Article
Biology
Jiyoon Beon, Sungwook Han, Hyeokjun Yang, Seung Eun Park, Kwangbeom Hyun, Song-Yi Lee, Hyun-Woo Rhee, Jeong Kon Seo, Jaehoon Kim, Seyun Kim, Daeyoup Lee
Summary: Inositol polyphosphate multikinase (IPMK) interacts with the chromatin remodeling complex SWI/SNF and regulates its function in mouse embryonic stem cells, contributing to transcription and differentiation.
Article
Biochemical Research Methods
Ayuko Kimura, Noriaki Arakawa, Hiroyuki Kagawa, Yayoi Kimura, Hisashi Hirano
Summary: The study demonstrates that changes in BRG1 phosphorylation levels can affect chromatin structure and levels of polyubiquitylated proteins in cells, promoting tumor development and drug resistance.
JOURNAL OF PROTEOMICS
(2021)
Article
Biochemistry & Molecular Biology
Osamu Araki, Motoyuki Tsuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Tomonori Masuda, Takaaki Yoshikawa, Munemasa Nagao, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yu Muta, Yukiko Hiramatsu, Takahisa Maruno, Yuki Nakanishi, Sho Koyasu, Toshihiko Masui, Etsuro Hatano, Dieter Saur, Akihisa Fukuda, Hiroshi Seno
Summary: The chromatin remodeler Brg1 plays a critical role in the survival, growth, and metastasis of pancreatic ductal adenocarcinoma (PDAC) cells. Brg1 regulates the hypoxia pathway, which is important for maintaining the stem-like properties of PDAC cells and promoting their metastasis. This study suggests that Brg1 could be a potential therapeutic target for PDAC.
Article
Oncology
Ping Zhou, Yiyun Fu, Weiya Wang
Summary: This study reported two rare cases of GI NEC with SMARCA4 deficiency and described their clinicopathological, radiographic, and histopathological features. SMARCA4 may be a promising targetable and prognostic biomarker.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiangpeng Meng, Jia Ma, Nan Meng, Tianyu Yun, Beifang Niu
Summary: SMARCA4 (BRG1)-deficient undifferentiated carcinoma is a rare and aggressive malignancy that can occur in various organs. This is the first reported case of SMARCA4 (BRG1)-deficient undifferentiated carcinoma of the gallbladder, with comprehensive genetic analysis suggesting additional genetic changes involved in tumorigenesis. Somatic mutations in CTNNB1, KRAS, PIK3CA, TP53, CREBBP, and FANCI genes were identified.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Mahsa Mollapour Sisakht, Mohammad Amir Amirkhani, Mohammad Ali Nilforoushzadeh
Summary: Therapeutic strategies based on epigenetic regulators are rapidly increasing due to recent advances in understanding the role of epigenetic factors in therapy response. Mutations in SWI/SNF subunits genes are important in a significant portion of melanomas, and exploring the potential of using inhibitors and synthetic lethality interactions between key subunits in melanoma progression is crucial. This article discusses the clinical application of SWI/SNF subunits as a promising therapeutic approach for melanoma.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yali He, Chuanhe Yang, Yinan Wang, Joshua R. Sacher, Michelle M. Sims, Lawrence M. Pfeffer, Duane D. Miller
Summary: The study reveals that BRG1 plays a critical role in regulating sensitivity of GBM to TMZ. The newly designed SRAPs can enhance the sensitivity of GBM cells to TMZ and its inhibitory effect.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Immunology
Dominik Schmiedel, Hadas Hezroni, Amit Hamburg, Ziv Shulman
Summary: The research reveals that Brg1 plays a critical role in B cell proliferation and germinal center formation through selective interactions with enhancers. Recruitment of Brg1 to enhancers increases chromatin accessibility, leading to the regulation of gene expression associated with cell cycle and supporting B cell proliferation and the formation of germinal center reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Reproductive Biology
Atefeh Abedini, David A. Landry, Angus D. Macaulay, Het Vaishnev, Ashna Parbhakar, Dalia Ibrahim, Reza Salehi, Vincent Maranda, Elizabeth Macdonald, Barbara C. Vanderhyden
Summary: The study investigates the role of BRG1 in female fertility using mutant mice. Depletion of Brg1 in granulosa cells causes sterility, while depletion in oocytes results in subfertility. These findings highlight the importance of BRG1 in regulating granulosa and oocyte functions during follicle growth and its necessity for oocyte developmental competence.
BIOLOGY OF REPRODUCTION
(2023)
Article
Chemistry, Medicinal
Chuanhe Yang, Yinan Wang, Michelle M. Sims, Yali He, Duane D. Miller, Lawrence M. Pfeffer
Summary: The study showed that PFI-3 can bind to BRDs in GBM cells, enhance the antiproliferative and cell death-inducing effects of TMZ in sensitive GBM cells, overcome chemoresistance in highly resistant GBM cells, and alter gene expression in GBM. Additionally, PFI-3 enhanced the anticancer effect of TMZ in an intracranial GBM animal model, leading to increased survival in animals with GBM tumors.
