期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 391, 期 1, 页码 756-761出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.11.133
关键词
Glutathione peroxidase; Oxidative stress; Diabetes; OGT; OGA
资金
- Korean Government [R0A-2007-000-20011-0]
- Ministry of Education, Science and Technology [R31-2008-000-10086-0, KRF-2006-005-J04502]
Hyperglycemia. induces activation of glutathione peroxidase 1 (GPX1). an anti-oxidant enzyme essential for cell survival during oxidative stress. However, the mechanism of GPX1 activation is unclear. Here. we report that hyperglycemia-induced protein glycosylation by O-linked N-acetylglucosamine (O-GlcNAL) IS Crucial for activation of GPX1 and for its binding to c-Abl and Aig kinases. GPX1 itself is modified with O-GlcNAc on its C-terminus. We also demonstrate that pharmacological injection of the O-GlcNAcase inhibitor NTZ induces GPX1 activation in the Mouse liver Our findings suggest a crucial role for GPX1 and its O-GlcNAc modification in hyperglycemia and diabetes mellitus. (C) 2009 Elsevier Inc All rights reserved
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