaychand Lalwani, Gil Benard, Maria Gloria Teixeira Sousa
Summary: This study found that human neutrophils can produce various morphotypes of NETs against Trichophyton rubrum, with the production of NETs depending on the dose and ROS secretion. Additionally, the production of ROS by human neutrophils in response to T. rubrum relies on NADPH oxidase and is independent of fungal viability. The NETs were able to kill T. rubrum. These results demonstrate that NETs may represent an important innate immune effector mechanism against T. rubrum infection.
Article
Integrative & Complementary Medicine
Celia Cristina Malaguti Figueiredo, Amanda da Costa Gomes, Filipe Oliveira Granero, Joao Luiz Bronzel Junior, Luciana Pereira Silva, Valdecir Farias Ximenes, Regildo Marcio Goncalves da Silva
Summary: The study explored the antiglycation and antioxidant activities of Tribulus terrestris crude dry extract and saponin fraction, demonstrating that the saponin fraction showed an increase in total saponins content and promising biological activities. The encapsulation method was efficient in maintaining the bioactive compounds' activity after release, providing potential for the development of new herbal medicine and food supplements formulations.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Biochemistry & Molecular Biology
Adriano de Souza Pessoa, Cintia Kazuko Tokuhara, Vanessa Svizzero Fakhoury, Ana Ligia Pagnan, Gabriela Silva Neubern de Oliveira, Mariana Liessa Rovis Sanches, Kelly Karina Inacio, Bruna Carolina Costa, Valdecir Farias Ximenes, Rodrigo Cardoso de Oliveira
Summary: Phenolic phytochemicals are organic compounds that have both antioxidant and pro-oxidant properties. The study found that methyl vanillate and its dimer, methyl divanillate, have pro-oxidant effects on breast cancer cells, reducing cell viability and affecting apoptosis and proliferation. The dimer showed greater efficacy and pro-oxidant effects compared to the monomer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Engineering, Environmental
Nathalia Mariana Pavan, Juliano Passaretti Filho, Guilherme Isquibola, Flavio Junior Caires, Valdecir Farias Ximenes
Summary: The applications of ozonized oils have increased in various medical fields. The oxidizing capacity of ozonized oils is related to their therapeutic effects. This study investigated the light emission caused by the oxidation of luminol by ozonized sesame oil. The results showed a linear correlation between ozonized oil concentration and light emission. The involvement of intermediate oxidative species was observed in the reaction. These findings contribute to the understanding of the microbicidal properties of ozonized oils and taurine chloramine.
OZONE-SCIENCE & ENGINEERING
(2023)
Letter
Immunology
Barbara Cristina Ramos, Carolina Sanchez Aranda, Amanda Oliveira Sobrinho, Dirceu Sole, Antonio Condino-Neto
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Allergy
Renata Harumi Cruz, Antonio Condino-Neto, Leticia Gomes de Pontes
Summary: Allergy is a complex condition that researchers are extensively studying, yet the underlying causes remain unclear. Current treatments fail to significantly improve patients' quality of life. New technologies, like the integration of allergy with peptidomics and bioinformatics tools, hold promise in filling the knowledge gaps for diagnosis and treatment. This review focuses on peptidomics and highlights findings regarding target proteins or biomarkers that can enhance our understanding of the mechanisms behind inflammation, organ damage, and the subsequent detrimental effects on quality of life or even mortality. (c) 2023 Codon Publications. Published by Codon Publications.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2023)
Review
Allergy
Giorgia Bucciol, Isabelle Meyts
Summary: Since the start of the COVID-19 pandemic, global sequencing efforts have made significant advancements in the field of inborn errors of immunity. Research has revealed that both known and novel inborn errors affecting type I interferon immunity play a critical role in severe COVID-19 cases, occurring in up to 5% of patients. Furthermore, autoantibodies against type I interferons have been found in around 20% of critically ill COVID-19 patients over 80 years old and 20% of fatal cases, with a higher prevalence in older males. Additionally, inborn errors impairing the regulation of type I interferon responses and RNA degradation have been identified as causes of multisystem inflammatory syndrome in children, which is a life-threatening condition that occurs following mild initial SARS-CoV-2 infection in children and young adults. Understanding these immunologic mechanisms can assist in the development of treatments for severe COVID-19, multisystem inflammatory syndrome in children, long COVID, and neuro-COVID.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Optics
Victoria Helloiza Silva Silveira, Marcela Rodrigues de Camargo, Camila Loreta Rocha, Carmen Lucia Cardoso, Valdecir Farias Ximenes
Summary: The study focuses on a chemiluminescent reaction mediated by cobalt(II) as an efficient catalyst for the oxidation of 2-methylindol by hydrogen peroxide. The reaction exhibits strong chemiluminescence, with selectivity towards 2-methylindol compared to other indole derivatives. Cobalt(II) outperforms nine other transition metals as a catalyst, and factors such as pH, buffer constituents, and H2O2 concentration were optimized for efficient light emission.
JOURNAL OF LUMINESCENCE
(2023)
Article
Immunology
Cristina Frias Sartorelli de Toledo Piza, Carolina Sanchez Aranda, Dirceu Sole, Stephen Jolles, Antonio Condino-Neto
Summary: This study aimed to investigate the correlation between calculated globulin (CG) and the gamma globulin fraction (Gamma) with serum IgG levels in adults. Linear regression models showed positive correlations between CG and Gamma levels with IgG levels. These findings suggest that CG and Gamma can be used to screen for antibody deficiencies in adults.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Valdecir F. Ximenes, Nathalia M. Pavan, Aguinaldo R. de Souza, Gabriel A. Barros, Nelson H. Morgon
Summary: There is evidence that nicotine enhances the damage caused by hypochlorous acid in biomolecules, and this study provides experimental and theoretical evidence of the catalytic effect of nicotine on the chlorination of pyranine.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)