Article
Cell Biology
Bongwoo Kim, Yi Luo, Xiaoming Zhan, Zilai Zhang, Xuanming Shi, Jiaqing Yi, Zhenyu Xuan, Jiang Wu
Summary: The core subunit BRG1 of the SWI/SNF-like BAF ATP-dependent chromatin remodeling complexes regulates neuronal activity-induced enhancers by affecting enhancer activities and inducibility. BRG1 phosphorylation induced by neuronal stimulations modulates its interaction with transcription co-factors, potentially influencing transcription outcomes. Non-phosphorylatable BRG1 fails to efficiently induce activity-dependent genes, while phosphomimic BRG1 increases enhancer activity and inducibility.
Article
Gastroenterology & Hepatology
Yongjie Zhou, Yuwei Chen, Xiaoyun Zhang, Qing Xu, Zhenru Wu, Xiaoyue Cao, Mingyang Shao, Yuke Shu, Tao Lv, Changli Lu, Mingjun Xie, Tianfu Wen, Jiayin Yang, Yujun Shi, Hong Bu
Summary: This study found that high expression of Brg1 is associated with poor prognosis in patients with iCCA, and that Brg1 plays a critical role in promoting HPC expansion, liver fibrosis, and iCCA development, mainly dependent on the Wnt/β-catenin signaling pathway. Targeting Brg1-expressing HPCs may be a promising therapeutic approach for liver cirrhosis and iCCA.
Article
Oncology
Marie-Isabelle Glueckstein, Sebastian Dintner, Tim Tobias Arndt, Dmytro Vlasenko, Gerhard Schenkirsch, Abbas Agaimy, Gernot Mueller, Bruno Maerkl, Bianca Grosser
Summary: This study investigated the clinical relevance of immunohistochemical expression of SWI/SNF complex proteins in 477 adenocarcinomas of the stomach and gastroesophageal junction. It found that aberrant expression of the complex was present in 32% of cases and was associated with negative prognosis. Determination of SWI/SNF status in genomically stable tumors could help identify patients who might benefit from new therapeutic options.
Article
Cell Biology
Tapan Sharma, Monserrat Olea-Flores, Anthony N. Imbalzano
Summary: Skeletal muscle differentiation is regulated by the mSWI/SNF chromatin remodeling family, which also plays a role in the regulation of the Wnt signaling pathway. Knockdown experiments showed that BRG1 is a regulator of Wnt pathway components, and reactivation of the pathway rescued defects in myogenic gene expression caused by BRG1 knockdown. Chromatin immunoprecipitation provided mechanistic insight into the transcriptional regulation of Wnt pathway genes by BRG1 and beta-catenin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Chiara Gelmi, Robert M. Verdijk, Laurien E. Houtzagers, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, T. H. Khanh Vu, Martine J. Jager
Summary: MITF is an important regulator of melanogenesis and melanocyte development. MITF loss in uveal melanoma is associated with a shift in epithelial-to-mesenchymal transition factors and increased inflammation. Low MITF expression is also related to genetic changes such as monosomy 3/BAP1 loss and 8q gain/amplification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Oncology
Katerina Vickova, Lubica Ondrusova, Jiri Reda, Jiri Vachtenheim, Petra Zakova
Article
Dermatology
Jiri Vachtenheim, Lubica Ondrusova
EXPERIMENTAL DERMATOLOGY
(2015)
Article
Oncology
Katerina Vlckova, Jiri Reda, Lubica Ondrusova, Mohammad Krayem, Ghanem Ghanem, Jiri Vachtenheim
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Cell Biology
K. Vlckova, L. Ondrusova, J. Vachtenheim, J. Reda, P. Dundr, M. Zadinova, P. Zakova, P. Pouckova
CELL DEATH & DISEASE
(2016)
Correction
Biochemistry & Molecular Biology
Jiri Vachtenheim, Lubica Ondrusova, Jan Borovansky
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2010)
Meeting Abstract
Oncology
Jiri Vachtenheim, Jiri Reda, Lubica Ondrusova, Petra Zakova
Review
Dermatology
Jiri Vachtenheim, Jan Borovansky
EXPERIMENTAL DERMATOLOGY
(2010)
Article
Oncology
Blanka Sestakova, Lubica Ondrusova, Jiri Vachtenheim
PIGMENT CELL & MELANOMA RESEARCH
(2010)
Article
Multidisciplinary Sciences
Lubica Ondrusova, Jiri Vachtenheim, Jiri Reda, Petra Zakova, Kamila Benkova
Review
Biology
Jiri Vachtenheim, Lubica Ondrusova
Summary: Advanced melanoma is difficult to cure, with resistant cells developing universally and requiring further drug therapy. Multiple mechanisms lead to the development of resistance, emphasizing the need for personalized treatment. Combined therapy may be an effective approach to reducing drug resistance.
Meeting Abstract
Medicine, Research & Experimental
Katerina VIckova, Jiri Vachtenheim, Lubica Ondrusova, Jiri Reda, Pavel Dundr, Marie Zadinova
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)
Meeting Abstract
Biochemistry & Molecular Biology
L. Ondrusova, J. Vachtenheim, Z. Tuhackova
Meeting Abstract
Biochemistry & Molecular Biology
Z. Tuhackova, M. Vojtechova, J. Tureckova, E. Sloncova, J. Vachtenheim
Meeting Abstract
Biochemistry & Molecular Biology
Jiri Vachtenheim, Blanka Sestakova
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)