Article
Biology
Wayne Mitchell, Jeffrey D. Tamucci, Emery L. Ng, Shaoyi Liu, Alexander Birk, Hazel H. Szeto, Eric R. May, Andrei T. Alexandrescu, Nathan N. Alder
Summary: Mitochondria play a key role in metabolic homeostasis and their dysfunction is associated with various diseases. This study analyzed the structure-activity relationship of tetrapeptide analogs with different aromatic side chain compositions and sequence registrations. The results showed that these analogs adopt compact reverse turn conformations when bound to membranes and exhibit differences in membrane interactions. The analogs had effects on membrane surface charge and were able to penetrate cells and target mitochondria without strict requirements for side chain composition or sequence register. The analog with tryptophan side chains showed the strongest impact on membrane properties and had the highest efficacy in cell culture studies.
Article
Oncology
Ioannis Drikos, Effrossyni Boutou, Panagiotis L. Kastritis, Constantinos E. Vorgias
Summary: The mutations M1775K and V1809F in the BRCT domain of BRCA1 affect its cellular localization, leading to cytoplasmic mislocalization after DNA damage induction. This alteration may impact the function of BRCA1 and contribute to diminished DNA repair observed in breast cancer cells.
ANTICANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yicong Wan, Yashuang Zhang, Huangyang Meng, Huixian Miao, Yi Jiang, Lin Zhang, Wenjun Cheng
Summary: In this study, 13 ovarian borderline tumor organoids were successfully generated and the anti-tumor activity of Bractoppin, a BRCA1 carboxy-terminal domain (BRCT) inhibitor, was tested. Bractoppin promotes organoid apoptosis by inhibiting cell cycle progression, inhibiting DSB damage repair, and promoting tumor cell apoptosis. Additionally, Bractoppin also promotes apoptosis of ovarian cancer cell lines and inhibits the repair ability of tumor cells. The study demonstrates the value of ovarian borderline tumor organoids in exploring molecular therapy drugs, with Bractoppin potentially serving as a valuable small molecule drug for BOT treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Fatemeh Yadegari, Leila Farahmand, Rezvan Esmaeili, Shiva Zarinfam, Keivan Majidzadeh-A
Summary: This study aimed to identify intolerant regions of the BRCA1 gene and understand their possible pathogenic mechanisms. The results showed that the RING domain and BRCT domain have the highest density of pathogenic mutations in BRCA1. Within the BRCT domain, the inter-BRCT linker is more intolerant. Molecular dynamics simulations demonstrated that mutations in the inter-BRCT linker lead to cancer susceptibility.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Lovely Jacob Aloor, Sinosh Skariyachan, Achuthan Chathrattil Raghavamenon, Kalavathi Murugan Kumar, Rajeswari Narayanappa, Akshay Uttarkar, Vidya Niranjan, Tom Cherian
Summary: This study aimed to design novel curcumin analogue inhibitors with antiproliferative and antitumor activity, and investigate their therapeutic potential for breast cancer. The designed analogues demonstrated better binding affinity to the selected tumor proteins compared to curcumin, and exhibited significant antiproliferative activities in vitro and tumor inhibition potential in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Patryk Ludzia, Edward D. Lowe, Gabriele Marciano, Shabaz Mohammed, Christina Redfield, Bungo Akiyoshi
Summary: The structure and dynamics of the unconventional kinetoplastid kinetochore protein KKT4 were characterized using X-ray crystallography, NMR spectroscopy, and crosslinking mass spectrometry. KKT4 was found to have a microtubule-binding domain and a BRCT domain, which likely interacts with other proteins through phosphorylation.
