Article
Veterinary Sciences
Marina Betancor, Belen Marin, Alicia Otero, Carlos Hedman, Antonio Romero, Tomas Barrio, Eloisa Sevilla, Jean-Yves Douet, Alvina Huor, Juan Jose Badiola, Olivier Andreoletti, Rosa Bolea
Summary: The transmission of atypical scrapie to cattle can lead to the emergence of BSE-like prion seeding activity, even though the infected cattle did not show clinical signs of prion disease.
VETERINARY RESEARCH
(2023)
Article
Neurosciences
Hasier Erana, Carlos M. Diaz-Dominguez, Jorge M. Charco, Enric Vidal, Ezequiel Gonzalez-Miranda, Miguel A. Perez-Castro, Patricia Pineiro, Rafael Lopez-Moreno, Cristina Sampedro-Torres-Quevedo, Leire Fernandez-Veiga, Juan Tasis-Galarza, Nuria L. Lorenzo, Aileen Santini-Santiago, Melisa Lazaro, Sandra Garcia-Martinez, Nuno Goncalves-Anjo, Maitena San-Juan-Ansoleaga, Josu Galarza-Ahumada, Eva Fernandez-Munoz, Samanta Giler, Mikel Valle, Glenn C. Telling, Marivi Geijo, Jesus R. Requena, Joaquin Castilla
Summary: This study presents a method that consistently induces spontaneous misfolding of recombinant PrP into prions within hours, providing unprecedented opportunities to investigate the mechanisms underlying sporadic prion diseases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mafalda Casanova, Carla Machado, Paula Tavares, Joao Silva, Christine Fast, Anne Balkema-Buschmann, Martin H. Groschup, Leonor Orge
Summary: Portugal was one of the first European countries to report cases of Atypical Scrapie (ASc), and they confirmed through murine bioassays that the ASc strain present in Portuguese sheep corresponds to ASc Nor98.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Maximo Sanz-Hernandez, Joseph D. Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Summary: The T183A variant of human PrP significantly enhances aggregation propensity, leading to amyloid formation under physiological conditions by the sole C-terminal domain of the protein. The study identified the structural characteristics of the misfolded intermediate promoting aggregation of T183A huPrP and the interactions preventing the population of this species in the wild-type protein, supporting the use of POM antibodies to suppress the aggregation of this amyloidogenic mutant.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Jonathan D. F. Wadsworth, Susan Joiner, Jacqueline M. Linehan, Kezia Jack, Huda Al-Doujaily, Helena Costa, Thea Ingold, Maged Taema, Fuquan Zhang, Malin K. Sandberg, Sebastian Brandner, Linh Tran, Turid Vikoren, Jorn Vage, Knut Madslien, Bjornar Ytrehus, Sylvie L. Benestad, Emmanuel A. Asante, John Collinge
Summary: This study investigated the zoonotic potential of CWD-infected Norwegian reindeer and moose by inoculating their brain tissue into transgenic mice overexpressing human prion protein. The results showed no evidence of prion transmission, indicating a low zoonotic potential for these isolates.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Veterinary Sciences
Eric D. Cassmann, Alexis J. Frese, Kelsey A. Becker, Justin J. Greenlee
Summary: The study found that the E211K genotype of H-BSE in cattle has a shorter incubation period in both homozygous and heterozygous forms, and the type of inoculum does not significantly affect the incubation period.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Suzanne Suleiman, Lynne I. McGuire, Angela Chong, Diane L. Ritchie, Aileen Boyle, Lee McManus, Fraser Brydon, Colin Smith, Richard Knight, Alison Green, Abigail B. Diack, Marcelo A. Barria
Summary: Three retrospective lymphoreticular tissue studies aimed to estimate the prevalence of vCJD in the UK following exposure to the BSE agent. The identification of positive specimens from both pre- and post-BSE-exposure periods raised questions about the nature and origin of the abnormal prion protein. The study successfully extracted and propagated infectious PrPSc from FFPE appendix tissue, providing a platform for further analysis of archived samples to evaluate the nature of the abnormal PrP detected.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Veterinary Sciences
Tyler A. Harm, Jodi D. Smith, Eric D. Cassmann, Justin J. Greenlee
Summary: The study evaluated the efficacy of different chemical treatments for scrapie inactivation, finding partial reduction in PrPSc immunoreactivity but also an impact on survival rate and incubation periods in experimental sheep.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Diego Sola, Rody Artigas, Diego R. Mediano, Pilar Zaragoza, Juan Jose Badiola, Inmaculada Martin-Burriel, Cristina Acin
Summary: Prion diseases are fatal neurodegenerative disorders caused by the conversion of cellular prion protein into an abnormal and misfolded isoform. The PRNP gene, which codes for PrP, plays a crucial role in the susceptibility and pathogenesis of prion diseases. This study discovered three novel PRNP polymorphisms in horses and predicted their potential impact on horse prion protein using computational programs. The findings suggest that changes in electrostatic potentials may lead to an increased propensity for amyloid aggregation.
VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Belen Marin, Alicia Otero, Severine Lugan, Juan Carlos Espinosa, Alba Marin-Moreno, Enric Vidal, Carlos Hedman, Antonio Romero, Marti Pumarola, Juan J. Badiola, Juan Maria Torres, Olivier Andreoletti, Rosa Bolea
Summary: Pigs may serve as a reservoir for C-BSE prions after exposure to atypical scrapie, supporting the emergence of C-BSE prions during interspecies passage of atypical scrapie.
SCIENTIFIC REPORTS
(2021)
Review
Virology
Jiyan Ma, Jingjing Zhang, Runchuan Yan
Summary: The generation of recombinant prions has provided valuable insights into the characteristics and effects of prions. Recombinant prions can exist in various misfolded conformations and have different outcomes when inoculated into wild-type animals. The ability to seed alone is not sufficient to determine prion activity, as authentic prions need to be both heritable and pathogenic. Research on recombinant prions is important for understanding the pathogenesis of prion diseases and the role of misfolded proteins in other neurodegenerative disorders.
Article
Clinical Neurology
Zhongyun Chen, Min Chu, Jing Zhang, Yu Kong, Kexin Xie, Yue Cui, Hong Ye, Li Liu, Junjie Li, Lin Wang, Liyong Wu
Summary: This study aimed to explore the clinical characteristics of sporadic fatal insomnia (sFI), assess its similarities and differences with fatal familial insomnia (FFI), and evaluate the influence of ethnicity on the phenotype of sFI patients. The results showed that sFI had a longer disease duration and a higher proportion of neuropsychiatric symptoms compared to FFI. Differences were also observed in MRI and EEG findings between sFI and FFI patients, especially in those with pathological changes associated with sporadic Creutzfeldt-Jakob disease. Moreover, there were variations in clinical characteristics based on ethnicity in sFI patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Hasier Erana, Beatriz San Millan, Carlos M. Diaz-Dominguez, Jorge M. Charco, Rosa Rodriguez, Irene Vieitez, Arrate Pereda, Rosa Yanez, Marivi Geijo, Carmen Navarro, Guiomar Perez de Nanclares, Susana Teijeira, Joaquin Castilla
Summary: Gerstmann-Straussler-Scheinker disease (GSS) is a rare neurodegenerative illness caused by pathogenic alterations in the prion protein (PrP) coding gene, leading to the formation of toxic prions and showing variability in clinical and neuropathological manifestations.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Zerui Wang, Kefeng Qin, Manuel V. Camacho, Ignazio Cali, Jue Yuan, Pingping Shen, Justin Greenlee, Qingzhong Kong, James A. Mastrianni, Wen-Quan Zou
Summary: The study provided evidence that CWD PrPSc can cross the species barrier to convert human PrP(C) into infectious PrPSc, leading to clinical prion disease in humanized transgenic mice.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Stefanie-Elisabeth Heumueller, Annika C. Hornberger, Alina S. Hebestreit, Andre Hossinger, Ina M. Vorberg
Summary: This translation provides an overview of the characteristics of prion invasion, replication, and dissemination, highlighting the unconventional nature of prions and their reliance on host cell machinery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Kristen A. Davenport, Davin M. Henderson, Jifeng Bian, Glenn C. Telling, Candace K. Mathiason, Edward A. Hoover
