期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 379, 期 2, 页码 368-373出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.12.074
关键词
Zyxin; LPP; Lipoma Preferred Partner; TRIP6; ZRP-1; Knockout; Migration; Fertility; Female lethality; Aberrant pregnancy
资金
- geconcerteerde onderzoeksacties [GOA-010-2002/2006, GOA/2006/13, GOA/2008/16]
- Scientific Research-Flanders [G.0290.7, KAN 1.5.108.02N, KAN 1.5.014.07]
- Fortis Bank Verzekeringen-programma voor Karlkeronderzock
- Foundation for Biochemical and Pharmaceutical Research and Education
- Belgian Federation against Cancer
- Fund for Scientific Research-Flanders and a recipient of a postdoctoraal beleidsmandaat van het BOF K.U.Leuven [PDM/06/253/BM]
LPP (Lipoma Preferred Partner) is a zyxin-related cell adhesion protein that is involved in the regulation of cell migration. We generated mice with a targeted disruption of the Lpp gene and analysed the importance of Lpp for embryonic development and adult functions. Aberrant Mendelian inheritance in heterozygous crosses suggested partial embryonic lethality of Lpp(-/-) females. Fertility of Lpp(-/-) males was proven to be normal, however, females from Lpp(-/-) x Lpp(-/-) crosses produced a strongly reduced number of offspring, probably due to a combination of female embryonic lethality and aberrant pregnancies. Apart from these developmental and reproductive abnormalities, Lpp(-/-) mice that were born reached adulthood without displaying any additional macroscopic defects. Oil the other hand, Lpp(-/-) mouse embryonic fibroblasts exhibited reduced migration capacity, reduced viability, and reduced expression of some Lpp interaction partners. Finally, we discovered a short nuclear form of Lpp, expressed mainly in testis via an alternative promoter. (c) 2008 Elsevier Inc. All rights reserved.
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