Article
Chemistry, Multidisciplinary
Tagwa A. Mohammed, Christoph M. Meier, Tadeas Kalvoda, Martina Kalt, Lubomir Rulisek, Michal S. Shoshan
Summary: The study introduces a cyclic tetrapeptide that selectively binds lead and eliminates its toxic effects on a cellular level, showing superior potency compared to current drugs. The lead-peptide complex exhibits remarkable strength, lacks toxicity, and demonstrates potential as a remedy for lead poisoning.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Jan Korbel, Simon David Lindner, Rudolf Hanel, Stefan Thurner
Summary: This paper discusses the derivation of entropy for structure-forming systems and the differences with Boltzmann-Gibbs entropy, as well as the derivation of fluctuation theorems for such systems. The study finds significant deviations in small systems, suggesting the use of canonical ensemble method to describe closed structure-forming systems.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marco C. Matthies, Ryan Krueger, Andrew E. Torda, Max Ward
Summary: This study presents a generalization of the McCaskill algorithm, allowing for the handling of continuous inputs and enabling end-to-end differentiable partition function calculations. It creates a bridge between RNA thermodynamics and differentiable programming tools, such as deep learning. By using gradient optimization, the inverse folding problem is tackled and meaningful gradients are obtained.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Albert Y. Liu, Xavier A. Calicdan, Gene N. Glover, Xue Luo, Gage T. Barroso, Brooke K. Hoppe, Kelsey M. Boyle, Leah S. Witus
Summary: This work investigates the role of a common motif-residues in peptide catalysts for aldol reactions. By varying the amino acids to affect beta-turn propensity, the study finds a correlation between peptide structure and reaction kinetics, but minimal effect on stereoselectivity. These findings may aid the design of future catalytic sequences.
Article
Chemistry, Inorganic & Nuclear
Clovis Poulin-Ponnelle, Magali Duvail, Thomas Dumas, Claude Berthon
Summary: In this study, molecular dynamics coupled with NMR spectroscopy was used to investigate the conformations of complexes in solution. Experimental confirmation was provided for the presence of different conformations, and additional insights were obtained through MD simulations.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Gary G. Scott, Tim Boerner, Martin E. Leser, Tim J. Wooster, Tell Tuttle
Summary: This study demonstrates the potential of using short peptides as emulsifiers in oil-water emulsions. The surface activity of the emulsions can be tuned by designing the peptide sequence, as confirmed by both computational screening and experimental studies.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Alexa L. Knight, Vinnie Widjaja, George P. Lisi
Summary: Mesophilic and thermophilic enzyme counterparts are studied to understand their functions under harsh conditions. Thermophiles regulate their structural ensemble through intra-protein communication and altered interactions with ligands to function well outside of standard temperature ranges. Recent studies have shown that the enhancement or diminution of allosteric crosstalk can be temperature-dependent and distinguish thermophilic enzymes from their mesophilic counterparts. However, the impact of temperature on allosteric function is understudied compared to other factors such as pH, mutations, or ligands.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Manuel Cordova, Lyndon Emsley
Summary: The determination of the molecular solid structure using NMR crystallography relies on generating a comprehensive set of candidate crystal structures and comparing computed chemical shifts with experimental values. However, exploring the polymorph landscape of molecular solids requires a significant computational power, leading to a bottleneck in candidate crystal generation. This study constructs three-dimensional interaction maps using a crystal structure database with associated chemical shifts to identify structural constraints for accelerating crystal structure prediction protocols, without requiring DFT-level chemical shift computations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Shahid N. Khan, John D. Persons, Michel Guerrero, Tatiana Ilina, Masayuki Oda, Rieko Ishima
Summary: The V54A mutation in HIV-1 protease not only decreases inhibitor affinity but also restores catalytic activity, as studied through various spectroscopic and enzymatic assays.