JOURNAL OF VIROLOGY
(2015)
Article
Microbiology
A. Christy Wyckoff, Sarah Kane, Krista Lockwood, Jeff Seligman, Brady Michel, Dana Hill, Aimee Ortega, Mihnea R. Mangalea, Glenn C. Telling, Michael W. Miller, Kurt Vercauteren, Mark D. Zabel
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Immunology
Sarah J. Kane, Taylor K. Farley, Elizabeth O. Gordon, Joshua Estep, Heather R. Bender, Julie A. Moreno, Jason Bartz, Glenn C. Telling, Matthew C. Pickering, Mark D. Zabel
JOURNAL OF IMMUNOLOGY
(2017)
Article
Cell Biology
Muhammad Waqas, Hye-Mi Lee, Jeeyoung Kim, Glenn Telling, Jin-Ki Kim, Dae-Hwan Kim, Chongsuk Ryou
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Yoshifumi Iwamaru, Candace K. Mathiason, Glenn C. Telling, Edward A. Hoover
Article
Multidisciplinary Sciences
Jifeng Bian, Vadim Khaychuk, Rachel C. Angers, Natalia Fernandez-Borges, Enric Vidal, Crystal Meyerett-Reid, Sehun Kim, Carla L. Calvi, Jason C. Bartz, Edward A. Hoover, Umberto Agrimi, Juergen A. Richt, Joaquin Castilla, Glenn C. Telling
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Medicine, Research & Experimental
Julie A. Moreno, Glenn C. Telling
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2018)
Article
Microbiology
Samia Hannaoui, Sara Amidian, Yo Ching Cheng, Camilo Duque Velasquez, Lyudmyla Dorosh, Sampson Law, Glenn Telling, Maria Stepanova, Debbie McKenzie, Holger Wille, Sabine Gilch
Article
Developmental Biology
Lindsay E. Parrie, Jenna A. E. Crowell, Glenn C. Telling, Richard A. Bessen
DEVELOPMENTAL BIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Kristen A. Davenport, Jeffrey R. Christiansen, Jifeng Bian, Michael Young, Joseph Gallegos, Sehun Kim, Aru Balachandran, Candace K. Mathiason, Edward A. Hoover, Glenn C. Telling
JOURNAL OF GENERAL VIROLOGY
(2018)
Article
Virology
Qi Yuan, Glenn Telling, Shannon L. Bartelt-Hunt, Jason C. Bartz
JOURNAL OF VIROLOGY
(2018)
Article
Multidisciplinary Sciences
Kristen A. Davenport, Clare E. Hoover, Jifeng Bian, Glenn C. Telling, Candace K. Mathiason, Edward A. Hoover
Article
Multidisciplinary Sciences
Adam Lyon, Charles E. Mays, Frank Borriello, Glenn C. Telling, Claudio Soto, Sandra Pritzkow
SCIENTIFIC REPORTS
(2019)
Review
Food Science & Technology
Antonia Ricci, Ana Allende, Declan Bolton, Marianne Chemaly, Robert Davies, Pablo Salvador Fernandez Escamez, Rosina Girones, Lieve Herman, Kostas Koutsoumanis, Roland Lindqvist, Birgit Norrung, Lucy Robertson, Giuseppe Ru, Moez Sanaa, Panagiotis Skandamis, Emma Snary, Niko Speybroeck, Benno Ter Kuile, John Threlfall, Helene Wahlstrom, Sylvie Benestad, Dolores Gavier-Widen, Michael W. Miller, Glenn C. Telling, Morten Tryland, Francesca Latronico, Angel Ortiz-Pelaez, Pietro Stella, Marion Simmons
Article
Food Science & Technology
Antonia Ricci, Ana Allende, Declan Bolton, Marianne Chemaly, Robert Davies, Pablo Salvador Fernandez Escamez, Rosina Girones, Lieve Herman, Kostas Koutsoumanis, Roland Lindqvist, Birgit Norrung, Lucy Robertson, Moez Sanaa, Panagiotis Skandamis, Emma Snary, Niko Speybroeck, Benno Ter Kuile, John Threlfall, Helene Wahlstrom, Sylvie Benestad, Dolores Gavier-Widen, Michael W. Miller, Giuseppe Ru, Glenn C. Telling, Morten Tryland, Angel Ortiz Pelaez, Marion Simmons
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)