Article
Multidisciplinary Sciences
Mona Al-Mugotir, Jeffrey J. Lovelace, Joseph George, Mika Bessho, Dhananjaya Pal, Lucas Struble, Carol Kolar, Sandeep Rana, Amarnath Natarajan, Tadayoshi Bessho, Gloria E. O. Borgstahl
Summary: Synthetic lethality is an effective strategy for developing selective chemotherapy against cancer cells, with RAD52 inactivation being synthetically lethal to HR-deficient cancer cell lines. Screening chemical libraries using FluorIA identified compounds like mitoxantrone and doxorubicin as effective inhibitors of the RPA:RAD52 protein-protein interaction, showing selective killing of BRCA1 and BRCA2 mutated cancer cells.
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Chemistry, Medicinal
Hannah M. King, Sandeep Rana, Sydney P. Kubica, Jayapal Reddy Mallareddy, Smitha Kizhake, Edward L. Ezell, Muhammad Zahid, Michael J. Naldrett, Sophie Alvarez, Henry C-H Law, Nicholas T. Woods, Amarnath Natarajan
Summary: CDK9, a member of the cyclin-dependent kinase family, is involved in transcriptional regulation. Researchers developed PROTAC 2, a compound that selectively degrades CDK9, sensitizing cells to growth inhibition by Venetoclax.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Satish Sagar, Sarbjit Singh, Jayapal Reddy Mallareddy, Yogesh A. Sonawane, John Napoleon, Sandeep Rana, Jacob Contreras, Christabelle Rajesh, Edward L. Ezell, Smitha Kizhake, Jered C. Garrison, Prakash Radhakrishnan, Amarnath Natarajan
Summary: A novel quinoxaline urea analog 84 was discovered to inhibit TNF alpha-induced NF kappa B and pancreatic cancer cell growth to a greater extent than the previously studied 13-197. Analog 84 exhibited higher potency and oral bioavailability compared to 13-197.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Medicinal
Jayapal Reddy Mallareddy, Sarbjit Singh, Lidia Boghean, Amarnath Natarajan
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Smit Kour, Sandeep Rana, Smitha Kizhake, Dragana Lagundzin, David Klinkebiel, Jayapal Reddy Mallareddy, Tom Huxford, Nicholas T. Woods, Amarnath Natarajan
Summary: The study introduces a novel approach using a spirocyclic dimer, SpiD7, to covalently modify RELA and inhibit TNF alpha-induced NF-kappa B activation. This strategy presents a previously unexplored method to target TNF alpha-induced nuclear translocation of RELA.
RSC CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Sandeep Rana, Smit Kour, Smitha Kizhake, Hannah M. King, Jayapal Reddy Mallareddy, Adam J. Case, Tom Huxford, Amarnath Natarajan
Summary: The IKK-NF kappa B complex is a crucial signaling node for gene expression in response to extracellular signals. This study identified SpiD3 as a potent anticancer agent that binds to and modifies RELA, resulting in inhibition of TNF alpha-induced signaling and blockade of cancer cell growth and migration. It showed strong inhibitory effects on leukemia cell lines, suggesting its potential as a therapeutic lead for hematological malignancies.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Smit Kour, Sandeep Rana, Sydney P. Kubica, Smitha Kizhake, Mudassier Ahmad, Catalina Munoz-Trujillo, David Klinkebiel, Sarbjit Singh, Jayapal Reddy Mallareddy, Surabhi Chandra, Nicholas T. Woods, Adam R. Karpf, Amarnath Natarajan
Summary: Inducing UPR by covalent modification of SEC residues represents a vulnerability in cancer cells and can be exploited to discover novel therapeutics.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Suravi Pramanik, Yingling Chen, Heyu Song, Irine Khutsishvili, Luis A. Marky, Sutapa Ray, Amarnath Natarajan, Pankaj K. Singh, Kishor K. Bhakat
Summary: This study identifies a novel role for the protein APE1 in regulating stable G4 formation and KRAS expression in PDAC, suggesting that G4 structures could be potential prognostic markers and therapeutic targets for PDAC.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
John Victor Napoleon, Satish Sagar, Sydney P. Kubica, Lidia Boghean, Smit Kour, Hannah M. King, Yogesh A. Sonawane, Ayrianne J. Crawford, Nagsen Gautam, Smitha Kizhake, Pawel A. Bialk, Eric Kmiec, Jayapal Reddy Mallareddy, Prathamesh P. Patil, Sandeep Rana, Sarbjit Singh, Janani Prahlad, Paul M. Grandgenett, Gloria E. O. Borgstahl, Gargi Ghosal, Yazen Alnouti, Michael A. Hollingsworth, Prakash Radhakrishnan, Amarnath Natarajan
Summary: Activation of IKK beta, characterized by phosphorylation of serine residues 177 and 181, has been implicated in the early onset of cancer. This study used various models to assess the role of IKK beta and its activation in cancer, and identified 39-100 as a potent inhibitor of MAP3K1. It was found that IKK beta activation is critical for tumor growth in Kras mutant pancreatic cancer, and the compound 39-100 inhibits MAP3K1-mediated IKK beta phosphorylation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan, James A. Bibb
Summary: Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction and its activity is implicated in various neuropsychiatric and neurodegenerative conditions. In this study, a novel brain-penetrant Cdk5 inhibitor 25-106 was identified, which showed promising effects on behavior and has significant potential as a neurological/neuropsychiatric therapeutic.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Rebecca Harris, Ming Yang, Christina Schmidt, Chloe Royet, Sarbjit Singh, Amarnath Natarajan, May Morris, Christian Frezza, Heike Laman
Summary: Fbxo7 plays a crucial role in cancer and Parkinson's disease by promoting Cdk6 activation and regulating the ubiquitination and phosphorylation of PFKP. Cells lacking Fbxo7 show reduced Cdk6 activity, and hematopoietic and lymphocytic cells are highly dependent on Fbxo7. Decreased Fbxo7 expression in T cells leads to increased glycolysis, but lower cell viability and activation levels.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Savanna Wallin, Sarbjit Singh, Gloria E. O. Borgstahl, Amarnath Natarajan
Summary: Mitoxantrone (MX) is a chemotherapeutic drug that inhibits topoisomerase II and has shown to have therapeutic effects on leukemias and advanced breast and prostate cancers. Recent studies have identified new protein-binding partners of MX and revealed its ability to modulate protein expression. By designing and synthesizing a MX-biotin probe, researchers can identify and study MX's cellular targets, expanding our understanding of its mechanism of action.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Rasangi Pathirage, Lorenza Favrot, Cecile Petit, Melvin Yamsek, Sarbjit Singh, Jayapal Reddy Mallareddy, Sandeep Rana, Amarnath Natarajan, Donald R. Ronning
Summary: As an adaptation for survival during infection, Mycobacterium tuberculosis becomes dormant, reducing its metabolism and growth. Two types of citrate synthases have been identified in M. tuberculosis, GltA2 and CitA. Previous work shows that CitA plays a role as a metabolic switch and can be a potential drug target for tuberculosis. The crystal structure of CitA was solved, revealing that it lacks an NADH binding site but contains a pyruvate binding site. Mutations in the pyruvate binding pocket increase the catalytic efficiency, and covalent modification of C143 of CitA by Ebselen inhibits enzyme activity. Evaluation of the druggability and mechanisms of targeting CitA with small-molecule compounds provides insights into potential drug development for tuberculosis.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
John Napoleon, Sarbjit Singh, Sandeep Rana, Mourad Bendjennat, Vikas Kumar, Smitha Kizhake, Nicholas Y. Palermo, Michel M. Ouellette, Tom Huxford, Amarnath Natarajan
Summary: IKK beta is a key regulator in the NF-kappa B pathway and serves as a drug target for chronic inflammatory diseases and cancer. The non-toxic inhibitor 13-197 was discovered to reduce tumor growth through ATP non-competitive inhibition, targeting an allosteric pocket between the kinase and ubiquitin like domains.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
